公开(公告)号：CA2402186A1

公开(公告)日：2001-09-13

申请号：CA2402186

申请日：2000-12-22

Applicant: BASF AG

Inventor： KIM JUN-WON ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  LEE HEUNG-SHICK ,  POMPEJUS MARKUS ,  KROEGER BURKHARD ,  HWANG BYUNG-JOON

IPC: C12N15/09 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/21 ,  C12N9/90 ,  C12N15/54 ,  C12P20060101 ,  C12P13/08 ,  C12P13/12 ,  C12P21/02 ,  C12R1/13

Abstract: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins form Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.

公开(公告)号：CZ20004536A3

公开(公告)日：2001-06-13

申请号：CZ20004536

申请日：1999-06-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K31/70 ,  A61K38/45 ,  A61K48/00 ,  C07K14/455 ,  C12N9/10 ,  C12N15/10 ,  C12N15/54 ,  C12Q1/6804 ,  G01N33/53 ,  C12Q1/68

公开(公告)号：NO20006153A

公开(公告)日：2001-02-02

申请号：NO20006153

申请日：2000-12-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N

CPC classification number: C12N9/1077 ,  A01K2217/05 ,  A61K38/00 ,  A61K49/00 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/00 ,  C12Q1/48 ,  C12Y204/0203 ,  G01N2333/91142

公开(公告)号：CA2590625A1

公开(公告)日：2001-01-11

申请号：CA2590625

申请日：2000-06-27

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG

IPC: C12N15/31 ,  C07K14/34 ,  C12P13/04 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/569

公开(公告)号：CA2383875A1

公开(公告)日：2001-01-04

申请号：CA2383875

申请日：2000-06-23

Applicant: BASF AG

Inventor： SCHROEDER HARTWIG ,  POMPEJUS MARKUS ,  KROEGER BURKHARD ,  HABERHAUER GREGOR ,  ZELDER OSKAR

IPC: G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/09 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, whic h encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells int o which the expression vectors have been introduced. The invention still furth er provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desire d compound from C. glutamicum based on genetic engineering of SMP genes in thi s organism.

公开(公告)号：CA2383865A1

公开(公告)日：2001-01-04

申请号：CA2383865

申请日：2000-06-23

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  HABERHAUER GREGOR ,  KROEGER BURKHARD ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG

IPC: G01N33/53 ,  C07H21/04 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/20 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/18 ,  C12N9/90 ,  C12N15/09 ,  C12N15/31 ,  C12N15/61 ,  C12N15/74 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12P21/06 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

Abstract: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still furth er provides isolated MP proteins, mutated MP proteins, fusion proteins, antigen ic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism .

公开(公告)号：CA2380871A1

公开(公告)日：2001-01-04

申请号：CA2380871

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  HABERHAUER GREGOR ,  ZELDER OSKAR ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG

IPC: C12N15/09 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/21 ,  C12N9/00 ,  C12N9/02 ,  C12N9/18 ,  C12N15/31 ,  C12N15/52 ,  C12P20060101 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12R1/15

Abstract: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still furth er provides isolated HA proteins, mutated HA proteins, fusion proteins, antigen ic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism .

公开(公告)号：DE19809978A1

公开(公告)日：1999-09-16

申请号：DE19809978

申请日：1998-03-09

Applicant: BASF AG

Inventor： KROEGER BURKHARD

IPC: A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C07K16/00 ,  A01K67/00 ,  C07H21/04 ,  C07K14/435 ,  C12N1/00 ,  C12N5/10 ,  C12N15/11 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/567 ,  G01N33/68

Abstract: An isolated protein (I) comprising a 300 amino acid (aa) sequence (2), reproduced, and derivatives of (2) having substitutions, inversions, insertions or deletions of one or more aa (provided they retain the essential biological properties of (2)), are new. Independent claims are also included for the following: (a) nucleic acid (II) encoding (I) or proteins with at least 60% identity with (2); (b) recombinant nucleic acid construct containing (I) linked to a regulatory element; (c) a host organism transformed with (II) or the construct of (b); (d) transgenic animals containing a (non-)functional construct of (b); (e) antibodies (Ab) that react selectively with (I); and (f) a method for identifying (ant)agonists or ligands (A) of (I).

公开(公告)号：DE59209064D1

公开(公告)日：1998-01-22

申请号：DE59209064

申请日：1992-09-23

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/14 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02

Abstract: PCT No. PCT/EP92/02198 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Sep. 23, 1992 PCT Pub. No. WO93/09231 PCT Pub. Date May 13, 1993A novel thrombin inhibitory protein from ticks with a molecular weight of about 26000 dalton and the partial amino acid sequences Val-Ala-Lys-Phe-Ala-X-Asn-Ser-Gly-Ser-Glu-Thr-Gly (SEQ ID NO: 8), His-Ala-Y-Phe-Glu (SEQ ID NO: 3), Arg-Val-Ser-Asp-Phe-Glu (SEQ ID NO: 4), Phe-Val-Tyr-Thr-Ile-Glu (SEQ ID NO: 6), where X and Y can be identical or different and each is a naturally occurring amino acid, is suitable for controlling diseases.

公开(公告)号：AT161046T

公开(公告)日：1997-12-15

申请号：AT92920588

申请日：1992-09-23

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/14 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02

Abstract: PCT No. PCT/EP92/02198 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Sep. 23, 1992 PCT Pub. No. WO93/09231 PCT Pub. Date May 13, 1993A novel thrombin inhibitory protein from ticks with a molecular weight of about 26000 dalton and the partial amino acid sequences Val-Ala-Lys-Phe-Ala-X-Asn-Ser-Gly-Ser-Glu-Thr-Gly (SEQ ID NO: 8), His-Ala-Y-Phe-Glu (SEQ ID NO: 3), Arg-Val-Ser-Asp-Phe-Glu (SEQ ID NO: 4), Phe-Val-Tyr-Thr-Ile-Glu (SEQ ID NO: 6), where X and Y can be identical or different and each is a naturally occurring amino acid, is suitable for controlling diseases.