公开(公告)号：AT190222T

公开(公告)日：2000-03-15

申请号：AT95942731

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：DE19839276A1

公开(公告)日：2000-03-02

申请号：DE19839276

申请日：1998-08-28

Applicant: BASF AG

Inventor： SPENGLER REINHARD ,  ROSENBERG JOERG

IPC: A61J3/06 ,  A61K9/20 ,  A61K9/28 ,  A61K47/04 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24

Abstract: The invention relates to a method for producing solid dosing forms by forming a plastic mixture comprised of at least one polymeric bonding agent, at least one active substance, and of optional common additives, and by shaping the plastic mixture into the solid dosing forms using a form tool. During shaping, an agent with modified surface properties is deposited on the surface of the plastic mixture in a finely dispersed manner. Said agent with modified surface properties is preferably a surfactant, a lipophilic compound, an antioxidant, a colorant or an agent with an antistatic action and/or lubricating action.

公开(公告)号：DE59309876D1

公开(公告)日：1999-12-23

申请号：DE59309876

申请日：1993-08-04

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.

公开(公告)号：DE59506608D1

公开(公告)日：1999-09-16

申请号：DE59506608

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

公开(公告)号：BR9711777A

公开(公告)日：1999-08-24

申请号：BR9711777

申请日：1997-09-11

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

Abstract: A process for producing solid dose forms by mixing at least one polymeric binder, with or without at least one active ingredient and with or without conventional additives, and shaping the mixture, where at least one of the components is employed in liquid form.

公开(公告)号：ZA9708219B

公开(公告)日：1999-03-12

申请号：ZA9708219

申请日：1997-09-12

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEFAN ,  ROSENBERG JOERG

IPC: A61K9/20 ,  A61K

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  A61K9/2086

公开(公告)号：NZ298414A

公开(公告)日：1999-02-25

申请号：NZ29841495

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JORG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：AU702198B2

公开(公告)日：1999-02-18

申请号：AU4434296

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

公开(公告)号：NZ302243A

公开(公告)日：1999-01-28

申请号：NZ30224396

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20 ,  A61K47/48

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：MX9805147A

公开(公告)日：1998-10-31

申请号：MX9805147

申请日：1998-06-24

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  ROSENBERG JOERG

IPC: A61K9/20 ,  A61K31/00 ,  A61K47/04 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00 ,  A61K09/20

Abstract: Preparaciones de analgésicos no esteroidales, con efecto antipirético y antiinflamatorio, se pueden obtener por la extrusion y configuracion de una masa fundida, que comprende, además de uno o más ingredientes activos, una mezcla de: a) 40-99.5% de un homopolímero de la N-vinilpirrolidona con un valor de Fikentscher K de 30, b) 0.25-59.75% en peso de copolímeros de N-vinilo solubles en agua y c) 0.25-20% en peso de una o más sales, aceptables fisiologicamente, de sodio o de potasio, donde las cantidades señaladas se basan en el total de los componentes a), b) y c).