公开(公告)号：WO2015095667A1

公开(公告)日：2015-06-25

申请号：PCT/US2014/071430

申请日：2014-12-19

Applicant: CAN TECHNOLOGIES, INC.

Inventor： KITTELSON, Jayd Marshal

IPC: G01N21/35 ,  G01N21/3563 ,  G01N33/02

CPC classification number: G01N15/0211 ,  A01K5/001 ,  B01F15/00214 ,  B01F15/00272 ,  B01F2215/0008 ,  G01N15/0205 ,  G01N15/0255 ,  G01N21/274 ,  G01N21/278 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/84 ,  G01N21/85 ,  G01N33/02 ,  G01N2021/8466 ,  G01N2021/8592 ,  G01N2201/127

Abstract: A method for developing a calibration for a near infrared reflectance spectrophotometer to predict the particle score of an ingredient, the method comprising (a) sorting a plurality of plant matter samples by size by passing such samples through a screen and subsequently calculating a particle score for the samples based on the number of samples passing through the screen, (b) measuring the absorbance or reflectance of the plurality of plant matter samples using the spectrophotometer, and (c) correlating the particle score from step (a) with the measured absorbance or reflectance from step (b),

Abstract translation: 一种用于开发用于近红外反射分光光度计的校准以预测成分的粒子分数的方法，所述方法包括（a）通过将所述样品通过筛网来分选多个植物物质样品，然后计算颗粒得分 基于通过筛选的样品数量的样品，（b）使用分光光度计测量多个植物物质样品的吸光度或反射率，和（c）将来自步骤（a）的颗粒分数与测量的吸光度或 来自步骤（b）的反射率，

公开(公告)号：WO2014160568A3

公开(公告)日：2014-12-31

申请号：PCT/US2014031186

申请日：2014-03-19

Applicant: WATERS TECHNOLOGIES CORP

Inventor： ANDREWS RICHARD W

IPC: G01N21/59

CPC classification number: G01N30/74 ,  G01N21/274 ,  G01N21/3103 ,  G01N21/59 ,  G01N30/8631 ,  G01N30/8665 ,  G01N2201/127

Abstract: The invention generally provides methods for improving the dynamic range of an absorbance detector and absorbance detectors having improved dynamic range. In an exemplary embodiment, the method includes receiving calibration data for a plurality of samples, the calibration data comprising an absorbance for a concentration of each of the samples, calculating a contribution of stray light to the calibration data, and correcting subsequent data by removing the contribution of stray light.

Abstract translation: 本发明总体上提供了用于改善具有改进的动态范围的吸光度检测器和吸光度检测器的动态范围的方法。 在示例性实施例中，该方法包括接收多个样本的校准数据，该校准数据包括每个样本的浓度的吸光度，计算杂散光对校准数据的贡献，以及通过去除 杂散光的贡献。

公开(公告)号：WO2014195355A1

公开(公告)日：2014-12-11

申请号：PCT/EP2014/061571

申请日：2014-06-04

Applicant: ROCHE DIAGNOSTICS GMBH ,  F.HOFFMANN-LA ROCHE AG

Inventor： KLEIDER, Wilhelm ,  KRÄMER, Hans-Dieter ,  SLUKA, Peter

IPC: G01N33/543 ,  G01N35/00

CPC classification number: G01N35/00693 ,  G01N21/59 ,  G01N27/26 ,  G01N33/50 ,  G01N33/6893 ,  G01N2035/00702 ,  G01N2201/127 ,  G01N2333/4737

Abstract: The invention provides for a method of analyzing a biological sample (404) using an analyzer (400) and an assay (408). The method comprises providing (100) the assay for producing the signal. The assay has two or more predetermined number of components. Each of predetermined number of components has a distinct relation between the intensive property and the signal. The method further comprises providing (102, 200) calibration samples with known values (430) for the intensive property and measuring (104, 202) a calibration signal (432) for each of the calibration samples. The method further comprises determining (106, 206) a calibration (434) by fitting a calibration function to the calibration signal for each of the calibration samples and the known values for the intensive property. The calibration function is equivalent to a constant plus an exponential decay term for each of the predetermined number of components. The method further comprises measuring (108, 208) the signal (436) of the biological sample using the analyzer and the assay and calculating (110, 210) the intensive property using the calibration.

