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公开(公告)号：AU4605999A
公开(公告)日：1999-12-30
申请号：AU4605999
申请日：1999-06-04
Applicant: BASF AG
Inventor： KOCK MICHAEL , HOGER THOMAS , KROGER BURKHARD , OTTERBACH BERND , LUBISCH WILFRIED , LEMAIRE HANS-GEORG
IPC: A01K67/027 , A61K38/00 , A61K38/45 , A61K48/00 , A61K49/00 , A61P43/00 , C07K14/455 , C12N1/15 , C12N1/19 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/54 , C12Q1/68 , G01N33/53 , C12N15/10 , A61K31/70
Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.
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公开(公告)号：MX9604382A
公开(公告)日：1997-10-31
申请号：MX9604382
申请日：1995-03-20
Applicant: BASF AG
Inventor： STERRER SYLVIA , ULTECH ANDREAS , HOGER THOMAS , LEMAIRE HANS-GEORG , BACH ALFRED
IPC: G01N33/566 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91
Abstract: La presente invencion se refiere a un proceso para la preparacion de líneas de células eucarioticas con expresion ectopica permanente de receptores de glutamato mediante la transformacion de las células con un ácido nucleico que codifica los receptores de glutamato, donde cuando menos una de las siguientes condiciones de cultivo se mantiene durante el establecimiento de la linea celular: a) cultivo de las células transformadas en un medio de cultivo que contiene un precursor de glutamato,b) cultivo de las células transformadas en presencia de un antagonista de receptor de glutamato, c) cultivo de las células transformadas en una primera fase en condiciones en las cuales se reprime la expresion de receptor de glutamato, y en una segunda fase en condiciones en las cuales se cancela dicha represion, y, la presente invencion se refiere también a las líneas celulares que pueden obtenerse de esta forma y al uso de las mismas.
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公开(公告)号：CA2182618A1
公开(公告)日：1995-08-10
申请号：CA2182618
申请日：1995-01-27
Applicant: BASF AG
Inventor： HOEGER THOMAS , ULTSCH ANDREAS , BACH ALFRED , STERRER SYLVIA , LEMAIRE HANS-GEORG
IPC: G01N33/567 , C07K14/705 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , A61K31/70
Abstract: The invention pertains to new glutamate receptor subunits and DNA sequences coding for them and to methods for producing DNA sequences and receptors. The invention also pertains to methods for identifying functional ligands for these receptors.
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Patent Agency Ranking
公开(公告)号：ES2063350T3
公开(公告)日：1995-01-01
申请号：ES90906924
申请日：1990-05-04
Applicant: BASF AG
Inventor： LEMAIRE HANS-GEORG , HILLEN HEINZ , MOELLER ACHIM , DAUM LOTHAR , DOERPER THOMAS , SUBKOWSKI THOMAS
IPC: A61K35/22 , A61K38/00 , A61K38/17 , A61K38/19 , A61P7/00 , A61P7/02 , A61P7/04 , A61P11/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K1/18 , C07K1/22 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/525 , C07K14/715 , C07K16/18 , C07K15/14 , A61K35/12
Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
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公开(公告)号：HU208162B
公开(公告)日：1993-08-30
申请号：HU374090
申请日：1990-05-04
Applicant: BASF AG
Inventor： LEMAIRE HANS-GEORG , HILLEN HEINZ , MOELLER ACHIM , DAUM LOTHAR , DOERPER THOMAS , SUBKOWSKI THOMAS
IPC: A61K35/22 , A61K38/00 , A61K38/17 , A61K38/19 , A61P7/00 , A61P7/02 , A61P7/04 , A61P11/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K1/18 , C07K1/22 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/525 , C07K14/715 , C07K16/18 , C07K15/04 , C07K15/14 , A61K37/00 , A61K35/12
Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
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公开(公告)号：HUT58352A
公开(公告)日：1992-02-28
申请号：HU374090
申请日：1990-05-04
Applicant: BASF AG
Inventor： LEMAIRE HANS-GEORG , HILLEN HEINZ , MOELLER ACHIM , DAUM LOTHAR , DOERPER THOMAS , SUBKOWSKI THOMAS
IPC: A61K35/22 , A61K38/00 , A61K38/17 , A61K38/19 , A61P7/00 , A61P7/02 , A61P7/04 , A61P11/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K1/18 , C07K1/22 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/525 , C07K14/715 , C07K16/18 , C07K15/14 , A61K37/02
Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
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公开(公告)号：ZA9003475B
公开(公告)日：1992-01-29
申请号：ZA9003475
申请日：1990-05-08
Applicant: BASF AG
Inventor： LEMAIRE HANS-GEORG , HANS-GEORG LEMAIRE , HILLEN HEINZ , HEINZ HILLEN , MOELLER ACHIM , ACHIM MOELLER , DAUM LOTHAR , LOTHAR DAUM , DOERPER THOMAS , THOMAS DOERPER , SUBKOWSKI THOMAS , THOMAS SUBKOWSKI
IPC: C07K20060101 , C07K
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公开(公告)号：HU903740D0
公开(公告)日：1992-01-28
申请号：HU374090
申请日：1990-05-04
Applicant: BASF AG
Inventor： LEMAIRE HANS-GEORG , HILLEN HEINZ , MOELLER ACHIM , DAUM LOTHAR , DOERPER THOMAS , SUBKOWSKI THOMAS
IPC: A61K35/22 , A61K38/00 , A61K38/17 , A61K38/19 , A61P7/00 , A61P7/02 , A61P7/04 , A61P11/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K1/18 , C07K1/22 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/525 , C07K14/715 , C07K16/18
Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
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