公开(公告)号：BR0313759A

公开(公告)日：2005-06-21

申请号：BR0313759

申请日：2003-08-26

Applicant: BASF AG

Inventor： GER BURKHARD KR ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  DER HARTWIG SCHR ,  HOFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with homoserine O-acetyltransferase (metA) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：BR0313758A

公开(公告)日：2005-06-21

申请号：BR0313758

申请日：2003-08-26

Applicant: BASF AG

Inventor： GER BURKHARD KR ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  DER HARTWIG SCHR ,  HOFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12 ,  C12R1/15

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with O-acetylhomoserine-sulfhydrolase (metY) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：BR0213771A

公开(公告)日：2004-10-19

申请号：BR0213771

申请日：2002-10-31

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C12Q1/68 ,  C12N15/63 ,  C12N15/77 ,  C12P1/04

Abstract: Isolated nucleic acid (I) that encodes any of 50 amino acid sequences (II) that have, at specific positions, an amino acid (aa) alteration. The specification includes (i) a table identifying the function of (II) and the nature/position of the amino acid exchange and (ii) sequences for (I) and (II). Independent claims are also included for the following: (1) vector that contains at least one (I); (2) host cell transfected with at least one vector of component (1); and (3) preparing fine chemicals by culturing cells of component (2).

公开(公告)号：BR0213774A

公开(公告)日：2004-10-13

申请号：BR0213774

申请日：2002-10-31

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  DER HARTWIG SCHR ,  GER BURKHARD KR ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/77 ,  C12P13/08 ,  C12N15/01 ,  C07K14/34 ,  C12N9/00 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：AU2003298216A1

公开(公告)日：2004-07-14

申请号：AU2003298216

申请日：2003-12-19

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  HAEFNER STEFAN ,  LIEBL WOLFGANG ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD

IPC: C12P13/04

Abstract: The invention relates to a method for producing an amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein said microorganism is partially or completely deficient in at least one of the gene loci of the the group which is formed by otsAB, treZ and treS, and subsequent isolation of the amino acid from the culture medium.

公开(公告)号：DE10239308A1

公开(公告)日：2004-03-11

申请号：DE10239308

申请日：2002-08-27

Applicant: BASF AG

Inventor： KROEGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12 ,  C12R1/15 ,  C12P11/00 ,  C07C323/58

Abstract: Fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A), concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with methionine synthase (metF) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms, removing water from the fermentation broth and optionally also up to 100 % of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：AU2003242537A1

公开(公告)日：2003-12-02

申请号：AU2003242537

申请日：2003-05-13

Applicant: BASF AG

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  LEE HEUNG-SHICK

IPC: C12N15/09 ,  C07K14/34 ,  C12N15/31 ,  C12P13/08

Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.

公开(公告)号：AU2002363458A1

公开(公告)日：2003-05-19

申请号：AU2002363458

申请日：2002-10-31

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  ZELDER OSKAR

IPC: C07K14/34 ,  C12N1/21 ,  C12P13/08 ,  C12N9/02 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to their use for constructing genetically improved microorganisms and to methods for producing fine chemicals, in particular, amino acids by using these genetically modified microorganisms.

公开(公告)号：AU2002349017A1

公开(公告)日：2003-05-19

申请号：AU2002349017

申请日：2002-10-31

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HABERHAUER GREGOR

IPC: C07K14/47 ,  C12N1/21 ,  C12N15/31 ,  C12N15/77 ,  C12P13/08 ,  C07K14/34 ,  C12N9/00

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof in the construction of genetically improved microorganisms and to a method for producing fine chemical products, in particular amino acids, by means of said genetically improved microorganisms.

公开(公告)号：AU2002346805A1

公开(公告)日：2003-05-19

申请号：AU2002346805

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  KLOPPROGGE CORINNA ,  KROGER BURKHARD ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS

IPC: C07H21/04 ,  C07K14/34 ,  C12N1/21 ,  C12N9/12 ,  C12N9/16 ,  C12N9/90 ,  C12N15/31 ,  C12P13/08 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.