公开(公告)号：DE50107940D1

公开(公告)日：2005-12-15

申请号：DE50107940

申请日：2001-02-07

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT DR ,  HAY WILLIAM C ,  HOFFMANN DR

IPC: G01J3/32 ,  G01J3/36 ,  G01J3/457 ,  G02B21/00

公开(公告)号：FR2859279B1

公开(公告)日：2005-11-25

申请号：FR0350497

申请日：2003-09-03

Applicant: JOBIN YVON SAS

Inventor： FRETEL EMMANUEL ,  DANTHEZ YVES ,  WALLERAND CATHERINE ,  MIRZA ARSHAD

IPC: G01J3/02 ,  G01J1/44 ,  G01J3/28 ,  G01J3/457 ,  H04N3/15

Abstract: A device and a method for spectroscopic measurement of the spectrum of a light beam. The method includes detecting the dispersed light fluxes of the beam on an imaging device comprising a matrix of photodetectors with active columns, directing the imaging device so that one wavelength is allocated to a line of photodetectors, determining for each light flux the exposure time tau i necessary to measure a maximal intensity I max and the sub-matrix M i of photodetectors associated with the light fluxes, allocating to the sub-matrix M i of photodetectors an exposure time tau' i so that tau' i is the largest integer divider of the total integration time T smaller than tau i , measuring and resetting, during the integration time T of said spectrum, at each time tau' i , the corresponding sub-matrix M i independently of the other sub-matrices M j with j<>i, and measuring the spectrum of the beam at the time T.

公开(公告)号：DE60102797T2

公开(公告)日：2005-09-08

申请号：DE60102797

申请日：2001-02-09

Applicant: EVOTEC AG

Inventor： KASK PEET

IPC: G01J3/28 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64

公开(公告)号：AU2003259056A1

公开(公告)日：2004-02-23

申请号：AU2003259056

申请日：2003-08-01

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： WOLF DAVID E ,  BULSECO DYLAN A

IPC: C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58

Abstract: Disclosed is a portable fluorescence correlation spectroscopy instrument that includes an excitation source, at least one of a light focusing element positioned to receive light emitted by the excitation source, a detector for detecting light, the detector positioned to receive light emitted by a sample excited by the excitation source, and a correlator coupled to the detector, the correlator for processing data received at the detector and providing data including autocorrelation data, crosscorrelation data, or a combination thereof.

公开(公告)号：SE0400398D0

公开(公告)日：2004-02-20

申请号：SE0400398

申请日：2004-02-20

Applicant: HEDQVIST ANDERS ,  HAERD TORLEIF

Inventor： HEDQVIST ANDERS ,  HAERD TORLEIF

IPC: G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N

Abstract: A method for fluorescence correlation spectroscopy in connection with studying a time-varying course, wherein molecules are exposed to energy for the purpose of exciting said molecules, wherein the subsequent emission, from said molecules, of fluorescence of a predetermined wavelength is detected, and wherein said energy is applied in pulses with a pulse frequency which at least amounts to two pulses per period of the time-varying course being studied.

公开(公告)号：CA2494478A1

公开(公告)日：2004-02-12

申请号：CA2494478

申请日：2003-08-01

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： BULSECO DYLAN A ,  WOLF DAVID E

IPC: C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58

Abstract: Disclosed is a portable fluorescence correlation spectroscopy instrument tha t includes an excitation source (10), at least one of alight focusing element (12) positioned to receive light emitted by the excitation source, a detecto r (40a, 40b) for detecting light, the detector positioned to receive light emitted by a sample excited by the excitation source, and a correlator coupl ed to the detector, the correlator for processing data received at the detector and providing data including autocorrelation data, crosscorrelation data, or a combination thereof.

公开(公告)号：CA2493993A1

公开(公告)日：2004-02-12

申请号：CA2493993

申请日：2003-08-01

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： BULSECO DYLAN A ,  WOLF DAVID E

IPC: C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58

Abstract: The invention features a method of assaying for the interaction of a probe a nd an unknown target, said method including a) exciting a sample with radiation , the sample including at least one unknown target, at least one probe, and at least one fluorescent tag, b) measuring the fluorescence from a subvolume of the sample, and c) analyzing the fluctuations of the fluorescence.

公开(公告)号：RU2217710C1

公开(公告)日：2003-11-27

申请号：RU2002112978

申请日：2002-05-13

IPC: G01J3/457

Abstract: FIELD: instrumentation used for interferometry, Fourier spectroscopy and holography. SUBSTANCE: according to manner measured luminous fluxes are directed in parallel one another, are mixed and dependence of average intensity on reciprocal time shift of luminous fluxes is recorded by photodetector. Novelty of approach is that luminous fluxes are directed in opposition and intensity ( N>1 ) is measured by intensity- sensitive photoelectric layers which are arranged perpendicular to luminous fluxes. Each i-th photoelectric layer is positioned at different distance from sources of first and second luminous fluxes. Signals containing readings of correlation function of measured luminous fluxes B(taui), are picked off N photoelectric layers. EFFECT: simultaneous reception of signals containing readings of correlation function of opposite luminous fluxes without any mechanical scanning of difference of ray paths of these luminous fluxes. 5 cl, 4 dwg

公开(公告)号：DE59808993D1

公开(公告)日：2003-08-14

申请号：DE59808993

申请日：1998-08-11

Applicant: DEUTSCHES KREBSFORSCH

Inventor： TEWES MICHAEL ,  LANGOWSKI JOERG

IPC: G01N21/64 ,  G01J3/28 ,  G01J3/44 ,  G01J3/457 ,  G01N21/03

Abstract: In the procedure, the light beams are incident parallel to the transparent medium and are deflected toward a focal point inside the transparent medium. This avoids the use of refractive lens systems. The focusing lens system according to the invention enables the bundling of light beams of different wavelength to a point inside the sample.This clearly simplifies the design and adjustment of a multicolor fluorescence correlation spectroscopy device.

公开(公告)号：DE10058577C2

公开(公告)日：2003-08-07

申请号：DE10058577

申请日：2000-11-21

Applicant: UNIV DRESDEN TECH

Inventor： STEINER GERALD ,  SALZER REINER ,  HOF MARTIN ,  BNES MARTIN

IPC: G01J3/44 ,  G01N21/64 ,  G02B21/16 ,  G01J3/457