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公开(公告)号：KR1020080022315A
公开(公告)日：2008-03-11
申请号：KR1020060085602
申请日：2006-09-06
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K36/75 , A61K8/97 , A61K2236/33 , A61K2236/37 , A61Q19/02 , Y10S514/844 , Y10S514/857
Abstract: An extract of Poncirus polyandra is provided to whiten the skin by inhibiting activity of melanocyte and tyrosinase, inhibit oxidation by removing DPPH(1.1-diphenyl-2-picrylhydrazyl) radical and suppress inflammation without side effects, so that the extract is useful for skin whitening, and prevention and treatment of inflammatory disease. An extract of Poncirus polyandra having skin-whitening, anti-oxidative and anti-inflammatory effects is prepared by washing immature Poncirus polyandra with water, pulverizing the washed Poncirus polyandra, freeze-drying the pulverized Poncirus polyandra, dipping the pulverized product in 70% ethanol with agitation at room temperature for 2-3 days, filtering the extract of Poncirus polyandra, concentrating the filtered extract of Poncirus polyandra under reduced pressure, suspending the concentrates in distilled water, and extracting the suspension with hexane, ethylacetate and butanol sequentially. A composition for whitening the skin or preventing and treating inflammatory disease comprises the extract of Poncirus polyandra.
Abstract translation: 通过抑制黑素细胞和酪氨酸酶的活性，通过除去DPPH（1.1-二苯基-2-苦基肼基）基团抑制氧化并抑制炎症而没有副作用，提供Pon irus提取物以增白皮肤，使得提取物可用于皮肤美白 ，以及预防和治疗炎症性疾病。 通过用水洗涤未成熟的Pon irus is is is is of of of of of of of of of of of of is is is is is is is ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol ethanol 在室温下搅拌2-3天，过滤茯苓提取物，减压浓缩滤液提取物，将浓缩物悬浮于蒸馏水中，并依次用己烷，乙酸乙酯和丁醇萃取悬浮液。 用于使皮肤美白或预防和治疗炎性疾病的组合物包括荚膜荚膜梭菌的提取物。
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公开(公告)号：KR100791282B1
公开(公告)日：2008-01-04
申请号：KR1020070019697
申请日：2007-02-27
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K8/97 , A61K2236/333 , A61Q19/02 , Y10S514/844
Abstract: An extract of Pimpinella komarovii is provided to secure excellent whitening effect and excellent antioxidative and anti-inflammatory activities. And a composition comprising the same as an effective ingredient is provided. An extract of Pimpinella komarovii with whitening activity is characterized in that it is prepared by hot-wind drying washed Pimpinella komarovii at a temperature of 40 deg.C, crushing the dried Pimpinella komarovii, dipping the crushed material of the Pimpinella komarovii in 70% ethanol with agitating for 2-3 days at room temperature, filtering the leachate using a filter to prepare a crude extract, and fractioning the crude extract using n-hexane, ethylacetate, and butanol in sequence. A composition for whitening, improving and preventing inflammatory diseases or antioxidizing comprises the extract of Pimpinella komarovii as an effective ingredient.
Abstract translation: 提供Pimpinella komarovii的提取物以确保优异的美白效果和优异的抗氧化和抗炎活性。 并提供包含与有效成分相同的组合物。 具有增白活性的金丝桃提取物的特征在于通过在40℃的温度下热风干燥洗涤的Pimpinella komarovii制备，粉碎干燥的Pimpinella komarovii，将Pimpinella komarovii的破碎物质浸入70％乙醇 在室温下搅拌2-3天，使用过滤器过滤渗滤液以制备粗提物，并按顺序使用正己烷，乙酸乙酯和丁醇对粗提物进行分馏。 用于增白，改善和预防炎性疾病或抗氧化的组合物包括作为有效成分的Pimpinella komarovii的提取物。
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公开(公告)号：KR101162761B1
公开(公告)日：2012-07-05
申请号：KR1020080007278
申请日：2008-01-23
Applicant: 재단법인 제주테크노파크
IPC: A61K31/35 , A61K31/352 , A61K36/752 , A61P3/04
Abstract: 본 발명은 비만 예방 또는 치료용 조성물에 관한 것으로, 구체적으로는 미성숙 감귤 추출물 또는 이로부터 분리한 리모시트린-3-글루코즈(limocitrin-3-glucose), 8-메톡시 퀘르세틴 3-오-[6”-(3”′-하이드록시-3”′-메틸-글루타로일)-베타-디-글루코피라노시드] (8-Methoxy Quercetin 3-
O -[6”-(3”'-hydroxy-3”'-methyl-glutaroyl)-
β -D-glucopyranoside]), 퀘르세틴3-오-[6”-(3”′-하이드록시-3”′-메틸-글루타로일)-베타-디-글루코피라노시드] (Quercetin 3-
O -[6”-(3”'-hydroxy-3”'-methyl-glutaroyl)-
β -D-glucopyranoside]) 및 5,6,7,8,3',4'-헥사메톡시퀘르세틴3-오-[6”-(3”'-하이드록시-글루타로일)-베타-디-글루코피라노시드](5,6,7,8,3',4'-HexaMethoxyQuercetin3-O-[6”-(3”'-hydroxy-3”'-methyl-glutaroyl)-β-D-glucopyranoside])로 이루어진 군으로부터 선택된 하나 이상의 화합물을 포함하는 비만 예방 또는 치료용 조성물에 관한 것이다. 또한, 본 발명은 상기 비만 예방 또는 치료용 조성물을 포함하는 약제학적 조성물 및 건강 기능성 식품에 관한 것이다.
