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1.发明申请비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물 审中-公开一种药物组合物，其包含作为活性成分的来自树的提取物，其部分或从其中分离的化合物
公开(公告)号：WO2011056037A2
公开(公告)日：2011-05-12
申请号：PCT/KR2010/007854
申请日：2010-11-08
CPC classification number: A61K36/54
Abstract: 본 발명은, 비목나무(Lindera erythrocarpa) 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명의 조성물은 PPAR-γ 길항제로서 암, 동맥경화, 류마티스 관절염, 다발성경화증, 알츠하이머 또는 비만의 예방 또는 치료에 유용하게 사용될 수 있다.
Abstract translation: 本发明涉及一种药物组合物，其含有作为活性成分的红木（Lindera erythrocarpa）的提取物，其部分或从其中分离的化合物，其中所述组合物包含PPAR-γ 作为拮抗剂，它们可以有效地用于预防或治疗癌症，动脉硬化，类风湿性关节炎，多发性硬化症，阿尔茨海默氏病或肥胖症。
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2.发明授权
公开(公告)号：KR101069907B1
公开(公告)日：2011-10-05
申请号：KR1020080087480
申请日：2008-09-04
Applicant: 재단법인 제주테크노파크
Abstract: 본발명비목나무유래추출물, 분획물또는화합물을함유하는피부미백용조성물은비목나무추출물, 이의용매분획물또는이로부터분리정제한사이클펜타디온화합물을유효성분으로서함유함으로써기존에미백제로알려진 Arbutin보다더욱높은멜라닌저해활성을보이는매우뛰어난효과를가진다.
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公开(公告)号：KR1020080109243A
公开(公告)日：2008-12-17
申请号：KR1020070057318
申请日：2007-06-12
Applicant: 재단법인 제주테크노파크
Abstract: The extracts of the Ishigeaceae plant showing the antidiabetic activity is provided. A pharmaceutical composition comprising the extracts of the Ishigeaceae plant is provided to improve anti-diabetic and anti-oxidative activities. The Ishigeaceae plant extract for prevention and improvement of diabetes is obtained from the Ishigeaceae plant, and is prepared by washing Ishige sinicola; dipping the washed Ishige sinicola in 70% ethanol and agitating it at room temperature for 2-3 days; filtering the leached product of Ishige sinicola to prepare the crude extract; and sequentially fractioning the crude extract with n-hexane, ethylacetate, and butanol to obtain fractions.
Abstract translation: 提供了表现出抗糖尿病活性的菊科植物的提取物。 提供了包含藤本科植物提取物的药物组合物以改善抗糖尿病和抗氧化活性。 石鳖科植物提取物用于预防和改善糖尿病是从石ae科植物获得的，并且通过洗涤中washing皮制备; 将洗涤的Ishige sinicola浸入70％乙醇中，并在室温下搅拌2-3天; 过滤中华白兰地浸出物，制备粗提物; 并用正己烷，乙酸乙酯和丁醇依次对粗提物进行分级，得到级分。
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4.发明公开비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 뇌졸중의 예방 및 치료용 조성물 有权用于预防和治疗含有作为活性成分的林德拉霉素的包含提取物，分离物或化合物的组合物
公开(公告)号：KR1020130142704A
公开(公告)日：2013-12-30
申请号：KR1020120066136
申请日：2012-06-20
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
Abstract: The present invention relates to a composition for prevention and treatment of stroke containing a Lindera erythrocarpa extract, a fraction thereof, or a compound isolated therefrom, as active ingredients. The Lindera erythrocarpa extract, the fraction thereof, or the compound isolated therefrom (methyl lucidone or methyl linderone) has no cytotoxicity to neurons, effectively inhibits neurotoxicity of microglia activated in stroke by effectively suppressing iNOS expression and NO generation in LPS-stimulated microglia; secretion of proinflammatory cytokines; and phosphorylation of ERK, p38, Akt, and the like and NF-κB signaling path, and exhibits neuroprotective effects against neuronal cell death. Therefore, The Lindera erythrocarpa extract, the fraction thereof, or the compound isolated therefrom is useful in prevention, function improvement, treatment, and assistance for treatment of stroke.
