公开(公告)号：WO2004080603A2

公开(公告)日：2004-09-23

申请号：PCT/US2004/006213

申请日：2004-03-01

Applicant: SARNOFF CORPORATION

Inventor： PLETCHER, Timothy, A. ,  KELLER, David ,  HO, Wen ,  POLINIAK, Eugene, S. ,  FURDA, John, P. ,  MCGINN, Thomas ,  PULTORAK, Donald, C. ,  KASHEF, Mortaza

IPC: B05B

CPC classification number: B05B5/08 ,  G03G15/0291 ,  G03G2215/028

Abstract: The invention is directed to a corona charging device having a powder feed with an outlet. The device has an internal charging cavity having an inlet and a charged powder outlet. The powder feed outlet is positioned at the internal charging cavity inlet. The device is adapted to guide a powder stream downstream from the powder feed outlet to the charged powder outlet. The device also includes a corona charger having one or more projections positioned and adapted to facilitate a corona ion flow from the projections and intersecting the powder stream. The device also includes a rotating ground electrode adapted to be charged or grounded to attract the corona flow from the projections, and to rotate segments of the ground electrode between the internal charging cavity and a ground electrode cleaner.

Abstract translation: 本发明涉及具有带出口的粉末进料的电晕充电装置。 该装置具有内部充电腔，其具有入口和带电粉末出口。 粉末进料口位于内部充气腔入口处。 该装置适于将粉末进料出口下游的粉末流引导到带电粉末出口。 该装置还包括电晕充电器，该电晕充电器具有一个或多个突起，所述突起定位并且适于促进电晕离子从突起流出并与粉末流相交。 该装置还包括旋转接地电极，其适于被充电或接地以吸引来自突起的电晕流，并且使接地电极的部分在内部充电腔和接地电极清洁器之间旋转。

公开(公告)号：WO2004047882A2

公开(公告)日：2004-06-10

申请号：PCT/US2003/036717

申请日：2003-11-18

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： PUI, David, Y., H. ,  CHEN, Da-Ren

IPC: A61L31/00

CPC classification number: B05B5/0255 ,  A61F2/86 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/622 ,  A61L2420/02 ,  B05B1/14 ,  B05B5/025 ,  B05B5/03 ,  B05B5/0533 ,  B05B5/08 ,  B05B5/082 ,  B05B7/066 ,  B05B7/0884 ,  B05B13/0228 ,  B05D1/002 ,  B05D1/04 ,  B05D1/045

Abstract: Methods and systems for coating at least a portion of a medical device (e.g., a stent structure) include providing a plurality of coating particles (e.g., monodisperse coating particles) in a defined volume. For example, the particles may be provided using one or more nozzle structures, wherein each nozzle structure includes at least one opening terminating at a dispensing end. The plurality of coating particles may be provided in the defined volume by dispensing a plurality of microdroplets having an electrical charge associated therewith from the dispensing ends of the one or more nozzle structures through use of a nonuniform electrical field between the dispensing ends and the medical device. Electrical charge is concentrated on the particle as the microdroplet evaporates. With a plurality of coating particles provided in the defined volume, such particles can be moved towards at least one surface of the medical device to form a coating thereon (e.g., using an electric field and/or a thermophoretic effect).

Abstract translation: 用于涂覆医疗装置（例如，支架结构）的至少一部分的方法和系统包括在限定体积内提供多个涂层颗粒（例如，单分散涂层颗粒）。 例如，可以使用一个或多个喷嘴结构来提供颗粒，其中每个喷嘴结构包括在分配端处终止的至少一个开口。 通过使用分配端和医疗装置之间的不均匀的电场，可以通过从一个或多个喷嘴结构的分配端分配具有与其相关联的电荷的多个微滴，来将多个涂层颗粒设置在限定的体积中 。 当微滴蒸发时，电荷集中在颗粒上。 利用设置在限定体积中的多个涂覆颗粒，这样的颗粒可以朝向医疗装置的至少一个表面移动以在其上形成涂层（例如，使用电场和/或热溶胶效应）。

