公开(公告)号：KR1020060104178A

公开(公告)日：2006-10-09

申请号：KR1020050026100

申请日：2005-03-29

Applicant: (주)케비젠 ,  신홍식

Inventor： 신홍식 ,  이훈 ,  박시호 ,  김희정 ,  신철호 ,  김준태

IPC: A61K8/97 ,  A61K8/19 ,  A61Q19/02

CPC classification number: A61K8/97 ,  A61K8/19 ,  A61K36/40 ,  A61K36/73 ,  A61K36/815 ,  A61K2236/33 ,  A61Q19/02 ,  Y10S514/844

Abstract: 본 발명은 산수유, 구기자, 복분자, 해송자, 진주가루 추출물을 함유하는 미백용 화장료 조성물을 제공한다.
본 발명의 미백용 화장료 조성물은 티로시나제 활성을 억제하는 효과가 있고, 멜라닌 생성을 억제하는 효과가 있으며, 세포독성이 낮아 피부에 자극이 없어 안전하므로 피부 미백용 화장품에 유용하게 사용될 수 있다.

公开(公告)号：KR100514593B1

公开(公告)日：2005-09-13

申请号：KR1020050004128

申请日：2005-01-17

Applicant: (주)케비젠

Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

IPC: C12N1/20

CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

Abstract: 본 발명은 공역화 리놀레인산(CLA)을 생산할 수 있는 신규한 균주에 관한 것이다.
본 발명의 균주에는 비피도박테리움 브레베(
Bifidobacterium breve ) CBG-C2 균주, 비피도박테리움 슈도카르테눌라툼(
Bifidobacterium pseudocartenulatum ) CBG-C4 균주 및 엔테로코커스 패시움(
Enterococcus faecium ) CBG-C5 균주가 포함된다.
본 발명의 균주는 CLA 생산 능력이 우수하며, CLA를 생성하여 배지로 분비하는 한편 균체 내에 축적할 수 있다. 또한 본 발명의 균주는 위산이나 담즙 등의 산과 항생물질에 대해 강한 내성을 지닌다.
본 발명의 균주를 포함하는 조성물은 수용성 다당류로 이루어진 피복물질 내에 본 발명의 균주와 CLA를 포함하는 캡슐제 형태로 제조되어, 기능성 식품 및 의약품으로 사용될 수 있다.

公开(公告)号：KR1020030089396A

公开(公告)日：2003-11-21

申请号：KR1020020066071

申请日：2002-10-29

Applicant: (주)케비젠

Inventor： 엄수종 ,  신홍식 ,  박시호 ,  백대헌 ,  전국체 ,  박명순 ,  박종섭 ,  노영쇠 ,  오덕근

IPC: A61K36/488 ,  A61P35/00

Abstract: PURPOSE: Provided is an anticancer composition comprising the alcohol extract of Pueraria sp. roots, which has excellent anticancer activity with less adverse effect and is thus useful for the prevention and treatment of cancer. CONSTITUTION: An anticancer composition is characterized by containing the alcohol extract of Pueraria sp. roots including Pueraria mirifica and Pueraria lobata. The alcohol extract is selected from PE1, PE2, PE3, PE4, Sub PE-A, Sub PE-B, Sub PE-C, Sub PE-D, Sub PE-E, Sub PE-F, Sub PE-G, Sub PE-H, Sub PE-D1, Sub PE-D2, and Sub PE-D3.

Abstract translation: 目的：提供包含葛根属酒精提取物的抗癌组合物。 根，具有优异的抗癌活性，副反应较少，因此可用于预防和治疗癌症。 构成：抗癌组合物的特征在于含有葛根属的酒精提取物。 根系包括葛根和葛根。 酒精提取物选自PE1，PE2，PE3，PE4，Sub PE-A，Sub PE-B，Sub PE-C，Sub PE-D，Sub PE-E，Sub PE-F，Sub PE-G，Sub PE-H，Sub-PE-D1，Sub-PE-D2，Sub-PE-D3。

