公开(公告)号：WO2019204048A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/025927

申请日：2019-04-05

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： WYNDHAM, Kevin D. ,  JUNG, Moon Chul ,  TARAFDER, Abhijit ,  LEVEILLE, SR., Wade P.

IPC: G01N30/34

Abstract: A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device 10 located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet 22, a fluidic outlet 24, wherein at least a portion of the fluidic flow path is located between the fluidic inlet 22 and the fluidic outlet 24 and at least one filter 16 disposed in the portion of the fluidic flow path, wherein the at least one filter 16 is made of a micromachined material. Liquid chromatography filtration methods are further disclosed.

公开(公告)号：WO2019142034A1

公开(公告)日：2019-07-25

申请号：PCT/IB2018/059640

申请日：2018-12-04

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TARAFDER, Abhijit

IPC: B01D15/40

CPC classification number: G01N30/32 ,  B01D15/40 ,  G01N30/30 ,  G01N30/7206 ,  G01N2030/025

Abstract: Exemplary embodiments are directed to methods and systems for managing fluid decompression. A fluid connector (703) is located downstream of a chromatography column and defines an interior bore (705) through which a fluid can pass. The interior bore has a reduced internal diameter at a downstream end compared to an upstream portion of the fluid connector. A cooling system (701) is configured to cool a portion of the fluid connector at or below a threshold temperature value associated with a phase separation of the fluid. A detector is located downstream of the fluid connector, and the detector is configured to receive the fluid exiting the cooled fluid connector.

公开(公告)号：WO2015175447A1

公开(公告)日：2015-11-19

申请号：PCT/US2015/030244

申请日：2015-05-12

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TARAFDER, Abhijit

IPC: G01N30/30 ,  G01N30/32 ,  G01N30/02

CPC classification number: G01N30/30 ,  G01N2030/025 ,  G01N2030/027

Abstract: A method for estimating temperature variation due to pressure drop in a mobile phase passing through a column in a high efficiency chromatographic separation system is provided. The method includes constructing a temperature triangle using a pressure- temperature thermodynamic plot of the mobile phase having isenthalpic curves of the mobile phase. Applications of the method include development of chromatographic methods for minimizing band broadening due to temperature variation and methods to mitigate the extent of temperature variation due to the pressure drop.

Abstract translation: 提供了一种用于估计在通过高效色谱分离系统中的柱的流动相中由于压降引起的温度变化的方法。 该方法包括使用具有流动相的等焓曲线的流动相的压力 - 温度热力学图来构建温度三角形。 该方法的应用包括开发用于最小化由于温度变化引起的带宽变化的色谱方法和减轻由于压降引起的温度变化程度的方法。

公开(公告)号：WO2019126130A1

公开(公告)日：2019-06-27

申请号：PCT/US2018/066171

申请日：2018-12-18

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JUNG, Moon Chul ,  TARAFDER, Abhijit ,  LEVEILLE, Wade P.

IPC: G01N30/32 ,  G01N30/34 ,  B01D29/00

CPC classification number: G01N30/14 ,  B01D15/18 ,  B01D15/26 ,  G01N1/34 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/143 ,  G01N2030/342

Abstract: The invention relates to the purification of liquids. A high surface area-to-volume chemically interactive purification medium is positioned at the outlet of a container that purifies the liquid as it is dispensed/extracted. In one embodiment a purification container (1000) has a box-shaped container body that includes a top surface (882), side surfaces (884) and a bottom surface (886) opposite and parallel to the top surface (882). A set of breathing holes (888) in the top surface enables air to vent into the container so that the flow of the dispensed liquid is not impeded by development of an internal vacuum. A purification module containing purification media (1020) is located at the bottom end of a vertically-oriented tube (890). A mating socket can be used to attach to and seal the top of the tube (890) to a tube/conduit to receive the purified liquid from the container (1000).

公开(公告)号：WO2018203230A1

公开(公告)日：2018-11-08

申请号：PCT/IB2018/053008

申请日：2018-05-01

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TARAFDER, Abhijit ,  FOGWILL, Michael O. ,  SHREVE, Joshua A. ,  MICHIENZI, Joseph D. ,  CIAVARINI, Steven J.

IPC: G01N30/32 ,  B01D15/40

CPC classification number: G01N30/28 ,  B01D15/10 ,  B01D15/16 ,  B01D15/40 ,  G01N30/32

Abstract: The present disclosure relates generally to a system and a method for improving performance of a chromatography system using a highly-compressible fluid based mobile phase (e.g., CO 2 ). In particular, the present disclosure relates to a system that uses a conduit, such s a convergent-divergent nozzle, for reducing pressure noise in a chromatography system using a highly-compressible fluid based mobile phase. The chromatography system can include a conduit, such as a convergent-divergent nozzle, disposed downstream of the column to reduce or prevent the propagation of pressure or density pulses from a back pressure regulator.

