公开(公告)号：WO02072047A3

公开(公告)日：2002-12-27

申请号：PCT/EP0201802

申请日：2002-02-20

Applicant: BASF AG ,  MEFFERT HELMUT ,  SANNER AXEL ,  TIEFENSEE KRISTIN ,  KOTHRADE STEPHAN

Inventor： MEFFERT HELMUT ,  SANNER AXEL ,  TIEFENSEE KRISTIN ,  KOTHRADE STEPHAN

IPC: A61K9/06 ,  A61K8/00 ,  A61K8/30 ,  A61K8/31 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/72 ,  A61K8/90 ,  A61K31/4164 ,  A61K47/32 ,  A61P17/16 ,  A61Q3/02 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q17/02 ,  A61Q19/00 ,  A61Q19/10 ,  C08F216/18 ,  C08F218/04 ,  C08F220/00 ,  C08F226/06 ,  C11D3/37 ,  A61K7/06 ,  A61K7/48

CPC classification number: A61Q19/00 ,  A61K8/90 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/10

Abstract: The invention relates to cosmetic or pharmaceutical agents having a liquid or gel consistency and containing at least one copolymer that, in turn, contains at least one N-vinyl lactam and at least one ethylenically unsaturated monomer with a longer-chain alkyl radical or alkenyl radical, said N-vinyl lactam and monomer being incorporated by polymerization in the copolymer. The invention also relates to the use of copolymers of the aforementioned type in cosmetic or pharmaceutical compositions.

Abstract translation: 本发明涉及的液体的凝胶状稠度的化妆品或药物组合物，其包含含有至少一种N-乙烯基内酰胺和具有长链烷基或链烯基共聚的至少一种烯属不饱和单体的至少一种共聚物。 本发明进一步涉及这种共聚物在化妆品或药物组合物中的用途。

公开(公告)号：WO9814164A3

公开(公告)日：1998-06-18

申请号：PCT/EP9705354

申请日：1997-09-29

Applicant: BASF AG ,  NIESSNER MANFRED ,  NILZ CLAUDIA ,  HOESSEL PETER ,  KOTHRADE STEPHAN ,  SANNER AXEL

Inventor： NIESSNER MANFRED ,  NILZ CLAUDIA ,  HOESSEL PETER ,  KOTHRADE STEPHAN ,  SANNER AXEL

IPC: A61K8/00 ,  A61K8/36 ,  A61K8/42 ,  A61K8/49 ,  A61K8/72 ,  A61K8/81 ,  A61K8/898 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  C08F226/02 ,  C08F226/06 ,  A61K7/06 ,  A61K7/48

CPC classification number: A61Q5/00 ,  A61K8/817 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  Y10S514/944 ,  Y10S514/945

Abstract: The present invention relates to the use of water-soluble copolymers consisting of such characteristic structural elements as a) acrylic acid amide of the general formula (I), where R et R stand, independently of each other, for H, alkyl, cycloalkyl, aryl or aralkyl, and b) units of the general formula (II), where A represents a chemical bond or an alkyl group, the R residues stand, independently of each other, for H, alkyl, cycloalkyl, aryl or arakyl or, together with the nitrogen atom to which they are linked, an aromatic or non aromatic five to seven member heterocyclic ring, possibly mono- or polysubstituted, possibly containing one or two more heteroatoms chosen from among O, N or S, and capable of being annelated with another aromatic or non aromatic five to seven member ring, and R represents H, alkyl or aralkyl. The invention also pertains to cosmetics containing said polymers. 00000

Abstract translation: 00000

公开(公告)号：WO9810752A3

公开(公告)日：1998-06-18

申请号：PCT/EP9704984

申请日：1997-09-11

Applicant: BASF AG ,  BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

Inventor： BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  A61K9/2086

Abstract: The present invention relates to a process for producing solid dosage forms by mixing at least one polymer binder, possibly at least one active substance and possibly the usual additives, as well as products derived from this mixture, of which at least one component is added in liquid state. 00000

Abstract translation: 00000

公开(公告)号：WO0032169A2

公开(公告)日：2000-06-08

申请号：PCT/EP9909309

申请日：1999-11-30

Applicant: BASF AG ,  BERNDL GUNTHER ,  KOTHRADE STEPHAN ,  KESSLER THOMAS ,  LANGE ARMIN ,  HOFMANN JUERGEN ,  REINHOLD ULRICH

Inventor： BERNDL GUNTHER ,  KOTHRADE STEPHAN ,  KESSLER THOMAS ,  LANGE ARMIN ,  HOFMANN JUERGEN ,  REINHOLD ULRICH

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

CPC classification number: B29C47/42 ,  A61J3/10 ,  A61J2200/20 ,  A61K9/1694 ,  A61K9/2095 ,  B29C47/0021

Abstract: The invention relates to a method for producing solid forms of administration by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).

Abstract translation: 本发明涉及一种通过熔体挤出制备固体剂型的方法。 在这种情况下，混合的聚合物粘合剂，至少一种药物活性成分和任选的其它添加剂，将混合物熔化到挤出机中并挤出它然后在连续塑料产物链的形式。 使用本发明的方法的特征在于，作为挤出机具有一个行星辊挤出机（10），其优选地具有一个中心轴（13）和6个行星主轴（14）。

公开(公告)号：WO9927916A3

公开(公告)日：1999-08-12

申请号：PCT/EP9807716

申请日：1998-11-30

Applicant: BASF AG ,  KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

Inventor： KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421

CPC classification number: A61K31/421 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23K40/25 ,  A23L27/74 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/2027 ,  A61K9/2095 ,  A61K31/277 ,  A23V2200/21 ,  A23V2250/30 ,  A23V2250/51088 ,  A23V2250/5118

Abstract: The invention relates to a method for producing solid dosing forms by mixing at least one polymeric binding agent, at least one active substance, and optional common additives while producing a plastic mixture and during shaping, whereby a copolymer from a N-vinyl lactam and from an copolymerizable monomer with a hydrophobic radical is used as a polymeric binding agent. Dosing forms which slowly release the active substance are obtained in a simple and economical manner.