Abstract translation: 本发明涉及一种用于预防和治疗含有Lindera erythrocarpa提取物，其一部分或从其分离的化合物作为活性成分的中风的组合物。 Lindera erythrocarpa提取物或其分离的化合物（甲基荧光酮或甲基哌啶酮）对神经元没有细胞毒作用，通过有效抑制LPS刺激的小胶质细胞中的iNOS表达和NO产生，有效抑制卒中活化的小胶质细胞的神经毒性; 促炎细胞因子的分泌; 和ERK，p38，Akt等的磷酸化和NF-κB信号通路，并表现出对神经元细胞死亡的神经保护作用。 因此，Lindera erythrocarpa提取物，其分数或从其分离的化合物可用于预防，功能改善，治疗和帮助治疗中风。
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5.发明授权비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물 有权包含LINDERA ERYTHROCARPA提取物，其分类或其分离的化合物的药物组合物
公开(公告)号：KR101291342B1
公开(公告)日：2013-07-30
申请号：KR1020100110687
申请日：2010-11-08
Applicant: 재단법인 제주테크노파크
Abstract: 본 발명은, 비목나무(Lindera erythrocarpa) 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명의 조성물은 PPAR-γ 길항제로서 암, 동맥경화, 류마티스 관절염, 다발성경화증, 알츠하이머 또는 비만의 예방 또는 치료에 유용하게 사용될 수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020110032931A
公开(公告)日：2011-03-30
申请号：KR1020090090696
申请日：2009-09-24
Applicant: 재단법인 제주테크노파크
IPC: C07C43/205 , A61K8/33 , A61K8/97 , A61Q19/02
Abstract: PURPOSE: A Lindera erythrocarpa-derived compound is provided to obtain a composition for skin whitening showing melanin inhibitory activity higher than existing albutin known as a whitening agent. CONSTITUTION: A method for separating a Lindera erythrocarpa-derived compound comprises the steps of: extracting Lindera erythrocarpa in a solvent to obtain Lindera erythrocarpa extracts; partitioning the Lindera erythrocarpa extracts into hexane, methylene chloride, ethyl acetate, and butanol to obtain solvent fractions; partitioning the Lindera erythrocarpa extracts by performing a primary silicagel column chromatography using hexane and ethyl acetate as a solvent; and applying a secondary silica gel column chromatography to the extracts using a mixed solvent of hexane and ethyl acetate.
Abstract translation: 目的：提供一种来源于林德拉克罗car甙的化合物，以获得一种皮肤美白组合物，其显示比已知的作为增白剂的已有的琥珀酸高的黑色素抑制活性。 构成：分离林多鱼赤藓醇衍生化合物的方法，包括以下步骤：在溶剂中提取枸杞子，获得枸杞子赤芍提取物; 将Lindera erythrocarpa提取物分配到己烷，二氯甲烷，乙酸乙酯和丁醇中，得到溶剂级分; 通过使用己烷和乙酸乙酯作为溶剂进行初级硅胶柱色谱法分离林德罗氏赤霉素提取物; 并使用己烷和乙酸乙酯的混合溶剂，在萃取液中进行二次硅胶柱色谱。
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公开(公告)号：KR1020110022013A
公开(公告)日：2011-03-04
申请号：KR1020110007040
申请日：2011-01-24
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K8/97 , A61K36/25 , A61K2236/333 , A61K2236/51 , A61Q19/02 , Y10S514/844
Abstract: PURPOSE: A method for preparing Hedera rhombea extract which suppresses melanogenesis and tyrosinase activity is provided to treat melasma, dots, freckles, or hyperpigmentation during pregnancy. CONSTITUTION: A whitening cosmetic composition contains 25-100ug/ml of Hedera rhombea as an active ingredient. A method for preparing ethyl acetate from Hedera rhombea comprises: a step of washing and drying Hedera rhombea by hot air; a step of pulverizing Hedera rhombea; a step of precipitating pulverized Hedera rhombea in an organic solvent, leaching, and filtering; a step of repeating leaching and filtering two or three times; a step of decompressing and freeze-drying to obtain a powder; and a step of partitioning the Hedera rhombea extract with ethyl acetate. The organic solvent is 70% ethanol.
Abstract translation: 目的：提供一种抑制黑色素生成和酪氨酸酶活性的Hedera rhombea提取物的方法，用于治疗怀孕期间的黑斑病，斑点，雀斑或色素沉着过度。 构成：美白化妆品组合物含有25-100ug / ml Hedera rhombea作为活性成分。 一种从海棠菱形体制备乙酸乙酯的方法，包括：用热空气洗涤和干燥新西兰菱形的步骤; 粉碎Hedera rhombea的一个步骤; 在有机溶剂中沉淀粉红色的菱形菱形的步骤，浸出和过滤; 重复浸出过滤两三次的步骤; 减压和冷冻干燥以获得粉末的步骤; 和用乙酸乙酯分配Hedera菱形提取物的步骤。 有机溶剂为70％乙醇。
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公开(公告)号：KR1020100005557A
公开(公告)日：2010-01-15
申请号：KR1020080065646
申请日：2008-07-07
Applicant: 재단법인 제주테크노파크
Abstract: PURPOSE: A composition containing Aster subulatus extract for improving skin condition is provided to ensure anti-inflammatory effect through anti-oxidation, meganogenesis suppression, and NO generation suppression. CONSTITUTION: A composition for improving skin condition contains Aster subulatus extract or its solvent fraction as an active ingredient. The Aster subulatu extract is obtained by pulverizing dried Aster subulatu, dipping the pulverized Aster subulatu in 70% ethanol, stirring for 2-3 days, filtering, compress-concentrating, and freeze-drying. The solvent fraction is ethanol extract, hexane fraction, methylenechloride fraction, ethylacetate fraction, butanol fraction, water fraction, or their mixture. The composition for improving skin condition is for skin whitening or anti-inflammation. The composition is formulated in a cosmetic composition or pharmaceutical composition.
