公开(公告)号：US20220011558A1

公开(公告)日：2022-01-13

申请号：US17482678

申请日：2021-09-23

Applicant: Femtonics Kft.

Inventor： Balazs ROZSA ,  Gergely KATONA ,  Pal MAAK ,  Mate VERESS ,  Andras FEHER ,  Gergely SZALAY ,  Peter MATYAS

IPC: G02B21/00 ,  G01N21/64 ,  G06T5/50

Abstract: The invention relates to a method for correcting motion artifacts of in vivo fluorescence measurements using a 3D laser scanning microscope containing two pairs of orthogonally arranged acousto-optic deflectors, the method comprising: selecting a region of interest, selecting a plurality of guiding points along the region of interest, extending the guiding points to objects selected from scanning lines and/or surface elements and/or volume elements which, together, substantially cover the region of interest, repeatedly scanning the objects by generating continuous drifts to cover the objects, projecting the obtained scanning data to frames and obtaining a time series of the frames, correcting motion artifacts by shifting the data of the successive frames with respect to each other so as to maximize fluorescence cross correlation between the data of the frames.

公开(公告)号：US09650664B2

公开(公告)日：2017-05-16

申请号：US14348903

申请日：2012-10-03

Applicant: FEMTONICS KFT

Inventor： Imre Gyula Csizmadia ,  Zoltan Mucsi ,  Gergely Szalay ,  Attila Kaszas ,  Csilla Lukacsne Haveland ,  Orsolya Majercsik ,  Attila Potor ,  Gergely Katona ,  Jozsef Balazs Rozsa ,  Dorina Gundisch ,  Balazs Chiovini ,  Denes Palfi

IPC: C12Q1/52 ,  C07D209/08 ,  C07D209/14 ,  C07D209/20 ,  C12Q1/32

CPC classification number: C12Q1/52 ,  C07D209/08 ,  C07D209/14 ,  C07D209/20 ,  C12Q1/32

Abstract: Use of photochemically cleavable compounds in course of one or multi-photon irradiation experiments.

公开(公告)号：US11927873B2

公开(公告)日：2024-03-12

申请号：US17268199

申请日：2019-08-14

Applicant: Femtonics Kft.

Inventor： Gergely Katona ,  András Fehér ,  Máté Veress ,  Pál Maák ,  Gergely Szalay ,  Balázs Chiovini ,  Zoltán Szadai ,  Linda Sulcz-Judák ,  Balázs József Rózsa

IPC: G02F1/33 ,  G01N21/64

CPC classification number: G02F1/33 ,  G01N21/645 ,  G01N2021/6463 ,  G01N2201/106

Abstract: The object of the invention relates to a method for scanning with an optical beam (50) using a first acousto-optic deflector (15, 15′) having an optical axis along a Z-axis and at least one acousto-optic crystal layer (14), involving directing the optical beam (50) in the first acousto-optic deflector (15, 15′), and deflecting the optical beam (50) along an X-axis perpendicular to the Z-axis by means of the first acousto-optic deflector (15, 15), during which generating a plurality of acoustic chirp signals (30) in the at least one acousto-optic crystal layer (14) of the acousto-optic deflector (15, 15′) by—generating a first acoustic chirp signal (30a) having a duration of τ in the acousto-optic crystal layer (14), then—generating a second acoustic chirp signal (30b) in the acousto-optic crystal layer (14) within a τ period of time counted from the start of the generation of the first acoustic chirp signal (30a).

公开(公告)号：US11156819B2

公开(公告)日：2021-10-26

申请号：US16290238

申请日：2019-03-01

Applicant: Femtonics Kft.

Inventor： Balazs Rozsa ,  Gergely Katona ,  Pal Maak ,  Mate Veress ,  Andras Feher ,  Gergely Szalay ,  Peter Matyas

IPC: G02B21/00 ,  G06K9/32 ,  G02F1/33

Abstract: A method for scanning along a substantially straight line (3D line) lying at an arbitrary direction in a 3D space with a given speed uses a 3D laser scanning microscope having a first pair of acousto-optic deflectors deflecting a laser beam in the x-z plane (x axis deflectors) and a second pair of acousto-optic deflectors deflecting the laser beam in the y-z plane (y axis deflectors) for focusing the laser beam in 3D. Further, a method for scanning a region of interest uses a 3D laser scanning microscope having acousto-optic deflectors for focusing a laser beam within a 3D space defined by an optical axis (Z) of the microscope and X, Y axes that are perpendicular to the optical axis and to each other.

