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    NEEDLE DRIVE, SYSTEM AND METHOD
    12.
    发明申请
    NEEDLE DRIVE, SYSTEM AND METHOD 审中-公开

    公开(公告)号：WO2021188530A1

    公开(公告)日：2021-09-23

    申请号：PCT/US2021/022552

    申请日：2021-03-16

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： BURNETT, Joshua, A. ,  SOLOW, Rose ,  SIMPSON, David, A. ,  LEMELIN, Marc, E.

    IPC: G01N30/24

    Abstract: A liquid chromatography sample manager includes a thermal chamber, a sample platter 110 mounted in the thermal chamber, and a needle drive including a base 230 having a shaft configured to rotate about a vertical axis, the base attachable to an interior of a sample manager of a liquid chromatography system. The needle drive further includes a needle assembly attached to the base, the needle assembly including a sample needle 122, and a drive system 112 attached to the base, the drive system including a sample needle motor configured to impart vertical movement of the sample needle.

    HIGH THROUGHPUT AFFINITY SAMPLE PREPARATION FOR MYCOTOXIN ANALYSIS
    13.
    发明申请
    HIGH THROUGHPUT AFFINITY SAMPLE PREPARATION FOR MYCOTOXIN ANALYSIS 审中-公开

    公开(公告)号：WO2021186365A1

    公开(公告)日：2021-09-23

    申请号：PCT/IB2021/052236

    申请日：2021-03-17

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： CHEN, Lingyun ,  LIU, Jianmin

    IPC: G01N33/569

    Abstract: The present disclosure relates to a method of separating a sample including a mycotoxin. The method includes flowing the sample through a column to load the sample on the column, washing the column to reduce impurities, eluting the mycotoxin from the column, collecting an eluted sample with the mycotoxin in a sample plate, sealing the eluted sample in the sample plate, transferring the sealed sample plate, removing the eluted sample from the transferred sample plate; and analyzing the removed eluted sample. The column can include an affinity resin, such as, for example, an immunoaffinity resin. The sample plate can be a 96-well plate.

    METHOD FOR DETERMINING A DWELL VOLUME OF A CHROMATOGRAPHIC SYSTEM
    16.
    发明申请
    METHOD FOR DETERMINING A DWELL VOLUME OF A CHROMATOGRAPHIC SYSTEM 审中-公开

    公开(公告)号：WO2021034874A1

    公开(公告)日：2021-02-25

    申请号：PCT/US2020/046884

    申请日：2020-08-19

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： HILL, Jason F. ,  GILAR, Martin ,  TARAFDER, Abhijit ,  DESJARDINS, Christopher

    IPC: G01N30/34 ,  G01N30/86

    Abstract: Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume. The method includes mixing a flow of a first solvent with a flow of a second solvent to form a solvent mixture. The flows of the first and second solvents are decreased and increased, respectively, to generate a gradient composition. A system pressure of the liquid chromatography system is measured to determine a pressure trace defined as the measured system pressure as a function of time. The dwell volume of the system is determined from a time delay determined between the gradient composition at the mixing location and the pressure trace. The method can be performed with a liquid chromatography system having a chromatographic column or a flow restrictor used in place of the chromatographic column.

    LINK CHAIN, CHAIN SYSTEM AND METHOD
    17.
    发明申请
    LINK CHAIN, CHAIN SYSTEM AND METHOD 审中-公开

    公开(公告)号：WO2021021780A1

    公开(公告)日：2021-02-04

    申请号：PCT/US2020/043826

    申请日：2020-07-28

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： MUSACCHIO, Jeffrey

    IPC: F16G13/20

    Abstract: Described is a chain including a plurality of links pivotally connected to each other such that the chain is configured to bend in one direction without back-bending. Each of the plurality of links including a link body include: an inner side facing a bending direction of the chain; an outer side facing opposite the bending direction of the chain; a back-bending prevention portion; a post feature extending laterally across the link body, and a connection feature configured to engage with the post feature of the first other of the pivotally connected plurality of links to create one direction pivotal attachment without back-bending between the links. Further disclosed is a chain system and methods of moving devices with a chain or chain system.

    METHOD OF LOADING SAMPLES INTO A SAMPLE MANAGER OF A CHROMATOGRAPHY SYSTEM
    18.
    发明申请
    METHOD OF LOADING SAMPLES INTO A SAMPLE MANAGER OF A CHROMATOGRAPHY SYSTEM 审中-公开

    公开(公告)号：WO2021021702A1

    公开(公告)日：2021-02-04

    申请号：PCT/US2020/043685

    申请日：2020-07-27

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： MUSACCHIO, Jeffrey

    IPC: G01N35/04 ,  G01N35/02 ,  G01N30/24 ,  G01N35/00

    Abstract: Described is a method for loading a sample-vial carrier into a sample manager of a liquid chromatography system. The method includes placing a sample-vial carrier onto a transfer drawer having first and second drawer magnets. The transfer drawer is transported into a sample tray of a sample manager using a drawer drive system of a transfer drawer receiving apparatus. The drawer drive system has a drive magnet that is engaged with the first drawer magnet during transport. The transport of the transfer drawer is terminated when the second drawer magnet is engaged with a sample tray magnet on the sample tray. The sample tray is rotated about an axis substantially perpendicular to a direction of transport of the transfer drawer to provide a shear force to disengage the first drawer magnet from the drive magnet.

    INTERFACE MODULE FOR TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY
    19.
    发明申请
    INTERFACE MODULE FOR TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY 审中-公开

    公开(公告)号：WO2020051073A1

    公开(公告)日：2020-03-12

    申请号：PCT/US2019/048975

    申请日：2019-08-30

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： CORMIER, Sylvain Gilles ,  PHOEBE JR., Charles H.

    IPC: G01N30/46 ,  G01N35/10 ,  B01D15/18 ,  G01N30/20

    Abstract: Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module. The interface module includes a valve module, a collection needle, a modifier module and a sample storage element. The valve module has a first port configured to receive an eluent from a first chromatography system, a second port configured to provide a fraction obtained from the eluent, a third port and a fourth port. The collection needle and the modifier module are in fluidic communication with the valve module at the third and fourth ports, respectively. The modifier module includes a source of a modifier solvent. The sample storage element is in fluidic communication with the valve module and is configured to receive a volume of the fraction for injection as a sample into a second chromatography system.

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