公开(公告)号：TR9801102T2

公开(公告)日：1998-12-21

申请号：TR9801102

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JURGEN ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

CPC classification number: A61K38/08

公开(公告)号：TR199801102T2

公开(公告)日：1998-12-21

申请号：TR9801102

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JURGEN ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：ZA973098B

公开(公告)日：1998-10-12

申请号：ZA973098

申请日：1997-04-11

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  KLINGE DAGMAR ,  AMBERG WILHELM ,  KLING ANDREAS ,  HILLEN HEINZ ,  UNGER LILIANE ,  ELGER BERND

IPC: C07D251/30 ,  A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  A61K31/529 ,  A61K31/53 ,  A61P7/00 ,  A61P9/00 ,  A61P9/02 ,  A61P9/12 ,  A61P13/00 ,  A61P13/08 ,  A61P13/12 ,  C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/48 ,  C07D403/12 ,  C07D491/044 ,  C07D ,  A61K

Abstract: The invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings defined in the description, to the preparation of these compounds and to their use as drugs.

公开(公告)号：ZA973096B

公开(公告)日：1998-10-12

申请号：ZA973096

申请日：1997-04-11

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  UNGER LILIANE ,  RASCHACK MANFRED ,  HERGENROEDER STEFAN ,  SCHULT SABINE

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/505 ,  A61P9/00 ,  A61P9/12 ,  A61P13/00 ,  A61P13/12 ,  C07D215/22 ,  C07D215/227 ,  C07D239/34 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D ,  A61K

Abstract: PCT No. PCT/EP97/01687 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Apr. 4, 1997 PCT Pub. No. WO97/38982 PCT Pub. Date Oct. 23, 1997Carboxylic acid derivatives of the formula I where the radicals have the meanings stated in the description, and the preparation of these agreements [sic] and their use as drugs are described.

公开(公告)号：ZA9703097B

公开(公告)日：1998-10-12

申请号：ZA9703097

申请日：1997-04-11

Applicant: BASF AG

Inventor： KLINGE DAGMAR ,  AMBERG WILHELM ,  BAUMANN ERNST ,  KLING ANDREAS ,  RIECHERS HARTMUT ,  UNGER LILIANE ,  RASCHACK MANFRED ,  HERGENROEDER STEFAN ,  SCHULT SABINE

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  A61P5/42 ,  A61P9/10 ,  A61P13/00 ,  A61P13/12 ,  C07D217/22 ,  C07D239/34 ,  C07D239/48 ,  C07D239/52 ,  C07D239/56 ,  C07D239/60 ,  C07D239/70 ,  C07D239/80 ,  C07D239/96 ,  C07D251/20 ,  C07D251/22 ,  C07D251/30 ,  C07D251/38 ,  C07D251/52 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D ,  A61K

CPC classification number: C07D217/22 ,  C07D239/34 ,  C07D239/48 ,  C07D239/52 ,  C07D239/56 ,  C07D239/60 ,  C07D239/80 ,  C07D239/96 ,  C07D251/20 ,  C07D251/22 ,  C07D251/30 ,  C07D251/38 ,  C07D251/52 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

公开(公告)号：MX9803662A

公开(公告)日：1998-09-30

申请号：MX9803662

申请日：1998-05-08

Applicant: BASF AG

Inventor： KLING ANDREAS ,  JANSSEN BERND ,  AMBERG WILHELM ,  HAUPT ANDREAS ,  RITTER KURT ,  BUSCHMANN ERNST ,  BERNARD HARALD ,  MULLER STEFAN ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  C07K7/06 ,  C07K07/06 ,  A61K38/08

Abstract: La presente invencion se refiere a los péptidos novedosos de la formula: A-B-D-E-F-L, en donde A, B, D, E, F y L tienen los significados mencionados en la especificacion, y su preparacion. Los compuestos novedosos son adecuados para controlar enfermedades.

公开(公告)号：AU6448298A

公开(公告)日：1998-09-29

申请号：AU6448298

申请日：1998-03-05

Applicant: BASF AG ,  BASF BIORESEARCH CORP

Inventor： RITTER KURT ,  AMBERG WILHELM ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS

IPC: A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K5/10 ,  C07K5/103 ,  C07K7/02 ,  A61K38/07

Abstract: The present invention relates to novel peptides useful as anti-cancer agents. The compounds of the invention are of Formula I,A-B-D-E-F-G(I)A, B, D, and E are alpha -amino acid residues. In one embodiment, F is an azacycloalkanecarboxylic acid residue. In this embodiment, G is a monovalent radical, for example, a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group. In another embodiment, F is an azacycloalkyl group and G is a heteroaryl group connected to F by a carbon-carbon bond. In another embodiment, the invention includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：CZ9801391A3

公开(公告)日：1998-09-16

申请号：CZ139198

申请日：1996-10-30

Applicant: BASF AG

Inventor： KLING ANDREAS ,  JANSSEN BERND ,  AMBERG WILHELM ,  HAUPT ANDREAS ,  RITTER KURT ,  BUSCHMANN ERNST ,  BERNARD HARALD ,  MULLER STEFAN ,  ZIERKE THOMAS ,  BARLOZZARI TERESA ,  DE ARRUDA MONIKA ,  ROBINSON SIMON

IPC: A61K38/00 ,  A61K31/00 ,  C07K7/06 ,  A61K38/08

CPC classification number: C07K7/06 ,  A61K38/00

公开(公告)号：CA2275256A1

公开(公告)日：1998-06-25

申请号：CA2275256

申请日：1997-12-04

Applicant: BASF AG

Inventor： UNGER LILIANE ,  RASCHACK MANFRED ,  KLING ANDREAS ,  HERGENROEDER STEFAN ,  RIECHERS HARTMUT ,  KLINGE DAGMAR ,  JANSEN ROLF ,  AMBERG WILHELM

IPC: C07D253/06 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D403/12 ,  C07D491/04 ,  C07D253/08 ,  C07D237/18 ,  C07D237/20 ,  C07D241/20 ,  C07D237/22

Abstract: The present invention relates to carboxylic acid derivatives of formula (I), wherein the substituents have the meaning cited in the description, as well as to the production and use of said substances as endothelin receptor antagonists.

公开(公告)号：ZA9610510B

公开(公告)日：1998-06-15

申请号：ZA9610510

申请日：1996-12-13

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JUERGEN ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06 ,  C07K ,  A61K

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.