Abstract translation: 本发明提供了使用分析器（400）和测定（408）分析生物样品（404）的方法。 该方法包括提供（100）用于产生信号的测定。 该测定具有两个或多个预定数量的组分。 每个预定数量的部件在密集性能和信号之间具有明显的关系。 该方法还包括提供具有用于密集特性的已知值（430）的（102,200）校准样本，并测量（104,202）每个校准样本的校准信号（432）。 该方法还包括通过将校准函数拟合到每个校准样本的校准信号和密集性质的已知值来确定（106,206）校准（434）。 校准功能等同于每个预定数量的组件的常数加上指数衰减项。 该方法还包括使用分析器测量（108,208）生物样品的信号（436），并使用校准计算（110,210）密集性质。

公开(公告)号：WO2014109205A1

公开(公告)日：2014-07-17

申请号：PCT/JP2013/084156

申请日：2013-12-19

Applicant: 株式会社日立ハイテクノロジーズ

Inventor： 神宮　孝広

IPC: G01N21/956

CPC classification number: G01N21/9501 ,  G01N21/93 ,  G01N21/956 ,  G01N2201/127

Abstract: 　使用環境や使用時間に関係なく、正確に校正可能な検査装置が実現される。搬送システム１１０上に回析格子１０７が形成された基準基板１００が搭載され照明光学系１０４からの光１０５による照明領域１０６が回析格子１０７上に形成され、検出光学系１０８に反射光を集光しセンサ１１１からの出力値を測定する。処理部１１２内に保存されたシミュレーション値とセンサ１１１からの出力値との差分が所定の許容範囲以内であるか否かを判断し、許容範囲内となるように光学系を調整する。検査装置の校正を行うための標準データを、回析格子を使用して得るように構成したので、使用環境や使用時間に関係なく、正確に校正可能な検査装置を実現することができる。

Abstract translation: 本发明的目的是实现能够精确校准的检查装置，而不管使用环境和使用时间如何。 在其上形成有衍射光栅（107）的参考基板（100）安装在传送系统（110）上; 在衍射光栅（107）上形成由照明光学系统（104）的光（105）照明的照明区域（106）。 反射光集中在检测光学系统（108）中; 并且从传感器（111）测量输出值。 确定保存在处理单元（112）中的模拟值与来自传感器（111）的输出值之间的差是否在规定的公差范围内，然后调整光学系统，使得它们在 公差范围。 可以实现能够精确校准而不管使用环境和使用时间的检查装置，因为该装置被配置为使得通过使用衍射光栅获得用于校准检查装置的参考数据。

公开(公告)号：WO2013096660A1

公开(公告)日：2013-06-27

申请号：PCT/US2012/071030

申请日：2012-12-20

Applicant: RUDOLPH TECHNOLOGIES, INC.

Inventor： OHREN, Dennis L. ,  VOGES, Christopher J. ,  ROTERING, Andrew E.

IPC: G01B11/00 ,  G01N21/88 ,  G01C5/00

CPC classification number: G02B7/28 ,  G01B11/00 ,  G01B11/026 ,  G01B11/0608 ,  G01N21/84 ,  G01N21/9501 ,  G01N2201/127 ,  H04N5/23212

Abstract: A focus height sensor in an optical system for inspection of semiconductor devices includes a sensor beam source that emits a beam of electromagnetic radiation. A reflector receives the beam of electromagnetic radiation from the sensor beam source and directs the beam toward a surface of a semiconductor device positioned within a field of view of the optical system. The reflector is positioned to receive at least a portion of the beam back from the surface of the semiconductor device to direct the returned beam to a sensor. The sensor receives the returned beam and outputs a signal correlating to a position of the surface within the field of view along an optical axis of the optical system.

