公开(公告)号：CA2960692C

公开(公告)日：2019-09-24

申请号：CA2960692

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present specification is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present specification is also directed to intermediates used in making such compounds, the preparation of such a compound, methods for inhibition of syk and/or JAK kinase activity, methods for inhibition of the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma. The present specification is also directed to pharmaceutical compositions containing such a compound and which are formulated for topical administration.

公开(公告)号：CY1118559T1

公开(公告)日：2017-07-12

申请号：CY161101026

申请日：2016-10-13

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: ΗπαρούσαεφεύρεσηαναφέρεταισεενώσειςτουτύπουΙ-ΙΙκαιταφαρμακευτικάαποδεκτάταυτομερή, άλατα, ήταστερεοϊσομερήαυτών, ταοποίαείναιαναστολείςτηςκινάσης Syk και/ή JAK. Ηπαρούσαεφεύρεσηεπίσηςαναφέρεταισεενδιάμεσαπουχρησιμοποιούνταιστηνσύνθεσητέτοιωνενώσεων, τηνπαρασκευήμίαςτέτοιαςένωσης, τιςφαρμακευτικέςσυνθέσειςπουπεριέχουνμίατέτοιαένωση, τιςμεθόδουςαναστολήςτηςδραστικότηταςτηςκινάσης Syk και/ή JAK, τιςμεθόδουςαναστολήςτηςσυσσωμάτωσηςτωναιμοπεταλίων, καιτιςμεθόδουςγιατηνπρόληψηή τηθεραπείαενόςαριθμούπαθήσεωνπουπροκαλούνταιτουλάχιστονενμέρειαπότηνδραστικότητατηςκινάσης Syk και/ή JAK, όπωςη καρδιαγγειακήνόσος, ηφλεγμονώδηςνόσος, ηαυτοάνοσηνόσοςκαιη πολλαπλασιαστικήδιαταραχήκυττάρων, ηθρόμβωση, ηαλλεργία, τοάσθμα, ηρευματοειδήςαρθρίτιδα, ηλευχαιμία, ήτολέμφωμαμη-Hodgkin.

公开(公告)号：CA2723205C

公开(公告)日：2017-03-14

申请号：CA2723205

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation,and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.

公开(公告)号：LT2321283T

公开(公告)日：2016-12-12

申请号：LT09755219

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：NZ625114A

公开(公告)日：2016-02-26

申请号：NZ62511412

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M

IPC: A61K31/4965 ,  C07D241/20 ,  C07D241/28

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：HK1201460A1

公开(公告)日：2015-09-04

申请号：HK15102026

申请日：2015-02-28

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K20060101

公开(公告)号：CL2014001346A1

公开(公告)日：2015-03-13

申请号：CL2014001346

申请日：2014-05-22

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  A61K31/4965 ,  A61P9/00 ,  A61P35/00

Abstract: COMPUESTOS DERIVADOS DE 3-AMINO-5-[(2-AMINO-2-OXOETIL)AMINO]PIRAZINA-2-CARBOXAMIDA, INHIBIDORES DE PIRAZINA QUINASA; COMPOSICIÓN Y MÉTODO PARA TRATAR UNA AFECCIÓN COMO ENFERMEDAD CARDIOVASCULAR, TRASTORNO DE PROLIFERACIÓN, ENTRE OTROS

公开(公告)号：MX2014006242A

公开(公告)日：2014-10-06

申请号：MX2014006242

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI ,  KANE BRIAN ,  JIA ZHAOZHONG J

IPC: A61K31/4965

Abstract: En la presente se proporcionan compuestos de pirazina para inhibir cinasa Syk, los intermedios utilizados para realizar dichos compuestos, métodos para su preparación, composiciones farmacéuticas de estos, métodos para inhibir la actividad de cinasa Syk, y métodos para tratar afecciones mediadas al menos en parte por la actividad cinasa Syk.

公开(公告)号：CA3094793A1

公开(公告)日：2013-05-30

申请号：CA3094793

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  A61K31/395 ,  A61K31/495 ,  A61K31/497 ,  C07D241/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

公开(公告)号：AU2011323484A1

公开(公告)日：2013-05-09

申请号：AU2011323484

申请日：2011-11-01

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D213/82 ,  A61K31/455 ,  A61P35/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D495/04

Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.