公开(公告)号：KR100457069B1

公开(公告)日：2004-11-10

申请号：KR1020010054440

申请日：2001-09-05

Applicant: 한국화학연구원

Inventor： 조광연 ,  황인택 ,  최경자 ,  이병회 ,  홍경식 ,  김흥태 ,  김진철 ,  장경수 ,  최용호

IPC: A01N63/02

Abstract: PURPOSE: Provided are a novel Pythium myriotylum strain, a pathogen of plants, and a method for the biological control of weeds using same, thereby effectively and selectively removing weeds from a rice field. CONSTITUTION: The novel strain, Pythium myriotylum MD2(KCTC 10034BP) is used for selectively controlling weeds selected from American black cherry, Monochoria vaginalis, yellow birtch, Chondostereum purpureum, Northern joint vetch, Colletotrichum gloeosporioides f. sp. aeschynomene, Morrenia odorata, Phyrophthora palmivora, Poa annua, Pseudomonas gladioli, etc.

Abstract translation: 用途：提供了一种新型的Pythium myriotylum菌株，植物病原体，以及使用它的生物防治杂草的方法，由此有效地选择性地从稻田中除去杂草。 组成：新菌株Pythium myriotylum MD2（KCTC 10034BP）用于选择性控制选自美国黑樱桃，Monochoria vaginalis，黄色birtch，Chondostereum purpureum，Northern joint vetch，Colletotrichum gloeosporioides f。 SP。 aeschynomene，Morrenia odorata，Phyrophthora palmivora，Poa annua，唐菖蒲假单胞菌等

公开(公告)号：KR100427262B1

公开(公告)日：2004-04-14

申请号：KR1020010042933

申请日：2001-07-16

Applicant: 한국화학연구원

Inventor： 박창식 ,  이현규 ,  김은경 ,  최경자

IPC: A01N43/42

Abstract: PURPOSE: A process for preparing a methoxy acrylate derivative containing sulfur having a new structure by bonding a 4-quinolinone group or a benzothiopyrane-4-one group to a methoxy acrylate group through sulfur is provided. Whereby, the product has an excellent antibacterial activity against various plant pathogenic bacteria and is useful as a microbial agent. CONSTITUTION: The titled compound of formula(1) is prepared by the reaction of a compound of formula(2) with a compound of formula(3) at -20 to 50deg.C in the presence of an inorganic or organic base. In formulae, R1, R2, R3 and R4 are each independently H, halogen, C1-3 alkyl, C1-3 alkoxy, nitro or C1-3 haloalkyl, R5 is H, halogen, C1-3 alkyl or -C(=O)-R6, R6 is C1-6 alkyl, X is S or NH, Y is CH or N, Z is halogen, toluene sulfonate(OTs) or methane sulfonate(-OMs).

Abstract translation: 目的：提供一种通过硫将4-喹啉酮基团或苯并硫杂吡喃-4-酮基团键合到甲氧基丙烯酸酯基团上来制备具有新结构的硫的甲氧基丙烯酸酯衍生物的方法。 由此，该产品对各种植物病原菌具有优异的抗菌活性，并且可用作微生物剂。 构成：式（1）标题化合物是通过式（2）化合物与式（3）化合物在无机或有机碱存在下于-20至50℃反应而制备的。 在通式中，R1，R2，R3和R4各自独立地为H，卤素，C1-3烷基，C1-3烷氧基，硝基或C1-3卤代烷基，R5为H，卤素，C1-3烷基或-C ）-R6，R6是C1-6烷基，X是S或NH，Y是CH或N，Z是卤素，甲苯磺酸酯（OTs）或甲磺酸酯（-OMs）。

公开(公告)号：KR1020030050072A

公开(公告)日：2003-06-25

申请号：KR1020010080458

申请日：2001-12-18

Applicant: 한국화학연구원

Inventor： 조광연 ,  김진철 ,  김흥태 ,  최경자 ,  장경수 ,  최용호

IPC: C12N1/14

Abstract: PURPOSE: A method for biological control of plant diseases using Chaetomium globosum F0142 and chaetoviridins A and B produced by the same is provided, thereby effectively controlling plant diseases. CONSTITUTION: A method for biological control of plant diseases using Chaetomium globosum F0142(KCTC 0957BP) and chaetoviridins A and B produced by the same comprises spraying the cultured medium, mycelia or spores of Chaetomium globosum F0142, or chaetoviridins A and B isolated from the Chaetomium globosum cultured medium to plants, wherein the plant disease is rice blast disease, late blight, leaf rust or phytophthora blight. The chaetoviridins A and B are represented by the formula(1) and (2) respectively, and purified by extraction of Chaetomium globosum F0142(KCTC 0957BP) with ethyl acetate, first silica gel column chromatography, thin layer chromatography and second silica gel column chromatography, sequentially.

