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    121.
    发明专利
    未知

    公开(公告)号：DE69027794D1

    公开(公告)日：1996-08-22

    申请号：DE69027794

    申请日：1990-02-14

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  JAMES MICHAEL K ,  BRACKEEN MARCUS F ,  JOHNSON MICHAEL ROSS ,  LEIGHTON HARRY JEFFERSON

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58 ,  C07D211/66

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    1,5-benzodiazepine compounds, their preparation and use, and pharmaceutical compositions containing them
    125.
    发明专利
    1,5-benzodiazepine compounds, their preparation and use, and pharmaceutical compositions containing them 未知

    公开(公告)号：IL113366D0

    公开(公告)日：1995-07-31

    申请号：IL11336695

    申请日：1995-04-13

    Applicant: GLAXO INC

    IPC: A61K31/55 ,  A61P1/00 ,  A61P1/16 ,  A61P3/04 ,  C07D243/12 ,  C07D401/04 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D498/04 ,  C07D

    Abstract: PCT No. PCT/EP95/01336 Sec. 371 Date Nov. 14, 1996 Sec. 102(e) Date Nov. 14, 1996 PCT Filed Apr. 13, 1995 PCT Pub. No. WO95/28391 PCT Pub. Date Oct. 26, 1995 (I) Benzo[b][1,4]diazepine compounds of formula (I), where R1 is selected from C1C6alkyl, C3-C6cycloalkyl, phenyl, or substituted phenyl; R2 is selected from C3-C6alkyl, C3C6cycloalkyl, C3-C6alkenyl, benzyl, phenylC1-C3alkyl of substituted phenyl; or NR1R2 together form 1,2,3,4-tetrahydroquinoline or benzazepine, mono-, di-, or trisubstituted independently with C1-6alkyl C1-6alkoxy or halogen substituents; p is an integer 0 or 1; q is an integer 0 or 1; r is an integer 0 or 1; t is an integer 0 or 1, provided that when r is 0 then t is 0; R3, R5, and R6 are independently hydrogen or C1-6alkyl; R4 is C1-6alkyl or C1-6alkenyl; R7 is selected from the group consisting of hydrogen, C1-6alkyl, C1-6cycloalkyl, C1-6alkenyl, phenyl, substituted phenyl, napthyl, heteroaryl, substituted heteroaryl, bicycloheteroaryl or substituted bicycloheteroaryl; or NR6R7 together form a saturated 5,6, or 7 membered ring optionally interrupted by 1,2,3 or 4 N, S or O heteroatoms, with the proviso that any two O or S atoms are not bonded to each other, m is an integer selected from the group of 0, 1, 2, 3 or 4; R8 and R9 are selected from a variety of substituents; Z is hydrogen or halogen; novel intermediates, a pharmaceutical composition for treating obesity, gall bladder stasis, disorders of pancreatic secretion, methods for such treatment and processes for preparing compounds of formula (I).

    Inhalation device
    126.
    发明专利
    Inhalation device 未知

    公开(公告)号：FI94593B

    公开(公告)日：1995-06-30

    申请号：FI884493

    申请日：1988-09-30

    Applicant: GLAXO INC

    Inventor： PALSON RICHARD CHARLES JULIUS ,  ARMSTRONG JOHN CREIGHTON

    IPC: A61M11/08 ,  A61M15/00 ,  A61M11/00

    Abstract: A device for dispensing an aerosol from an aerosol module A includes a cocking device comprising lever 36 and spring 60 for readying it for release of the pressurized aerosol, a sear 64 for retaining the cocking device in a non-operative position following readying and a vane 79 operable by inhalation on the part of a user to disable the sear to thus release the cocking device to effect expulsion of aerosol from the aerosol module.

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