公开(公告)号：JP2013050213A

公开(公告)日：2013-03-14

申请号：JP2012220623

申请日：2012-10-02

Applicant: Waters Technologies Corp ,  ウオーターズ・テクノロジーズ・コーポレイシヨン

Inventor： DOURDEVILLE THEODORE ,  RUBINO FRANK A ,  JOUDREY KURT D ,  LUONGO JOSEPH A ,  ANGELOSANTO JOHN

IPC: F16K31/06

CPC classification number: F16K15/183 ,  F04B7/0076 ,  F16K31/047 ,  F16K37/0041 ,  Y10T137/0318

Abstract: PROBLEM TO BE SOLVED: To provide a driving method for a fluid circuit control valve used for analysis equipment, which contributes to improvement in properties of valve closing and the like.SOLUTION: An embodiment 10 of a valve includes: an inlet 14, an outlet 16 and a passageway 18 connecting the inlet 14 and the outlet 16; a flow determining component 22 for allowing communication/blocking of the passageway 18; and a voice coil-type linear positioning component 26 that is arranged to operate the flow determining component 22 to determine communication/blocking of a flow path, wherein a control signal directed to the linear positioning component 26 is computer-controlled to achieve reliable valve sealing properties, rapid responsiveness, and improved controllability in a small flow rate, and the displacement of an actuator 38 for operating the flow determining component 22 is detected to improve control accuracy.

Abstract translation: 要解决的问题：提供用于分析设备的流体回路控制阀的驱动方法，其有助于提高阀关闭等性能。 阀的实施例10包括：入口14，出口16和连接入口14和出口16的通道18; 用于允许通道18的通信/阻塞的流动确定部件22; 以及音圈型线性定位部件26，其布置成操作流动确定部件22以确定流动路径的通信/阻塞，其中针对线性定位部件26的控制信号被计算机控制以实现可靠的阀门密封 性能，快速响应性和改进的小流量控制性，并且检测用于操作流量确定部件22的致动器38的位移，以提高控制精度。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2013011608A

公开(公告)日：2013-01-17

申请号：JP2012175009

申请日：2012-08-07

Applicant: Waters Technologies Corp ,  ウオーターズ・テクノロジーズ・コーポレイシヨン

Inventor： JOSE DE CHORAR ,  NEIL ALMEIDA

IPC: G01N30/34 ,  G01N30/26

CPC classification number: B01F15/0243 ,  B01D15/166 ,  B01F3/0861 ,  B01F5/0077 ,  B01F5/0268 ,  B01F5/0602 ,  B01F5/0695 ,  B01F5/0696 ,  G01N30/06 ,  G01N30/34 ,  G01N2030/347

Abstract: PROBLEM TO BE SOLVED: To provide an assembly for mixing fluids (i.e., gases or liquids).SOLUTION: Disclosed is an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as, for example, chromatography. A mixer assembly 100 includes, inter alia, a housing 10, an inlet fitting 40, and a mixer cartridge assembly 60. The housing 10 has a fluid receiving section 16 and a fluid discharge section 18 with an outlet 20 formed therein. A central bore 22 extends between the fluid receiving section 16 and the fluid discharge section 18. The inlet fitting 40 is engaged with the housing 10 and has a first port 42 and a second port 44 formed therein that extend from the fitting exterior to the fluid receiving section 16 of the housing 10.

Abstract translation: 要解决的问题：提供用于混合流体（即，气体或液体）的组件。 解决方案：公开了一种精确混合两种或更多种高压流体源并适用于例如色谱法的应用的组件。 混合器组件100尤其包括壳体10，入口配件40和混合器筒组件60.壳体10具有流体接收部分16和流体排出部分18，其中形成有出口20。 中心孔22在流体接收部分16和流体排放部分18之间延伸。入口配件40与壳体10接合并且具有形成在其中的第一端口42和第二端口44，该第一端口42和第二端口44从配件外部延伸到流体 （C）2013，JPO＆INPIT

公开(公告)号：JP2012090275A

公开(公告)日：2012-05-10

申请号：JP2011241231

申请日：2011-11-02

Applicant: Waters Technologies Corp ,  ウオーターズ・テクノロジーズ・コーポレイシヨン

Inventor： GILBY ANTHONY C

IPC: H04N5/357 ,  G01J3/28 ,  H01L27/146 ,  H04N3/15

CPC classification number: G01J3/28 ,  G01J3/2803 ,  H04N5/332 ,  H04N5/3456 ,  H04N5/357 ,  H04N5/361

Abstract: PROBLEM TO BE SOLVED: To improve the signal-to-noise ratio of measurements made using a self-scanned photodiode array to detect UV, visible, and IR portions of a spectrum in a spectro-photometer.SOLUTION: A self scanning photodiode array allows low signal pixels to accumulate charge for multiples of predetermined exposure time tbefore being read. The pattern of exposures, the integers M, where i runs from 1 to N, the number of pixels in the array, is chosen such that the pixels accumulate as much charge as possible without exceeding saturation.