Abstract translation: 目的：提供使用球毛壳菌F0142和由其生产的凝血酶原A和B的植物病害生物防治方法，从而有效控制植物病害。 构成：使用球毛壳菌F0142（KCTC 0957BP）和由其产生的切杆菌素A和B的植物病害的生物防治方法包括喷洒球形梭菌F0142的培养培养基，菌丝体或孢子，或从毛壳菌分离的凝血因子A和B 球藻培养基至植物，其中植物病是稻瘟病，晚疫病，叶锈病或疫病疫苗。 川to嗪A和B分别由式（1）和（2）表示，并用乙酸乙酯萃取球毛壳菌F0142（KCTC 0957BP），首先用硅胶柱层析，薄层色谱和第二次硅胶柱色谱法提纯 ，顺序。

公开(公告)号：KR1020010078028A

公开(公告)日：2001-08-20

申请号：KR1020010003269

申请日：2001-01-19

Applicant: 한국화학연구원

Inventor： 조광연 ,  유주현 ,  임희경 ,  최경자

IPC: A01N25/30

CPC classification number: A01N25/30 ,  A01N25/04 ,  A01N25/14 ,  A01N43/84

Abstract: PURPOSE: Provided are surfactant compositions to enhance the absorbency of fungicide, dimethomorph, into plant leaf thereby reducing the dosage while increasing protecting/curing effect of the fungicide. A fungicide composition containing them, non ionic surfactant and agriculturally allowed carrier is also described. CONSTITUTION: The compositions are comprised of non ionic surfactant, 0-20wt.% additional emulsifier or assistant dispersants and 0-97wt.% carrier. The surfactants are at least one selected from polyoxyethylene stearyl ether, polyoxyethylene cetyl ether, polyoxyethylene oleyl ether and polyoxyethylene lauryl ester where the additional polymerization rate of ethylene oxide is 5-25 moles. The additional emulsifier and assistant dispersant are selected from polyoxyethylene nonylphenyl ether, polyoxyethylene tristearylphenyl ether, polyoxyethylene polyoxypropylene tristearyl ether, polyoxyethylene alkylaryl sulfonate, sodium dodecylbenzene sulfonate and sodium dioctylsulfosuccinate. The carriers are water, non water soluble organic solvent, water mixed organic solvent, natural or synthetic minerals and natural or synthetic polymers.

Abstract translation: 目的：提供表面活性剂组合物，以增强杀真菌剂，烯酰吗啉在植物叶中的吸收性，从而减少剂量，同时增加杀真菌剂的保护/固化效果。 还描述了含有它们的杀真菌剂组合物，非离子表面活性剂和农业上允许的载体。 组成：组合物由非离子表面活性剂，0-20重量％的另外的乳化剂或辅助分散剂和0-97重量％的载体组成。 表面活性剂是选自聚氧乙烯硬脂基醚，聚氧乙烯十六烷基醚，聚氧乙烯油基醚和聚氧乙烯月桂基酯中的至少一种，其中环氧乙烷的另外的聚合速率为5-25摩尔。 另外的乳化剂和辅助分散剂选自聚氧乙烯壬基苯基醚，聚氧乙烯三硬脂基苯基醚，聚氧乙烯聚氧丙烯三硬脂醚，聚氧乙烯烷基芳基磺酸钠，十二烷基苯磺酸钠和二辛基磺基琥珀酸钠。 载体是水，非水溶性有机溶剂，水混合有机溶剂，天然或合成矿物质和天然或合成聚合物。

