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公开(公告)号：WO2005032488A3
公开(公告)日：2005-05-12
申请号：PCT/US2004032921
申请日：2004-09-29
Applicant: PORTOLA PHARM INC , SCARBOROUGH ROBERT M , HUANG WOLIN , PANDEY ANJALI , BAUER SHAWN M , ZHANG XIAOMING , JIA ZHAOZHONG J
Inventor： SCARBOROUGH ROBERT M , HUANG WOLIN , PANDEY ANJALI , BAUER SHAWN M , ZHANG XIAOMING , JIA ZHAOZHONG J
IPC: A61K20060101 , A61K31/517 , A61P7/02 , C07D409/12 , C07D409/14
CPC classification number: C07D409/12 , C07D409/14
Abstract: 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
Abstract translation: 提供了2,4-二氧代-3-喹唑啉基芳基磺酰脲化合物，其用于抑制ADP-血小板聚集，特别是在治疗血栓形成和血栓形成相关病症或病症中。
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公开(公告)号：WO2012061418A3
公开(公告)日：2012-08-02
申请号：PCT/US2011058826
申请日：2011-11-01
Applicant: PORTOLA PHARM INC , JIA ZHAOZHONG J , SONG YONGHONG , XU QING , KANE BRIAN , BAUER SHAWN M , PANDEY ANJALI
Inventor： JIA ZHAOZHONG J , SONG YONGHONG , XU QING , KANE BRIAN , BAUER SHAWN M , PANDEY ANJALI
IPC: C07D213/82 , A61K31/455 , A61P35/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D495/04
CPC classification number: C07C237/42 , C07C237/30 , C07C2601/14 , C07D209/08 , C07D209/40 , C07D213/74 , C07D213/82 , C07D231/12 , C07D231/38 , C07D233/56 , C07D239/48 , C07D249/06 , C07D249/08 , C07D257/04 , C07D261/14 , C07D275/03 , C07D277/42 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
Abstract translation: 本发明涉及作为Syk激酶抑制剂的式I化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这类化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制Syk激酶活性的方法，抑制血小板聚集的方法以及预防或治疗一些 至少部分由Syk激酶活性介导的病症，如非霍奇金淋巴瘤。
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公开(公告)号：WO2014058921A3
公开(公告)日：2014-10-23
申请号：PCT/US2013063942
申请日：2013-10-08
Applicant: PORTOLA PHARM INC
Inventor： BAUER SHAWN M , JIA ZHAOZHONG J , SONG YONGHONG , PANDEY ANJALI
IPC: C07D239/02 , C07D239/48
CPC classification number: C07D405/14 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12
Abstract: Provided are substituted pyrimidinyl compounds for inhibition of JAK and/or Syk kinase, pharmaceutical compositions thereof, methods for inhibiting JAK and/or Syk kinase activity, and methods for treating conditions mediated at least in part by JAK and/or Syk kinase activity.
Abstract translation: 提供用于抑制JAK和/或Syk激酶的取代的嘧啶基化合物，其药物组合物，用于抑制JAK和/或Syk激酶活性的方法，以及用于治疗至少部分由JAK和/或Syk激酶活性介导的疾病的方法。
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公开(公告)号：WO2012061428A3
公开(公告)日：2012-10-11
申请号：PCT/US2011058838
申请日：2011-11-01
Applicant: PORTOLA PHARM INC , BAUER SHAWN M , SONG YONGHONG , XU QING , ROSE JACK W , JIA ZHAOZHONG J , KANE BRIAN , HUANG WOLIN , PANDEY ANJALI , MEHROTRA MUKUND
Inventor： BAUER SHAWN M , SONG YONGHONG , XU QING , ROSE JACK W , JIA ZHAOZHONG J , KANE BRIAN , HUANG WOLIN , PANDEY ANJALI , MEHROTRA MUKUND
IPC: C07D213/82 , A61K31/455 , A61P35/00 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
CPC classification number: C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods ofinhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
Abstract translation: 本发明涉及作为JAK激酶抑制剂的式I化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制JAK激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗多种 至少部分由JAK激酶活性介导的病症，例如不期望的血栓形成和非霍奇金淋巴瘤。
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公开(公告)号：WO2009131687A3
公开(公告)日：2010-01-07
申请号：PCT/US2009002512
申请日：2009-04-22
Applicant: PORTOLA PHARM INC , SONG YONGHONG , XU QING , BAUER SHAWN M , JIA ZHAOZHONG J , MEHROTRA MUKUND , PANDEY ANJALI
Inventor： SONG YONGHONG , XU QING , BAUER SHAWN M , JIA ZHAOZHONG J , MEHROTRA MUKUND , PANDEY ANJALI