Abstract translation: 本发明涉及一种用于通过将至少一种聚合物粘合剂，至少一种活性成分，并在适当的常规添加剂，以形成塑料混合物制备固体剂型，和成形，使用如聚合物粘合剂的N-乙烯基内酰胺的共聚物和可共聚的单体 与疏水性残留物一起使用。 以简单和廉价的方式，获得缓慢释放活性成分的剂型。

公开(公告)号：DK1035841T3

公开(公告)日：2002-09-02

申请号：DK98965716

申请日：1998-11-30

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421

Abstract: Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.

公开(公告)号：AT209026T

公开(公告)日：2001-12-15

申请号：AT97909334

申请日：1997-09-29

Applicant: BASF AG

Inventor： NIESSNER MANFRED ,  NILZ CLAUDIA ,  HOESSEL PETER ,  KOTHRADE STEPHAN ,  SANNER AXEL

IPC: A61K8/00 ,  A61K8/36 ,  A61K8/42 ,  A61K8/49 ,  A61K8/72 ,  A61K8/81 ,  A61K8/898 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  C08F226/02 ,  C08F226/06 ,  A61K7/06 ,  A61K7/48

Abstract: A cosmetic composition comprising water-soluble copolymer, which as characteristic structural elements comprisesa) vinylcarboxamide units of the general formula IwhereR1 and R2 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, andb) units of the general formula IIwhereA is a chemical bond or an alkylene group,the radicals R3 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, or together with the nitrogen atom to which they are bonded, form an unsubstituted, mono- or polysubstituted, five- to seven-membered, heterocyclic, aromatic or nonaromatic ring, which if appropriate contains one or two further heteroatoms, selected from among O, N and S, it being possible for the heterocyclic ring to be fused to a further five- or six-membered, aromatic or nonaromatic ring,R4 is H, alkyl or aralkyl.

公开(公告)号：DE19847618A1

公开(公告)日：2000-04-20

申请号：DE19847618

申请日：1998-10-15

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  BREITENBACH JOERG ,  KRULL HARALD ,  KESLER THOMAS ,  LANGE ARMIN ,  MAIER WERNER ,  REINHOLD ULRICH

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/192 ,  A61K31/215

Abstract: Solid dosage forms are produced from a plastic mixture obtained by processing a polymeric binder with active agent under controlled conditions which reduce the initial K value (Fikentscher) of the binder of above 75 by less than 15. Production of solid dosage forms comprises: (a) preparing a plastic mixture from polymeric binder(s) with a K value (Fikentscher) above 75, active agent(s) and optionally conventional additives under temperature and shearing energy input conditions which reduce the molecular weight degradation of the binder by less than 15 K; and (b) forming the plastic mixture into the dosage forms.

公开(公告)号：DE19843903A1

公开(公告)日：2000-03-30

申请号：DE19843903

申请日：1998-09-24

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  BERNDL GUNTHER ,  SANNER AXEL ,  SIMON DIRK

IPC: A61K9/20 ,  A61K9/22

Abstract: A solid dosage form contains a copolymer of an N-vinyl-lactam and methyl methacrylate, having a limited water uptake, as polymeric binder. A solid dosage form comprises least one polymeric binder, at least one active agent (A) and optionally conventional additives, where the binder is a copolymer of at least one N-vinyl-lactam of formula (I) (10-60 wt. %) with methyl methacrylate (40-90 wt. %), having a water uptake on swelling of less than 50 wt. % (based on the weight of the binder). n = 1-3. An Independent claim is included for the preparation of the dosage form, by mixing the components (directly or after preliminary melting) and shaping the obtained plastic mixture into the required dosage form.

公开(公告)号：BR9712152A

公开(公告)日：1999-08-31

申请号：BR9712152

申请日：1997-09-29

Applicant: BASF AG

Inventor： NIESSENER MANFRED ,  NILZ CLAUDIA ,  HOSSEL PETER ,  KOTHRADE STEPHAN ,  SANNER AXEL

IPC: A61K8/00 ,  A61K8/36 ,  A61K8/42 ,  A61K8/49 ,  A61K8/72 ,  A61K8/81 ,  A61K8/898 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  C08F226/02 ,  C08F226/06 ,  A61K7/06 ,  A61K7/48

Abstract: A cosmetic composition comprising water-soluble copolymer, which as characteristic structural elements comprisesa) vinylcarboxamide units of the general formula IwhereR1 and R2 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, andb) units of the general formula IIwhereA is a chemical bond or an alkylene group,the radicals R3 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, or together with the nitrogen atom to which they are bonded, form an unsubstituted, mono- or polysubstituted, five- to seven-membered, heterocyclic, aromatic or nonaromatic ring, which if appropriate contains one or two further heteroatoms, selected from among O, N and S, it being possible for the heterocyclic ring to be fused to a further five- or six-membered, aromatic or nonaromatic ring,R4 is H, alkyl or aralkyl.