Abstract translation: 要解决的问题：提高使用自扫描光电二极管阵列进行的测量的信噪比，以检测分光光度计中的光谱的UV，可见光和IR部分。 解决方案：自扫描光电二极管阵列允许低信号像素在读取之前对预定曝光时间t 0 的倍数累积电荷。 曝光模式，整数M i ，其中我从1到N运行阵列中的像素数，使得像素累积尽可能多的电荷 不超过饱和。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2014013248A

公开(公告)日：2014-01-23

申请号：JP2013176327

申请日：2013-08-28

Applicant: Waters Technologies Corp ,  ウオーターズ・テクノロジーズ・コーポレイシヨン

Inventor： THEODORE A DOURDEVILLE

IPC: G01N30/60 ,  G01N30/54

CPC classification number: G01N30/606 ,  B23K20/023 ,  B23K20/233 ,  B23K20/24 ,  B23K2201/14 ,  B23K2203/14 ,  G01N30/6095

Abstract: PROBLEM TO BE SOLVED: To provide nano-scale microfluidic HPLC instruments that offer similar ease-of-use and reliable operation to that of prior analytical-scale or microbore-scale instruments by providing any or all of the following advantages of the reduced length and/or number of sections of interconnect tubing, easier fabrication, lower-cost fabrication, improved ease-of-use of capillary-scale and nano-scale LC, reduced dead-volume, reduced size, disposable devices, integrated devices, small devices, and high-pressure liquid chromatography in diffusion-bonded monoliths.SOLUTION: An HPLC apparatus includes a heat exchanger formed from diffusion-bonded first and second titanium substrates. At least two conduits for counterflow are defined between the first and second substrates.

Abstract translation: 要解决的问题：提供纳米尺度微流体HPLC仪器，通过提供减少长度的任何或全部以下优点，提供与以前的分析尺度或微孔尺度仪器相似的易于使用和可靠的操作， /或互连管段的数量，更容易制造，低成本制造，毛细管尺度和纳米尺度LC的改进易用性，减少的死体积，减小的尺寸，一次性装置，集成装置，小装置， 和扩散粘合的整料中的高压液相色谱法。溶液：HPLC装置包括由扩散键合的第一和第二钛基材形成的热交换器。 用于逆流的至少两个导管限定在第一和第二基板之间。

公开(公告)号：WO2016164544A8

公开(公告)日：2016-11-17

申请号：PCT/US2016026386

申请日：2016-04-07

Applicant: WATERS TECHNOLOGIES CORP

Inventor： JACKSON MICHAEL R ,  SEITH CHRISTOPHER ,  BARRETT NATHAN ,  O'DONNELL KARA ,  ALMEIDA NEAL B ,  LU WEN ,  USOWICZ JAMES E ,  SOK MARUTH ,  JOUDREY KURT D ,  SHREVE JOSHUA A

IPC: B01D15/08 ,  B01D15/18 ,  G01N30/30

CPC classification number: F25B25/005 ,  B01D15/40 ,  G01N30/30

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.

Abstract translation: 本公开涉及用于冷却泵头并在多个泵头之间提供平衡的冷却和热传递的方法，系统和设备。 用于泵送密度变化很大且温度变化较小的流体的多泵系统（例如基于CO 2的色谱系统的流动相）需要高度稳定的温度条件。 为了在多个泵头与冷却剂流体之间实现基本相等的平均热传递，冷却剂流体可以以递归和/或平行冷却剂流动模式流过泵头内的冷却剂通路。 这种递归和/或平行的冷却剂流体流动模式提供了增加的温度稳定性，可压缩性和通过多泵系统的流体密度。

公开(公告)号：WO2016164542A8

公开(公告)日：2016-11-17

申请号：PCT/US2016026383

申请日：2016-04-07

Applicant: WATERS TECHNOLOGIES CORP

Inventor： JACKSON MICHAEL R ,  SEITH CHRISTOPHER ,  BALA SENTHIL ,  FREDETTE COLIN

IPC: G01N33/30 ,  B01D15/16 ,  B01D15/40

CPC classification number: G01N30/84 ,  B01D15/40 ,  G01N30/32 ,  G01N30/82

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as C02, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

Abstract translation: 本公开涉及用于冷却过饱和或混合相溶液以增加其中溶解的气体的溶解度的方法，系统和装置。 在液相色谱系统中，流动相可以包括包括气体如CO 2的加压混合物，并且在馏分收集和/或检测之前，通过气/液分离器提取一部分气体。 冷却离开气/液分离器的基本液相洗脱液增加了仍溶解在洗脱液中的任何剩余气体的溶解度。 残余气体的增加的溶解度防止了气体，提供了更一致的洗脱液通过系统的流动，并且导致对所需样品的更有效的收集和分析。

公开(公告)号：WO2016149316A1

公开(公告)日：2016-09-22

申请号：PCT/US2016022563

申请日：2016-03-16

Applicant: WATERS TECHNOLOGIES CORP

Inventor： ROSANO THOMAS G ,  WOOD MICHELLE

IPC: G01N30/72 ,  G01N30/86 ,  G01N33/536

CPC classification number: G01N30/86 ,  G01N30/72 ,  G01N2030/8813

Abstract: Provided herein are definitive screening techniques for qualitatively and quantitatively detecting analytes in biological specimens.

