公开(公告)号：CA2418972C

公开(公告)日：2010-03-23

申请号：CA2418972

申请日：2001-08-16

Applicant: BASF AG

Inventor： ISAK HEINZ ,  SENDHOFF NORBERT ,  SCHUTZ FRANZ ,  THERRE JORG ,  DROGEMULLER MICHAEL ,  FRANKE DIRK ,  MUNZINGER MANFRED ,  WECK ALEXANDER ,  BURKART KIRSTEN

IPC: C07D285/34 ,  A01N25/12 ,  A01N43/88

Abstract: A method for the production of a particle-containing preparation of tetrahydro-3,5-dimethyl-1,3,5-thiadiazin-2-thione, by combination of a first aqueous solution containing methylammonium-N-methyldithiocarbamate with a second solution containing formaldehyde and separation and drying of the solid formed is disclosed. The invention is characterised in that the first and second solutions are combined such that over the duration of the reaction the ratio of the concentration of dithiocarbamate functions and formaldehyde in the reaction mixture remains essentially constant over time.

公开(公告)号：AU9547501A

公开(公告)日：2002-02-25

申请号：AU9547501

申请日：2001-08-16

Applicant: BASF AG

Inventor： ISAK HEINZ ,  SENDHOFF NORBERT ,  SCHUTZ FRANZ ,  THERRE JORG ,  DROGEMULLER MICHAEL ,  FRANKE DIRK ,  MUNZINGER MANFRED ,  WECK ALEXANDER ,  BURKART KIRSTEN

IPC: A01N25/12 ,  A01N43/88 ,  C07D285/34

Abstract: Described is a process for the preparation of a particulate tetrahydro-3,5-dimethyl-1,3,5-thiadiazine-2-thione product by combining a first aqueous solution comprising methylammonium N-methyldithiocarbamate with a second aqueous solution comprising formaldehyde, followed by separation and drying of the resulting solid, which comprises combining the first and the second aqueous solutions in such a way that the ratio between the concentrations of dithiocarbamate functions and of formaldehyde is essentially constant in the reaction mixture over time during the duration of the reaction.

公开(公告)号：AU2003210356A1

公开(公告)日：2003-09-16

申请号：AU2003210356

申请日：2003-02-26

Applicant: BASF AG

Inventor： GUMBEL HELMUT ,  KNEUPER HEINZ-JOSEF ,  BECKER RAINER ,  BERTLEIN GERHARD ,  DROGEMULLER MICHAEL

IPC: A61K8/00 ,  A61K8/49 ,  A61Q17/04 ,  C07D251/70 ,  C07D251/54 ,  A61K7/44

Abstract: Process for the preparation of the tautomeric form I of 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine by crystallization from a tautomer mixture in the presence of one or more solvents chosen from the group consisting of aliphatic alcohols having 2 to 8 carbon atoms, aliphatic carboxylic alkyl esters having a total of 3 to 10 carbon atoms, aromatic carboxylic alkyl esters having a total of 8 to 12 carbon atoms, aliphatic carbonic esters having a total of 3 to 9 carbon atoms, carbonitriles having a total of 2 to 8 carbon atoms, dialkyl ketones having a total of 3 to 6 carbon atoms and aliphatic sulfones having a total of 3 to 6 carbon atoms, where the solvent or the solvent mixture may additionally comprise up to 30% by weight of a hydrocarbon. I is used as light protection agent in cosmetic preparations.

公开(公告)号：AU5210998A

公开(公告)日：1998-07-23

申请号：AU5210998

申请日：1998-01-16

Applicant: BASF AG

Inventor： DROGEMULLER MICHAEL ,  BOMM VOLKER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST

IPC: C07D215/42 ,  A61K8/00 ,  A61Q17/04 ,  C07C225/14 ,  C07C229/54 ,  C07C237/30 ,  C07C309/46 ,  C07C311/39 ,  C09K3/00 ,  C07C309/29 ,  C07C311/38 ,  A61K7/42 ,  A61K31/165 ,  A61K31/18 ,  A61K31/135 ,  A61K31/185 ,  A61K31/47

Abstract: Arylaminomethylene-camphor derivatives of formula (I) are new: R1 = H or Me; R2 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-6C alkenyl; 3-8C cycloalkenyl or aryl (optionally substituted); R3 = H, 1-6C alkyl, 3-8C cycloalkyl, aryl (optionally substituted), 1-6C alkoxy or 1-8C acyl; and Ar = aryl or heteroaryl (both optionally substituted); NB the double bond is Z or E configuration.

公开(公告)号：AU748711B2

公开(公告)日：2002-06-13

申请号：AU7997798

申请日：1998-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS ,  DROGEMULLER MICHAEL ,  BOMM VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C69/76 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  A61K7/44 ,  A61K31/165 ,  A61K31/215 ,  C07C57/48 ,  C07C57/30

Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.