公开(公告)号：KR1020010018591A

公开(公告)日：2001-03-05

申请号：KR1019990034614

申请日：1999-08-20

Applicant: 한국화학연구원

Inventor： 박창식 ,  최은복 ,  김은숙 ,  최경자

IPC: C07D403/14

Abstract: PURPOSE: The 1-phenyl 4-azolyl pyrazole derivatives, a producing method thereof, and a bactericidal composition containing the derivatives useful for agriculture and gardening are provided for killing a wide range of plant bacteria having tolerance to the conventional bactericides. CONSTITUTION: The 1-phenyl 4-azolyl pyrazole derivatives useful as a bactericidal agent are represented by the formula (1), in which n is an integer of 0 to 2; X is 1 to 3 of C1-C3 alkyl, 1 to 3 of chloro, 1 to 3 of fluoro, 1 to 3 of C1-3 alkoxy, nitro, trihaloalkyl, 3,4-ethylenedioxy, or substituted or unsubstituted phenyl or phenoxy; Y is hydrogen, 1 to 3 of C1-C3 alkyl, 1 to 3 of chloro, 1 to 3 of fluoro, 1 to 3 of C1-3 alkoxy, nitro, trihaloalkyl, or substituted or unsubstituted phenyl; and Z is CH or N. The 1-phenyl 4-azolyl pyrazole derivatives is produced by reacting azolyl alpha-oxo ketenedithioacetal of formula (2) with phenylhydrazin of formula (3) in organic solvents. The bactericidal composition contains an effective amount of the 1-phenyl 4-azolyl pyrazole derivatives.

Abstract translation: 目的：提供1-苯基4-噻唑基吡唑衍生物及其制备方法和含有用于农业和园艺的衍生物的杀菌组合物，用于杀死对常规杀菌剂具有耐受性的广泛范围的植物细菌。 构成：用作杀菌剂的1-苯基4-噻唑基吡唑衍生物由式（1）表示，其中n为0-2的整数; X为1至3个C 1 -C 3烷基，1至3个氯，1至3个氟，1至3个C 1-3烷氧基，硝基，三卤代烷基，3,4-亚乙二氧基或取代或未取代的苯基或苯氧基; Y是氢，1至3个C 1 -C 3烷基，1至3个氯，1至3个氟，1至3个C 1-3烷氧基，硝基，三卤代烷基或取代或未取代的苯基; 并且Z是CH或N. 1-苯基4-噻唑基吡唑衍生物通过式（2）的唑基α-氧代烯酮二硫缩醛与式（3）的苯肼在有机溶剂中反应来制备。 该杀菌组合物含有有效量的1-苯基4-唑基吡唑衍生物。

公开(公告)号：KR1020000002286A

公开(公告)日：2000-01-15

申请号：KR1019980022959

申请日：1998-06-18

Applicant: 한국화학연구원

Inventor： 이재현 ,  최일영 ,  지성기 ,  최경자

IPC: C07D413/04

Abstract: PURPOSE: Oxazinyl derivatives of the formula (I) wherein: R is H or methyl; X is H, Cl, trifluoromethyl, 2,4-dichlorophenyl, methoxy, or fluoro; Y is morpholine, piperidine, pyrrole, pyrrolidine, imidazole, or triazole; Z is phenyl, 2-fluorophenyl, 3-fluorophenyl, 2,4-chlorophenyl, or benzyl) which can be used as bactericide for agriculture and gardening are prepared. CONSTITUTION: The acetophenone derivatives of the formula (II) are provided in carbon disulfide and brome is added to the solution to give dibromoacetophenone derivatives, which is dissolved in methanol and hydroxyamine HCl salt is added to give oxime derivatives of the formula (III). The oxime of the formula (III) is dissolved in methylene chloride and cycled with arylether compound of the formula (IV) to give bromooxazine derivatives of the formula (V), which are dissolved in THF and reacted with morpholine, piperidine, pyrrole, pyrrolidine, imidazole, or triazole to give the compound of the formula (I).

Abstract translation: 目的：式（I）的恶嗪基衍生物，其中：R为H或甲基; X是H，Cl，三氟甲基，2,4-二氯苯基，甲氧基或氟; Y是吗啉，哌啶，吡咯，吡咯烷，咪唑或三唑; Z是可用作农业和园艺杀菌剂的苯基，2-氟苯基，3-氟苯基，2,4-氯苯基或苄基）。 构成：将式（II）的苯乙酮衍生物提供在二硫化碳中，并将brome加入到溶液中，得到溶解在甲醇中的二溴苯乙酮衍生物，加入羟胺HCl盐，得到式（III）的肟衍生物。 将式（III）的肟溶解在二氯甲烷中，并与式（Ⅳ）的芳基醚化合物一起循环，得到式（Ⅴ）的溴恶嗪衍生物，它们溶于THF中，与吗啉，哌啶，吡咯，吡咯烷 ，咪唑或三唑，得到式（I）化合物。

公开(公告)号：KR100240198B1

公开(公告)日：2000-01-15

申请号：KR1019970038087

申请日：1997-08-09

Applicant: 한국화학연구원

Inventor： 박창식 ,  김범태 ,  박노균 ,  최경자

IPC: C07C251/16 ,  C07C65/00 ,  C07C323/56 ,  A01N37/00

CPC classification number: A01N37/50 ,  A01N37/38 ,  C07C69/736 ,  C07C235/78 ,  C07C251/42 ,  C07C323/56

