公开(公告)号：US20160111643A1

公开(公告)日：2016-04-21

申请号：US14886736

申请日：2015-10-19

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Han-Woong YEOM ,  Sung-Hwan KIM

IPC: H01L49/00

CPC classification number: H01L49/006 ,  B82Y10/00

Abstract: The disclosure describes a topological insulator having a new surface electronic state and a preparation method thereof, and more particularly, to a topological insulator having a new surface electronic state, the topological insulator including a unimolecular metal layer formed on a 3D topological insulator, and a method of preparing a topological insulator having a new surface electronic state, the method including: heating and cooling at least one selected from the group consisting of tellurium (Te) and selenium (Se), and bismuth (Bi) to prepare an alloy; and forming a unimolecular metal layer on the alloy.

Abstract translation: 本发明描述了具有新的表面电子状态的拓扑绝缘体及其制备方法，更具体地，涉及具有新的表面电子状态的拓扑绝缘体，所述拓扑绝缘体包括形成在3D拓扑绝缘体上的单分子金属层，以及 制备具有新的表面电子状态的拓扑绝缘体的方法，该方法包括：加热和冷却选自碲（Te）和硒（Se）和铋（Bi）中的至少一种以制备合金; 并在合金上形成单分子金属层。

公开(公告)号：US20160089455A1

公开(公告)日：2016-03-31

申请号：US14670805

申请日：2015-03-27

Applicant: SNU R&DB FOUNDATION ,  Institute for Basic Science ,  The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Taeghwan Hyeon ,  Kun NA ,  Daishun LING ,  Wooram PARK

IPC: A61K49/12 ,  A61K49/18 ,  C08G69/40 ,  C08G81/00

CPC classification number: C08G69/40 ,  A61K49/1857 ,  C08G69/08 ,  C08G81/00

Abstract: The present invention relates to MRI contrasting agent for contrasting cancer cell which contains ultrafine nanoparticles. More particularly, the present invention is directed to a self-assembled ligand composition comprising a ligand A, which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range, MRI contrast agent for contrasting cancer cell comprising said ligand composition and MRI contrasting nanoparticles, and the methods for preparing them.

Abstract translation: 本发明涉及用于对比含有超细纳米颗粒的癌细胞的MRI对比剂。 更具体地，本发明涉及包含在特定pH范围分离的配体A和在特定pH范围内表面电荷变化的配体B的自组装配体组合物，用于对比癌症的MRI造影剂 包含所述配体组合物和MRI对比纳米颗粒的细胞及其制备方法。

公开(公告)号：US12251690B2

公开(公告)日：2025-03-18

申请号：US17418581

申请日：2020-01-03

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Taeghwan Hyeon ,  Byounghoon Lee

IPC: B01J21/06 ,  B01J23/46 ,  B01J23/72 ,  B01J23/745 ,  B01J23/75 ,  B01J23/755 ,  B01J35/39 ,  B01J35/51 ,  B01J37/00 ,  B01J37/02 ,  B01J37/04 ,  B01J37/08

Abstract: A single atom catalyst and a method of forming the same are provided. The single atom catalyst comprises a support comprising a first metal oxide and a second metal atom located in the first metal oxide. The method of forming the single atom catalyst comprises forming a sacrificial nanoparticle, coating the sacrificial nanoparticle with a first metal oxide, adsorbing a second metal atom to the first metal oxide, forming a sacrificial layer on the support, and heating the first metal oxide.

公开(公告)号：US20250011438A1

公开(公告)日：2025-01-09

申请号：US18667700

申请日：2024-05-17

Applicant: Institute for Basic Science

Inventor： Gou Young Koh ,  Jeomil Bae ,  Jaeryung Kim

IPC: C07K16/28 ,  A61K31/713 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P27/06 ,  C12N5/10 ,  C12N15/63

Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.

公开(公告)号：US20240294945A1

公开(公告)日：2024-09-05

申请号：US18025446

申请日：2021-09-17

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Kayeong LIM ,  Sung lk CHO ,  Beum-Chang KANG ,  Seonghyun LEE ,  Hyunji LEE ,  Young Geun MOK ,  Ji Min LEE ,  Eugene CHUNG

IPC: C12N15/90 ,  A61K48/00 ,  C12N9/22 ,  C12N9/78 ,  C12N15/10 ,  C12N15/82

CPC classification number: C12N15/90 ,  A61K48/005 ,  C12N9/22 ,  C12N9/78 ,  C12N15/102 ,  C12N15/82

Abstract: The present invention relates to a cytosine or adenine deaminase in an isolated form or a variant thereof, a non-toxic full-length cytosine deaminase or a variant thereof, a fusion protein comprising same, a composition for base editing, and a method for editing a base by using same.