公开(公告)号：KR100821377B1

公开(公告)日：2008-04-11

申请号：KR1020067011632

申请日：2003-11-15

Applicant: (주)케비젠

Inventor： 신홍식 ,  박시호 ,  백대헌 ,  오덕근 ,  엄수종

IPC: C12N1/20 ,  C12N9/90 ,  C07H3/02

Abstract: 본 발명은 내열성 아라비노오스 이성화효소 활성을 갖는 신규한 지오바실러스 더모디니트리피컨스 CBG-A1(
Geobacillus thermodenitrificans CBG-A1) 균주, 그 효소 및 타가토오스의 생산방법에 관한 것이다.
본 발명의 균주는 내열성 아라비노오스 이성화효소를 생산하며, 이 효소는 높은 온도에서도 안정적으로 효소반응을 촉매할 수 있다.
본 발명의 타가토스 생산 방법은, 알긴산나트륨, 알루미나 또는 실리카 중에서 선택된 한 담체에 아라비노스 이성화효소를 부착시키고, 글루타알데하이드를 이용하여 가교 처리함으로써 고정화시킨다.
본 발명의 균주, 그에 의해 생산되는 내열성 아라비노오스 이성화효소 및 타가토오스의 생산방법은 타가토스의 대량 생산에 효율적으로 사용될 수 있다.

公开(公告)号：KR1020060114460A

公开(公告)日：2006-11-07

申请号：KR1020050036398

申请日：2005-04-29

Applicant: (주)케비젠 ,  재단법인서울대학교산학협력재단

Inventor： 허행전 ,  이기원 ,  신홍식 ,  박시호 ,  이형주

IPC: A61K31/201

Abstract: A composition for prevention of disease mediated with gap junction damage comprising 9Z, 11E conjugated linoleic acid as an effective ingredient is provided to recover the intercellular communication through the damaged gap junction, and maintain homeostasis. The composition for prevention of disease mediated with gap junction damage comprises 9Z, 11E conjugated linoleic acid as an effective ingredient, wherein the 9Z, 11E conjugated linoleic acid is produced from Enterococcus faecium CBG-C5(KACC 91002), and inhibits phosphorylation of extracellular signal-regulated kinase that is produced when the gap junctional intercellular communication is inhibited by hydrogen peroxide.

Abstract translation: 提供用于预防由间隙连接损伤介导的疾病的组合物，其包含9Z，11E共轭亚油酸作为有效成分，以通过损伤的间隙连接处恢复细胞间连通，并维持体内平衡。 用间隙连接损伤介导的疾病预防组合物包含9Z，11E共轭亚油酸作为有效成分，其中9Z，11E共轭亚油酸由屎肠球菌CBG-C5（KACC 91002）产生，并抑制细胞外信号的磷酸化 当间隙连接的细胞间通讯被过氧化氢抑制时产生的 - 调节的激酶。

公开(公告)号：KR1020050033871A

公开(公告)日：2005-04-13

申请号：KR1020050014553

申请日：2005-02-22

Applicant: (주)케비젠

Inventor： 엄수종 ,  신홍식 ,  박시호 ,  백대헌 ,  전국체 ,  박명순 ,  박종섭 ,  노영쇠 ,  오덕근

IPC: A61K8/97 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08

Abstract: Provided are anticancer compositions comprising the alcohol extract of Pueraria sp. root. The compositions have excellent anticancer effects with less adverse side effects and is thus useful for prevention and treatment of various kinds of cancers. Therefore, the compositions are applied to anticancer-pharmaceuticals and cosmetics. The cosmetic composition comprises, as an active ingredient, the alcohol extract of Pueraria sp. root, wherein Pueraria sp. includes Pueraria mirifica and Pueraria lobata. The alcohol extract is at least one kind selected from PE1, PE2, PE3, PE4, Sub PE-A, Sub PE-B, Sub PE-C, Sub PE-D, Sub PE-E, Sub PE-F, Sub PE-G, Sub PE-H, Sub PE-D1, Sub PE-D2 and Sub PE-D3. The extract inhibits the proliferation of cancer cells to prevent and treat cancers. And it has skin stability, increases skin elasticity, has skin moisturizing effect and prevents skin wrinkles.

