Abstract:
PURPOSE: A pharmaceutical composition containing EGCG(epigallocatechin gallate) is provided to suppress differentiation of cytotoxic Th17 cells and to prevent or treat Sjogren syndrome, Behcet syndrome, or lupus. CONSTITUTION: A composition for preventing or treating Sjogren syndrome, Behcet syndrome, or lupus contains EGCG(epigallocatechin gallate) compound or salt thereof as an active ingredient. The EGCG suppresses or reduces differentiation of undifferentiated T cells into Th17 cells. A method for activating regulatory T cells comprises a step of treating the EGCG compounds or salt thereof to the T cells(Treg) in vitro. A functional food for treating or preventing Sjogren syndrome, Behcet syndrome, or lupus contains the EGCG compound or salt thereof as an active ingredient. A composition for suppressing immunity contains the EGCG compounds or salt thereof as an active ingredient.
Abstract:
PURPOSE: A pharmaceutical composition containing Vitis vinifera for preventing or treating osteoarthritis is provided. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoarthritis contains Vitis vinifera extract and pharmaceutically acceptable carrier. Osteoarthritis is caused by aging, obesity or trauma. The Vitis vinifera extract contains 80-130 of procyanidolic value(PCV), 30% or less (+) catechin and (-) epicatechin, and 95-105% of proanthocyanidine. A method for producing Vitis vinifera extract comprises: a step of extracting Vitis vinifera and mixture of acetone and water at room temperature and filtering; a step of distilling remaining liquid and removing acetone; a step of saturating sodium chloride and filtering; a step of extracting with ethyl acetate and concentrating; and a step of adding chloroform and precipitating.
Abstract:
A method for preparing extracts from seeds of Vitis Vinifera is provided to reduce the quantity of acetone consumed for extraction by using a mixed solvent of water and acetone while securing a high yield. A method for preparing extracts from seeds of Vitis Vinifera comprises the following steps of: extracting an extract from a mixture of pulverized seeds of the Vitis Vinifera and a acetone/water mixed solvent in a mixing ratio of 1 to 1-2 at a room temperature and filtering the extract; removing the acetone by distilling the obtained extract and saturating the extract with sodium chloride; extracting the saturated extract by ethylacetate and concentrating the extract; and adding chloroform to the concentrated extract to obtain precipitate.
Abstract:
본 발명은 레바미피드를 유효성분으로 포함하는 암 또는 면역질환의 예방 또는 치료용 조성물에 관한 것으로서, 보다 구체적으로 본 발명은 레바미피드 화합물 또는 그의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 암 또는 면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 레바미피드 화합물은 염증성 사이토카인을 생성 및 분비하는 세포 독성 Th17 세포의 분화를 억제하는 효과가 우수하고, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)의 활성을 증진시키는 효과가 우수하므로 각종 암 질환 또는 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용할 수 있다.
Abstract:
PURPOSE: An ROR alpha is provided to suppress the activation of Th17 cells and to regulate immune response, thereby effectively treating and preventing various allergic diseases or autoimmune diseases. CONSTITUTION: A method for reducing the activation of Th17 cells comprises the step of promoting the expression or activation of ROR alpha by transducing a recombinant expression vector containing ROR alpha genes into Th17 cells. ROR alpha gene has a sequence of sequence number 11 or 12. The recombinant expression vector contains a promoter or an enhancer which promotes the expression or activation of ROR alpha. A composition for preventing and treating Th17 cell activation-related diseases contains an agent for promoting the expression or activation of ROR alpha; or Th17 cells in which the agent is transduced, as an active ingredient.
Abstract:
PURPOSE: A composition containing retinal for preventing or treating cancer or immune diseases is provided to enhance immune-modulating T cell activity. CONSTITUTION: A composition for preventing or treating cancer or immune disease contains retinal compounds of pharmaceutically acceptable salt thereof as an active ingredient. The retinal promotes or enhances regulatory T cell activity or proliferation. A method for reducing or suppressing differentiation of immature T cell into Th17 cell in vitro comprises a step of treating retinal compound or pharmaceutically acceptable salt to the undifferentiated T cells.
Abstract:
PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract is provided to reduce acetone use and to prevent and treat rheumatic arthtritis. CONSTITUTION: A pharmaceutical composition for preventing or treating rheumatic arthritis contains Vitis vinifera seed extract and pharmaceutically acceptable carrier thereof. The extract is obtained by pulverizing Vitis vinifera seeds, extracting the seeds with a mixture solvent of acetone and water, removing acetone and saturating sodium chloride, extracting liquid with ethyl acetate and concentrating, adding chloroform and filtering.