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    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품
    4.
    发明公开
    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품 有权
    生产微生物的共轭亚油酸（CLA），其将CLA分解成生物质中的中和和累积物，包含其的包封组合物和使用其的功能性食品

    公开(公告)号：KR1020050023364A

    公开(公告)日：2005-03-09

    申请号：KR1020050004128

    申请日：2005-01-17

    Applicant: (주)케비젠

    Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

    IPC: C12N1/20

    CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

    Abstract: PURPOSE: Provided are a conjugated linoleic acid(CLA) producing microorganism, a capsulated composition comprising the same microorganism, and the functional food using the same composition, which microorganism has improved conjugated linoleic acid(CLA) producing activity, secretes CLA into the medium and accumulates CLA within the biomass, and has tolerance against acids such as acid in the stomach and bile juice and antibiotics. CONSTITUTION: The CLA producing microorganism which converts linoleic acid(LA) into conjugated linoleic acid(CLA) is provided, wherein the CLA producing microorganism is Enterococcus faecium CBG-C5(KACC 91002). The capsulated composition for prevention and treatment of cancer, arteriosclerosis, diabetes and obeseness comprises the CLA producing microorganism Enterococcus faecium CBG-C5(KACC 91002), wherein the coating material is water-soluble polysaccharides. The functional food containing the capsulated composition is provided, wherein the food is yoghurt, cheese, kimchi and jang(fermented soybean).

    Abstract translation: 目的：提供共轭亚油酸（CLA）生产微生物，包含相同微生物的包封组合物和使用相同组成的功能性食品，该微生物具有改善的共轭亚油酸（CLA）产生活性，将CLA分泌到培养基中， 在生物质内积累CLA，并且具有对胃酸，胆汁和抗生素等酸的耐受性。 构成：提供将亚油酸（LA）转化为共轭亚油酸（CLA）的CLA产生微生物，其中CLA产生微生物是屎肠球菌CBG-C5（KACC91002）。 用于预防和治疗癌症，动脉硬化，糖尿病和软绵绵的包封组合物包括CLA产生微生物屎肠球菌CBG-C5（KACC91002），其中涂层材料是水溶性多糖。 提供含有封装组合物的功能性食品，其中食品是酸奶，奶酪，泡菜和姜（发酵大豆）。

    신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물
    5.
    发明公开
    신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물 有权
    含有衍生物的新型复方衍生物，制剂方法和抗癌药物组合物

    公开(公告)号：KR1020020090850A

    公开(公告)日：2002-12-05

    申请号：KR1020020015016

    申请日：2002-03-20

    Applicant: (주)케비젠

    Inventor： 신홍식 ,  엄수종 ,  노영쇠 ,  박시호 ,  권윤자 ,  박명순 ,  한혜숙 ,  김소미 ,  김동명 ,  오덕근 ,  박종섭 ,  배태성

    IPC: C07C235/78

    Abstract: PURPOSE: A novel retinoid derivative, its preparation method, a compound used for preparing the derivative, and an anticancer medicine composition containing the derivative are provided, which retinoid derivative shows the excellent anticancer activity and no toxic side effect. CONSTITUTION: The retinoid derivative is represented by the formula I, wherein R¬1 and R¬2 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, -RCO(CH2)mCHCH3CH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬3 is H; R¬1 and R¬3 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬2 is H; R¬1 is OH, SH, NH2, COOH, -R(CH2)mCH3, R¬2 is H, and R¬3 is H, OH or Cl; R¬3 is OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, R¬2 is H, and R¬1 is H, OH or Cl; or R¬1, R¬2 and R¬3 are independent each another and are OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2; and R is CH2, O, NH or S, R¬4 is H or an alkyl group of C1-C6, and m is an integer of 0-5.

    Abstract translation: 目的：提供一种新型类视黄醇衍生物及其制备方法，用于制备衍生物的化合物和含有该衍生物的抗癌药物组合物，其视黄酸衍生物显示出优异的抗癌活性，无毒副作用。 构型：类视黄醇衍生物由式I表示，其中R 1和R 2彼此独立，为OH，SH，NH 2，COOH，-R（CH 2）m CH 3，-RCOCO（CH 2）m CH 3，-RCO （CH 2）m CHCH 3 CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 3 3是H; R 1和R 3彼此独立地是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，-OCOO（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 12是H; R 1是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，R 2是H，R 3是H，OH或Cl; R 3是OH，SH，NH 2，COOH，-R（CH 2）m CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 2是H，R 1是H，OH或Cl; 或R 1，R 2和R 3彼此独立，并且是OH，SH，NH 2，COOH，-R（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2; 且R为CH 2，O，NH或S，R 4为H或C 1 -C 6烷基，m为0-5的整数。