公开(公告)号：WO2018189654A1

公开(公告)日：2018-10-18

申请号：PCT/IB2018/052464

申请日：2018-04-09

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MICHIENZI, Joseph D. ,  SHREVE, Joshua A. ,  HILL, Jason F. ,  TARAFDER, Abhijit ,  FOGWILL, Michael O. ,  FADGEN, Keith

IPC: G01N30/86 ,  G01N30/32 ,  B01D15/40

Abstract: Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.

公开(公告)号：WO2018134736A1

公开(公告)日：2018-07-26

申请号：PCT/IB2018/050274

申请日：2018-01-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JUNG, Moon Chul ,  BELANGER, Jonathan L. ,  SONG, Xiangjin ,  TARAFDER, Abhijit ,  JARRELL, Joseph A. ,  LEVEILLE, SR., Wade P.

IPC: G01M3/20 ,  G01M3/26 ,  G01N30/02

CPC classification number: G01N30/88 ,  G01M3/202 ,  G01M3/26 ,  G01N30/02 ,  G01N30/04 ,  G01N30/26 ,  G01N30/6052 ,  G01N30/8675 ,  G01N2030/889

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：WO2017070156A1

公开(公告)日：2017-04-27

申请号：PCT/US2016/057616

申请日：2016-10-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TARAFDER, Abhijit

IPC: G01N30/16 ,  G01N30/20 ,  G01N30/22 ,  G01N30/38

CPC classification number: G01N30/06 ,  G01N30/20

Abstract: A significant reduction in extra-column band broadening can be achieved by decoupling the injection system from the main solvent flow line. In addition, by decoupling the injection system from the main solvent flow line, additional components (e.g., filters, valves, etc.) can be introduced into the chromatography system without increasing the negative band broadening effects. Systems and methods herein provide not only for such decoupling but also for filtering precipitates from the system. As a result, a larger volume of sample can be injected into the present systems without compromising separation yield. In addition, an increase the column loading per batch, an increase the overall yield of separations, and greater system efficiency (i.e., less time lost for cleaning and maintenance) can be realized.

Abstract translation: 通过将注入系统与主溶剂流动管线分离，可以实现柱外带宽加宽的显着减少。 另外，通过将注射系统与主溶剂流动管线分离，可将额外的组分（例如过滤器，阀等）引入色谱系统中而不增加负带增宽效应。 这里的系统和方法不仅提供这种解耦，而且提供用于过滤来自系统的沉淀物。 结果，可以将更大量的样品注入本系统而不会影响分离收率。 另外，可以实现每批色谱柱装载量的增加，分离总收率的提高，以及更高的系统效率（即减少清洗和维护所需的时间）。

公开(公告)号：WO2019082155A1

公开(公告)日：2019-05-02

申请号：PCT/IB2018/058398

申请日：2018-10-26

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TARAFDER, Abhijit ,  HILL, Jason F. ,  SHREVE, Joshua A.

IPC: G01N30/30

Abstract: Methodologies, systems, and computer-readable media are provided for controlling the mass flow rate within a CO 2 based chromatography system. The pressure within a CO 2 pump is measured and received at a computing system, and the computing system retrieves a target temperature value corresponding to the new pressure measurement within the CO 2 pump. The computing system then generates a temperature control command that controls a CO 2 pump heater or cooler in order to achieve the target temperature value at the CO 2 pump. Thus, a target mass flow rate of CO 2 from the CO 2 pump is achieved by adjusting the temperature of the CO 2 pump in response to changes in pressure.

公开(公告)号：WO2018134735A1

公开(公告)日：2018-07-26

申请号：PCT/IB2018/050273

申请日：2018-01-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TARAFDER, Abhijit ,  JUNG, Moon Chul ,  BELANGER, Jonathan L. ,  SONG, Xiangjin ,  LEVEILLE, Wade P. ,  BROUSMICHE, Darryl W.

IPC: G01M3/04 ,  G01N30/02

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. A coating is disposed to conform to at least one component of a chromatography system, such as a fitting or a section of tubing. The coating is made of or contains a responsive material that can undergo a detectable change when exposed to a chromatographic fluid or mobile phase. The change of the responsive material can indicate the presence of the fluid or mobile phase, a change in at least one physical property of the coating to prevent passage of the fluid or mobile phase, or a combination thereof.