公开(公告)号：JP2007522448A

公开(公告)日：2007-08-09

申请号：JP2006551341

申请日：2005-01-24

Applicant: インコム,インコーポレイテッドIncom,Inc.

Inventor： カシュ，ジェイソン ,  デタランド，マイケル，エー． ,  マイノット，マイケル，ジェー．

IPC: G01N21/03 ,  B01L3/00 ,  G01N21/25 ,  G01N21/27 ,  G02B6/08

CPC classification number: G02B6/08 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/02 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  G01N21/03 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2201/0833

Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.

公开(公告)号：JP2006145533A

公开(公告)日：2006-06-08

申请号：JP2005333755

申请日：2005-11-18

Applicant: Grifols Sa ,  グリフォルス,エセ.ア.

Inventor： PAGES PINYOL JOSEP

IPC: G01N21/27 ,  G01J3/02 ,  G01J3/12 ,  G01J3/28 ,  G01N21/03 ,  G01N21/13 ,  G01N21/25 ,  G01N21/59 ,  G01N21/75 ,  G01N21/77 ,  G01N35/02

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/2803 ,  G01N21/03 ,  G01N21/13 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N2201/0461 ,  G01N2201/082 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: PROBLEM TO BE SOLVED: To measure a series of gas samples and to perform measurement for investigating the progress with the elapse of time of the absorbance of a specific liquid.
SOLUTION: This measuring instrument of the absorbance of a liquid sample is equipped with the body for housing a reaction container which houses the liquid sample to be analyzed, and the body has a means for passing a light signal having a controlled wavelength through the reaction container and is equipped with a means for guiding the light signal to a scanning head for capturing the light signal by a single CCD sensor, to constitute a digital processing system for measuring the absorbance of the corresponding sample.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：测量一系列气体样品并进行测量以随着特定液体的吸光度的时间的流逝来调查进展。

解决方案：该液体样品的吸光度的测量仪器装备有用于容纳容纳要分析的液体样品的反应容器的主体，并且本体具有用于使具有受控波长的光信号通过的装置 该反应容器配备有用于将光信号引导到用于通过单个CCD传感器捕获光信号的扫描头的装置，以构成用于测量相应样品的吸光度的数字处理系统。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP3597729B2

公开(公告)日：2004-12-08

申请号：JP12936599

申请日：1999-05-11

Applicant: 日立ソフトウエアエンジニアリング株式会社

Inventor： 健太郎 宍戸 ,  顕次 山本 ,  以子 百合野

IPC: C40B40/06 ,  G01N21/64 ,  G01N21/78 ,  G01N27/447 ,  G01N33/487 ,  G01N33/58 ,  G01N35/00 ,  G01N37/00

CPC classification number: G01N21/6452 ,  B01J2219/00536 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/06 ,  G01N27/44721 ,  G01N33/487 ,  G01N33/582 ,  G01N35/00069 ,  G01N2201/0833

公开(公告)号：US20240307867A1

公开(公告)日：2024-09-19

申请号：US18174463

申请日：2023-02-24

Applicant: Early is Good, Inc.

Inventor： Thakshila Udayakanthi HABARAKADA LIYANAGE ,  Asel Ananda HABARAKADA LIYANAGE

IPC: B01L3/00 ,  B82Y30/00 ,  G01N21/65 ,  G01N33/00 ,  G01N33/543

CPC classification number: B01L3/502707 ,  B82Y30/00 ,  G01N21/658 ,  G01N33/0031 ,  G01N33/54346 ,  G01N2201/0833

Abstract: The present invention includes composition and method that can be used in analyte detection. Certain embodiments are directed to fiber arrays comprising plurality of nanoparticles linked to one or more fibers, where a fiber is linked to the nanoparticle through a linker. The fiber array can be provided in different sizes and shapes.

公开(公告)号：US11781989B2

公开(公告)日：2023-10-10

申请号：US17652941

申请日：2022-03-01

Applicant: ADVANCED NANO TECHNOLOGIES LIMITED

Inventor： Norman McMillan ,  Martina O'Neill ,  Sven Riedel ,  Liam McDonnell

IPC: G01N21/65

CPC classification number: G01N21/658 ,  G01N2201/023 ,  G01N2201/0224 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/10

Abstract: A method of analysing a sample in the form of a droplet provided on a sample-receiving surface includes providing a light source and a detector in a housing, positioning said sample-receiving surface in or on the housing, and focussing an incident beam of light to a focal point in the vicinity of the sample. Light is detected from the sample resulting from an interaction with the sample, the sample-receiving surface, or the atmosphere surrounding the sample. At least one parameter of the detected light is measured, and the sample-receiving surface is translated relative to the housing such that the focal point is at a different region of the sample, the sample-receiving surface, or the atmosphere surrounding the sample. The step of measuring one or more parameters of the detected light is repeated following the translating step.

