公开(公告)号：EP3006077A1

公开(公告)日：2016-04-13

申请号：EP14804072.8

申请日：2014-05-29

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： HASHIMOTO, Eiji ,  MATSUDO, Toshiyuki ,  NISHIMURA, Shinpei ,  TOKUMOTO, Seiji

IPC: A61M37/00 ,  B81C1/00

CPC classification number: B05C15/00 ,  A61M37/0015 ,  A61M2037/0053 ,  B05C3/00 ,  B05C21/00 ,  B05D3/0486 ,  B81B2201/055 ,  B81C99/0025 ,  F24F3/14 ,  F24F3/1603

Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

Abstract translation: 本发明提供一种用于制造治疗性微针的系统，其构造成通过用含有药物的涂布液涂布微针来调节用于制造治疗性微针的涂布室内的空气环境，所述制造用微生物的制造系统包括空气压缩机， 配置为调节从空气压缩机供给的空气的湿度的湿度调节器，以及被配置为从供给到涂布室内部的空气中除去微生物的空气过滤器。

公开(公告)号：EP2586596A4

公开(公告)日：2015-01-21

申请号：EP11797981

申请日：2011-06-07

Applicant: JAPAN SCIENCE & TECH AGENCY

Inventor： IKUTA KOJI ,  IKEUCHI MASASHI

IPC: B29C67/00 ,  A61M37/00 ,  B81C1/00

CPC classification number: B29C67/0081 ,  A61M2037/0023 ,  A61M2037/0053 ,  B29C64/135 ,  B29L2031/7544 ,  B33Y10/00 ,  B33Y70/00 ,  B81B2201/055 ,  B81C1/00373 ,  B81C2201/0188 ,  Y10T428/2933 ,  Y10T428/31678

公开(公告)号：EP2586596A1

公开(公告)日：2013-05-01

申请号：EP11797981.5

申请日：2011-06-07

Applicant: Japan Science and Technology Agency

Inventor： IKUTA Koji ,  IKEUCHI Masashi

IPC: B29C67/00

CPC classification number: B29C67/0081 ,  A61M2037/0023 ,  A61M2037/0053 ,  B29C64/135 ,  B29L2031/7544 ,  B33Y10/00 ,  B33Y70/00 ,  B81B2201/055 ,  B81C1/00373 ,  B81C2201/0188 ,  Y10T428/2933 ,  Y10T428/31678

Abstract: Disclosed is a method for producing a three-dimensional polymer-metal complex microstructure including forming a polymer structure by stereolithography using a photocurable resin having a reactive group X and dipping it in a liquid of a metal-containing nanoparticle having a reactive group X' which is bound to the reactive group X, thereby forming a metal-containing layer on the polymer structure through binding the reactive group X and the reactive group X'.
According to this method, it is possible to produce a polymer-metal complex structure having a steric structure and to produce a three-dimensional polymer-metal complex microstructure which does not denature biomolecules in a metal complexation process.

公开(公告)号：EP2303766A2

公开(公告)日：2011-04-06

申请号：EP09770428.2

申请日：2009-06-24

Applicant: U-Needle Holding B.V.

Inventor： BERENSCHOT, Johan, Willem ,  WISSINK, Jeroen, Mathijn ,  TAS, Niels, Roelof ,  DE BOER, Meint, Jelle

IPC: B81B1/00

CPC classification number: A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B81B2201/055

Abstract: The present invention provides a microneedle, comprising a shaft of a monocrystalline material having at least three walls which are formed by a crystal plane of the monocrystalline material; and a tip connected to an end of the shaft comprising at least three walls which are formed by a crystal plane of the material. The material is preferably silicon. Two of the walls of the tip are formed by the same crystal planes as two walls of the shaft. These two walls are formed by a crystal plane. Preferably, three walls of the tip are formed by a crystal plane.

Abstract translation: 本发明提供一种微针，其包括具有由单晶材料的晶面形成的至少三个壁的单晶材料的轴; 以及连接到所述轴的端部的尖端，包括由所述材料的晶面形成的至少三个壁。 该材料优选为硅。 尖端的两个壁由与轴的两个壁相同的晶面形成。 这两个壁由<111>晶面形成。 优选地，尖端的三个壁由<111>晶面形成。

公开(公告)号：EP2100850A1

公开(公告)日：2009-09-16

申请号：EP08152571.9

申请日：2008-03-11

Applicant: Stichting voor de Technische Wetenschappen ,  UNIVERSITEIT TWENTE

Inventor： Lüttge, Regina ,  Bystrova, Svetlana Nikolajevna

IPC: B81C5/00 ,  A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

Abstract: The invention relates to a method of manufacturing of a microneedle array comprising the steps of using a filler material for replicating a prefabricated master mold to produce the microneedle array with pre-defined geometry, wherein for the filler material a water or alcohol based ceramic or polymer-ceramic slurry is selected. The invention further relates to a microneedle array 16.

Abstract translation: 本发明涉及一种制造微针阵列的方法，包括以下步骤：使用填充材料来复制预制的母模，以产生具有预定几何形状的微针阵列，其中对于填充材料，基于水或醇的陶瓷或聚合物 - 陶瓷浆料被选择。 本发明还涉及一种微针阵列16。

公开(公告)号：EP2060950A1

公开(公告)日：2009-05-20

申请号：EP07792659.0

申请日：2007-08-17

Applicant: Toppan Printing Co., Ltd.

