公开(公告)号：CA2510181C

公开(公告)日：2011-03-08

申请号：CA2510181

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： BURCH RONALD ,  CARTER RICHARD B ,  LAZAR JEFF

IPC: A61K31/165 ,  A61K9/00 ,  A61K31/05 ,  A61K31/16 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/06 ,  A61K47/10 ,  C07C231/02 ,  C07C233/20

Abstract: The present invention provides compositions and methods for relieving pain at a site in a human or animal in need thereof by administering at a site in a human or animal in need thereof a dose of capsaicinoid.

公开(公告)号：EA011708B1

公开(公告)日：2009-04-28

申请号：EA200500986

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： BURCH RONALD ,  CARTER RICHARD B ,  LAZAR JEFF

IPC: A61K31/045 ,  A61K9/00 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/00 ,  A61K45/06 ,  A61K47/10 ,  A61P29/02 ,  C07C231/02 ,  C07C233/20

Abstract: Настоящееизобретениеотноситсяк композициями способамдляоблегченияболив участкеорганизмачеловекаилиживотногопосредствомвведенияинъецируемой, имплантируемойилиинфильтрируемойкомпозиции, содержащейдозусинтетическоготранс-капсаицинав количестве, эффективномдляденервацииданногоучасткабезоказаниядействиявнеотдельногоместоположения, идляослабленияболи, исходящейизуказанногоучастка, причемданнаядозанаходитсяв пределахприблизительноот 1 до 5000 мкгсинтетическоготранс-капсаицинас чистотойпоменьшеймереприблизительно 95%, гдеуказаннуюдозуинъецируютилиимплантируютв отдельныйучастокорганизмачеловекаилиживотного, иданнаядозаварьируетприблизительноот 1 до 15000 мкгсинтетическоготранс-капсаицинас чистотойпоменьшеймереприблизительно 95%, гдеуказаннуюдозуинфильтрируютв участокхирургическоговмешательстваилив открытуюрану.

公开(公告)号：IL183332D0

公开(公告)日：2007-10-31

申请号：IL18333207

申请日：2007-05-21

Applicant: ALGORX PHARMACEUTICALS INC ,  BURCH RONALD ,  ANDERSON TIMOTHY A ,  LAZAR JEFF

IPC: A61K20100101

公开(公告)号：CA2596194A1

公开(公告)日：2006-06-01

申请号：CA2596194

申请日：2005-11-23

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： LAZAR JEFF ,  ANDERSON TIMOTHY A ,  BURCH RONALD

IPC: A61K31/04

公开(公告)号：CA2521925A1

公开(公告)日：2004-10-28

申请号：CA2521925

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  BURCH RONALD ,  RAMIYA PREMCHANDRAN H ,  CHEN WEI ,  MCILVAIN SHARON

IPC: C07C233/22 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carri ed through the entire synthesis process.

公开(公告)号：WO2004092122A3

公开(公告)日：2005-12-29

申请号：PCT/US2004010745

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC ,  MCILVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

Inventor： MCILVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

IPC: A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

CPC classification number: C07C231/02 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  A61K2300/00 ,  C07C57/03 ,  C07C233/20

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.

Abstract translation: 本发明提供了通过利用反应几何形式从合成反应开始设定并通过整个合成过程进行的方法来合成辣椒素和/或辣椒素样化合物的反式异构体的方法。

公开(公告)号：WO2004058286A1

公开(公告)日：2004-07-15

申请号：PCT/US2003/040356

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS, INC. ,  BURCH, Ronald ,  CARTER, Richard, B. ,  LAZAR, Jeff

Inventor： BURCH, Ronald ,  CARTER, Richard, B. ,  LAZAR, Jeff

IPC: A61K35/78

CPC classification number: C07C231/02 ,  A61K9/0019 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00 ,  C07C233/20

Abstract: The present invention provides compositions and methods for relieving pain at a site in a human or animal in need thereof by administering at a site in a human or animal in need thereof a dose of capsaicinoid.

Abstract translation: 本发明提供通过在有需要的人或动物的部位施用一定剂量的辣椒素来缓解在有需要的人或动物的部位的疼痛的组合物和方法。

公开(公告)号：BRPI0516912A2

公开(公告)日：2009-06-23

申请号：BRPI0516912

申请日：2005-11-23

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： BURCH RONALD ,  ANDERSON TIMOTHY A ,  LAZAR JEFF

IPC: A61K31/04

公开(公告)号：AU2004230915B2

公开(公告)日：2008-08-07

申请号：AU2004230915

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： MCILVAIN SHARON ,  RAMIYA PREMCHANDRAN H ,  CARTER RICHARD B ,  ANDERSON THIMOTHY A ,  BURCH RONALD ,  CHEN WEI

IPC: A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.

公开(公告)号：NZ542887A

公开(公告)日：2008-05-30

申请号：NZ54288704

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： MCILVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

IPC: A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: Disclosed are methods for synthesizing the trans isomer of capasaicin and/or capasaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.