公开(公告)号：AU748711B2

公开(公告)日：2002-06-13

申请号：AU7997798

申请日：1998-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS ,  DROGEMULLER MICHAEL ,  BOMM VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C69/76 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  A61K7/44 ,  A61K31/165 ,  A61K31/215 ,  C07C57/48 ,  C07C57/30

Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.

公开(公告)号：AU742274B2

公开(公告)日：2001-12-20

申请号：AU3519397

申请日：1997-08-21

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMUELLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/40 ,  A61K8/49 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C255/40 ,  C07D307/52 ,  C07D317/54 ,  C07D333/24 ,  A61K7/42 ,  C07D333/22

Abstract: The use of compounds of formula (I) as UV-A filters in cosmetic products (optionally in combination with standard UV absorbers) to protect the human skin against sunlight is claimed. R1-R3 = H or (cyclo)aliphatic group containing up to 18 C, or two of these groups can combine to form a 5 or 6-membered ring ; R4 = optionally substituted (hetero)aryl containing 5-12 ring atoms ; and R5 = R4 or H. Also claimed are (i) cosmetic products containing (I) for protecting the epidermis layer against UV radiation with a wavelength of 280-400 nm and (ii) compounds of formula (II) : R7-R9 = lower alkyl ; R6 = 2-thienyl (optionally substituted with lower alkyl), 4-(3,5-di-t-butyl)-1-hydroxyphenyl or 4-(3,5-di-t-butyl)-1-alkoxyphenyl.

公开(公告)号：DE59607052D1

公开(公告)日：2001-07-12

申请号：DE59607052

申请日：1996-10-25

Applicant: BASF AG

Inventor： HOLDERBAUM MARTIN ,  AUMUELLER ALEXANDER ,  SPERLING KARIN ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/92 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

Abstract: PCT No. PCT/EP96/04637 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97/17054 PCT Pub. Date May 15, 1997A sunscreen-containing cosmetic formulation to protect the human epidermis from UV light in the range from 280 to 400 nm, which formulation includes a cosmetically suitable carrier, together with compounds which absorb in the UV-B region and as photostable UV-A filters effective amounts of compounds of the formula I as defined in the specification.

公开(公告)号：BR0002699A

公开(公告)日：2001-01-30

申请号：BR0002699

申请日：2000-06-19

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST

IPC: C07D233/64 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/49 ,  A61K47/22 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D239/70 ,  C07D263/56 ,  C07D277/64 ,  A61K7/40

Abstract: Use of new and known bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. Also new is their use for the protection of plastics. Use of bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. R and R = CN; alkylcarbonyl; alkoxycarbonyl; aryloxycarbonyl; or optionally substituted aminocarbonyl; R = H; 1-20C alkyl; 3-20C cycloalkyl; or -CH2-CH2-SO3 M ; M = cation; X = -O-; -S-; or -N(R )-; Z' = group of formula (ii) or (iii): R = H; alkyl, cycloalkyl, alkoxy, cycloalkoxy, alkoxycarbonyl, alkyl-NH-CO-, (alkyl)2-NH-CO-, alkyl-NH- or (alkyl)2N- (each with up to 20C); CN; NH2; or SO3 M and more than 1 R can be present. Independent claims are also included for: (1) the use of compounds (I) as light screening agents for the protection of plastics; (2) (I; Z' = (iii); and (3) (I; Z' = (ii); R4 = R40; R1, R2 = R10, R20 respectively) R and R = CN or 2-10C alkoxycarbonyl optionally substituted with -(CH2)n-SO3 M ; R = H; CH3; or -(CH2)n-SO3 M ; R = H; 1-8C alkyl; 1-8C alkoxy; or -SO3 M ; n = 2 or 3; M = H or HN(R )(R )(R ) ; R -R = H lower alkyl optionally substituted with OH; or a metal cation; but at least one -(CH2)n-SO3 M or -SO3 M must be present.

