公开(公告)号：KR1019970005298B1

公开(公告)日：1997-04-15

申请号：KR1019930009768

申请日：1993-06-01

Applicant: 한국화학연구원

Inventor： 김완주 ,  이태석 ,  남근수 ,  김봉진 ,  박명환 ,  하재두 ,  공재양

IPC: C07D471/04 ,  C07D401/04

Abstract: Novel quinoline derivatives(I) exhibiting superior antimicrobial activity and pharmaceutically acceptable salts thereof are prepared. The carboxyl group of the quinoline compound is activated by carboxylic acid-active reagent and reacted with compound having activated methylene group and alkali or alkali earth metals to give the title compound. In formula I, R1 is C1-3 lower alkyl, halogen-substituted lower alkyl, phenyl or halogen-substituted phenyl; R2 is H, lower alkyl or amino; R3 is halogen or (substituted) heterocyclic compound; X is N or C-R4(where, R4 is H, halogen, lower alkyl, or lower alkoxy); Y and Z are H, ester, cyano, nitro, acyl, (substituted) amido, lower alkylsulfoxy, or lower alkylsulfone group.

Abstract translation: 制备具有优异抗菌活性的新喹啉衍生物（I）及其药学上可接受的盐。 喹啉化合物的羧基被羧酸活性试剂活化，与具有活性亚甲基的化合物和碱金属或碱土金属反应，得到标题化合物。 在式I中，R 1是C 1-3低级烷基，卤素取代的低级烷基，苯基或卤素取代的苯基; R2是H，低级烷基或氨基; R3是卤素或（取代的）杂环化合物; X是N或C-R4（其中R4是H，卤素，低级烷基或低级烷氧基）; Y和Z是H，酯，氰基，硝基，酰基，（取代的）酰氨基，低级烷基亚磺酰基或低级烷基砜基。