    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품
    6.
    发明公开
    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품 有权
    生产微生物的共轭亚油酸（CLA），其将CLA分解成生物质中的中和和累积物，包含其的包封组合物和使用其的功能性食品

    公开(公告)号：KR1020050023363A

    公开(公告)日：2005-03-09

    申请号：KR1020050004127

    申请日：2005-01-17

    Applicant: (주)케비젠

    Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

    IPC: C12N1/20

    CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

    Abstract: PURPOSE: A conjugated linoleic acid(CLA) producing microorganism, a capsulated composition comprising the same microorganism, and the functional food using the same composition are provided, which microorganism has improved conjugated linoleic acid(CLA) producing activity, secretes CLA into the medium and accumulates CLA within the biomass, and has tolerance against acids such as acid in the stomach and bile juice and antibiotics. CONSTITUTION: The CLA producing microorganism which converts linoleic acid(LA) into conjugated linoleic acid(CLA) is provided, wherein the CLA producing microorganism is Bifidobacterium pseudocartenulatum CBG-C4(KACC 91003, KCTC 10208BP). The capsulated composition for prevention and treatment of cancer, arteriosclerosis, diabetes and obeseness comprises the CLA producing microorganism, wherein the coating material is water-soluble polysaccharides. The functional food containing the capsulated composition is provided, wherein the food is yoghurt, cheese, kimchi and jang(fermented soybean).

    Abstract translation: 目的：提供共轭亚油酸（CLA）产生微生物，包含相同微生物的包封组合物和使用相同组成的功能性食品，该微生物具有改善的共轭亚油酸（CLA）生产活性，将CLA分泌到培养基中， 在生物质内积累CLA，并且具有对胃酸，胆汁和抗生素等酸的耐受性。 构成：提供将亚油酸（LA）转化为共轭亚油酸（CLA）的CLA产生微生物，其中CLA产生微生物是假双杆菌CBG-C4（KACC 91003，KCTC 10208BP）。 用于预防和治疗癌症，动脉硬化，糖尿病和肥胖症的包封组合物包括产生CLA的微生物，其中所述涂层材料是水溶性多糖。 提供含有封装组合物的功能性食品，其中食品是酸奶，奶酪，泡菜和姜（发酵大豆）。

    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품
    7.
    发明公开
    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품 有权
    可生产含有联氨酸的新型微生物，包含其的封装组合物及其制备方法

    公开(公告)号：KR1020030081180A

    公开(公告)日：2003-10-17

    申请号：KR1020030023164

    申请日：2003-04-12

    Applicant: (주)케비젠

    Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

    IPC: C12N1/20

    CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

    Abstract: PURPOSE: A novel microorganism capable of producing conjugated linoleic acid, a capsulated composition comprising the same, and a preparation method thereof are provided. The microorganism has high conjugated linoleic acid production yield and gastric juice and bile acid tolerance. CONSTITUTION: A microorganism capable of producing conjugated linoleic acid is provided, wherein the microorganism is Bifidobacterium breve CBG-C2 KACC 91001 and KCTC 10462BP, Bifidobacterium pseudocartenulatum CBG-C4 KACC 91003, and Enterococcus faecium CBG-C5 KACC 91002 and KCTC 10208BP. The capsulated composition for prevention and treatment of diseases capable of being inhibited by the conjugated linoleic acid, such as cancer, sclerosis of the arteries, diabetes and corpulence comprises the microorganism capable of producing conjugated linoleic acid.

    Abstract translation: 目的：提供一种能够生产共轭亚油酸的新型微生物，包含其的包封组合物及其制备方法。 该微生物具有高共轭亚油酸产量和胃液和胆汁酸耐受性。 构成：提供能够产生共轭亚油酸的微生物，其中微生物是双歧双歧杆菌CBG-C2KACC91001和KCTC10462BP，假双歧杆菌CBG-C4KACC 91003和屎肠球菌CBG-C5 KACC 91002和KCTC 10208BP。 用于预防和治疗能够被共轭亚油酸抑制的疾病的包封组合物，例如癌症，动脉硬化，糖尿病和败血症包括能够产生共轭亚油酸的微生物。

    효소 활성이 증가된 인간 베타, 베타 - 카로틴 15, 15' -디옥시게나제의 유전자 변이체
    8.
    发明公开
    효소 활성이 증가된 인간 베타, 베타 - 카로틴 15, 15' -디옥시게나제의 유전자 변이체 无效
    人类BETA，具有改善酶活性的十五碳十二烷酸的突变体基因