Abstract translation: 用于检查半导体器件的光学系统中的焦点高度传感器包括发射电磁辐射束的传感器光束源。 反射器接收来自传感器光束源的电磁辐射束，并将光束引向位于光学系统的视野内的半导体器件的表面。 反射器定位成从半导体器件的表面接收光束的至少一部分，以将返回的光束引导到传感器。 传感器接收返回的光束，并沿着光学系统的光轴输出与视场内的表面的位置相关的信号。

公开(公告)号：WO2012012377A2

公开(公告)日：2012-01-26

申请号：PCT/US2011/044454

申请日：2011-07-19

Applicant: BIOMERIEUX, INC. ,  CLAY, Bradford, G.

Inventor： CLAY, Bradford, G.

IPC: C12Q1/04 ,  C12M1/34

CPC classification number: G01N33/84 ,  C12M41/26 ,  C12M41/34 ,  C12M41/36 ,  G01N21/3151 ,  G01N21/78 ,  G01N21/783 ,  G01N21/80 ,  G01N2021/3181 ,  G01N2201/127

Abstract: A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or C0 2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.

Abstract translation: 一种用于血液培养瓶的检测器装置，其包含由血培养瓶内的样品介质的pH或CO 2变化而使颜色变化的比色传感器。 检测器装置包括照亮比色传感器的传感器LED，照亮比色传感器的参考LED，用于选择性地和交替地激活传感器LED和参考LED的控制电路和光电检测器。 光电检测器在比色传感器与传感器LED和参考LED的选择性和交替照明期间测量来自比色传感器的反射率，并产生强度信号。 参考LED被选择为具有照明的峰值波长，使得来自参考LED的照明的光电检测器的强度信号基本上不受比色传感器的颜色的变化的影响。

公开(公告)号：WO2010019960A3

公开(公告)日：2010-08-19

申请号：PCT/US2009054071

申请日：2009-08-17

Applicant: LITMUS RAPID B LLC ,  BUZATU DAN A ,  WILKES JON G ,  MOSKAL TED A ,  NEVIUS BILL ,  TAYLOR JASON T ,  TUCKER RANDAL K ,  MILLER MELINDA ,  RAMSANOOP SHAWN

Inventor： BUZATU DAN A ,  WILKES JON G ,  MOSKAL TED A ,  NEVIUS BILL ,  TAYLOR JASON T ,  TUCKER RANDAL K ,  MILLER MELINDA ,  RAMSANOOP SHAWN

IPC: C12Q1/02 ,  C12M1/34 ,  G01N33/52 ,  G01N35/08

CPC classification number: C12Q1/04 ,  C12Q1/06 ,  G01N1/38 ,  G01N15/1012 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/6486 ,  G01N33/569 ,  G01N33/56911 ,  G01N2001/028 ,  G01N2015/1402 ,  G01N2201/06113 ,  G01N2201/127 ,  Y10T436/101666

Abstract: In various embodiments, the present disclosure describes methods and systems for detecting microbes in a sample. The methods are generally applicable to quantifying the number of target bacteria in a sample counted from a detection region of a flow cytometer histogram. The detection methods can be employed in the presence of other microorganisms and other non-target microbe components to selectively quantify the amount of a target microbe. The methods are advantageous over those presently existing for testing of foodstuffs and diagnostic evaluation in their speed, accuracy and ease of use. Various swab collection devices and kits useful for practicing the present disclosure are also described herein.