公开(公告)号：WO2004024339A1

公开(公告)日：2004-03-25

申请号：PCT/GB2003/003926

申请日：2003-09-11

Applicant: PHOQUS PHARMACEUTICALS LIMITED ,  HALLETT, Martin, David

Inventor： HALLETT, Martin, David

IPC: B05B5/08

CPC classification number: A61K9/2072 ,  B05B5/08 ,  B05B12/20

Abstract: A method and apparatus for providing a pattern on a solid dosage form, in which powder material is applied in a pattern to a substrate (3). A mask (5) having an aperture is provided between a source (1) of the powder material and the substrate (3) and the powder material is applied to the substrate through the mask (5). Relative movement of the substrate with respect to the source (1) of powder material is effected during the pattern application process.

Abstract translation: 一种用于在固体剂型上提供图案的方法和装置，其中以图案将粉末材料施加到基底（3）上。 在粉末材料的源（1）和基板（3）之间设置具有孔径的掩模（5），并且通过掩模（5）将粉末材料施加到基板。 相对于粉末材料源（1）的衬底的相对移动在图案施加过程中进行。

公开(公告)号：WO02092142A3

公开(公告)日：2003-01-03

申请号：PCT/GB0202240

申请日：2002-05-14

Applicant: ELECTROSOLS LTD ,  KEATES RICHARD ,  COFFEE RONALD ALAN ,  ESSEX-LOPRESTI JOHNATHAN ,  DAVIES DAVID NEVILLE ,  WAN MARGARET ,  POLLARD MARIE

Inventor： KEATES RICHARD ,  COFFEE RONALD ALAN ,  ESSEX-LOPRESTI JOHNATHAN ,  DAVIES DAVID NEVILLE ,  WAN MARGARET ,  POLLARD MARIE

IPC: A61K9/00 ,  A61L27/52 ,  A61L27/54 ,  B05B5/025 ,  B05B5/08 ,  G02B1/04 ,  A61L26/00 ,  A61M11/00 ,  B05B5/043 ,  B05B5/053 ,  B05B5/16 ,  B29D11/00 ,  G02C7/04

CPC classification number: A61L27/54 ,  A61K9/0051 ,  A61L27/52 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2430/16 ,  B05B5/025 ,  B05B5/08 ,  B05B5/084 ,  G02B1/043

Abstract: An eye covering (700) for covering an exposed surface portion of an eye, the covering comprising a body having front and rear surfaces (702a and 701a) with the rear surface being shaped to conform to said exposed surface portion (701, 702) and at least a portion of the body comprising biologically compatible polymer fibre.

Abstract translation: 一种用于覆盖眼睛的暴露表面部分的眼罩（700），所述覆盖物包括具有前表面和后表面（702a和701a）的本体，其后表面被成形为符合所述暴露表面部分（701,702）和 身体的至少一部分包含生物相容的聚合物纤维。

公开(公告)号：WO2002092142A2

公开(公告)日：2002-11-21

申请号：PCT/GB2002/002240

申请日：2002-05-14

Applicant: ELECTROSOLS LIMITED ,  KEATES, Richard ,  COFFEE, Ronald, Alan ,  ESSEX-LOPRESTI, Johnathan ,  DAVIES, David, Neville ,  WAN, Margaret ,  POLLARD, Marie

Inventor： KEATES, Richard ,  COFFEE, Ronald, Alan ,  ESSEX-LOPRESTI, Johnathan ,  DAVIES, David, Neville ,  WAN, Margaret ,  POLLARD, Marie

IPC: A61L26/00

CPC classification number: A61L27/54 ,  A61K9/0051 ,  A61L27/52 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2430/16 ,  B05B5/025 ,  B05B5/08 ,  B05B5/084 ,  G02B1/043

Abstract: An eye covering (700) for covering an exposed surface portion of an eye, the covering comprising a body having front and rear surfaces (702a and 701a) with the rear surface being shaped to conform to said exposed surface portion (701, 702) and at least a portion of the body comprising biologically compatible polymer fibre.

