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公开(公告)号：KR1020140011029A
公开(公告)日：2014-01-28
申请号：KR1020120071586
申请日：2012-07-02
Applicant: 서울대학교산학협력단
Abstract: The present invention relates to a lipase activity measurement method in a reversed micellar system without the interference of AOT which can effectively remove AOT interfering when the lipase activity in the reversed micellar system is measured using a polar solvent, and can remarkably reduce errors when measuring the lipase activity in a non-polar layer.
Abstract translation: 本发明涉及一种没有AOT干扰的反胶束体系中的脂肪酶活性测定方法，当使用极性溶剂测定反胶束体系中的脂肪酶活性时，可有效去除AOT的干扰，能够显着降低测定时的误差 非极性层中的脂肪酶活性。
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公开(公告)号：KR102255734B1
公开(公告)日：2021-05-26
申请号：KR1020190025325
申请日：2019-03-05
Applicant: 서울대학교산학협력단 , 원광대학교산학협력단
IPC: A61K31/7048 , A61K36/704 , A61P3/04 , A23L33/105
Abstract: 본발명은국내자생약용식물인마디풀(Polygonum aviculare L.)로부터추출한췌장라이페이스(pancreatic lipase) 저해능을가진천연신소재아비큘라린(Avicularin, quercetin-3-O-α-L-arabinofuranoside)에관한것이다. 본발명에의하면, 천연물마디풀내 췌장라이페이스저해유효성분규명을통해천연물기반의안전한신소재아비큘라린을발굴하였는데, 췌장라이페이스저해기반건강기능식품소재로활용할수 있다. 또한, 본발명에서발굴한아비큘라린은췌장라이페이스에일부가역적변화를일으키는비경쟁적성격이강한혼합형태저해제로작용하는데, 기질농도증가에따른저해효과소멸(경쟁적저해제)나췌장라이페이스의비가역적변성(비가역성저해)가발생하지않는다. 이를통해본 발명은종래기술과달리효과적이면서도안전한천연물기반의췌장라이페이스저해제를제공하는것이다.
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Patent Agency Ranking
公开(公告)号：KR1020170021595A
公开(公告)日：2017-02-28
申请号：KR1020150116185
申请日：2015-08-18
Applicant: 서울대학교산학협력단
IPC: C12N9/18 , C12P1/02 , C12P7/64 , A23L3/3571 , C12N9/20
Abstract: 본발명은글리세린지방산에스테르의-1 위치만을특이적으로가수분해또는에스테르화하는서열번호 2의아미노산서열을갖는리파아제및 피키아() 효모를이용한그것의생산방법에관한것으로, 본발명의코디셉스밀리타리스유래의-1 위치특이적라이페이스를이용할경우, 글리세롤골격구조의 1번위치에만특이적으로작용함으로써 1-모노글리세라이드및 2,3-다이글리세라이드와같은특이한재구성지방질및 생리활성물질을고효율로생산하는데적용할수 있다.
Abstract translation: 本发明涉及其制备方法，使用脂肪酶，和具有SEQ ID NO：2的氨基酸序列毕赤（）酵母：2或经酯水解，筛选仅在本发明的具体的，协调sepseu甘油脂肪酸酯的-1位 MS -1以外不断较少衍生赖的特定位置使用时面对，通过仅在1-甘油单酯，和2,3-二甘油酯和不寻常的重建脂肪和生理活性的甘油骨架的特定位置1作用，如 它可以应用于生产高效率的材料。
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公开(公告)号：KR101687735B1
公开(公告)日：2016-12-19
申请号：KR1020150132128
申请日：2015-09-18
Applicant: 서울대학교산학협력단
Abstract: 본발명은제조된리포좀을이소프로필알코올 (isopropyl alcohol), 에탄올, 메탄올중 선택되는어느하나이상으로채운용기에넣은후 동결건조시키는것과리포좀제조를위해사용되는인지질용해용용매로에틸아세테이트 (ethyl acetate)와-헥산(hexane)의혼합용매를사용하는것을특징으로하는리포좀동결분체의제조방법에관한것이다. 본발명은인지질을에틸아세테이트와-헥산의혼합용매에녹여사용하기때문에, 기존의유독한클로로포름을사용하는방법과달리식품산업에사용할수 있는장점이있다. 또한, 본발명은제조된리포좀을이소프로필알코올, 에탄올, 메탄올중 선택되는어느하나이상으로채운용기에넣은후 동결건조시킴으로써, 동결건조과정에서리포좀구조가파괴되고, 활성물질의누출이일어나는등 리포좀입자의안정성이저하되는것을막을수 있는장점이있으며, 복원시거의완벽한형태로원상회복되는장점이있다.
