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    Organomimetic devices and methods of use and manufacturing thereof
    2.
    发明专利
    Organomimetic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2019253903B2

    公开(公告)日：2021-10-07

    申请号：AU2019253903

    申请日：2019-10-25

    Applicant: HARVARD COLLEGE

    Inventor： FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E ,  HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG

    IPC: B01L3/00 ,  C12M3/00

    Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232

    Low shear microfluidic devices and methods of use and manufacturing thereof
    4.
    发明专利
    Low shear microfluidic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2014386209A1

    公开(公告)日：2016-07-21

    申请号：AU2014386209

    申请日：2014-12-19

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  HAMILTON GERALDINE A ,  HASSELL BRYAN ,  HINOJOSA CHRISTOPHER D

    IPC: C12N5/02

    Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.

    Organomimetic devices and methods of use and manufacturing thereof
    5.
    发明专利
    Organomimetic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2019253903A1

    公开(公告)日：2019-11-14

    申请号：AU2019253903

    申请日：2019-10-25

    Applicant: HARVARD COLLEGE

    Inventor： HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG ,  FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E

    IPC: B01L3/00 ,  C12M3/00

    Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232

    Low shear microfluidic devices and methods of use and manufacturing thereof
    7.
    发明专利
    Low shear microfluidic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2014386209A2

    公开(公告)日：2016-09-29

    申请号：AU2014386209

    申请日：2014-12-19

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  HAMILTON GERALDINE A ,  HASSELL BRYAN ,  HINOJOSA CHRISTOPHER D

    IPC: C12N5/02

    Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.

    Low shear microfluidic devices and methods of use and manufacturing thereof
    8.
    发明专利
    Low shear microfluidic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2014386209B2

    公开(公告)日：2021-03-11

    申请号：AU2014386209

    申请日：2014-12-19

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  HAMILTON GERALDINE A ,  HASSELL BRYAN ,  HINOJOSA CHRISTOPHER D ,  LUCCHESI CAROLINA

    IPC: C12N5/02

    Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.

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