公开(公告)号：US20210318590A1

公开(公告)日：2021-10-14

申请号：US17268199

申请日：2019-08-14

Applicant: Femtonics Kft.

Inventor： Gergely KATONA ,  András FEHÉR ,  Máté VERESS ,  Pál MAÁK ,  Gergely SZALAY ,  Balázs CHIOVINI ,  Zoltán SZADAI ,  Linda SULCZ-JUDÁK ,  Balázs József RÓZSA

IPC: G02F1/33 ,  G01N21/64

Abstract: The object of the invention relates to a method for scanning with an optical beam (50) using a first acousto-optic deflector (15, 15′) having an optical axis along a Z-axis and at least one acousto-optic crystal layer (14), involving directing the optical beam (50) in the first acousto-optic deflector (15, 15′), and deflecting the optical beam (50) along an X-axis perpendicular to the Z-axis by means of the first acousto-optic deflector (15, 15), during which generating a plurality of acoustic chirp signals (30) in the at least one acousto-optic crystal layer (14) of the acousto-optic deflector (15, 15′) by—generating a first acoustic chirp signal (30a) having a duration of τ in the acousto-optic crystal layer (14), then—generating a second acoustic chirp signal (30b) in the acousto-optic crystal layer (14) within a τ period of time counted from the start of the generation of the first acoustic chirp signal (30a).

公开(公告)号：US12096749B2

公开(公告)日：2024-09-24

申请号：US17626700

申请日：2020-07-09

Applicant: FEMTONICS KFT.

Inventor： Gergely Dobos ,  Domonkos Péter Pinke ,  Tamás Tompa ,  Pál Maák ,  Máté Marosi ,  Gergely Katona ,  Gergely Szalay ,  Balázs Rózsa

IPC: A01K15/02 ,  G02B27/00 ,  G06F1/16 ,  G06F3/01

CPC classification number: A01K15/02 ,  G02B27/0093 ,  G06F1/163 ,  G06F3/013

Abstract: The present invention relates to a virtual reality simulator (10) for small laboratory animals (100), in particular rodents, which comprises a head clamping mechanism (20) for securing the laboratory animal (100) and virtual reality glasses (40) with two wings (30), each of the wings (30) having a display (34) and a lens system (36) spaced therefrom and connected together by a light barrier cover (32), and the virtual reality glasses (40) are configured to allow the two wings (30) to align with each of the eyes (101) of the laboratory animal (100), respectively. The invention further relates to a method applying such a simulator (10).

公开(公告)号：US20170212406A1

公开(公告)日：2017-07-27

申请号：US15039598

申请日：2013-11-28

Applicant: Femtonics Kft.

Inventor： Balazs Jozsef Rozsa ,  Gergely Katona ,  Pal Andor Maak

IPC: G02F1/33

CPC classification number: G02F1/332 ,  G02F1/11 ,  G02F1/113 ,  G02F1/33 ,  G02F1/335 ,  G02F2203/07 ,  G02F2203/58 ,  H03H9/00 ,  H03H9/02535 ,  H03H9/02574 ,  H03H9/64

Abstract: The invention relates to an acousto-optic deflector comprising a bulk of acousto-optic medium and acoustic wave generator coupled to the bulk, characterised by that the acoustic wave generator comprises at least two different electro-acoustic transducers for generating acoustic waves in the bulk.

公开(公告)号：US20140234883A1

公开(公告)日：2014-08-21

申请号：US14348903

申请日：2012-10-03

Applicant: FEMTONICS KFT

Inventor： Imre Gyula Csizmadia ,  Zoltan Mucsi ,  Gergely Szalay ,  Attila Kaszas ,  Csilla Lukacsne Haveland ,  Orsolya Majercsik ,  Attila Potor ,  Gergely Katona ,  Jozsef Balazs Rozsa ,  Dorina Gundisch ,  Balazs Chiovini ,  Denes Palfi

IPC: C12Q1/52 ,  C07D209/14 ,  C12Q1/32 ,  C07D209/20

CPC classification number: C12Q1/52 ,  C07D209/08 ,  C07D209/14 ,  C07D209/20 ,  C12Q1/32

Abstract: Use of photochemically cleavable compounds in course of one or multi-photon irradiation experiments.

