公开(公告)号：CA1271489A

公开(公告)日：1990-07-10

申请号：CA527727

申请日：1987-01-20

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KARBACH STEFAN ,  RECKER HANS-GERT ,  THYES MARCO

IPC: C07C47/238 ,  C07C45/00 ,  C07C45/51 ,  C07C47/21 ,  C07C47/22 ,  C07C47/228 ,  C07C47/232 ,  C07C47/24 ,  C07C47/277 ,  C07C67/00 ,  C07D301/12 ,  C07D303/14 ,  C07D303/16 ,  C07D303/32 ,  C07C47/20 ,  C07C79/36

Abstract: Alpha,beta-substituted acroleins of the general formula I (I), where A and B are identical or different and are each C1-C4-alkyl, naphthyl, biphenyl or phenyl which may be monosubstituted or polysubstituted by halogen, nitro, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, phenoxy or phenylsulfonyl, are prepared by a process in which a compound of the general formula III ( III ), where A has the above meanings and R1 and R2 are identical or different and are each C1-C4-alkyl or together possess the carbon atoms required to complete a ring, is reacted with a phosphorus compound of the general formula IV or V (IV) (V), where B the meanings stated above, R1 and R2 are as defined above and X? is a halide ion, in the presence of a base. The alpha,beta-substituted acroleins can be further processed to give hydroxymethyloxiranes.

公开(公告)号：NO160258C

公开(公告)日：1989-03-29

申请号：NO823682

申请日：1982-11-05

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22

公开(公告)号：AU578739B2

公开(公告)日：1988-11-03

申请号：AU4783485

申请日：1985-09-24

Applicant: BASF AG

Inventor： FRICKEL FRITZ FRIEDER ,  NUERRENBACH AXEL ,  THYES MARCO

IPC: A61K31/41 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07D20060101 ,  C07D257/04

公开(公告)号：DE3644463A1

公开(公告)日：1988-07-07

申请号：DE3644463

申请日：1986-12-24

Applicant: BASF AG

Inventor： THYES MARCO ,  STEINER GERD

IPC: C07C63/331 ,  C07C51/00 ,  C07C51/353 ,  C07C63/66 ,  C07C63/74 ,  C07C65/28 ,  C07C67/00 ,  C07C201/00 ,  C07C205/06 ,  C07C205/56 ,  C07C253/00 ,  C07C255/50 ,  C07C255/57 ,  C07C121/64 ,  C07C79/46

Abstract: (Z)-2-(2-arylethenyl)arylcarboxylic acids of the general formula I (I) where A is a group for completing an aromatic ring system and Ar is an aromatic radical, are prepared by reacting a 2-formylarylcarboxylic acid of the general formula II (II) with an (arylmethyl)phosphonium salt of the general formula III (III) where R1, R2 and R3 are each organic radicals and X is halogen, in the presence of a base at from (-20 DEG ) to +30 DEG C. by carrying out the reaction in the presence of a C1-C5-alkanol and/or a C2-C4-alkanediol.

公开(公告)号：HU194169B

公开(公告)日：1988-01-28

申请号：HU437285

申请日：1985-11-15

Applicant: BASF AG

Inventor： HIMMELE WALTER ,  WIERSDORFF WALTER-WIELANT ,  THYES MARCO

IPC: C07D211/12 ,  C07D211/14 ,  C07D211/16 ,  C07D295/023

Abstract: Piperidines substituted in the 3- and/or 4-position are prepared by reacting a glutardialdehyde substituted in the 2- and/or 3-position with ammonia or a primary amine and hydrogen at elevated temperature and under superatmospheric pressure in the presence of a hydrogenation catalyst.

公开(公告)号：FI74955B

公开(公告)日：1987-12-31

申请号：FI823762

申请日：1982-11-03

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22

公开(公告)号：FI73425B

公开(公告)日：1987-06-30

申请号：FI822203

申请日：1982-06-18

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：ZA8605148B

公开(公告)日：1987-03-25

申请号：ZA8605148

申请日：1986-07-10

Applicant: BASF AG

Inventor： STEINER GERD ,  THYES MARCO

IPC: C07D333/00 ,  C07D409/14 ,  C07D495/14 ,  C07D

CPC classification number: C07D409/14 ,  C07D495/14

公开(公告)号：AU4783485A

公开(公告)日：1986-03-27

申请号：AU4783485

申请日：1985-09-24

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  NUERRENBACH AXEL ,  THYES MARCO

IPC: A61K31/41 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07D20060101 ,  C07D257/04

公开(公告)号：DK148536B

公开(公告)日：1985-07-29

申请号：DK257481

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: A61K31/50 ,  C07D237/04

Abstract: Novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are substituted in the p-position of the phenyl ring by a carbamate or thiocarbamate group, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders, and as anti-hypertensives.