Abstract translation: 提供的是包含葛根属酒精提取物的抗癌组合物。 根。 该组合物具有优异的抗癌作用，副作用较小，因此可用于预防和治疗各种癌症。 因此，将组合物应用于抗癌药和化妆品。 化妆品组合物包含作为活性成分的葛根属酒精提取物。 根，其中葛根属 包括葛根和葛根。 酒精提取物选自PE1，PE2，PE3，PE4，Sub PE-A，Sub PE-B，Sub PE-C，Sub PE-D，Sub PE-E，Sub PE-F，Sub PE -G，Sub-PE-H，Sub-PE-D1，Sub-PE-D2和Sub-PE-D3。 提取物抑制癌细胞的增殖以预防和治疗癌症。 它具有皮肤稳定性，增加皮肤弹性，具有皮肤保湿效果，防止皮肤皱纹。

公开(公告)号：KR1020050023363A

公开(公告)日：2005-03-09

申请号：KR1020050004127

申请日：2005-01-17

Applicant: (주)케비젠

Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

IPC: C12N1/20

CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

Abstract: PURPOSE: A conjugated linoleic acid(CLA) producing microorganism, a capsulated composition comprising the same microorganism, and the functional food using the same composition are provided, which microorganism has improved conjugated linoleic acid(CLA) producing activity, secretes CLA into the medium and accumulates CLA within the biomass, and has tolerance against acids such as acid in the stomach and bile juice and antibiotics. CONSTITUTION: The CLA producing microorganism which converts linoleic acid(LA) into conjugated linoleic acid(CLA) is provided, wherein the CLA producing microorganism is Bifidobacterium pseudocartenulatum CBG-C4(KACC 91003, KCTC 10208BP). The capsulated composition for prevention and treatment of cancer, arteriosclerosis, diabetes and obeseness comprises the CLA producing microorganism, wherein the coating material is water-soluble polysaccharides. The functional food containing the capsulated composition is provided, wherein the food is yoghurt, cheese, kimchi and jang(fermented soybean).

Abstract translation: 目的：提供共轭亚油酸（CLA）产生微生物，包含相同微生物的包封组合物和使用相同组成的功能性食品，该微生物具有改善的共轭亚油酸（CLA）生产活性，将CLA分泌到培养基中， 在生物质内积累CLA，并且具有对胃酸，胆汁和抗生素等酸的耐受性。 构成：提供将亚油酸（LA）转化为共轭亚油酸（CLA）的CLA产生微生物，其中CLA产生微生物是假双杆菌CBG-C4（KACC 91003，KCTC 10208BP）。 用于预防和治疗癌症，动脉硬化，糖尿病和肥胖症的包封组合物包括产生CLA的微生物，其中所述涂层材料是水溶性多糖。 提供含有封装组合物的功能性食品，其中食品是酸奶，奶酪，泡菜和姜（发酵大豆）。

公开(公告)号：KR100466719B1

公开(公告)日：2005-01-17

申请号：KR1020020006318

申请日：2002-02-04

Applicant: (주)케비젠 ,  주식회사 일화

Inventor： 김동명 ,  박세호 ,  신홍식 ,  박시호

IPC: A61K9/58

Abstract: PURPOSE: Provided is a method for preparing the spherical microcapsule of the red ginseng or ginseng extract powders which is stable to the chemical reaction and non-irritative, and conceals the bitter taste of the red ginseng or ginseng by coating the red ginseng or ginseng extract powders with at least one of water soluble polymers. CONSTITUTION: The method for preparing the spherical microcapsule of the red ginseng or ginseng extract powders comprises a step for warming the solution obtained by adding sugar, water soluble starch or hydrophilic polymer to the purified water and then drying it to form the particulate solid state core seeds; a step for coating the core seeds with the red ginseng or ginseng extract powders to form the particulate of 500 to 800 micrometers, thereby preparing the rapid release type spherical microcapsule; a step for coating the rapid release type spherical microcapsule with the polymer coating solution in an amount of 20 to 40 % by total weight of coating film composition of a delayed release type spherical microcapsule to form the delayed release type spherical microcapsule of 1000 to 1200 micrometers; a step for hardening and drying the coating film of the delayed release type spherical microcapsule to a moisture content of 1 to 10 % by total weight of the coating film capsule composition; and a step for meshing the dried microcapsule to 1000 to 1200 micrometers.

