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公开(公告)号：AU2010214783B2
公开(公告)日：2011-07-21
申请号：AU2010214783
申请日：2010-09-02
Applicant: FLUIDIGM CORP
Inventor： ROBERT GROSSMAN , MARC UNGER , PHILLIP LAM , HOU-PU CHOU , JAKE KIMBALL , MARTIN PIEPRZYK
IPC: G01N15/06 , B01J19/00 , B01L3/00 , B01L3/06 , B01L9/00 , B01L99/00 , C30B7/00 , C30B29/58 , G01N33/00 , G01N33/48
Abstract: A microfluidic system, comprising: a receiving station, the receiving station adapted to receive a microfluidic device having a plurality of 5 chambers, the microfluidic device coupled to a carrier, with at least some of the plurality of chambers coupled to a plurality of inlets in the carrier; an interface plate adapted to engage at least one of the inlets in the carrier; 10 a fluid source coupled to the interface plate and adapted to provide pressurized fluid to at least one of the inlets in the carrier; and a controller coupled to the fluid source and to the interface plate for directing fluid from the fluid source 1 to the carrier. 23891131 (GHMatters) 26108/10
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公开(公告)号：CA2782181A1
公开(公告)日：2011-06-03
申请号：CA2782181
申请日：2010-11-30
Applicant: FLUIDIGM CORP
Inventor： WANG JING , WOUDENBERG TIMOTHY M
IPC: A61L2/00
Abstract: A method for rendering a microfluidic device suitable for reuse for nucleic acid analysis is provided. The method may include flowing a nucleic acid inactivating solution into a microfluidic channel of the device by pumping; and then flowing a wash solution into the channel by pumping, thereby displacing the nucleic acid inactivating solution from the channel, whereby any residual nucleic acid from a prior use of the device is inactivated.
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公开(公告)号：MX2010002556A
公开(公告)日：2010-08-02
申请号：MX2010002556
申请日：2008-09-08
Applicant: FLUIDIGM CORP
Inventor： RAMAKRISHNAN RAMESH
IPC: G01N33/48
Abstract: La presente invención es concerniente con métodos y sistemas para determinar la variación del número de copia de un polinucleótido objetivo en un genoma de un sujeto, que incluye técnicas a base de amplificación. Los métodos pueden incluir preamplificación de la muestra seguida por distribución de muestra y una pluralidad de volúmenes de reacción, detección cuantitativa de un polinucleótido objetivo y un polinucleótido de referencia y análisis para determinar el número de copia relativo de la secuencia de polinucleotido objetivo en el genoma del sujeto.
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公开(公告)号：AU2005208879A1
公开(公告)日：2005-08-11
申请号：AU2005208879
申请日：2005-01-25
Applicant: FLUIDIGM CORP
Inventor： CHOU HOU-PU , GROSSMAN ROBERT , LAM PHILLIP , KIMBALL JAKE , PIEPRZYK MARTIN , UNGER MARC
Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.
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公开(公告)号：CA2532530A1
公开(公告)日：2005-02-10
申请号：CA2532530
申请日：2004-07-28
Applicant: FLUIDIGM CORP
Inventor： TAYLOR COLIN JON , DUBE SIMANT , SUN GANG
Abstract: A method for processing an image of a microfluidic device. The method includ es receiving a first image of a microfluidic device. The first image correspond s to a first state. Additionally, the method includes receiving a second image of the microfluidic device. The second image corresponds to a second state. Moreover, the method includes transforming the first image and the second image into a third coordinate space. Also, the method includes obtaining a third image based on at least information associated with the transformed first image and the transformed second image, and processing the third image to obtain information associated with the first state and the second state.
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Patent Agency Ranking
公开(公告)号：CA2807591A1
公开(公告)日：2004-10-21
申请号：CA2807591
申请日：2004-04-05
Applicant: FLUIDIGM CORP
Inventor： MCBRIDE LINCOLN , LUCERO MICHAEL , UNGER MARC , NASSEF HANY RAMEZ , FACER GEOFFREY
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公开(公告)号：AU2003277853A1
公开(公告)日：2004-01-06
申请号：AU2003277853
申请日：2003-06-23
Applicant: FLUIDIGM CORP
Inventor： MANGER IAN D , BARCO JOSEPH W , NASSEF HANY R
IPC: B01L3/00 , B81C20060101 , F04B19/00 , F04B43/02 , G01N21/00 , G01N33/53 , G01N33/543 , G01N33/566 , G01N37/00
Abstract: A microfluidic device includes a plurality of first flow channels and a plurality of second flow channels, each such second flow channel intersecting multiple of the first flow channels to define intersecting volumes and a plurality of looped flow channels that each include segments of the flow channels between the intersecting volumes to define a closed loop. The microfluidic device also includes a plurality of control valves each such control valve having a control channel and a deformable segment disposed to restrict flow through a respective one of the first and second flow channels in response to an actuation force applied to the control channel to deflect the deformable segment. The microfluidic device further includes a pump operatively disposed to regulate flow through one of the looped flow channels to regulate flow by the recirculating pump.
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公开(公告)号：CA2480728A1
公开(公告)日：2003-10-16
申请号：CA2480728
申请日：2003-04-01
Applicant: FLUIDIGM CORP
Inventor： MANGER IAN D , THRONDSET WILLIAM , NASSEF HANY RAMEZ , NORTON PIERCE , FARRELL KEVIN , FOWLER BRIAN , HAO CUNSHENG CASEY , LIAU YISH-HANN , JAVADI SHERVIN , DARIDON ANTOINE , CHOU HOU-PU
IPC: G01N37/00 , B01L3/00 , C12M1/00 , C12M1/34 , C12M3/00 , C12N1/00 , C12Q1/02 , G01N15/02 , G01N15/14
Abstract: The invention provides systems (2000), including microfluidic mechanisms, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. These mechanisms may enable controlle d input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any number of suitable times in the system to allow particles to be sorted, cultured, mixed, treate d, and/or assayed, among others. These combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
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公开(公告)号：CA2467587A1
公开(公告)日：2003-06-12
申请号：CA2467587
申请日：2002-11-27
Applicant: FLUIDIGM CORP
Inventor： WIENECKE ANJA , YI YONG , FACER GEOFFREY , UNGER MARC A , LUCERO MICHAEL , MIYASHITA-LIN EMILY , MANGER IAN DAVID
IPC: G01N33/53 , B01F13/00 , B01L3/00 , C12M1/00 , C12Q1/25 , C12Q1/68 , C40B40/02 , C40B50/06 , C40B60/12 , C40B60/14 , F04B43/02 , G01N1/00 , G01N1/28 , G01N27/447 , G01N35/00 , G01N37/00 , C12M1/36 , G01N15/06 , C12N11/16 , C12P19/34
Abstract: A variety of elastomeric-based microfluidic devices and methods for using an d manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagent s have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and ge ne expression analyses.
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公开(公告)号：EP2506882A4
公开(公告)日：2017-05-17
申请号：EP10834067
申请日：2010-11-30
Applicant: FLUIDIGM CORP
Inventor： WANG JING , WOUDENBERG TIMOTHY M
CPC classification number: B08B9/027 , B01L3/5027 , B01L99/00 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084
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