IPC: C07D239/48 , A61K31/506 , A61K31/52 , A61P9/00 , A61P29/00 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/04 , C07D473/16
CPC classification number: C07D471/04 , C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D473/16
Abstract: The present invention is directed to compounds of formula (I)-(II) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
Abstract translation: 本发明涉及作为syk和/或JAK激酶抑制剂的式（I） - （II）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制性syk和/或JAK激酶活性的方法，抑制血小板聚集的方法以及预防方法 或治疗至少部分通过syk和/或JAK激酶活性介导的许多病症，例如不期望的血栓形成和非霍奇金淋巴瘤。
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Patent Agency Ranking
公开(公告)号：WO2013192049A3
公开(公告)日：2014-02-13
申请号：PCT/US2013046006
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , KANE BRIAN , ROSE JACK , BAUER SHAWN M , SONG YONGHONG , XU QING , PANDEY ANJALI
IPC: A01N43/64 , A01N43/707 , A61K31/53
CPC classification number: C07D253/075 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
Abstract translation: 提供用于抑制Syk激酶的三嗪化合物，用于制备这种化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法，以及至少部分地通过Syk激酶活性介导的病症的治疗方法。
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公开(公告)号：WO2013192046A2
公开(公告)日：2013-12-27
申请号：PCT/US2013045987
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： SONG YONGHONG , XU QING , SRAN ARVINDER , BAUER SHAWN M , JIA ZHAOZHONG J , KANE BRIAN , PANDEY ANJALI
IPC: A61K31/4709 , C07D401/02
CPC classification number: C07D417/12 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: Provided are picolinamide compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
Abstract translation: 提供了用于抑制Syk激酶的吡啶酰胺化合物，用于制备这种化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法，以及用于至少部分地通过Syk激酶活性介导的病症的治疗方法。
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公开(公告)号：WO2009136995A2
公开(公告)日：2009-11-12
申请号：PCT/US2009002401
申请日：2009-04-16
Applicant: PORTOLA PHARM INC , JIA ZHAOZHONG J , VENKATARAMANI CHANDRASEKAR , HUANG WOLIN , MEHROTRA MUKUND , SONG YONGHONG , XU QING , BAUER SHAWN M , PANDEY ANJALI
Inventor： JIA ZHAOZHONG J , VENKATARAMANI CHANDRASEKAR , HUANG WOLIN , MEHROTRA MUKUND , SONG YONGHONG , XU QING , BAUER SHAWN M , PANDEY ANJALI
IPC: C07D239/48 , A61K31/506 , A61P9/00 , A61P35/00 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC classification number: C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: The present invention is directed to compounds of formula I-V and tattooers thereof or pharmaceutically acceptable salts, esters, and pro drugs thereof which are inhibitors of sky kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
Abstract translation: 本发明涉及作为天sky素抑制剂的式I-V化合物及其纹身或其药学上可接受的盐，酯和其前体药物。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制syk激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗数字的方法 至少部分通过syk激酶活性介导的病症，例如不期望的血栓形成和非霍奇金淋巴瘤。
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公开(公告)号：EP2782580A4
公开(公告)日：2015-10-07
申请号：EP12851734
申请日：2012-11-23
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , KANE BRIAN , XU QING , BAUER SHAWN M , SONG YONGHONG , PANDEY ANJALI , DICK RYAN
IPC: A61K31/506 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07H13/12
CPC classification number: C07H15/26 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07H13/12
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10.发明公开
公开(公告)号：EP1668002A4
公开(公告)日：2006-12-20
申请号：EP04789522
申请日：2004-09-29
Applicant: PORTOLA PHARM INC
Inventor： SCARBOROUGH ROBERT M , HUANG WOLIN , PANDEY ANJALI , BAUER SHAWN M , ZHANG XIAOMING , JIA ZHAOZHONG J
IPC: C07D409/12 , A61K20060101 , A61K31/517 , A61P7/02 , C07D409/14
CPC classification number: C07D409/12 , C07D409/14
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