公开(公告)号：AU4089900A

公开(公告)日：2000-12-21

申请号：AU4089900

申请日：2000-06-16

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  PRECHTL FRANK DR ,  WUNSCH THOMAS DR ,  WESTENFELDER HORST

IPC: C07D233/64 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/49 ,  A61K47/22 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D239/70 ,  C07D263/56 ,  C07D277/64 ,  A61K31/498 ,  A61K31/538 ,  A61K31/5415 ,  A61K7/42

Abstract: Use of new and known bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. Also new is their use for the protection of plastics. Use of bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. R and R = CN; alkylcarbonyl; alkoxycarbonyl; aryloxycarbonyl; or optionally substituted aminocarbonyl; R = H; 1-20C alkyl; 3-20C cycloalkyl; or -CH2-CH2-SO3 M ; M = cation; X = -O-; -S-; or -N(R )-; Z' = group of formula (ii) or (iii): R = H; alkyl, cycloalkyl, alkoxy, cycloalkoxy, alkoxycarbonyl, alkyl-NH-CO-, (alkyl)2-NH-CO-, alkyl-NH- or (alkyl)2N- (each with up to 20C); CN; NH2; or SO3 M and more than 1 R can be present. Independent claims are also included for: (1) the use of compounds (I) as light screening agents for the protection of plastics; (2) (I; Z' = (iii); and (3) (I; Z' = (ii); R4 = R40; R1, R2 = R10, R20 respectively) R and R = CN or 2-10C alkoxycarbonyl optionally substituted with -(CH2)n-SO3 M ; R = H; CH3; or -(CH2)n-SO3 M ; R = H; 1-8C alkyl; 1-8C alkoxy; or -SO3 M ; n = 2 or 3; M = H or HN(R )(R )(R ) ; R -R = H lower alkyl optionally substituted with OH; or a metal cation; but at least one -(CH2)n-SO3 M or -SO3 M must be present.

公开(公告)号：AU3680199A

公开(公告)日：2000-06-08

申请号：AU3680199

申请日：1999-06-25

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  WUNSCH THOMAS ,  WESTENFELDER HORST

IPC: A61K47/06 ,  A61K8/00 ,  A61K8/30 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K31/00 ,  A61K31/075 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61P17/00 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/04 ,  C07C59/40 ,  C07C69/612 ,  C07C69/618 ,  C07C69/73 ,  C07C69/734 ,  C07C69/738 ,  C07C233/40 ,  C07C309/12 ,  C07C309/58 ,  C07C309/59 ,  C09K3/00 ,  A61K7/42 ,  A61K7/06 ,  C07C233/22

公开(公告)号：DE19828463A1

公开(公告)日：1999-12-30

申请号：DE19828463

申请日：1998-06-26

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K47/06 ,  A61K8/00 ,  A61K8/30 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K31/00 ,  A61K31/075 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61P17/00 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/04 ,  C07C59/40 ,  C07C69/612 ,  C07C69/618 ,  C07C69/73 ,  C07C69/734 ,  C07C69/738 ,  C07C233/40 ,  C07C309/12 ,  C07C309/58 ,  C07C309/59 ,  C09K3/00 ,  A61K7/08 ,  A61K7/44 ,  C07C233/22 ,  C07C233/35 ,  C07C235/34 ,  C07C255/00

公开(公告)号：AU706868B2

公开(公告)日：1999-06-24

申请号：AU7491996

申请日：1996-10-25

Applicant: BASF AG

Inventor： HOLDERBAUM MARTIN ,  AUMULLER ALEXANDER ,  SPERLING KARIN ,  WESTENFELDER HORST ,  WUNSCH THOMAS

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/92 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

Abstract: PCT No. PCT/EP96/04637 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97/17054 PCT Pub. Date May 15, 1997A sunscreen-containing cosmetic formulation to protect the human epidermis from UV light in the range from 280 to 400 nm, which formulation includes a cosmetically suitable carrier, together with compounds which absorb in the UV-B region and as photostable UV-A filters effective amounts of compounds of the formula I as defined in the specification.

公开(公告)号：DE19755650A1

公开(公告)日：1999-04-22

申请号：DE19755650

申请日：1997-12-15

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  HAREMZA SYLKE DR ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST ,  WUENSCH THOMAS DR

IPC: A61K8/40 ,  A61K31/275 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

公开(公告)号：DE19745506A1

公开(公告)日：1999-04-22

申请号：DE19745506

申请日：1997-10-15

Applicant: BASF AG

Inventor： SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST

IPC: A61K47/22 ,  A61K8/00 ,  A61K8/67 ,  A61K31/07 ,  A61Q5/00 ,  A61Q5/06 ,  A61Q19/00 ,  A61K7/48

Abstract: Ascorbyl-2'-phosphoric acid ester is used for preventing discoloration in cosmetic and pharmaceutical compositions containing vitamin A and/or vitamin A derivatives, without the lack of stability or unpleasant odour associated with known additives. The use of ascorbyl-2'-phosphoric acid ester is claimed for stabilizing vitamin A and/or vitamin A derivatives in cosmetic and pharmaceutical compositions.