온주밀감, 미성숙과, 비만-
公开(公告)号：KR1020090020216A
公开(公告)日：2009-02-26
申请号：KR1020070084778
申请日：2007-08-23
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K8/97 , A61K36/03 , A61K2236/333 , A61Q19/02 , Y10S514/844
Abstract: A whitening composition containing the extract of Dictyota is provided to improve the inhibitory activity of tyrosinase in the cell and inhibitory activity of melanin formation, so that the composition is usable for the functional cosmetics. The whitening composition contains the extract of Dictyota which is prepared by washing the brown algae of Dictyota with the flowing water; drying the brown algae of Dictyota at 40 deg. C for 3 days and pulverizing it; extracting the pulverized product with 70% ethanol at room temperature for 2-3 days; filtering the extract; repeating the extracting and filtering process 2-3 times; concentrating the filtered solution under reduced pressure, and freeze-drying the concentrate to prepare the crude extract; and fractionating the crude extract with solvent having different polarity sequentially.
Abstract translation: 提供含有Dictyota提取物的增白组合物，以改善酪氨酸酶在细胞中的抑制活性和黑色素形成的抑制活性，使得该组合物可用于功能性化妆品。 美白组合物含有Dictyota的提取物，其通过用流动的水洗涤Dictyota的棕色藻类而制备; 在40度干燥Dictyota的棕色藻类。 C 3天，粉碎; 用70％乙醇在室温下萃取粉碎产物2-3天; 过滤提取物; 重复提取和过滤2-3次; 在减压下浓缩过滤的溶液，并冷冻干燥浓缩物以制备粗提取物; 并用依次具有不同极性的溶剂对粗提物进行分馏。
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公开(公告)号：KR101749579B1
公开(公告)日：2017-06-22
申请号：KR1020140037160
申请日：2014-03-28
Applicant: 재단법인 제주테크노파크 , 재단법인 경기도경제과학진흥원
Abstract: 본발명은조록나무의추출물을유효성분으로포함하는천식예방또는치료용조성물에관한것이다. 본발명에따른조록나무추출물은 GSNO 리덕타아제와 PDE4A1의활성을동시에억제하는작용을하므로, 효과적인천식예방또는치료용조성물로사용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020150112624A
公开(公告)日：2015-10-07
申请号：KR1020140037160
申请日：2014-03-28
Applicant: 재단법인 제주테크노파크 , 재단법인 경기도경제과학진흥원
CPC classification number: A61K36/73 , A23L33/105 , A23V2002/00 , A23V2200/314 , A23V2250/21 , Y10S514/826
Abstract: 본발명은조록나무의추출물을유효성분으로포함하는천식예방또는치료용조성물에관한것이다. 본발명에따른조록나무추출물은 GSNO 리덕타아제와 PDE4A1의활성을동시에억제하는작용을하므로, 효과적인천식예방또는치료용조성물로사용될수 있다.
Abstract translation: 本发明涉及一种用于预防或治疗含有外消旋外消旋提取物作为活性成分的哮喘的组合物。 根据本发明，外消旋体提取物抑制S-亚硝基谷胱甘肽（GSNO）还原酶和磷酸二酯酶4A1（PDE4A1）的活性，从而能够用作预防或治疗哮喘的有效组合物。
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公开(公告)号：KR101042005B1
公开(公告)日：2011-06-16
申请号：KR1020090090696
申请日：2009-09-24
Applicant: 재단법인 제주테크노파크
IPC: C07C43/205 , A61K8/33 , A61K8/97 , A61Q19/02
Abstract: 본 발명은 비목나무 유래 화합물, 이의 분리 방법 및 이를 함유하는 피부 미백용 조성물에 관한 것으로, 더욱 상세하게는 비목나무(
Lindera erythrocarpa ) 추출물의 용매 분획물로부터 분리한 화합물과 이의 분리 방법 및 상기 화합물을 함유함으로써 멜라닌 생합성을 억제할 수 있는 피부 미백용 조성물에 관한 것이다.