Abstract translation: 目的：提供一种制备红参或人参提取物粉末的球形微胶囊的方法，该球形微胶囊对化学反应和非刺激性是稳定的，并通过涂覆红参或人参提取物来掩盖红参或人参的苦味 粉末与至少一种水溶性聚合物。 构成：制备红参或人参提取物粉末的球形微胶囊的方法包括将通过加入糖，水溶性淀粉或亲水性聚合物得到的溶液加热到纯化水中，然后干燥以形成颗粒状固体核的步骤 种子; 用红参或人参提取物粉末包覆核心种子以形成500-800微米的颗粒，由此制备快速释放型球形微囊; 以延迟释放型球状微胶囊的涂膜组合物的总重量为20至40％的量涂覆快速释放型球状微胶囊以形成1000至1200微米的缓释型球状微胶囊的步骤 ; 将所述延迟释放型球形微胶囊的涂膜硬化并干燥至所述涂膜胶囊组合物的总重量的1至10％的水分含量的步骤; 以及将干燥的微胶囊啮合至1000至1200微米的步骤。

公开(公告)号：KR100424251B1

公开(公告)日：2004-03-22

申请号：KR1020010025012

申请日：2001-05-08

Applicant: (주)케비젠 ,  신홍식

Inventor： 신홍식 ,  박명순 ,  노영쇠 ,  권윤자 ,  박시호 ,  엄수종 ,  장판식 ,  조성동

IPC: C07C227/18

Abstract: PURPOSE: A novel method for preparing α-L-aspartyl-L-phenylalanine methyl ester·HCl salt is provided, to reduce the amount of by-products, to allow the by-products to be reused after hydrolysis and to increase the production yield by 20% or more. CONSTITUTION: The method comprises the steps of reacting L-aspartic acid with trimethyl silyl chloride in the presence of an alcohol solvent to esterify the β-COOH selectively to obtain α-L-aspartyl-L-phenylalanine methyl ester·HCl. Preferably the alcohol solvent is selected from the group consisting of methyl alcohol, ethyl alcohol, allyl alcohol and benzyl alcohol. Preferably the method comprises further the steps of protecting an amine group with -CHO, Boc, benzyloxycarbonyl group, or -C(O)OR¬2 (R2 is methyl. ethyl or isobutyl group) by using acetic anhydride and formic acid.

Abstract translation: 目的：提供一种制备α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐的新方法，以减少副产物的量，使副产物在水解后重新使用和 将产量提高20％以上。 构成：该方法包括以下步骤：在醇溶剂存在下使L-天冬氨酸与三甲基甲硅烷基氯化物反应以选择性酯化β-COOH以获得α-L-天冬氨酰-L-苯丙氨酸甲酯和amp ; middot; HCl中。 优选醇溶剂选自甲醇，乙醇，烯丙醇和苯甲醇。 优选地，该方法还包括通过使用乙酸酐和甲酸，用-CHO，Boc，苄氧基羰基或-C（O）OR 2（R 2为甲基，乙基或异丁基）保护胺基的步骤。

公开(公告)号：KR1020030081180A

公开(公告)日：2003-10-17

申请号：KR1020030023164

申请日：2003-04-12

Applicant: (주)케비젠

Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

IPC: C12N1/20

CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

Abstract: PURPOSE: A novel microorganism capable of producing conjugated linoleic acid, a capsulated composition comprising the same, and a preparation method thereof are provided. The microorganism has high conjugated linoleic acid production yield and gastric juice and bile acid tolerance. CONSTITUTION: A microorganism capable of producing conjugated linoleic acid is provided, wherein the microorganism is Bifidobacterium breve CBG-C2 KACC 91001 and KCTC 10462BP, Bifidobacterium pseudocartenulatum CBG-C4 KACC 91003, and Enterococcus faecium CBG-C5 KACC 91002 and KCTC 10208BP. The capsulated composition for prevention and treatment of diseases capable of being inhibited by the conjugated linoleic acid, such as cancer, sclerosis of the arteries, diabetes and corpulence comprises the microorganism capable of producing conjugated linoleic acid.

Abstract translation: 目的：提供一种能够生产共轭亚油酸的新型微生物，包含其的包封组合物及其制备方法。 该微生物具有高共轭亚油酸产量和胃液和胆汁酸耐受性。 构成：提供能够产生共轭亚油酸的微生物，其中微生物是双歧双歧杆菌CBG-C2KACC91001和KCTC10462BP，假双歧杆菌CBG-C4KACC 91003和屎肠球菌CBG-C5 KACC 91002和KCTC 10208BP。 用于预防和治疗能够被共轭亚油酸抑制的疾病的包封组合物，例如癌症，动脉硬化，糖尿病和败血症包括能够产生共轭亚油酸的微生物。