    公开(公告)号：KR1020030062126A

    公开(公告)日：2003-07-23

    申请号：KR1020020002561

    申请日：2002-01-16

    Applicant: (주)케비젠

    Inventor： 엄수종 ,  장판식 ,  김소미 ,  박찬수 ,  한혜숙 ,  신원필 ,  신홍식 ,  박시호 ,  김동명

    IPC: C12N15/53

    CPC classification number: C12N9/0069 ,  C12P7/02 ,  C12Y113/11063

    Abstract: PURPOSE: Mutant genes of human beta, beta-carotene 15, 15'-dioxygenase having improved enzyme activity are provided, so that enzyme proteins expressed from the mutant genes can be used in various fields related to the vitamin A production. CONSTITUTION: Mutant genes of human beta, beta-carotene 15, 15'-dioxygenase are produced by error-prone PCR using a human beta, beta-carotene 15, 15'-dioxygenase gene as templates, and have the enzyme activity of the expressed protein of 1100 pmol/h. A method for producing vitamin A comprises digesting beta-carotene using the expressed human beta, beta-carotene 15, 15'-dioxygenase. A method for producing vitamin A comprises transforming a host cell using the mutant genes of human beta, beta-carotene 15, 15'-dioxygenase, and culturing the transformed host cell in a medium, wherein the host cell is a plant cell, a prokaryotic cell, a yeast cell, an insect cell, a mammal cell or a poultry cell.

    Abstract translation: 目的：提供具有改善的酶活性的人β，β-胡萝卜素15,15'-双加氧酶的突变基因，使得从突变基因表达的酶蛋白可用于与维生素A生产相关的各种领域。 构成：使用人β，β-胡萝卜素15,15'-双加氧酶基因作为模板，通过易错PCR产生人β，β-胡萝卜素15,15'-双加氧酶的突变基因，并具有表达的酶活性 蛋白质为1100 pmol / h。 生产维生素A的方法包括使用表达的人β，β-胡萝卜素15,15'-双加氧酶消化β-胡萝卜素。 生产维生素A的方法包括使用人β，β-胡萝卜素15,15'-双加氧酶的突变基因转化宿主细胞，并在培养基中培养转化的宿主细胞，其中宿主细胞是植物细胞，原核 细胞，酵母细胞，昆虫细胞，哺乳动物细胞或家禽细胞。

    아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법
    10.
    发明授权
    아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법 有权
    아라비노스이성화효소의고정화에의한타가토스의생산방

    公开(公告)号：KR100464061B1

    公开(公告)日：2004-12-30

    申请号：KR1020020026615

    申请日：2002-05-15

    Applicant: (주)케비젠

    Inventor： 오덕근 ,  김소미 ,  신홍식 ,  엄수종 ,  노영쇠 ,  박종섭 ,  김동명 ,  박시호

    IPC: C12P19/02

    Abstract: PURPOSE: A method for producing tagatose by immobilization of arabinose isomerase is provided. Tagatose is cheaply and effectively mass-produced by maintaining the enzyme activity for a long time. CONSTITUTION: A method for producing tagatose by immobilization of arabinose isomerase comprises binding arabinose isomerase to resin, bridging arabinose isomerase with glutaraldehyde to immobilize the arabinose isomerase, and reacting the immobilized arabinose isomerase with substrate, wherein the concentration of arabinose isomerase is 10 mg/ml; the resin is sodium alginate, alumina or silica; the sodium alginate is used by dissolving 1.5 to 4.0% of sodium alginate in water; the alumina is used by dissolving 60 to 70% of alumina in 50 mM tris buffer solution; the silica is used by dissolving 60 to 70% of silica in 50 mM tris buffer solution; substrate is galactose; the galactose is used by dissolving 45 to 55% of galactose in pH 7 to 8 tris buffer solution; and the reaction temperature is 55 to 65 deg. C.

    Abstract translation: 目的：提供一种通过固定阿拉伯糖异构酶来生产塔格糖的方法。 塔格糖通过长期维持酶活性而廉价且有效地大量生产。 构成：通过固定阿拉伯糖异构酶生产塔格糖的方法包括将阿拉伯糖异构酶与树脂结合，将阿拉伯糖异构酶与戊二醛桥接以固定阿拉伯糖异构酶，并使固定的阿拉伯糖异构酶与底物反应，其中阿拉伯糖异构酶的浓度为10mg / ml ; 该树脂是海藻酸钠，氧化铝或二氧化硅; 海藻酸钠通过在水中溶解1.5至4.0％的海藻酸钠来使用; 通过在50mM tris缓冲溶液中溶解60-70％的氧化铝来使用氧化铝; 二氧化硅是通过将60-70％的二氧化硅溶解在50mM tris缓冲溶液中而使用的; 底物是半乳糖; 半乳糖通过在pH 7至8 Tris缓冲溶液中溶解45-55％半乳糖来使用; 反应温度为55〜65℃。 C。

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