페닐프로판(phenylpropane) 화합물, 비목나무, 추출물, 용매분획, 미백, 멜라닌, 티로시나제-
18.发明公开비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물 有权包含LINDERA ERYTHROCARPA提取物，其分类或其分离的化合物的药物组合物
公开(公告)号：KR1020110050397A
公开(公告)日：2011-05-13
申请号：KR1020100110687
申请日：2010-11-08
Applicant: 재단법인 제주테크노파크
Abstract: PURPOSE: A composition containing Lindera erythrocarpa extract, fraction, or compounds isolated from the extract and fraction is provided to prevent or treat cancer, arteriosclerosis, rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, or obesity. CONSTITUTION: A pharmaceutical composition for preventing or treating cancer, arteriosclerosis, rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, or obesity contains Lindera erythrocarpa extract, fraction or compounds isolated form the extract or fraction as an active ingredient. The Lindera erythrocarpa extract is isolated using water, C1-C4 alcohol, or mixture solvent thereof.
Abstract translation: 目的：提供含有从提取物和级分分离的Lindera erythrocarpa提取物，级分或化合物的组合物，以预防或治疗癌症，动脉硬化，类风湿性关节炎，多发性硬化，阿尔茨海默氏病或肥胖症。 构成：用于预防或治疗癌症，动脉硬化症，类风湿性关节炎，多发性硬化症，阿尔茨海默病或肥胖症的药物组合物含有从提取物或级分分离形成的作为活性成分的林德拉红果提取物，级分或化合物。 使用水，C1-C4醇或其混合溶剂分离林德拉红果提取物。
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19.发明公开
公开(公告)号：KR1020100028440A
公开(公告)日：2010-03-12
申请号：KR1020080087480
申请日：2008-09-04
Applicant: 재단법인 제주테크노파크
Abstract: PURPOSE: A composition for skin whiteing containing Lindera erythrocarpa extract or fraction and compound derived from Lindera erythrocarpa is provided to suppress melanin and ensure excellent whitening effects. CONSTITUTION: A composition for skin whitening contains Lindera erythrocarpa extract and solvent fraction thereof. The Lindera erythrocarpa extract is ethanol extract. The solvent fraction is hexane, methylene chloride, ethyl acetate, butanol, water or complex. The composition for skin whitening contains cyclpentadione compound as an active ingredient. The cyclepentadion is quercitrin, kaempferol-3-O-rhamnopyranoside, quercetin-3-O-arabinofuranoside, caffeic acid ethyl ester, cinamic acid methyl ester, lucidone, methyl linderone, or kanakugiol.
Abstract translation: 目的：提供含有Lindera erythrocarpa提取物或级分的衍生自Lindera erythrocarpa的皮肤白化组合物以抑制黑色素并确保优异的美白效果。 构成：用于皮肤美白的组合物含有Lindera erythrocarpa提取物及其溶剂级分。 Lindera erythrocarpa提取物是乙醇提取物。 溶剂馏分为己烷，二氯甲烷，乙酸乙酯，丁醇，水或络合物。 用于皮肤美白的组合物含有环戊二酮化合物作为活性成分。 槲皮素是槲皮素，山奈酚-3-O-鼠李糖吡喃糖苷，槲皮素-3-O-阿拉伯呋喃糖苷，咖啡酸乙酯，肉桂酸甲酯，荧光酮，甲基哌啶酮或者kanakugol。
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公开(公告)号：KR100864203B1
公开(公告)日：2008-10-17
申请号：KR1020070044570
申请日：2007-05-08
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K8/97 , A61K36/73 , A61Q19/02 , Y10S514/844 , Y10S514/857
Abstract: A composition comprising the extract of Malus micromalus Makino is provided to whiten the skin by inhibiting melanin biosynthesis and activity of tyrosinase, suppress oxidation and inflammation, and improve economical efficiency and safety of use by using natural plant. A composition for whitening the skin comprises the extract of Malus micromalus Makino which is prepared by washing leaf, branch, flower or fruit of Malus micromalus Makino with water, drying it with hot wind of 40 deg. C for 3 days, pulverizing the dried Malus micromalus Makino, dipping the pulverized Malus micromalus Makino in 70% ethanol and stirring it at room temperature for 2-3 days, filtering the stirred solution to obtain the crude extract of Malus micromalus Makino, and fractionating the crude extract with other solvent with different polarity.
Abstract translation: 通过抑制黑色素生物合成和酪氨酸酶的活性，抑制氧化和炎症，提高使用天然植物的经济效益和使用安全性，提供含有马蹄芥属提取物的组合物。 用于使皮肤美白的组合物包括通过用水洗涤马鞭草的叶子，分枝，花或果实制备的马蹄芥的提取物，用40℃的热风干燥。 3天，粉碎干燥的马蹄豆，将粉碎的Malus micromalus Makino浸在70％乙醇中并在室温下搅拌2-3天，过滤搅拌溶液，得到Malus micromalus Makino粗提物，分馏 粗提物与其他溶剂具有不同的极性。
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