公开(公告)号：AT277916T

公开(公告)日：2004-10-15

申请号：AT95903870

申请日：1994-12-21

Applicant: CELLTECH R&D LTD

Inventor： WARRELLOW GRAHAM JOHN ,  BOYD EWAN CAMPBELL ,  ALEXANDER RIKKI PETER ,  EATON MICHAEL ANTHONY WILLIAM

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4418 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D213/64 ,  C07D231/20 ,  C07D261/12

Abstract: Compounds of general formula (1): (1) wherein Y is a halogen atom or a group -OR1 where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 is a hydrogen or halogen atom or an -OR9 group, where R9 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl group, or a formyl, carboxamido or thiocarboxamido group; R4 is a group -(CH2)nAr, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1,2 or 3; R5 is a C3-9 carbocyclic ketone optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; R6 is a hydrogen atom or an optionally substituted alkyl group; R7 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.

公开(公告)号：GB0417776D0

公开(公告)日：2004-09-15

申请号：GB0417776

申请日：2004-08-10

Applicant: CELLTECH R&D LTD

公开(公告)号：GB0417115D0

公开(公告)日：2004-09-01

申请号：GB0417115

申请日：2004-07-30

Applicant: CELLTECH R&D LTD

公开(公告)号：AU2004210776A1

公开(公告)日：2004-08-26

申请号：AU2004210776

申请日：2004-02-06

Applicant: CELLTECH R&D LTD

Inventor： LAWSON ALASTAIR DAVID GRIFFITH ,  POPPLEWELL ANDREW GEORGE

IPC: A61K47/48 ,  C07K16/24 ,  C12N15/13 ,  C12N15/85 ,  C12N5/10 ,  A61K39/395

Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1², therapeutic uses of the antibody molecule and methods for producing said antibody molecule.

公开(公告)号：NZ516596A

公开(公告)日：2004-07-30

申请号：NZ51659601

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N15/09 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

Abstract: The application discloses an antibody molecule having specificity for human TNFalpha , comprising a heavy chain containing at least one CDR derived from a mouse monoclonal antibody. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF alpha.

公开(公告)号：AT270266T

公开(公告)日：2004-07-15

申请号：AT00987574

申请日：2000-12-22

Applicant: CELLTECH R&D LTD

Inventor： LANGHAM BARRY JOHN ,  ALEXANDER RIKKI PETER ,  HEAD JOHN CLIFFORD ,  LINSLEY JANEEN MARSHA ,  PORTER JOHN ROBERT ,  ARCHIBALD SARAH CATHERINE ,  WARRELLOW GRAHAM JOHN

IPC: C07C229/34 ,  C07C229/36 ,  C07D471/04 ,  C07C225/20 ,  C07C229/46 ,  C07D295/12 ,  A61K31/13 ,  A61K31/435 ,  A61P29/00

Abstract: Squaric acid derivatives of formula (1) are described:whereinR1 is a group Ar1Ar2Alk- in whichAr1 is an optionally substituted aromatic or heteroaromatic group;Ar2 is an optionally substituted phenylene or nitrogen-containing six-membered heteroarylene group; and Alk is a chain-CH2-CH(R)-, -CH=C(R)-,in which R is a carboxylic acid (-CO2H) or a derivative or biostere thereof;R2 is a hydrogen atom or a C1-6 alkyl group;L1 is a covalent bond or a linker atom or group;n is zero or the integer 1;Alk1 is an optionally substituted aliphatic chain;R3 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group: and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.

公开(公告)号：ZA200305372B

公开(公告)日：2004-07-12

申请号：ZA200305372

申请日：2003-07-11

Applicant: CELLTECH R&D LTD

Inventor： BAILEY STUART ,  BROWN JULIEN ALISTAIR ,  BRAND STEPHEN ,  JOHNSON JAMES ANDREW ,  PORTER JOHN ROBERT ,  HEAD JOHN CLIFFORD

IPC: A61P20060101 ,  C07C20060101 ,  C07D20060101 ,  C07D ,  A61P ,  C07C

公开(公告)号：MXPA04001212A

公开(公告)日：2004-07-08

申请号：MXPA04001212

申请日：2002-08-07

Applicant: CELLTECH R&D LTD

Inventor： HAZEL JOAN DYKE

IPC: A61K31/453 ,  A61P1/00 ,  A61P1/02 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12 ,  A61K31/445 ,  C07D309/08

Abstract: Un compuesto de formula (I) en donde: R1 y R2, los cuales pueden ser iguales o diferentes, cada uno es un atomo de hidrogeno o un grupo CF3, CF2H o CFH2, con la condicion de que cuando uno de R1 o R2 es un atomo de hidrogeno el otro es un grupo CF3, CF2H o CFH2; y sus sales, solvatos o hidratos. Los compuestos son inhibidores potentes de la MMP que ventajosamente no provocan tendonitis en un modelo animal relevante. Los compuestos pueden suponerse que con de uso en la medicina, especialmente cuando se desea la prevencion de efectos secundarios como dolor articular.

公开(公告)号：GB0411805D0

公开(公告)日：2004-06-30

申请号：GB0411805

申请日：2004-05-26

Applicant: CELLTECH R&D LTD

公开(公告)号：GB0410021D0

公开(公告)日：2004-06-09

申请号：GB0410021

申请日：2004-05-05

Applicant: CELLTECH R&D LTD

IPC: A61K38/17 ,  A61K39/395 ,  C07K14/435 ,  C07K14/47

Abstract: The present invention relates to new uses of FLJ20584 in the diagnosis, screening, treatment and prophylaxis of ovarian and lung cancer. The invention also provides compositions comprising FLJ20584, including vaccines, antibodies that are immunospecific for FLJ20584 and agents which interact with or modulate the expression or activity of FLJ20584 or which modulate the expression of the nucleic acid which codes for FLJ20584.