公开(公告)号：AT185349T

公开(公告)日：1999-10-15

申请号：AT96925744

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  ULRICH KARL ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  ZIERKE THOMAS

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.

公开(公告)号：ZA982093B

公开(公告)日：1999-09-12

申请号：ZA982093

申请日：1998-03-12

Applicant: BASF AG

Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS

IPC: A61K31/337 ,  A61K38/07 ,  A61K38/08 ,  A61K38/00 ,  A61K38/15 ,  A61P35/00 ,  C07K5/08 ,  C07K5/10 ,  C07K7/00 ,  A61K ,  C07D ,  C07C

Abstract: The present invention provides compositions and methods for the treatment of cancer in a subject wherein compounds of Formula I as defined herein in combination with paclitaxel, taxotere or modified taxane or taxoid analogs provide enhanced anticancer effects over the effects achieved with the individual compounds.

公开(公告)号：ZA9802093B

公开(公告)日：1999-09-12

申请号：ZA9802093

申请日：1998-03-12

Applicant: BASF AG

Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS

IPC: A61K38/00 ,  A61K31/337 ,  A61K38/07 ,  A61K38/08 ,  A61K38/15 ,  A61P35/00 ,  C07K5/08 ,  C07K5/10 ,  C07K7/00 ,  A61K ,  C07C ,  C07D

CPC classification number: A61K38/07 ,  A61K38/08 ,  A61K31/335 ,  A61K2300/00

公开(公告)号：ZA981957B

公开(公告)日：1999-09-09

申请号：ZA981957

申请日：1998-03-09

Applicant: BASF AG

Inventor： RITTER KURT ,  AMBERG WILHELM ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS

IPC: A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K5/10 ,  C07K5/103 ,  C07K7/02 ,  A61K ,  C07D ,  C07K ,  C07C

Abstract: The present invention relates to novel peptides useful as anti-cancer agents. The compounds of the invention are of Formula I,A-B-D-E-F-G(I)A, B, D, and E are alpha -amino acid residues. In one embodiment, F is an azacycloalkanecarboxylic acid residue. In this embodiment, G is a monovalent radical, for example, a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group. In another embodiment, F is an azacycloalkyl group and G is a heteroaryl group connected to F by a carbon-carbon bond. In another embodiment, the invention includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：HU9900089A2

公开(公告)日：1999-05-28

申请号：HU9900089

申请日：1996-10-30

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  DE ARRUDA MONIKA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  ROBINSON SIMON ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  C07K7/06 ,  A61K38/08

Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.

公开(公告)号：AU705143B2

公开(公告)日：1999-05-13

申请号：AU6615496

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  ULRICH KARL ,  KLING ANDREAS ,  MULLER STEFAN ,  RITTER KURT ,  ZIERKE THOMAS

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.

公开(公告)号：ES2126279T3

公开(公告)日：1999-03-16

申请号：ES95917962

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND

IPC: A61K38/00 ,  A61P35/00 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.

公开(公告)号：BR9611987A

公开(公告)日：1999-02-17

申请号：BR9611987

申请日：1996-12-11

Applicant: BASF AG

Inventor： WYMANN JURGEN ,  BERNARD HARALD ,  ULLRICH MARTINA ,  BARLOZZARI TEREZA ,  RITTER KURT ,  LIETZ HELMUT ,  KLING ANDREAS ,  JANSSEN BERND ,  HEGE HANS-GUENTHER ,  HAUPT ANDREAS ,  BUSCHMANN ERNEST ,  AMBERG WILHELM ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：ZA976725B

公开(公告)日：1999-02-12

申请号：ZA976725

申请日：1997-07-29

Applicant: BASF AG

Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS ,  GRIESINGER CHRISTIAN ,  JANSSEN BERND ,  BELIK DANIEL ,  BORETZKY MICHAEL ,  PETTIT GEORGE R

IPC: A61K38/00 ,  A61P1/00 ,  A61P11/00 ,  A61P15/00 ,  A61P35/00 ,  C07K7/02 ,  C07K ,  A61K

公开(公告)号：CO4700527A1

公开(公告)日：1998-12-29

申请号：CO96029751

申请日：1996-06-07

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: Péptidos novedosos de la fórmula IR1 R2 N-CHX-CO-A-B-D-E-(F)t-K I en donde R1 es metilo, etilo o isopropilo; R2 es hidrógeno, metilo o etileno; R1 -N-R2 juntos pueden ser un anillo de pirrolidina; A es un residuo de valil, isoleucil, leucil, 2-tert-butilglicil, 2-etilglicil-norleucil o norvalil; B es un residuo de N-metil-valil, -leucil,-isoleucil, norvalil, norleucil, 2-tert-butilglicil, -3-tert-butilalamil, o 2-etilglicil; D es un residuo 3,4-de hidroprolil, 4-fluoroprolil, 4,4-difluoroprolil, azetidina-2-carbonil, 3-metilprolil, 4-metilprolil, o 5-metilpropil; E es un residuo propil, homopropil,hidroxipropil o tiazolidina-4-carbonil;F es un residuo de valil, 2-tert-butilglicil- isoleucil, leucil, 2-ciclohexilglicil, norleucil, norvalil, neopentilglicil, alanil, ß-alanil o aminoisobutiroil;X es alkilo (preferiblemente C2-5 ), ciclopropil, o ciclopentilo; t es 0 o 1; y K es alkoxi (preferiblemente C1-4 ), benxiloxi o una traza amino substituida o no substituida; y las sales de los mismos con ácido tolerados fisiológicamente.