Abstract translation: 目的：提供含有改善皮肤状况的Aster subulatus提取物的组合物，以通过抗氧化，组织抑制和NO产生抑制来确保抗炎作用。 构成：用于改善皮肤状况的组合物含有Aster subulatus提取物或其溶剂级分作为活性成分。 通过粉碎干燥的Aster subulatu，将粉碎的Aster subulatu浸入70％乙醇中，搅拌2-3天，过滤，压缩浓缩和冷冻干燥获得Aster subulatu提取物。 溶剂馏分为乙醇提取物，己烷馏分，二氯甲烷馏分，乙酸乙酯馏分，丁醇馏分，水馏分或其混合物。 用于改善皮肤状况的组合物用于皮肤美白或抗炎。 将组合物配制在化妆品组合物或药物组合物中。
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公开(公告)号：KR100791282B1
公开(公告)日：2008-01-04
申请号：KR1020070019697
申请日：2007-02-27
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K8/97 , A61K2236/333 , A61Q19/02 , Y10S514/844
Abstract: An extract of Pimpinella komarovii is provided to secure excellent whitening effect and excellent antioxidative and anti-inflammatory activities. And a composition comprising the same as an effective ingredient is provided. An extract of Pimpinella komarovii with whitening activity is characterized in that it is prepared by hot-wind drying washed Pimpinella komarovii at a temperature of 40 deg.C, crushing the dried Pimpinella komarovii, dipping the crushed material of the Pimpinella komarovii in 70% ethanol with agitating for 2-3 days at room temperature, filtering the leachate using a filter to prepare a crude extract, and fractioning the crude extract using n-hexane, ethylacetate, and butanol in sequence. A composition for whitening, improving and preventing inflammatory diseases or antioxidizing comprises the extract of Pimpinella komarovii as an effective ingredient.
Abstract translation: 提供Pimpinella komarovii的提取物以确保优异的美白效果和优异的抗氧化和抗炎活性。 并提供包含与有效成分相同的组合物。 具有增白活性的金丝桃提取物的特征在于通过在40℃的温度下热风干燥洗涤的Pimpinella komarovii制备，粉碎干燥的Pimpinella komarovii，将Pimpinella komarovii的破碎物质浸入70％乙醇 在室温下搅拌2-3天，使用过滤器过滤渗滤液以制备粗提物，并按顺序使用正己烷，乙酸乙酯和丁醇对粗提物进行分馏。 用于增白，改善和预防炎性疾病或抗氧化的组合物包括作为有效成分的Pimpinella komarovii的提取物。
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10.发明授权비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 뇌졸중의 예방 및 치료용 조성물 有权用于预防和治疗含有卒中的提取物，从林地赤藓红分离的级分或化合物作为活性成分的组合物
公开(公告)号：KR101503372B1
公开(公告)日：2015-03-16
申请号：KR1020120066136
申请日：2012-06-20
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
Abstract: 본 발명은 비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 뇌졸중의 예방 및 치료용 조성물에 관한 것으로, 본 발명에 따른 비목나무(Lindera erythrocarpa) 추출물, 이의 분획물, 또는 이로부터 분리한 화합물(메틸 루시돈, 메틸 린데론)은 신경세포에 대한 독성이 없고, LPS-자극된 미세신경교세포에서 iNOS 발현 및 NO 생성; 전염증 사이토카인의 분비; ERK, p38, Akt 등의 인산화 및 NF-κB 신호전달 경로를 효과적으로 억제하여 뇌졸중에서 활성화되는 미세신경교세포(microglia)의 신경세포 독성을 효과적으로 저해시키며, 신경세포 사멸에 대한 신경세포 보호 효과를 나타냄으로써 뇌졸중의 예방 및 기능개선과 치료 및 치료 보조 등에 유용하게 사용될 수 있다.
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