公开(公告)号：US20180356338A1

公开(公告)日：2018-12-13

申请号：US15778447

申请日：2016-11-18

Applicant: NEC CORPORATION

Inventor： Akihiro TANAKA

IPC: G01N21/3504

CPC classification number: G01N21/3504 ,  G01N21/39 ,  G01N2201/061 ,  G01N2201/063 ,  G01N2201/0833

Abstract: In order to perform gas detection at multiple locations with a simple configuration and at a low cost, the gas detection device is provided with: a transmission unit for outputting to a transmission path, as a first optical signal, pulse light that has a temporally changing wavelength and that is generated by pulse light modulated by an optical wavelength modulator; and a reception unit for receiving a second optical signal output from a sensor head outputting the first optical signal propagated through the atmosphere as the second optical signal, converting the second optical signal received into an electric the signal detecting, by each sensor head, a predetermined type of gas contained in the atmosphere based on a temporal change in amplitude of the electric signal, and outputting a result of detection of the gas.

公开(公告)号：US20180348136A1

公开(公告)日：2018-12-06

申请号：US15776649

申请日：2016-11-16

Applicant: ChemImage Corporation

Inventor： Patrick TREADO ,  Shona STEWART ,  Aaron SMITH ,  Heather GOMER

IPC: G01N21/65 ,  G01N21/17 ,  G01J3/44 ,  G01N33/53 ,  G16H50/20

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0833

Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

公开(公告)号：US20180306827A1

公开(公告)日：2018-10-25

申请号：US15961626

申请日：2018-04-24

Applicant: Lightwave Science, Inc.

Inventor： William Bryan Pierce, III ,  Jason D. Pierce

IPC: G01N33/94 ,  G01N21/84 ,  G01J3/28 ,  G01N21/25 ,  G01N21/35 ,  G01N21/3563

CPC classification number: G01N33/948 ,  G01J3/0218 ,  G01J3/2803 ,  G01N21/255 ,  G01N21/35 ,  G01N21/3554 ,  G01N21/3563 ,  G01N21/474 ,  G01N21/84 ,  G01N33/5097 ,  G01N2021/4742 ,  G01N2021/8466 ,  G01N2201/0221 ,  G01N2201/0692 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/129

Abstract: A system including a light source, sampling tray, and a plurality of fiber optics positioned to achieve high contrast to improve accuracy and eliminate the need to rotate the sample. A composite light image from the fiber optics is fed to a spectrometer which converts the reflected light into a fingerprint corresponding to the concentration of at least one substance in the sample. The fingerprint is processed by a statistical model to determine concentration level of the at least one substance in the sample and the concentration level is then displayed.

公开(公告)号：US20180223335A1

公开(公告)日：2018-08-09

申请号：US15941383

申请日：2018-03-30

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: C12Q1/686 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US09952233B2

公开(公告)日：2018-04-24

申请号：US15404994

申请日：2017-01-12

Applicant: Lightwave Science, Inc.

Inventor： William Bryan Pierce, III ,  Jason D. Pierce

IPC: G01J3/00 ,  G01N33/94 ,  G01N21/84 ,  G01N21/25 ,  G01N21/3563 ,  G01N21/47

CPC classification number: G01N33/948 ,  G01J3/2803 ,  G01N21/255 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/474 ,  G01N21/84 ,  G01N2021/4742 ,  G01N2021/8466 ,  G01N2201/0221 ,  G01N2201/0692 ,  G01N2201/0833 ,  G01N2201/129

Abstract: A system including a light source, sampling tray, and a plurality of fiber optics positioned to achieve high contrast to improve accuracy and eliminate the need to rotate the sample. A composite light image from the fiber optics is fed to a spectrometer which converts the reflected light into a fingerprint corresponding to the concentration of at least one substance in the sample. The fingerprint is processed by a statistical model to determine concentration level of the at least one substance in the sample and the concentration level is then displayed.