公开(公告)号：KR100821377B1

公开(公告)日：2008-04-11

申请号：KR1020067011632

申请日：2003-11-15

Applicant: (주)케비젠

Inventor： 신홍식 ,  박시호 ,  백대헌 ,  오덕근 ,  엄수종

IPC: C12N1/20 ,  C12N9/90 ,  C07H3/02

Abstract: 본 발명은 내열성 아라비노오스 이성화효소 활성을 갖는 신규한 지오바실러스 더모디니트리피컨스 CBG-A1(
Geobacillus thermodenitrificans CBG-A1) 균주, 그 효소 및 타가토오스의 생산방법에 관한 것이다.
본 발명의 균주는 내열성 아라비노오스 이성화효소를 생산하며, 이 효소는 높은 온도에서도 안정적으로 효소반응을 촉매할 수 있다.
본 발명의 타가토스 생산 방법은, 알긴산나트륨, 알루미나 또는 실리카 중에서 선택된 한 담체에 아라비노스 이성화효소를 부착시키고, 글루타알데하이드를 이용하여 가교 처리함으로써 고정화시킨다.
본 발명의 균주, 그에 의해 생산되는 내열성 아라비노오스 이성화효소 및 타가토오스의 생산방법은 타가토스의 대량 생산에 효율적으로 사용될 수 있다.

公开(公告)号：KR1020050033871A

公开(公告)日：2005-04-13

申请号：KR1020050014553

申请日：2005-02-22

Applicant: (주)케비젠

Inventor： 엄수종 ,  신홍식 ,  박시호 ,  백대헌 ,  전국체 ,  박명순 ,  박종섭 ,  노영쇠 ,  오덕근

IPC: A61K8/97 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08

Abstract: Provided are anticancer compositions comprising the alcohol extract of Pueraria sp. root. The compositions have excellent anticancer effects with less adverse side effects and is thus useful for prevention and treatment of various kinds of cancers. Therefore, the compositions are applied to anticancer-pharmaceuticals and cosmetics. The cosmetic composition comprises, as an active ingredient, the alcohol extract of Pueraria sp. root, wherein Pueraria sp. includes Pueraria mirifica and Pueraria lobata. The alcohol extract is at least one kind selected from PE1, PE2, PE3, PE4, Sub PE-A, Sub PE-B, Sub PE-C, Sub PE-D, Sub PE-E, Sub PE-F, Sub PE-G, Sub PE-H, Sub PE-D1, Sub PE-D2 and Sub PE-D3. The extract inhibits the proliferation of cancer cells to prevent and treat cancers. And it has skin stability, increases skin elasticity, has skin moisturizing effect and prevents skin wrinkles.

Abstract translation: 提供的是包含葛根属酒精提取物的抗癌组合物。 根。 该组合物具有优异的抗癌作用，副作用较小，因此可用于预防和治疗各种癌症。 因此，将组合物应用于抗癌药和化妆品。 化妆品组合物包含作为活性成分的葛根属酒精提取物。 根，其中葛根属 包括葛根和葛根。 酒精提取物选自PE1，PE2，PE3，PE4，Sub PE-A，Sub PE-B，Sub PE-C，Sub PE-D，Sub PE-E，Sub PE-F，Sub PE -G，Sub-PE-H，Sub-PE-D1，Sub-PE-D2和Sub-PE-D3。 提取物抑制癌细胞的增殖以预防和治疗癌症。 它具有皮肤稳定性，增加皮肤弹性，具有皮肤保湿效果，防止皮肤皱纹。

公开(公告)号：KR1020050023363A

公开(公告)日：2005-03-09

申请号：KR1020050004127

申请日：2005-01-17

Applicant: (주)케비젠

Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

IPC: C12N1/20

CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

Abstract: PURPOSE: A conjugated linoleic acid(CLA) producing microorganism, a capsulated composition comprising the same microorganism, and the functional food using the same composition are provided, which microorganism has improved conjugated linoleic acid(CLA) producing activity, secretes CLA into the medium and accumulates CLA within the biomass, and has tolerance against acids such as acid in the stomach and bile juice and antibiotics. CONSTITUTION: The CLA producing microorganism which converts linoleic acid(LA) into conjugated linoleic acid(CLA) is provided, wherein the CLA producing microorganism is Bifidobacterium pseudocartenulatum CBG-C4(KACC 91003, KCTC 10208BP). The capsulated composition for prevention and treatment of cancer, arteriosclerosis, diabetes and obeseness comprises the CLA producing microorganism, wherein the coating material is water-soluble polysaccharides. The functional food containing the capsulated composition is provided, wherein the food is yoghurt, cheese, kimchi and jang(fermented soybean).

Abstract translation: 目的：提供共轭亚油酸（CLA）产生微生物，包含相同微生物的包封组合物和使用相同组成的功能性食品，该微生物具有改善的共轭亚油酸（CLA）生产活性，将CLA分泌到培养基中， 在生物质内积累CLA，并且具有对胃酸，胆汁和抗生素等酸的耐受性。 构成：提供将亚油酸（LA）转化为共轭亚油酸（CLA）的CLA产生微生物，其中CLA产生微生物是假双杆菌CBG-C4（KACC 91003，KCTC 10208BP）。 用于预防和治疗癌症，动脉硬化，糖尿病和肥胖症的包封组合物包括产生CLA的微生物，其中所述涂层材料是水溶性多糖。 提供含有封装组合物的功能性食品，其中食品是酸奶，奶酪，泡菜和姜（发酵大豆）。

公开(公告)号：KR1020030081180A

公开(公告)日：2003-10-17

申请号：KR1020030023164

申请日：2003-04-12

Applicant: (주)케비젠

Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

IPC: C12N1/20

CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

Abstract: PURPOSE: A novel microorganism capable of producing conjugated linoleic acid, a capsulated composition comprising the same, and a preparation method thereof are provided. The microorganism has high conjugated linoleic acid production yield and gastric juice and bile acid tolerance. CONSTITUTION: A microorganism capable of producing conjugated linoleic acid is provided, wherein the microorganism is Bifidobacterium breve CBG-C2 KACC 91001 and KCTC 10462BP, Bifidobacterium pseudocartenulatum CBG-C4 KACC 91003, and Enterococcus faecium CBG-C5 KACC 91002 and KCTC 10208BP. The capsulated composition for prevention and treatment of diseases capable of being inhibited by the conjugated linoleic acid, such as cancer, sclerosis of the arteries, diabetes and corpulence comprises the microorganism capable of producing conjugated linoleic acid.

Abstract translation: 目的：提供一种能够生产共轭亚油酸的新型微生物，包含其的包封组合物及其制备方法。 该微生物具有高共轭亚油酸产量和胃液和胆汁酸耐受性。 构成：提供能够产生共轭亚油酸的微生物，其中微生物是双歧双歧杆菌CBG-C2KACC91001和KCTC10462BP，假双歧杆菌CBG-C4KACC 91003和屎肠球菌CBG-C5 KACC 91002和KCTC 10208BP。 用于预防和治疗能够被共轭亚油酸抑制的疾病的包封组合物，例如癌症，动脉硬化，糖尿病和败血症包括能够产生共轭亚油酸的微生物。