Abstract translation: 一种用于覆盖眼睛的暴露表面部分的眼罩（700），所述覆盖物包括具有前表面和后表面（702a和701a）的本体，其后表面被成形为符合所述暴露表面部分（701,702）和 身体的至少一部分包含生物相容的聚合物纤维。

公开(公告)号：WO0173431A3

公开(公告)日：2002-07-04

申请号：PCT/US0107311

申请日：2001-03-06

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： LOEWY ZVI ,  MATTHIES DENNIS LEE

IPC: G01N33/50 ,  A61J1/03 ,  A61J3/00 ,  A61K9/22 ,  A61K9/52 ,  A61K9/70 ,  B05B5/08 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50 ,  G01N33/52 ,  G01N33/543

CPC classification number: A61J3/00 ,  A61J1/035 ,  A61K9/70 ,  B05B5/08 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50 ,  G01N33/521 ,  G01N33/54386

Abstract: The present invention provides an integrated structural unit that includes a diagnostic form that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate, a deposit that is disposed on the substrate, and a spreading layer that overlies the deposit and is used to retain and spread a sample of liquid which is to be assayed. The deposit comprises a powder, including the active ingredient(s). The diagnostic form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

Abstract translation: 本发明提供了一种综合结构单元，其包括诊断形式，其包括至少一种活性成分，所述活性成分的存在量有利地不超过预定目标量的约5％。 在一个实施例中，单元形式包括衬底，设置在衬底上的沉积物和覆盖在沉积物上并用于保留和铺展待测定的液体样品的铺展层。 沉积物包含包含活性成分的粉末。 通过使用静电卡盘和带电粉末输送装置将粉末静电沉积在基底上的干粉沉积装置产生诊断形式。

公开(公告)号：WO0137783A3

公开(公告)日：2001-12-27

申请号：PCT/US0042084

申请日：2000-11-10

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： O'MARA KERRY DENNIS ,  KELLER DAVID ,  MCGINN JOSEPH THOMAS

IPC: B65G53/58 ,  A61K9/14 ,  B05B5/025 ,  B05B5/03 ,  B05B5/043 ,  B05B5/047 ,  B05B5/08 ,  B05B5/16 ,  B65G53/44 ,  B05B5/04

CPC classification number: B05B5/032 ,  B05B5/043 ,  B05B5/047 ,  B05B5/08 ,  B05B5/1683 ,  Y10S239/07 ,  Y10T137/2076 ,  Y10T137/2273

Abstract: A diffuser (518) comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits (520) through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the "boundary layer" near the wall of the diffuser. A second flow control feature comprises one or more annular slits (548) or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.

Abstract translation: 扩散器（518）包括具有沿流体流动方向增加的横截面积的导管。 在一个实施例中，扩散器用于减少在静电沉积设备中发生的流动波动的发生率和严重性。 在一些实施例中，扩散器包括一个或多个流量控制特征。 第一流量控制特征包括一个或多个适当形状的环形狭缝（520），具有比通过扩散器移动的主要流体更大动量的流体通过该狭缝被注入到扩散器壁附近的“边界层”中。 第二流动控制特征包括一个或多个环形狭缝（548）或可选地设置在围绕扩散器的圆周的适当位置处的狭缝或孔，通过该狭缝或狭孔移除在边界层中流动的一部分流体。 在一个实施例中，通过在这样的环形狭缝或多个狭缝之间产生压差实现边界层流动移除。 除了其它益处之外，这种流量控制特征减少了扩散器中主流体的流动分离的任何倾向。

公开(公告)号：WO1996039256A1

公开(公告)日：1996-12-12

申请号：PCT/US1996009439

申请日：1996-06-06

Applicant: DAVID SARNOFF RESEARCH CENTER, INC.

