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    New butynol I esterase, for stereospecific hydrolysis or transesterification of esters, to produce optically active reaction products
    131.
    发明专利
    New butynol I esterase, for stereospecific hydrolysis or transesterification of esters, to produce optically active reaction products 未知

    公开(公告)号：DE10042892A1

    公开(公告)日：2002-03-14

    申请号：DE10042892

    申请日：2000-08-31

    Applicant: BASF AG

    Inventor： HAUER BERNHARD ,  FRIEDRICH THOMAS ,  NUEBLING CHRISTOPH ,  STUERMER RAINER

    IPC: C12N1/21 ,  C12N9/16 ,  C12P41/00 ,  C12N9/14 ,  C07K14/21 ,  C12N15/63

    Abstract: A protein (I) with butynol I esterase (BIE) activity comprising at least one of 4 partial sequence polypeptides (S1-4) and their functional equivalents, is new. A protein (I) with butynol I esterase (BIE) activity comprises at least one of 4 partial sequence polypeptides (S1-4) and their functional equivalents. Independent claims are also included for the following: (1) polynucleotides (II) that encode (I), and complementary polynucleotides and sequences that hybridize to them; (2) an expression cassette (EC) comprising at least one (II), operably linked to regulators; (3) a recombinant vector for transforming eukaryotic or prokaryotic hosts, containing (II) or EC; (4) preparation of (I) by culturing organisms that produce (I), either endogenously or after transformation; (5) (I) produced by the method in (4); Pseudomonas glumae Lu2023 (DSM 13176), or its variants or mutants; (6) microorganisms containing the vector of (4); (7) method for enantioselective ester hydrolysis or transesterification using (I); and (8) optically active alcohols, carboxylic acids or esters prepared using (I). Phe-Ile-Glu-Thr-Leu-Gly-Leu-Glu-Arg-Pro-Val-Leu-Val-Gly-His-Ser-Leu-Gl y-Gly-Ala-Ile-Ala-Leu-Ala-Val-Gly-Leu-Asp-Tyr-Pro-Glu-Arg (S1) Ile-Ala-Leu-Ile-Ala-Pro-Leu-Thr-His-Thr-Glu-Thr-Glu-Pro (S2) Gly-Gly-Gly-Met-Met-Gly-Leu-Arg-Pro-Glu-Ala-Phe-Tyr-Ala-Ala-Ser-Ser-As p-Leu-Val (S3) Ala-Ile-Asp-Ala-Ile-Phe-Ala-Pro-Glu-Pro-Val (S4)

    135.
    发明专利
    未知

    公开(公告)号：ES2109373T3

    公开(公告)日：1998-01-16

    申请号：ES92920588

    申请日：1992-09-23

    Applicant: BASF AG

    Inventor： FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED

    IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/14 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02

    Abstract: PCT No. PCT/EP92/02198 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Sep. 23, 1992 PCT Pub. No. WO93/09231 PCT Pub. Date May 13, 1993A novel thrombin inhibitory protein from ticks with a molecular weight of about 26000 dalton and the partial amino acid sequences Val-Ala-Lys-Phe-Ala-X-Asn-Ser-Gly-Ser-Glu-Thr-Gly (SEQ ID NO: 8), His-Ala-Y-Phe-Glu (SEQ ID NO: 3), Arg-Val-Ser-Asp-Phe-Glu (SEQ ID NO: 4), Phe-Val-Tyr-Thr-Ile-Glu (SEQ ID NO: 6), where X and Y can be identical or different and each is a naturally occurring amino acid, is suitable for controlling diseases.

    136.
    发明专利
    未知

    公开(公告)号：AT148744T

    公开(公告)日：1997-02-15

    申请号：AT92924598

    申请日：1992-11-19

    Applicant: BASF AG

    Inventor： STRUBE KARL-HERMANN ,  BIALOJAN SIEGFRIED ,  KROEGER BURKHARD ,  FRIEDRICH THOMAS

    IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

    Abstract: PCT No. PCT/EP92/02661 Sec. 371 Date May 18, 1994 Sec. 102(e) Date May 18, 1994 PCT Filed Nov. 19, 1992 PCT Pub. No. WO93/11239 PCT Pub. Date Oct. 6, 1993.Novel thrombin-inhibitory proteins from terrestrial leeches of the genus Haemadipsa with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys, or an amino-acid sequence which is obtained by C-terminal truncation of this sequence by from one to twelve amino acids, are described. The proteins are suitable for controlling diseases. Also described are the nucleic acids coding for these proteins.

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