Abstract: 본 발명은 살균 활성이 강력하고 독성이 낮으며 약효의 지속성이 개선된 하기 일반식(I)의 트리플루오르메틸기가 치환된 알케닐기를 갖는 신규의 프로페노익 에스테르 및 아미드 유도체 및 이를 함유하는 살균제 조성물에 관한 것이다.
[화학식 1]

(상기식에서, X는 CH 또는 N을 나타내고, Y는 0 또는 S를 나타내고, Z는 0 또는 NH를 나타내며, R은 n-헥실 또는 수소, 탄소수 1-4 개의 알킬, 할로알킬, 알콕시, 메틸렌디옥시 또는 염소, 불소 및 취소중에서 선택된 하나 또는 복수로 치환된 페닐 또는 티오펜기를 나타낸다.)

公开(公告)号：KR100134811B1

公开(公告)日：1998-01-06

申请号：KR1019940031777

申请日：1994-11-29

Applicant: 한국화학연구원

Inventor： 박창식 ,  연규환 ,  최경자

IPC: C07D265/02 ,  A01N43/72

公开(公告)号：KR1019970011458B1

公开(公告)日：1997-07-11

申请号：KR1019940031777

申请日：1994-11-29

Applicant: 한국화학연구원

Inventor： 박창식 ,  연규환 ,  최경자

IPC: C07D265/02 ,  A01N43/72

Abstract: Chlorooxyimido acetate is halogenated in the presence of base or in the absence of base such as sodium carbonate, potassium carbonate, trimethylamine or pyridine in solvent such as dichloromethane, chloroform, carbon tetrachloride, benzene, toluene, etc., to yield cyclopenta-(d)-(1,2)-oxazine-4-carboxylic acid derivatives of general formula(I) having great effect on diseases occurred by bacteria such as rhizoctonia solani, pyricularia oryzae, corticium centrifugum, etc. In general formula(I), Het represents hetero-aromatic ring, R1 represents hydrogen atom, low molecular weight alcohols having 1 to 6 carbon atoms, etc., and R2, R3, R4 respectively represent hydrogen atom, alkyl having 1 to 3 of carbon atoms, alkoxy, nitro group, halogen atoms or benzene.

Abstract translation: 在碱存在下或在不存在碱例如碳酸钠，碳酸钾，三甲胺或吡啶的溶剂如二氯甲烷，氯仿，四氯化碳，苯，甲苯等中卤化氯乙酰亚氨酸乙酯，得到环戊烷（d ） - 具有对细菌如立枯丝核菌（Solizoctonia solani），稻瘟菌（pyricularia oryzae），皮质离心液等离子体等引起的疾病引起的疾病影响很大的通式（I）的（1,2） - 恶嗪-4-羧酸衍生物。在通式（I）中，Het 表示杂芳香环，R 1表示氢原子，具有1〜6个碳原子的低分子量醇等，R 2，R 3，R 4分别表示氢原子，碳原子数1〜3的烷基，烷氧基，硝基， 卤原子或苯。

公开(公告)号：KR1019960017650A

公开(公告)日：1996-06-17

申请号：KR1019940031777

申请日：1994-11-29

Applicant: 한국화학연구원

Inventor： 박창식 ,  연규환 ,  최경자

IPC: C07D265/02 ,  A01N43/72

Abstract: 본 발명은 광범위한 살균력을 갖는 다음 일반식(Ⅰ)로 표시되는 싸이클로펜탄〔d〕〔1,2〕옥사진-4-카르복실산 유도체

(상기식에서, R은 메칠, 에칠, n-프로필 또는 i-프로필이고, R
1 는 수소, 할로겐원소, CH
2 CO
2 R′, COR
4 또는 CR
4 =NYR″이며, R
2 는 수소, 할로겐원소 또는 CH
2 CO
2 R′이며, R
3 는 수소, 할로겐원소 또는 CH
2 CO
2 R′이며, R
4 는 수소, C
1 ∼C
5 알킬기, C
1 ∼C
5 할로알킬기, 페닐, 한 개 또는 두 개의 할로겐 원자로 치환된 페닐 또는 C
1 ∼C
3 알킬기로 치환된 페닐이며, R′은 메틸 또는 에틸이며, R″는 C
1 ∼C
3 알킬, C
3 알케닐, 페닐, 한 개 또는 두 개의 할로겐 워자로 치환된 페닐 또는 C
1 ∼C
3 알킬기로 치환된 페닐이고, Y는 산소원자 또는 질소원자이다).