Inventor： TOMONO, Takao

IPC: G03F7/20 ,  A61M5/31 ,  A61M37/00

CPC classification number: B81C1/00111 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B81B2201/055 ,  G03F7/201 ,  G03F7/2022 ,  Y10T428/24479

Abstract: A method of manufacturing a master plate includes the steps of forming a photoresist film on a substrate, disposing a photomask having a plurality of island radiation shields on the photoresist film followed by integrating the photomask and the photoresist film, applying light from a light source to the photoresist film through the photomask for selectively exposing the photoresist film, and developing the photoresist film to form a master plate, in which the method includes irradiating the photoresist film with the light from plural directions through the photomask to selectively expose the photoresist film from the respective directions.

Abstract translation: 通过INTEGRA婷光掩模和光致抗蚀剂膜，电影，来自光源的施加光制造主版的方法包括：形成光致抗蚀剂薄膜上的基材，设置具有冰岛辐射屏蔽的光致抗蚀剂的多个光掩模的步骤膜随后 光致抗蚀剂膜通过光掩模以选择性暴露所述光致抗蚀剂膜，电影，和显影光致抗蚀剂膜，以形成母盘，其中，所述方法包括：通过光掩模照射光致抗蚀剂膜与从多个方向的光选择性地从膜的暴露光致抗蚀剂 respectivement方向。

公开(公告)号：EP1985579A2

公开(公告)日：2008-10-29

申请号：EP08154893.5

申请日：2008-04-21

Applicant: Interuniversitair Microelektronica Centrum (IMEC) ,  Katholieke Universiteit Leuven

Inventor： Aarts, Arno ,  Neves, Hercules Pereira ,  Van Hoof, Chris ,  Beyne, Eric ,  Puers, Robert

IPC: B81C3/00

CPC classification number: B81C3/008 ,  A61B5/04001 ,  A61B5/0478 ,  A61B2562/125 ,  A61N1/0529 ,  A61N1/0531 ,  B81B2201/055 ,  Y10T29/49222

Abstract: In the present invention a device for sensing and/or actuation purposes is presented in which microstructures (20) comprising shafts (2) with different functionality and dimensions can be inserted in a modular way. That way out-of-plane connectivity, mechanical clamping between the microstructures (20) and a substrate (1) of the device, and electrical connection between electrodes (5) on the microstructures (20) and the substrate (1) can be realized. Also connections to external circuitry can be realised. Also microfluidic channels (10) in the microstructures (20) can be connected to external equipment. Also a method to fabricate and assemble the device is provided.

Abstract translation: 在本发明中，提供了用于感测和/或致动目的的装置，其中可以以模块化方式插入包括具有不同功能和尺寸的轴（2）的微结构（20）。 通过这种方式，可以实现平面外连接，微结构（20）和器件的衬底（1）之间的机械夹紧以及微结构（20）和衬底（1）上的电极（5）之间的电连接 。 还可以实现与外部电路的连接。 微结构（20）中的微流体通道（10）也可以连接到外部设备。 还提供了一种制造和组装该装置的方法。

公开(公告)号：EP1888454A2

公开(公告)日：2008-02-20

申请号：EP06772762.8

申请日：2006-06-08

Applicant: 3M Innovative Properties Company

Inventor： FREDERICKSON, Franklyn L. ,  FERGUSON, Dennis E.

IPC: B81C1/00 ,  B29C33/00

CPC classification number: B81C99/009 ,  B29C33/00 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

Abstract: The present invention is directed to a method of forming a mold for use in making molded articles having a plurality of microprojections. Additionally, the present invention provides a method of forming a molded article having a plurality of microprojections. In one aspect, a mold workpiece is provided, a tool having a tip with a shape corresponding to the microprojection, wherein the hardness of the tool is greater than that of the mold workpiece, is pressed into the mold workpiece and removed, thereby creating a mold with a microprojection cavity suitable for use in making the molded article.

公开(公告)号：EP1786580A1

公开(公告)日：2007-05-23

申请号：EP05771798.5

申请日：2005-08-16

Applicant: Fuctional Microstructures Limited

Inventor： KIRBY, Andrew James

IPC: B21G1/08 ,  A61M37/00 ,  B29C67/00

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C37/0053 ,  B29C64/135 ,  B29C2035/0827 ,  B29L2031/759 ,  B33Y80/00 ,  B81B2201/055

Abstract: A method of manufacturing microneedles is provided, the method comprising (i) depositing a substance onto a first surface and (ii) forming a solid needle-like shape from the substance. The substance may be deposited in non-solid form and subsequently solidified. A method of providing an array of such microneedles is also described.

Abstract translation: 一种包括具有一个或多个微针的基底的装置，所述微针可通过以下步骤生产：（i）将物质沉积在第一表面上，和（ii）从所述物质形成固体针状形状。

公开(公告)号：EP1086214A4

公开(公告)日：2007-05-02

申请号：EP99928580

申请日：1999-06-10

Applicant: GEORGIA TECH RES INST

Inventor： PRAUSNITZ MARK R ,  ALLEN MARK G ,  MCALLISTER DEVIN V ,  HENRY SEBASTIEN ,  CROS FLORENT PAUL MARCEL

IPC: C12N15/09 ,  A61B5/00 ,  A61B5/15 ,  A61B17/20 ,  A61K9/70 ,  A61M35/00 ,  A61M37/00 ,  A61N1/30 ,  B81C1/00 ,  C12N15/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B81B2201/055

Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers. In a preferred embodiment, the microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.