公开(公告)号：AU7997798A

公开(公告)日：1999-02-25

申请号：AU7997798

申请日：1998-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS ,  DROGEMULLER MICHAEL ,  BOMM VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C69/76 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  A61K7/44 ,  A61K31/165 ,  A61K31/215 ,  C07C57/48 ,  C07C57/30

Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.

公开(公告)号：SK285932B6

公开(公告)日：2007-11-02

申请号：SK1922003

申请日：2001-08-16

Applicant: BASF AG

Inventor： ISAK HEINZ ,  SENDHOFF NORBERT ,  SCHUTZ FRANZ ,  THERRE JORG ,  DROGEMULLER MICHAEL ,  FRANKE DIRK ,  MUNZINGER MANFRED ,  WECK ALEXANDER ,  BURKART KIRSTEN

IPC: C07D285/00 ,  A01N25/00 ,  A01N25/12 ,  A01N43/00 ,  A01N43/88 ,  C07D285/34

Abstract: Described is a process for the preparation of a particulate tetrahydro-3,5-dimethyl-1,3,5-thiadiazine-2-thione product by combining a first aqueous solution comprising methylammonium N-methyldithiocarbamate with a second aqueous solution comprising formaldehyde, followed by separation and drying of the resulting solid, which comprises combining the first and the second aqueous solutions in such a way that the ratio between the concentrations of dithiocarbamate functions and of formaldehyde is essentially constant in the reaction mixture over time during the duration of the reaction, and separating the solid form the resulting suspension.

公开(公告)号：EA005202B1

公开(公告)日：2004-12-30

申请号：EA200300221

申请日：2001-08-16

Applicant: BASF AG

Inventor： ISAK HEINZ ,  SENDHOFF NORBERT ,  SCHUTZ FRANZ ,  THERRE JORG ,  DROGEMULLER MICHAEL ,  FRANKE DIRK ,  MUNZINGER MANFRED ,  WECK ALEXANDER ,  BURKART KIRSTEN

IPC: A01N25/12 ,  A01N43/88 ,  C07D285/34

Abstract: Визобретенииописываетсяспособполученияпорошковойкомпозициитетрагидро-3,5-диметил-1,3,5-тиадиазин-2-тиона, осуществляемыйпутемобъединениядвухводныхрастворов, одинизкоторыхсодержит N-метилдитиокарбаматметиламмония, адругойсодержитформальдегид, споследующимвыделениемобразовавшегосятвердогопродуктаи егосушкой. Такойспособотличаетсятем, чтопервыйи второйводныерастворыобъединяюттакимобразом, чтобысоотношениеконцентрацийфункциональныхгруппдитиокарбаматаи формальдегидав реакционнойсмесинапротяжениивсейреакцииоставалосьпрактическипостоянным.

公开(公告)号：SK1922003A3

公开(公告)日：2003-08-05

申请号：SK1922003

申请日：2001-08-16

Applicant: BASF AG

Inventor： ISAK HEINZ ,  SENDHOFF NORBERT ,  SCHUTZ FRANZ ,  THERRE JORG ,  DROGEMULLER MICHAEL ,  FRANKE DIRK ,  MUNZINGER MANFRED ,  WECK ALEXANDER ,  BURKART KIRSTEN

IPC: A01N25/12 ,  A01N43/88 ,  C07D285/34

Abstract: Described is a process for the preparation of a particulate tetrahydro-3,5-dimethyl-1,3,5-thiadiazine-2-thione product by combining a first aqueous solution comprising methylammonium N-methyldithiocarbamate with a second aqueous solution comprising formaldehyde, followed by separation and drying of the resulting solid, which comprises combining the first and the second aqueous solutions in such a way that the ratio between the concentrations of dithiocarbamate functions and of formaldehyde is essentially constant in the reaction mixture over time during the duration of the reaction.

公开(公告)号：CA2418972A1

公开(公告)日：2003-02-11

申请号：CA2418972

申请日：2001-08-16

Applicant: BASF AG

Inventor： BURKART KIRSTEN ,  WECK ALEXANDER ,  ISAK HEINZ ,  SENDHOFF NORBERT ,  FRANKE DIRK ,  MUNZINGER MANFRED ,  THERRE JORG ,  DROGEMULLER MICHAEL ,  SCHUTZ FRANZ

IPC: A01N25/12 ,  A01N43/88 ,  C07D285/34

Abstract: A method for the production of a particle-containing preparation of tetrahyd ro- 3,5-dimethyl-1,3,5-thiadiazin-2-thione, by combination of a first aqueous solution containing methylammonium-N-methyldithiocarbamate with a second solution containing formaldehyde and separation and drying of the solid form ed is disclosed. The invention is characterised in that the first and second solutions are combined such that over the duration of the reaction the ratio of the concentration of dithiocarbamate functions and formaldehyde in the reaction mixture remains essentially constant over time.