Abstract translation: 在一次或多光子照射实验过程中使用光化学裂解化合物。

公开(公告)号：WO2013098568A1

公开(公告)日：2013-07-04

申请号：PCT/HU2012/000003

申请日：2012-01-05

Applicant: FEMTONICS KFT. ,  RÓZSA, Balázs ,  KATONA, Gergely ,  VERESS, Máté ,  MAÁK, Pál ,  SZALAY, Gergely

Inventor： RÓZSA, Balázs ,  KATONA, Gergely ,  VERESS, Máté ,  MAÁK, Pál ,  SZALAY, Gergely

IPC: G02F1/33 ,  G02B21/00 ,  G02B27/00

CPC classification number: G02F1/33 ,  G02B5/04 ,  G02B21/002 ,  G02B21/0036 ,  G02B27/0031 ,  G02B27/30

Abstract: The invention relates to a compensator system adapted to compensate for the angular dispersion of electromagnetic beams deflected by at least one acousto-optic deflector of an optical system, wherein the angular dispersion of each deflected beam is dependent on the deflection angle obtained by the deflecting acoustic frequency of the acousto-optic deflector, characterised in that the compensator system comprises: - a first lens group for spatially separating the deflected beams of different deflection angle and angular dispersion by focusing the beams substantially into the focal plane, - a compensator element having a first surface and a second surface, and being arranged such that the first surface of the compensator element lies substantially in the focal plane of the first lens group, and the first and second surfaces of the compensator element have nominal radiuses R 1 and R 2 that together work as prisms with tilt angles β and prism opening angles α p that vary with the distance from the optical axis so as to compensate for the angular dispersion of the spatially separated deflected beams, - a second lens group arranged so as to substantially parallelise the different wavelength components of each deflected beam exiting the compensator element while maintaining the angular variation of the beams deflected at different acoustic frequencies. The invention further relates to method for compensating for the angular dispersion of electromagnetic beams deflected by at least one acousto-optic deflector of an optical system, wherein the angular dispersion of each deflected beam is dependent on the deflection angle obtained by the deflecting acoustic frequency, characterised by - spatially separating the deflected beams of different deflection angle and angular dispersion by focusing the beams via a first lens group substantially into the focal plane of the first lens group, - compensating for the angular dispersion of the spatially separated deflected beams in accordance with the angular dispersion of the given beam, - substantially parallelising the spectral components of each deflected beam while maintaining the angular variation of the beams deflected at different acoustic frequencies.

Abstract translation: 本发明涉及一种补偿器系统，其适于补偿由光学系统的至少一个声光偏转器偏转的电磁波束的角度色散，其中每个偏转光束的角度色散取决于由偏转声学获得的偏转角 声光偏转器的频率，其特征在于补偿器系统包括： - 第一透镜组，用于通过将光束基本聚焦到焦平面中来将不同偏转角和角度色散的偏转光束空间分离， - 补偿元件，其具有 第一表面和第二表面，并且被布置成使得补偿元件的第一表面基本上位于第一透镜组的焦平面中，并且补偿元件的第一和第二表面具有共同工作的标称半径R1和R2 作为具有倾斜角度β和棱镜开口角度的棱镜随着分布而变化的棱镜 以便补偿空间分离的偏转光束的角度色散; - 第二透镜组，其布置成基本上平行于离开补偿元件的每个偏转光束的不同波长分量，同时保持 不同声频偏转的光束。 本发明还涉及用于补偿由光学系统的至少一个声光偏转器偏转的电磁光束的角度色散的方法，其中每个偏转光束的角度色散取决于由偏转声频率获得的偏转角， 其特征在于 - 通过将所述光束经由第一透镜组基本上聚焦到所述第一透镜组的焦平面中，将所述偏转光束的偏转角和角度色散空间分离， - 补偿空间分离的偏转光束的角度色散， 给定光束的角度色散， - 基本上平行于每个偏转光束的光谱分量，同时保持以不同声频偏转的光束的角度变化。

公开(公告)号：US20240010913A1

公开(公告)日：2024-01-11

申请号：US18265207

申请日：2021-12-04

Applicant: FEMTONICS KFT.

Inventor： J. Balázs RÓZSA ,  Gergely KATONA ,  Zoltán MUCSI ,  Ervin KOVÁCS ,  Attila CSOMOS

IPC: C09K11/06 ,  C07F3/06 ,  G01N33/84 ,  C07D401/06 ,  C07D471/14

CPC classification number: C09K11/06 ,  C07F3/06 ,  G01N33/84 ,  C07D401/06 ,  C07D471/14 ,  G01N2021/6439

Abstract: The present invention relates to novel red fluorescent sensors for detecting metal ions, preferably zinc ions, which have a chemical structure corresponding to a compound of general formula I. These sensors are very useful for determining the concentration and distribution of zinc in living cells or tissues, preferably in a laser microscopic assay.