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121.发明专利
公开(公告)号：CA3007084A1
公开(公告)日：2017-07-06
申请号：CA3007084
申请日：2016-12-02
Applicant: HARVARD COLLEGE
Inventor： HAJIPOURAN BENAM KAMBEZ , NOVAK RICHARD , INGBER DONALD E
Abstract: A device is directed to simulating a function of a tissue, and includes a first structure defining a first chamber, a second structure defining a second chamber, and a porous membrane located at an interface region between the first chamber and the second chamber. The membrane has a first side facing toward the first chamber and a second side facing toward the second chamber, the membrane separating the first chamber from the second chamber. The first side includes a fluid-permeable, stimulus-responsive polymer gel thereon, the second side including at least one layer of cells adhered thereon.
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公开(公告)号：RU2612915C2
公开(公告)日：2017-03-13
申请号：RU2013143537
申请日：2012-02-28
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , KIM HYUN JUNG
Abstract: Группаизобретенийотноситсяк областибиохимии. Предложенасистемакультивированияклеток, системадляоценкиэффекторныхагентовкишечника, содержащаясистемукультивированияклеток, такжепредложеныспособыкультивированияклеток, получениякишечногоорганоидаи оценкилеченияэффекторныхагентовкишечника. Системакультивированияклетоксодержитустройствос жидкостнымканалом, источникжидкости, мембранув канале, эпителиальныеклеткикишечниканаповерхностимембраныи прилипшиек клеткамкишечникабактериальныеклетки. Способкультивированияклетоквключаетобеспечениеустройстваэпителиальнымиклеткамикишечникаи бактериальнымиклетками, снабжениеегокультуральнойсредойприскоростипотока, достаточнойдляочисткиоторганическихкислоти несвязанныхбактериальныхклеток. Способполучениякишечногоорганоидавключаетподачукультуральнойсредыв системуи культивированиеэпителиальныхклетоккишечникаи бактериальныхклеток. Способоценкилечениякишечникавключаетконтактированиеэпителиальныхклетоккишечникаилибактериальныхклетокв системес предполагаемымэффекторнымагентомкишечникаи измерениеоткликаклеток. Изобретениеобеспечиваетразвитиемодели, имитирующеймеханические, структурные, поглощающие, транспортныеи патофизиологическиесвойствакишечника. 5 н. и 36 з.п. ф-лы, 23 ил., 1 табл.
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公开(公告)号：CA2979982A1
公开(公告)日：2016-09-22
申请号：CA2979982
申请日：2016-03-16
Applicant: HARVARD COLLEGE
Inventor： COON JAMES , HAMKINS-INDIK TIAMA , INGBER DONALD E , INGRAM MILES , LEVNER DANIEL , NOVAK RICHARD , PUERTA JEFFERSON , SHEA DANIEL E , SLIZ JOSIAH , WEN NORMAN
Abstract: A method for micro-molding a polymeric membrane and including pouring a predetermined volume of curable polymer unto a micro-fabricated mold having a post array with pillars, and overlaying the polymer with a support substrate. A spacer, such as a rubber spacer, is placed in contact with the support substrate and a force is applied to an exposed side of the spacer to compress the support substrate and the polymer together. While applying the force, the polymer is cured on the mold for a predetermined time period and at a predetermined temperature to form a polymeric membrane having a pore array with a plurality of pores corresponding to the plurality of pillars of the post array. The polymeric membrane is removed from the support substrate.
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公开(公告)号：AU2014386207A1
公开(公告)日：2016-07-28
申请号：AU2014386207
申请日：2014-12-19
Applicant: FERNANDEZ-ALCON JOSE , HARVARD COLLEGE , WEN NORMAN , NOVAK RICHARD
Inventor： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
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公开(公告)号：AU2014386209A1
公开(公告)日：2016-07-21
申请号：AU2014386209
申请日：2014-12-19
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , HAMILTON GERALDINE A , HASSELL BRYAN , HINOJOSA CHRISTOPHER D
IPC: C12N5/02
Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
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Patent Agency Ranking
公开(公告)号：HK1209021A1
公开(公告)日：2016-03-24
申请号：HK15108577
申请日：2015-09-02
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , KORIN NETANEL , KANAPATHIPILLAI MATHUMAI , UZUN OKTAY , PAPA ANNE-LAURE
IPC: A61K20060101
Abstract: The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.
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公开(公告)号：AU2016200506A1
公开(公告)日：2016-02-18
申请号：AU2016200506
申请日：2016-01-28
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , KORIN NETANEL , KANAPATHIPILLAI MATHUMAI
IPC: A61K47/48
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公开(公告)号：IN6589DEN2012A
公开(公告)日：2015-10-23
申请号：IN6589DEN2012
申请日：2012-07-25
Applicant: HARVARD COLLEGE
Inventor： SUPER MICHAEL , WAY JEFFREY CHARLES , INGBER DONALD E
IPC: C07K19/00
Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases blood borne infections or sepsis. An aspect of the invention provides for mannose binding lectin (MBL) which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses bacteria fungi protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.
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公开(公告)号：CA2913155A1
公开(公告)日：2014-11-27
申请号：CA2913155
申请日：2014-05-21
Applicant: HARVARD COLLEGE
Inventor： SUPER MICHAEL , WATTERS ALEXANDER L , SNELL PHILIP T , INGBER DONALD E
Abstract: Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.
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公开(公告)号：AU2013225823A1
公开(公告)日：2014-09-18
申请号：AU2013225823
申请日：2013-02-28
Applicant: HARVARD COLLEGE
Inventor： SUPER MICHAEL , INGBER DONALD E , CARTWRIGHT MARK J , WATTERS ALEXANDER , WORKMAN JOHN SAMUEL , LEVNER DANIEL , ROTTMAN MARTIN
Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.
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