公开(公告)号：WO2022094031A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056981

申请日：2021-10-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LEVEILLE, Wade P. ,  CORMIER, Sylvain G. ,  FOGWILL, Michael O. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  ANTOCCI, Joseph D.

IPC: G01N30/60 ,  G01N30/46

Abstract: Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.

公开(公告)号：WO2013032835A1

公开(公告)日：2013-03-07

申请号：PCT/US2012/051981

申请日：2012-08-23

Applicant: WATERS TECHNOLOGIES CORPORATION ,  MICHIENZI, Joseph D.

Inventor： MICHIENZI, Joseph D.

IPC: F16L19/02

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: Described is a reusable fitting for attaching a conduit to a port. The fitting includes a housing, a spring, a retainer and a cap. The retainer is capable of locking and unlocking a conduit in the fitting. The fitting provides a high pressure fluid-tight seal and a substantially zero void volume at the junction of two fluidic conduits. The fitting is removable, reusable and replaceable, and allows a user to make and remake connections of a capillary to a fluidic port without permanently binding a ferrule to a specific capillary and thus to a specific port. The fitting can be replaced if part or all of the fitting is damaged during use.

Abstract translation: 描述的是用于将导管附接到端口的可重复使用的配件。 配件包括壳体，弹簧，保持器和盖。 保持器能够锁定和解锁配件中的导管。 该配件在两个流体管道的连接处提供高压流体密封和基本为零的空隙体积。 该配件是可拆卸的，可重复使用的并且可更换的，并且允许使用者将毛细管连接到流体端口，而不必将套圈永久地固定到特定的毛细管并因此连接到特定的端口。 如果零件或全部配件在使用过程中损坏，可以更换配件。

公开(公告)号：WO2013032833A1

公开(公告)日：2013-03-07

申请号：PCT/US2012/051974

申请日：2012-08-23

Applicant: WATERS TECHNOLOGIES CORPORATION ,  MICHIENZI, Joseph D.

Inventor： MICHIENZI, Joseph D.

IPC: B01D15/08

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: Described is a tubing assembly which includes a permanently deformable outer tube, an intermediate tube and an inner tube. A radial seal is provided by a uniform radial crimp having a non-zero longitudinal length at a longitudinal location on the tubing assembly. In some embodiments one or both ends of the assembly have a uniform radial crimp and are polished so that the ends of two or more of the tubes are substantially flush with each other to thereby block the passage of fluids between the ends of the tubes. In other embodiments the uniform radial crimps are at other longitudinal locations where a high pressure seal is desired. The longitudinal length and the depth of each uniform radial crimp can be formed to accommodate the requirements of a particular application so that leakage along the tubing assembly is prevented and void volume is reduced or eliminated.

Abstract translation: 描述了一种管组件，其包括永久变形的外管，中间管和内管。 通过在管组件上的纵向位置处具有非零纵向长度的均匀径向压接件来提供径向密封。 在一些实施例中，组件的一端或两端具有均匀的径向压接并且被抛光，使得两个或更多个管的端部彼此基本齐平，从而阻止流体在管的端部之间的通过。 在其它实施例中，均匀的径向卷曲位于需要高压密封的其它纵向位置处。 可以形成每个均匀径向卷曲的纵向长度和深度以适应特定应用的要求，从而防止沿着管道组件的泄漏并减少或消除空隙体积。

公开(公告)号：WO2021149003A1

公开(公告)日：2021-07-29

申请号：PCT/IB2021/050501

申请日：2021-01-22

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LEVEILLE, Wade P. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  JONES, Emrys ,  PRINGLE, Steven Derek ,  HATTAN, Stephen Joseph ,  ROMAN, Gregory T.

IPC: H01J49/14 ,  H01J49/16 ,  B05B12/32 ,  B05B5/03 ,  H01J49/142 ,  H01J49/167

Abstract: A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.

公开(公告)号：WO2021087212A1

公开(公告)日：2021-05-06

申请号：PCT/US2020/058129

申请日：2020-10-30

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： BASILE, Mark J. ,  MUSACCHIO, Jeffrey ,  FOGWILL, Michael O. ,  BESNER, Sebastien ,  MICHIENZI, Joseph D. ,  LEVEILLE, Wade P.

IPC: G01N30/30 ,  G01N30/74 ,  G01N30/62 ,  G01N21/03 ,  G01N21/05

Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.

公开(公告)号：WO2018193334A1

公开(公告)日：2018-10-25

申请号：PCT/IB2018/052465

申请日：2018-04-09

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： HILL, Jason F. ,  FOGWILL, Michael O. ,  MICHIENZI, Joseph D. ,  SHREVE, Joshua A. ,  TARAFDER, Abhijit

IPC: G01N30/86 ,  G01N30/60 ,  B01D15/40 ,  G01N30/32

CPC classification number: B01D15/40 ,  B01D15/163 ,  G01N30/32 ,  G01N30/60 ,  G01N30/6039 ,  G01N30/8658 ,  G01N30/8668 ,  G01N30/8672 ,  G01N30/8693 ,  G01N2030/027 ,  G01N2030/8648

Abstract: Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile. In some such methods, a length, an area, and a particle size of a first column in the first system and a flow rate in the first separation procedure are identifiable. Some such methods also involve selecting a combination of a length, an area, and a particle size of a second column in the second system and a flow rate for the second separation procedure. These methods may involve calculating a target length, a target area, or a target particle size for the second column in the second system or a target flow rate for the second separation procedure.

