公开(公告)号：NO20076553L

公开(公告)日：2008-02-19

申请号：NO20076553

申请日：2007-12-19

Applicant: ARRAY BIOPHARMA INC

Inventor： TOPALOV GEORGE ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD

IPC: C07D487/04 ,  A61K31/4985 ,  A61P35/00

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：NO20076553A

公开(公告)日：2008-02-19

申请号：NO20076553

申请日：2007-12-19

Applicant: ARRAY BIOPHARMA INC

Inventor： TOPALOV GEORGE ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD

IPC: C07D487/04 ,  A61K31/4985 ,  A61P35/00

CPC classification number: C07D487/04

公开(公告)号：CA2620864A1

公开(公告)日：2007-03-08

申请号：CA2620864

申请日：2006-08-31

Applicant: ARRAY BIOPHARMA INC

Inventor： WENGLOWSKY STEVEN MARK ,  REN LI ,  LYSSIKATOS JOSEPH P ,  SCHLACTER STEPHEN T ,  MIKNIS GREG ,  RAST BRYSON ,  LAIRD ELLEN ,  TARLTON EUGENE ,  BUCKMELTER ALEXANDRE J

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：CA2609299A1

公开(公告)日：2006-11-23

申请号：CA2609299

申请日：2006-05-18

Applicant: ARRAY BIOPHARMA INC

Inventor： TOPALOV GEORGE ,  LYSSIKATOS JOSEPH P ,  NEWHOUSE BRAD ,  HANSEN JOSH ,  LAIRD ELLEN ,  WELCH MIKE ,  GRINA JONAS

IPC: C07D487/04 ,  A61K31/4985 ,  A61P35/00

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：AU2005295403A1

公开(公告)日：2006-04-27

申请号：AU2005295403

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  ALLEN SHELLEY ,  WALLACE ELI M ,  LAIRD ELLEN ,  AICHER TOM ,  ROBINSON JOHN ,  ZHAO QIAN ,  HANS JEREMY

IPC: A61K38/04 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/675 ,  C07D413/04 ,  C07D417/04

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：MY191016A

公开(公告)日：2022-05-28

申请号：MYPI2017702034

申请日：2015-12-04

Applicant: ARRAY BIOPHARMA INC ,  CELGENE CORP

Inventor： HICKEN ERIK JAMES ,  ALLEN SHELLEY ,  BOYS MARK LAURENCE ,  CHICARELLI MARK J ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GAUDINO JOHN ,  HINKLIN RONALD JAY ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  ROBINSON JOHN E ,  TANG TONY P ,  BURGESS LAURENCE E ,  RIEGER ROBERT ANDREW ,  PHENEGER JED ,  SATOH YOSHITAKA ,  LEFTHERIS KATERINA ,  RAHEJA RAJ K ,  BENNETT BRYDON L

IPC: C07D487/04 ,  A61K31/4985 ,  A61P29/00 ,  A61P37/00

Abstract: Compounds of Formula I: I and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

公开(公告)号：ECSP21093541A

公开(公告)日：2022-01-31

申请号：ECDI202193541

申请日：2021-12-28

Applicant: ARRAY BIOPHARMA INC

Inventor： METCALF ANDREW T ,  COOK ADAM W ,  MORENO DAVID A ,  PRIGARO BRETT JOSEPH ,  LAIRD ELLEN ,  BARBOUR PATRICK ,  PAJK SPENCER PHILLIP ,  NEWHOUSE BRADLEY JON ,  BROWN KATIE KEATON ,  HICKEN ERIK JAMES ,  TARLTON EUGENE ,  REN LI ,  KAHN DEAN RUSSELL

IPC: C07D239/90 ,  A61K31/517 ,  A61P35/00 ,  C07C271/28 ,  C07D239/91 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12

Abstract: Se adjunta resumen de la invención

公开(公告)号：CL2021000467A1

公开(公告)日：2021-10-22

申请号：CL2021000467

申请日：2021-02-24

Applicant: ARRAY BIOPHARMA INC

Inventor： HINKLIN RONALD JAY ,  ALLEN SHELLEY ,  BARBOUR PATRICK ,  COOK ADAM ,  DAHLKE JOSHUA ,  GAUDINO JOHN ,  LAIRD ELLEN ,  MCNULTY OREN T ,  ZHAO QIAN

IPC: A61K31/437 ,  A61P35/00 ,  C07D471/04

Abstract: La presente invención se refiere a compuestos de la Fórmula I: I y estereoisómeros, tautómeros y sales de los mismos farmacéuticamente aceptables, en donde R1, R2, R9, X1 y G son como se definen en la presente, los cuales son inhibidores de una o más cinasas TAM y/o cinasa c-Met, y son útiles en el tratamiento y prevención de enfermedades las cuales pueden ser tratadas con un inhibidor de cinasa TAM y/o un inhibidor de cinasa c-Met.

公开(公告)号：HUE054371T2

公开(公告)日：2021-09-28

申请号：HUE15819933

申请日：2015-12-04

Applicant: ARRAY BIOPHARMA INC ,  CELGENE CORP

Inventor： ALLEN SHELLEY ,  BOYS MARK LAURENCE ,  CHICARELLI MARK J ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GAUDINO JOHN ,  HICKEN ERIK JAMES ,  HINKLIN RONALD JAY ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  ROBINSON JOHN E ,  TANG TONY P ,  BURGESS LAURENCE E ,  RIEGER ROBERT ANDREW ,  PHENEGER JED ,  SATOH YOSHITAKA ,  LEFTHERIS KATERINA ,  RAHEJA RAJ K ,  BENNETT BRYDON L

IPC: C07D487/04 ,  A61P29/00 ,  A61P37/00

公开(公告)号：PH12021500017A1

公开(公告)日：2021-09-13

申请号：PH12021500017

申请日：2021-02-23

Applicant: ARRAY BIOPHARMA INC

Inventor： HINKLIN RONALD JAY ,  ALLEN SHELLEY ,  BARBOUR PATRICK ,  COOK ADAM ,  DAHLKE JOSHUA ,  GAUDINO JOHN ,  LAIRD ELLEN ,  MCNULTY OREN T ,  ZHAO QIAN

IPC: A61K31/437 ,  A61P35/00 ,  C07D471/04

Abstract: Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.