Abstract translation: 在各种实施方案中，本公开描述了用于检测样品中微生物的方法和系统。 该方法通常适用于定量从流式细胞仪直方图的检测区域计数的样品中的目标细菌数。 检测方法可以在其他微生物和其他非目标微生物组分的存在下使用，以选择性地量化目标微生物的量。 这些方法比目前存在的用于食品测试和诊断评估的方法在其速度，准确性和易用性方面是有利的。 本文还描述了可用于实施本公开的各种拭子收集装置和试剂盒。

公开(公告)号：WO2007034530A3

公开(公告)日：2007-06-07

申请号：PCT/IT2006000677

申请日：2006-09-22

Applicant: UNIV PADOVA ,  BERZAGHI PAOLO

Inventor： BERZAGHI PAOLO

IPC: G01N21/35 ,  G01N21/85

CPC classification number: G01N21/3563 ,  A01D41/1277 ,  G01N21/276 ,  G01N2201/127 ,  G01N2201/12723 ,  G01N2201/128

Abstract: A system for the qualitative analysis of an agricultural product comprises a scanning cell (1) for the transmittance of a sample of an agricultural product, means for the emission of a quantity of light (6) and means for the detection of a quantity of light (5,50), at least one optical sensor (9,90) and a remote control unit (10) connected to the above mentioned at least one optical sensor (9,90). The system is characterized by the fact that said means for the detection of a quantity of light (5) are mounted in a mobile manner on said cell (1) and arranged frontally to said means of emission of a quantity of light (6), in such a way that the distance between said means of emission (6) and said means of detection (5) can be altered.

Abstract translation: 用于定量分析农产品的系统包括用于透射农产品样品的扫描单元（1），用于发射一定量的光的装置（6）以及用于检测光量的装置 （5,50），连接到上述至少一个光学传感器（9,90）的至少一个光学传感器（9,90）和远程控制单元（10）。 该系统的特征在于，用于检测一定量的光（5）的所述装置以可移动的方式安装在所述单元（1）上并且正面地布置到所述一定量的光（6）的所述发射装置上， 使得所述发射装置（6）和所述检测装置（5）之间的距离可以改变。

公开(公告)号：WO2006066581A1

公开(公告)日：2006-06-29

申请号：PCT/DK2005/000798

申请日：2005-12-16

Applicant: FOSS ANALYTICAL A/S ,  JUHL, Henrik, Vilstrup

Inventor： JUHL, Henrik, Vilstrup

IPC: G01J3/453 ,  G01J3/28

CPC classification number: G01J3/4535 ,  G01J3/28 ,  G01N21/274 ,  G01N21/276 ,  G01N21/359 ,  G01N2021/3595 ,  G01N2201/127

Abstract: The invention provides a method for standardising an infrared spectrometer based on spectral patterns of constituents of atmospheric air naturally occurring in the spectrometer. The invention also provides a spectrometer applying the method. The method selects a spectral pattern in a recorded spectrum and determines a wavelength dependent position value for a feature, such as the centre of the pattern. This value is compared to a reference value that may be obtained from a spectrum recorded by a master instrument, and a standardisation formula can be determined. The absorption peaks from CO 2 ( g )around 2350 cm -1 are preferred as the selected pattern. The method renders the use of reference samples unnecessary and allows for the standardisation to be performed simultaneously with the recording of a spectrum of a sample of interest.

Abstract translation: 本发明提供了一种基于光谱仪中天然存在的大气的成分的光谱图来标准化红外光谱仪的方法。 本发明还提供了一种应用该方法的光谱仪。 该方法选择所记录的光谱中的光谱图案，并确定诸如图案中心的特征的波长相关位置值。 将该值与可由主仪表记录的光谱获得的参考值进行比较，并且可以确定标准化公式。 作为所选择的图案，优选在2350cm -1附近的CO 2（

公开(公告)号：WO2006047182A2

公开(公告)日：2006-05-04

申请号：PCT/US2005037606

申请日：2005-10-21

Applicant: OPTISCAN BIOMEDICAL CORP ,  HALL W DALE

Inventor： HALL W DALE

IPC: G01N19/00

CPC classification number: G01N21/274 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1495 ,  A61B2560/0223 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/35 ,  G01N35/00693 ,  G01N35/00712 ,  G01N2201/1215 ,  G01N2201/127

Abstract: A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of know analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

Abstract translation: 描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。 该方法减少了在存在干扰物的情况下分析物浓度的误差。 该方法包括使用对具有一定范围的已知分析物和干扰化合物浓度的大群体获得的一组测量。 从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。