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公开(公告)号：KR1020160032917A
公开(公告)日：2016-03-25
申请号：KR1020140123662
申请日：2014-09-17
Applicant: 서울대학교산학협력단
CPC classification number: C08J3/075 , A61K9/06 , A61K47/36 , A61K47/42 , C08J2205/022
Abstract: 본발명은마이크로유체칩을이용하여나노크기의알지네이트하이드로겔을제조하는방법에관한것으로서, 상기마이크로유체칩은, 플랫폼; 상기플랫폼내부에구비되는메인채널; 상기메인채널일측에연결되는제1유입채널; 상기메인채널의다른일측에구비되는배출부; 상기제1유입채널과상기배출부사이에위치하도록상기메인채널에연결되는제2유입채널; 및상기제2유입채널의배출구에구비되며, 다수의미세구멍을가지는미세구멍어레이부;를포함하고, 상기나노크기의알지네이트하이드로겔은, 칼슘알지네이트프리겔용액(calcium alginate pre-gel solution)을상기마이크로유체칩의제1유입채널에유입시켜메인채널로흘려주는단계 (A); 폴리엘라이신용액(Poly-L-lysine solution)을상기마이크로유체칩의제2유입채널에유입시켜메인채널로흘려주는단계 (B); 및상기메인채널로유입된칼슘알지네이트프리겔용액및 폴리엘라이신(Poly L lysin) 용액이메인채널내부를지나면서나노크기의알지네이트하이드로겔을형성하는단계 (C);를포함하는과정으로부터제조되며, 상기칼슘알지네이트프리겔용액은, 알지닉산용액(alginic acid solution)을상기마이크로유체칩의제1유입채널에유입시켜메인채널로흘려주는단계 (a); 염화칼슘용액(calcium chloride solution)을상기마이크로유체칩의제2유입채널에유입시켜메인채널로흘려주는단계 (b); 및상기메인채널로유입된일지닉산용액및 염화칼슘용액이메인채널내부를지나면서칼슘알지네이트프리겔용액을형성하는단계 (c);를포함하는과정으로부터제조되는것을특징으로한다. 본발명의마이크로유체칩을이용한나노크기의알지네이트하이드로겔제조방법은나노크기로균일하고신속하게제조할수 있으면서도간단한구성만으로도대량의알지네이트하이드로겔을제조할수 있다.
Abstract translation: 本发明涉及使用微流控芯片的纳米级藻酸盐水凝胶的制造方法，其中所述微流体芯片包括：平台; 主渠道 第一入口通道; 排放单元; 第二入口通道; 和细孔阵列单元。 使用本发明的微流控芯片的纳米级藻酸盐水凝胶的制造方法可以均匀且快速地生成藻酸盐水凝胶，并且可以产生大量的藻酸盐水凝胶。
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公开(公告)号：KR1020140051624A
公开(公告)日：2014-05-02
申请号：KR1020120117874
申请日：2012-10-23
Applicant: 서울대학교산학협력단
IPC: A01N31/08 , A23L3/3481 , A61K31/192
CPC classification number: A01N43/08 , A23L3/34635 , A61K8/676 , A61K31/375 , A61K2800/522 , A61K2800/524 , A61Q17/005
Abstract: The present invention relates to an antibiotic composition containing erythorbyl laurate as an active ingredient and usage thereof. The erythorbyl laurate of the present invention is confirmed to have antibacterial activities against Gram-positive bacteria, thereby being added to food, cosmetics, and feed as an antimicrobial agent, and being used as a hand sanitizer or other medicine forms for external application.
Abstract translation: 本发明涉及含有月桂酸赤藓酸酯作为活性成分的抗生素组合物及其用途。 确认本发明的赤藓酸月桂酸酯具有对革兰氏阳性菌的抗菌活性，作为抗微生物剂添加到食品，化妆品，饲料中，作为手部消毒剂或其他外用药品使用。
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公开(公告)号：KR1020130010579A
公开(公告)日：2013-01-29
申请号：KR1020110071290
申请日：2011-07-19
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/26 , C12Y113/11012 , G01N33/52
Abstract: PURPOSE: A method for measuring lipoxygenase activity is provided to effectively remove surfactant which interferes conjugated diene detection using ethanol and to accurately measure the lipoxygenase activity. CONSTITUTION: A method for measuring lipoxygenase activity comprises: a step of mixing a sample containing alpha-linoleic acid, surfactant, and lipoxygenase in a non-polar solvent and inducing reverse micelle formulation and enzyme reaction; a step of adding 30-90%(v/v) ethanol to the reactant and centrifuging; and a step of collecting supernatant and measuring absorbance at 234 nm. The non-polar solvent is isooctane. The surfactant is dioctyl sulfosuccinate(AOT). The sample containing lipoxygenase is derived from a plant containing lipoxygenase.
Abstract translation: 目的：提供一种测定脂氧合酶活性的方法，以有效去除使用乙醇干扰共轭二烯检测的表面活性剂，并准确测定脂氧合酶活性。 构成：脂肪氧合酶活性测定方法包括：将含有α-亚油酸，表面活性剂和脂氧合酶的样品混合在非极性溶剂中并诱导反胶束配制和酶反应的步骤; 向反应物中加入30-90％（v / v）乙醇并离心的步骤; 以及收集上清液并测量234nm处吸光度的步骤。 非极性溶剂是异辛烷。 表面活性剂是二辛基磺基琥珀酸盐（AOT）。 含有脂氧合酶的样品来自含有脂氧合酶的植物。
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