Abstract translation: 本文提供了定性和定量检测生物标本中分析物的确定筛选技术。

公开(公告)号：WO2013090147A3

公开(公告)日：2016-02-04

申请号：PCT/US2012068520

申请日：2012-12-07

Applicant: WATERS TECHNOLOGIES CORP

Inventor： LUONGO JOSEPH A ,  DOBBS CRAIG HAMILTON

IPC: G01N30/00

CPC classification number: B01D15/14 ,  B01D15/166 ,  G01N30/20 ,  G01N30/34 ,  G01N30/38 ,  Y10T137/0363 ,  Y10T137/85986

Abstract: A liquid chromatography system includes a gradient proportioning valve in fluidic communication with sources of solvent. From the solvent sources, the gradient proportioning valve produces a low-pressure gradient stream. A first pump is in fluidic communication with the gradient proportioning valve to receive, pressurize, and move the pressurized low-pressure gradient stream to a flow-combining device. A second pump operates in parallel with the first pump and moves a pressurized solvent stream to the flow-combining device where the pressurized solvent stream combines with the low-pressure gradient stream to produce a high-pressure gradient stream. A second gradient proportioning valve can produce, from a second plurality of sources of solvent, a second low-pressure gradient stream, wherein the solvent stream moved by the second pump to the flow-combining device and combined with the other low-pressure gradient stream comprises the second low-pressure gradient stream.

Abstract translation: 液相色谱系统包括与溶剂源流体连通的梯度比例阀。 从溶剂来源，梯度比例阀产生低压梯度流。 第一泵与梯度比例阀流体连通，以将加压的低压梯度流接收，加压并移动到流动组合装置。 第二泵与第一泵平行操作并将加压溶剂流移动到流动组合装置，其中加压溶剂流与低压梯度流结合以产生高压梯度流。 第二梯度比例阀可以从第二多个溶剂源产生第二低压梯度流，其中溶剂流由第二泵移动到流动组合装置并与其它低压梯度流 包括第二低压梯度流。

公开(公告)号：WO2014160568A3

公开(公告)日：2014-12-31

申请号：PCT/US2014031186

申请日：2014-03-19

Applicant: WATERS TECHNOLOGIES CORP

Inventor： ANDREWS RICHARD W

IPC: G01N21/59

CPC classification number: G01N30/74 ,  G01N21/274 ,  G01N21/3103 ,  G01N21/59 ,  G01N30/8631 ,  G01N30/8665 ,  G01N2201/127

Abstract: The invention generally provides methods for improving the dynamic range of an absorbance detector and absorbance detectors having improved dynamic range. In an exemplary embodiment, the method includes receiving calibration data for a plurality of samples, the calibration data comprising an absorbance for a concentration of each of the samples, calculating a contribution of stray light to the calibration data, and correcting subsequent data by removing the contribution of stray light.

Abstract translation: 本发明总体上提供了用于改善具有改进的动态范围的吸光度检测器和吸光度检测器的动态范围的方法。 在示例性实施例中，该方法包括接收多个样本的校准数据，该校准数据包括每个样本的浓度的吸光度，计算杂散光对校准数据的贡献，以及通过去除 杂散光的贡献。

公开(公告)号：WO2013134468A8

公开(公告)日：2014-08-28

申请号：PCT/US2013029524

申请日：2013-03-07

Applicant: WATERS TECHNOLOGIES CORP

Inventor： SHREVE JOSHUA A ,  TRUDEAU STEVEN D ,  LINDERSON PAUL ,  MAILLET JOHN JR

IPC: B01D15/08

CPC classification number: B01D53/0454 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N2030/328

Abstract: Exemplary embodiments of the present disclosure include systems, apparatuses, and methods that are directed to controlling pressure in a pressurized flow system, such as a C02-based chromatography system or other pressurized flow systems. Exemplary embodiments of the present disclosure comprise one or more apparatuses, systems or methods for implementing multiple pressure regulators to control pressure. In addition to providing pressure control, apparatuses, systems and methods described herein dampen damaging thermal effects caused by pressure drops of a mobile phase including C02.

Abstract translation: 本公开的示例性实施方案包括系统，装置和方法，其涉及控制加压流系统中的压力，例如基于CO 2的色谱系统或其它加压流系统。 本公开的示例性实施例包括用于实现多个压力调节器以控制压力的一个或多个装置，系统或方法。 除了提供压力控制之外，本文所述的装置，系统和方法还抑制由包括CO 2的流动相的压降引起的热效应的破坏。