公开(公告)号：RS59000B1

公开(公告)日：2019-08-30

申请号：RSP20190841

申请日：2014-10-31

Applicant: REGENERON PHARMA ,  UNIV HEALTH NETWORK UHN

Inventor： PURCELL NGAMBO LISA ARLEEN ,  HIGGINS SARAH J ,  KAIN KEVIN C

IPC: A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K39/395 ,  A61P33/06

公开(公告)号：HUE043194T2

公开(公告)日：2019-08-28

申请号：HUE14854037

申请日：2014-10-17

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  FEHER MIKLOS ,  PAULS HEINZ W

IPC: A61P35/00

公开(公告)号：HK1254968A1

公开(公告)日：2019-08-02

申请号：HK18114075

申请日：2018-11-05

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  NOSTRO MARIA CRISTINA ,  HOLTZINGER AUDREY ,  SARANGI FARIDA

IPC: C12N20060101 ,  C12Q20060101

公开(公告)号：CA2803446C

公开(公告)日：2019-06-04

申请号：CA2803446

申请日：2011-07-04

Applicant: UNIV HEALTH NETWORK

Inventor： PAN GUOHUA ,  MASON JACQUELINE M ,  WEI XIN ,  FEHER MIKLOS

IPC: A61K31/496 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4439 ,  A61P35/00

Abstract: Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation. In particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.

公开(公告)号：AU2014324043B2

公开(公告)日：2019-05-09

申请号：AU2014324043

申请日：2014-08-06

Applicant: UNIV HEALTH NETWORK UHN TECHNOLOGY DEVELOPMENT AND COMMERCIALIZATION

Inventor： MONNIER PHILIPPE P ,  TASSEW NARDOS G

IPC: C07K14/705 ,  A61K31/137 ,  A61K38/17 ,  A61K39/395 ,  A61P9/10 ,  A61P25/00 ,  C07K14/435 ,  G01N33/53

Abstract: Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent may include blocking the cis interaction between RGMa and Neogenin and/or disrupting lipid rafts. In turn, this promotes neuronal cell survival and axon growth and/or regeneration. Also disclosed herein is a method of treating a disease in a subject in need thereof. The method may include administering the agent to the subject. Further disclosed herein is a method of identifying an agent that modulates the cis interaction between RGMa and Neogenin.

公开(公告)号：SI3057965T1

公开(公告)日：2019-04-30

申请号：SI201431110

申请日：2014-10-17

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  FEHER MIKLOS ,  PAULS HEINZ W

IPC: C07D413/00 ,  A61K31/00 ,  A61P35/00

公开(公告)号：AU2017272172B2

公开(公告)日：2019-04-04

申请号：AU2017272172

申请日：2017-12-05

Applicant: UNIV HEALTH NETWORK

Inventor： TUSCHE MICHAEL W ,  MAK TAK W ,  OHASHI PAMELA S ,  LANG PHILIPP ,  LANG KARL ,  BRENNER DIRK ,  LIN GLORIA

IPC: A61K38/17 ,  A61P3/10 ,  A61P19/02 ,  A61P37/00

Abstract: METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.

公开(公告)号：IL264173D0

公开(公告)日：2019-02-28

申请号：IL26417319

申请日：2019-01-09

Applicant: UNIV HEALTH NETWORK

IPC: A61K20060101

Abstract: The present invention relates to a novel co-crystal of the compound of formula (I):wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.

公开(公告)号：PT2291640T

公开(公告)日：2019-02-26

申请号：PT09749361

申请日：2009-05-20

Applicant: UNIV HEALTH NETWORK

Inventor： RALPH SEBASTIAN DACOSTA ,  BRIAN C WILSON ,  KAI ZHANG

IPC: G01N21/64 ,  A61B5/1455 ,  A61B6/00 ,  A61B10/02 ,  A61G99/00 ,  A61M16/00 ,  A61N5/06 ,  G01N21/94 ,  G01N33/02 ,  G01N33/15 ,  G01N33/52

公开(公告)号：TR201901658T4

公开(公告)日：2019-02-21

申请号：TR201901658

申请日：2009-05-20

Applicant: UNIV HEALTH NETWORK

Inventor： RALPH SEBASTIAN DACOSTA ,  BRIAN C WILSON ,  KAI ZHANG

IPC: A61B5/1455 ,  A61B10/02 ,  A61B6/00 ,  A61G99/00 ,  A61M16/00 ,  A61N5/06 ,  G01N21/64 ,  G01N21/94 ,  G01N33/02 ,  G01N33/15 ,  G01N33/52

Abstract: Floresan bazlı görüntüleme ve izleme için bir cihaz ve metot açıklanmaktadır. Özellikle, cihaz ve metot, hem insan hem de hayvan uygulamaları için yara bakımı gibi biyokimyasal ve/ veya biyolojik ve biyolojik olmayan maddelerin izlenmesi için uygun olabilir.