公开(公告)号：US20240271117A1

公开(公告)日：2024-08-15

申请号：US18566904

申请日：2022-06-07

Applicant: INSTITUTE FOR BASIC SCIENCE ,  Ulsan National Institute of Science and Technology

Inventor： Yoon-Kyoung CHO ,  Kumar SUMMIT

IPC: C12N11/04 ,  C12N11/18

CPC classification number: C12N11/04 ,  C12N11/18

Abstract: The present invention relates to a nano-vesicle reactor and a method for producing the same. Specifically, the present invention provides a composition for producing a nano-vesicle reactor, characterized by comprising a first vesicle containing a first receptor on its surface and a second vesicle containing a second receptor on its surface, wherein the first receptor and the second receptor are bound with each other through a ligand system so that the first vesicle and the second vesicle are fused to form the nano-vesicle reactor; and a method for producing the above nano-vesicle reactor. The nano-vesicle reactor of the present invention can be utilized in production of energy inside a cell through cellular enzymatic reaction, a drug delivered system, and a diagnostic system.

公开(公告)号：US12049436B2

公开(公告)日：2024-07-30

申请号：US17536383

申请日：2021-11-29

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung Lee ,  Suresh Vasimalla ,  Seungeun Lee

IPC: C07C231/10 ,  B01J21/06 ,  B01J35/39 ,  B01J37/16 ,  C01G23/08 ,  C07C233/65 ,  C07D295/192 ,  C07D401/04

CPC classification number: C07C231/10 ,  B01J21/063 ,  B01J35/39 ,  B01J37/16 ,  C01G23/08 ,  C07C233/65 ,  C07D295/192 ,  C07D401/04

Abstract: Provided is a preparing method of an amide directly from a tertiary amine by using a reduced titanium dioxide (Blue TiO2), which is formed by mixing a titanium dioxide having an anatase phase and a rutile phase with a reducing agent and selectively reducing any one of the anatase phase and the rutile phase, as a photocatalyst.

公开(公告)号：US11998901B2

公开(公告)日：2024-06-04

申请号：US17676078

申请日：2022-02-18

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok Chang ,  Seung Youn Hong ,  Yoon Su Park ,  Yeongyu Hwang ,  Yeong Bum Kim

IPC: C07D207/267 ,  B01J31/22 ,  C07D209/34 ,  C07D209/46 ,  C07D209/52 ,  C07D209/54 ,  C07D209/56 ,  C07D209/70 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07F15/06 ,  C07F17/02 ,  C07J43/00

CPC classification number: B01J31/2295 ,  C07D207/267 ,  C07D209/46 ,  C07D209/52 ,  C07D209/54 ,  C07D209/56 ,  C07D209/70 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07F17/02 ,  C07J43/003 ,  B01J2231/60

Abstract: The present invention relates to a novel metal complex, a method for producing same, and a method for producing a gamma-lactam compound using same, and the metal complex according to the present invention is used as a catalyst for producing a gamma-lactam compound and can efficiently produce a gamma-lactam compound with an excellent yield and excellent selectivity.

公开(公告)号：US20240018492A1

公开(公告)日：2024-01-18

申请号：US18247108

申请日：2021-09-29

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Chul-Yong PARK

IPC: C12N9/22 ,  C12N15/10 ,  C12N15/63 ,  C12N9/12

CPC classification number: C12N9/22 ,  C12N15/102 ,  C12N15/63 ,  C12N9/1276 ,  C12N2310/20 ,  C12Y207/07049

Abstract: The present invention relates to: a prime editing composition comprising a prime editor protein or a nucleic acid encoding same, and a prime editing guide RNA (pegRNA); and a prime editing method.

公开(公告)号：US20230256417A1

公开(公告)日：2023-08-17

申请号：US18110028

申请日：2023-02-15

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung Lee ,  Jung Sue CHOI ,  Hak Sung LEE ,  Yeon Su HAN ,  Tae Hun YANG ,  Hyun KO

IPC: B01J23/30 ,  B01J21/06 ,  B01J31/06 ,  B01J31/38 ,  B01J35/00 ,  B01J37/04 ,  B01J37/00 ,  B01J37/02 ,  A61L9/20 ,  B01D53/86 ,  B01D53/00 ,  B01D53/88

CPC classification number: B01J23/30 ,  B01J21/063 ,  B01J31/061 ,  B01J31/38 ,  B01J35/0013 ,  B01J37/04 ,  B01J37/0018 ,  B01J37/0219 ,  B01J37/0217 ,  A61L9/20 ,  B01D53/8668 ,  B01D53/007 ,  B01D53/885 ,  A61L2209/12 ,  A61L2209/14 ,  B01D2255/20707 ,  B01D2255/20776 ,  B01D2255/802 ,  B01D2257/708 ,  B01D2259/804 ,  B01D2255/915

Abstract: The present application relates to a filter having a photocatalyst attached thereto, which comprises: a substrate; and a photocatalyst bonded on the substrate, in which the photocatalyst has each photocatalyst bonded and combined by a polymer binder, and the substrate and the photocatalyst are bonded by a hydrophilic polymer binder.