公开(公告)号：WO2018158730A1

公开(公告)日：2018-09-07

申请号：PCT/IB2018/051324

申请日：2018-03-01

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： FOGWILL, Michael O. ,  JARRELL, Joseph A. ,  MICHIENZI, Joseph D. ,  MCDONALD, Thomas S.

IPC: B01D15/40 ,  G01N30/32 ,  G01N30/34 ,  G01N30/62

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/40 ,  G01N30/34 ,  G01N30/36 ,  G01N30/62 ,  G01N30/7233 ,  G01N2030/326 ,  G01N2030/347 ,  G01N2030/623

Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO 2 -based chromatography system. A first CO 2 pump operates in constant flow mode and delivers CO 2 to a chromatography column, and liquid modifier is introduced to the chromatography column according to a gradient. A second CO 2 pump is disposed downstream of the column and operates in constant pressure mode to introduce CO 2 into a flow stream at an output of the column. Liquid modifier is also introduced into the flow stream at the output of the column according to a reverse gradient compared to the gradient entering the chromatography column.

公开(公告)号：WO2018031443A1

公开(公告)日：2018-02-15

申请号：PCT/US2017/045687

申请日：2017-08-07

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MUSACCHIO, Jeffrey ,  MICHIENZI, Joseph D. ,  FADGEN, Keith

IPC: F16K15/12 ,  F16K1/12 ,  F16K1/46 ,  F16K15/00 ,  F16K15/02 ,  F16K15/10 ,  F16K15/08

Abstract: A check valve includes a first valve body having a chamber in which second and third valve bodies are located. The check valve also includes a spring-energized seal disposed in the chamber. The spring-energized seal includes a compliant seal body having an annular shape and a resilient member, such as a cantered spring or O-ring, disposed in a pocket of the seal body. The resilient member applies a force to portions of the seal body to prevent the passage of fluid from a valve inlet port to a valve outlet port unless the differential fluid exceeds the cracking pressure of the check valve.

Abstract translation: 止回阀包括具有腔室的第一阀体，第二阀体和第三阀体位于该腔室中。 止回阀还包括设置在腔室中的弹簧加压密封件。 弹簧加压密封件包括具有环形形状的柔性密封体和设置在密封体的口袋中的弹性构件，诸如带刻度的弹簧或O形环。 弹性构件对密封体的部分施加力，以防止流体从阀入口端口流向阀出口端口，除非差动流体超过止回阀的开启压力。

公开(公告)号：WO2018022958A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/044291

申请日：2017-07-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： FOGWILL, Michael O. ,  HILL, Jason F. ,  MICHIENZI, Joseph D. ,  SHREVE, Joshua A. ,  TARAFDER, Abhijit

IPC: G01N30/32 ,  B01D15/16 ,  G01N30/30 ,  B01D15/40

CPC classification number: B01D15/16 ,  B01D15/40 ,  G01N30/30 ,  G01N30/32

Abstract: Methods for transferring a carbon dioxide based separation procedure from a first chromatographic system to a second one are disclosed. An average column pressure for the separation in the first system is identified. A measured average column pressure for the separation in the second system is determined. The measured average column pressure is compared with the identified average column pressure. To more closely match the identified average column pressure, the methods involve one or more of: (a) altering the flow rate of the mobile phase in the second system; (b) altering the composition of the mobile phase in the second system; and/or (c) adding a restrictive element between the inlets of a first column and the detector in the second system.

Abstract translation: 公开了用于将基于二氧化碳的分离程序从第一色谱系统转移至第二色谱系统的方法。 确定第一个系统中分离的平均柱压。 确定第二个系统中分离的实测平均柱压。 将测得的平均柱压与所确定的平均柱压进行比较。 为了更接近地匹配所识别的平均柱压力，所述方法涉及以下一项或多项：（a）改变第二系统中流动相的流速; （b）改变第二系统中流动相的组成; 和/或（c）在第一系统的入口和第二系统中的检测器之间添加限制元件。

公开(公告)号：WO2013028765A1

公开(公告)日：2013-02-28

申请号：PCT/US2012/051876

申请日：2012-08-22

Applicant: WATERS TECHNOLOGIES CORPORATION ,  MICHIENZI, Joseph D. ,  MURPHY, James P. ,  KEENE, Russell L.

Inventor： MICHIENZI, Joseph D. ,  MURPHY, James P. ,  KEENE, Russell L.

IPC: B01D15/08

CPC classification number: G01N30/06 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1827 ,  G01N30/16 ,  G01N30/6095 ,  G01N30/88 ,  G01N33/49 ,  G01N2001/383 ,  G01N2030/009 ,  G01N2030/062

Abstract: An apparatus for use in a chromatography system includes a first microfluidic substrate having a first fluidic channel. One end of the first fluidic channel terminates at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first fluidic channel terminates at a second fluidic port on a second side of the first microfluidic substrate. A second microfluidic substrate has a second fluidic channel. One end of the second fluidic channel terminates at a first fluidic port on a first side of the second microfluidic substrate. The first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the fluidic port of the second microfluidic substrate aligns with one of the fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second fluidic channels.

Abstract translation: 用于色谱系统的装置包括具有第一流体通道的第一微流体衬底。 第一流体通道的一端终止在第一微流体衬底的第一侧上的第一流体端口处，并且第一流体通道的相对端终止于第一微流体衬底的第二侧上的第二流体端口。 第二微流体衬底具有第二流体通道。 第二流体通道的一端终止在第二微流体衬底的第一侧上的第一流体端口处。 第二微流体衬底的第一侧邻接第一微流体衬底的第二侧，使得第二微流体衬底的流体端口与第一微流体衬底的流体端口中的一个对准，并且对准产生流体路径，其包括第一微流体衬底 和第二流体通道。