Inventor： DAVID SARNOFF RESEARCH CENTER, INC. ,  PLETCHER, Timothy, Allen

IPC: B05B05/025

CPC classification number: G03G17/00 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/02 ,  A61M15/025 ,  B05B5/08 ,  B05B12/16 ,  B41J2/4155

Abstract: A substrate (104) having a planar conductive plating (106) located on a first surface of a dielectric layer (108) and having a conductive collection trace (110) on a second surface of the dielectric layer (108) such that the conductive plating (106) and collection trace (110) have a parallel, spaced apart relation. The collection trace (110) is charged by supplying a voltage to the plating (106) and the trace (110) to establish a voltage differential across the dielectric layer (108). The material to be deposited (116) is charged to a polarity opposite that of the trace (110) so that the deposited material (102) is electrostatically retained.

Abstract translation: 具有位于介电层（108）的第一表面上并且在介电层（108）的第二表面上具有导电收集迹线（110）的平面导电电镀（106）的衬底（104），使得导电电镀 （106）和收集痕迹（110）具有平行的间隔开的关系。 通过向电镀（106）和迹线（110）提供电压以在电介质层（108）两端形成电压差来对收集迹线（110）进行充电。 待沉积的材料（116）被充电到与痕迹（110）相反的极性，使得沉积的材料（102）被静电保持。

公开(公告)号：WO1992014451A1

公开(公告)日：1992-09-03

申请号：PCT/GB1992000323

申请日：1992-02-21

Applicant: HOECHST UK LIMITED ,  STANIFORTH, John, Nicholas ,  GROSVENOR, Martin, Paul

Inventor： HOECHST UK LIMITED

IPC: A61K09/28

CPC classification number: B05D1/06 ,  A61K9/2893 ,  B05B5/08 ,  B05B5/084 ,  B05B5/087 ,  B05B16/95 ,  B05D3/0254 ,  B05D2258/00

Abstract: A method of coating substrates of medicinal products with a dry powder includes the following steps: feeding the medicinal substrates onto a conveying belt (1); supplying the dry powder to a region (5) through which the substrates are to be conveyed; conveying the medicinal substrates on the conveying belt (1) through the region (5) with the conveying belt and/or the substrates maintained at a different electric potential from the dry powder, whereby the dry powder is attracted to the exposed surfaces of the substrates but is unable to reach the coated surfaces of the substrates in contact with the conveying belt, and treating the dry powder coatings to convert the powder into a fused film secured to the substrates.

公开(公告)号：WO1991002394A1

公开(公告)日：1991-02-21

申请号：PCT/AU1990000339

申请日：1990-08-09

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... ,  AUSPHARM INTERNATIONAL LIMITED ,  SZIRMAI, Stephen, George

Inventor： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... ,  AUSPHARM INTERNATIONAL LIMITED

IPC: H01T23/00

CPC classification number: C23C24/00 ,  B05B5/08

Abstract: Production of an electrosuspension of particles (5), comprising an insulating container (3) fitted with two spaced apart electrodes (2, 4) between which a high electrical potential is applied. At least one of the electrodes (2) is mounted for rotation by an associated electric motor (20). The electrode mounted for rotation preferably has a drum like configuration formed by a plurality of circumferentially spaced apart conductors (6). In a second aspect the invention produces an electrosuspension of micronised particles where one of the electrodes is in contact with a bed of particles and a second electrode is spaced above the particles. Field concentrating conductors are connected with the second electrode to generate ions and irradiate the surface of the particulate material with ions of opposite polarity to the first electrode.

Abstract translation: 制备颗粒（5）的电悬浮液，其包括装配有两个间隔开的电极（2,4）的绝缘容器（3），其间施加高电位。 电极（2）中的至少一个安装成由相关的电动机（20）旋转。 安装用于旋转的电极优选地具有由多个周向间隔开的导体（6）形成的鼓状构造。 在第二方面，本发明产生微粉化的颗粒的电悬浮液，其中一个电极与颗粒床接触，并且第二电极在颗粒上方间隔开。 场集中导体与第二电极连接以产生离子并用与第一电极相反极性的离子照射颗粒材料的表面。