-
1.发明申请비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물 审中-公开一种药物组合物，其包含作为活性成分的来自树的提取物，其部分或从其中分离的化合物
公开(公告)号：WO2011056037A2
公开(公告)日：2011-05-12
申请号：PCT/KR2010/007854
申请日：2010-11-08
CPC classification number: A61K36/54
Abstract: 본 발명은, 비목나무(Lindera erythrocarpa) 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명의 조성물은 PPAR-γ 길항제로서 암, 동맥경화, 류마티스 관절염, 다발성경화증, 알츠하이머 또는 비만의 예방 또는 치료에 유용하게 사용될 수 있다.
Abstract translation: 本发明涉及一种药物组合物，其含有作为活性成分的红木（Lindera erythrocarpa）的提取物，其部分或从其中分离的化合物，其中所述组合物包含PPAR-γ 作为拮抗剂，它们可以有效地用于预防或治疗癌症，动脉硬化，类风湿性关节炎，多发性硬化症，阿尔茨海默氏病或肥胖症。
-
2.发明公开쪽동백나무 조추출물, 이의 분획물 또는 그 분획물에서 분리된 생리활성물질을 유효성분으로 함유하는 식품조성물 또는 약학 조성물 有权包含STYRAX OBASSIA SIEBOLD和ZUCC提取物，其分类或其分离物的生物物质的食品组合物或药物组合物
公开(公告)号：KR1020130014945A
公开(公告)日：2013-02-12
申请号：KR1020110076709
申请日：2011-08-01
Applicant: 재단법인 제주테크노파크
CPC classification number: A23L33/105 , A23V2002/00 , A23V2250/21 , A61K36/82
Abstract: PURPOSE: A food composition or pharmaceutical composition is provided for an anti-oxidative, hypoglycemic, anti-inflammatory and anti-obesity effect which contains styrax obassia crude extract, its fractions or the bioactive substance separated from the fractions as an active ingredient. CONSTITUTION: The composition for the anti-oxidative effect contains styrax obassia crude extract or its ethylacetate fraction as an active ingredient. The composition for the hypoglycemic effect contains styrax obassia crude extract, its ethylacetate fraction or its butanol fraction as an active ingredient. The composition for the anti-inflammatory effect contains styrax obassia crude extract, its methylenechloride fraction or its ethylacetate fraction as an active ingredient. The composition for the anti-obesity effect contains styrax obassia crude extract, its hexan fraction or its butanol fraction as an active ingredient. The composition for the anti-obesity effect contains an enhancing saponine A and an enhancing saponine B which are bioactive substances separated from the butanol fraction of the styrax obassia crude extract as an active ingredient. The styrax obassia crude extract is produced extracting styrax obassia using methanol. The composition is the food composition and pharmaceutical composition. [Reference numerals] (AA) Signal 1
Abstract translation: 目的：提供食物组合物或药物组合物用于抗氧化，降血糖，抗炎和抗肥胖的作用，其中含有作为活性成分的馏分或其部分或生物活性物质。 构成：抗氧化作用的组合物含有辛辣粗提物或其乙酸乙酯部分作为活性成分。 用于降血糖作用的组合物含有辛酸粗提物，其乙酸乙酯部分或其丁醇部分作为活性成分。 用于抗炎作用的组合物含有辛酸粗提物，其二氯代甲酸酯级分或其乙酸乙酯级分作为活性成分。 用于抗肥胖效果的组合物含有辛辣粗提物，其己糖级分或其丁醇级分作为活性成分。 用于抗肥胖效果的组合物含有增强皂苷A和增强皂苷B，其作为生物活性物质，其与作为活性成分的苦参粗提物的丁醇部分分离。 使用甲醇提取石蕊obassia obassia产生的styrax obassia粗提取物。 组合物是食品组合物和药物组合物。 （附图标记）（AA）信号1
-
3.发明授权
公开(公告)号：KR101069907B1
公开(公告)日：2011-10-05
申请号：KR1020080087480
申请日：2008-09-04
Applicant: 재단법인 제주테크노파크
Abstract: 본발명비목나무유래추출물, 분획물또는화합물을함유하는피부미백용조성물은비목나무추출물, 이의용매분획물또는이로부터분리정제한사이클펜타디온화합물을유효성분으로서함유함으로써기존에미백제로알려진 Arbutin보다더욱높은멜라닌저해활성을보이는매우뛰어난효과를가진다.
-
公开(公告)号：KR1020120131511A
公开(公告)日：2012-12-05
申请号：KR1020110049717
申请日：2011-05-25
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
IPC: A61K31/357 , A61P1/16
Abstract: PURPOSE: A composition containing diphlorethohydroxycarmalol extracted from Ishige okamurae is provided to prevent and treat liver injury caused by carbon tetrachloride. CONSTITUTION: A composition for preventing or treating liver injury contains DPHC(diphlorethohydroxycarmalol) of chemical formula 1 or pharmaceutical acceptable salts thereof as an active ingredient. The compound is derived from Ishige okamurae plants. The composition for preventing or treating liver injury contains Ishige okamurae plant extract as an active ingredient. The extract is prepared using water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, acetic acid, formic acid, citric acid, diethyl ether, or cyclohexane. A functional food for preventing or treating liver injury contains DPHC or the extract containing the same as an active ingredient.
Abstract translation: 目的：提供一种含有从山茱萸提取的双色羟基卡马洛的组合物，用于预防和治疗四氯化碳引起的肝损伤。 构成：用于预防或治疗肝损伤的组合物含有化学式1的DPHC（二舒昔洛夫羟基卡马拉）或其药学上可接受的盐作为活性成分。 该化合物衍生自Ishige okamurae植物。 用于预防或治疗肝损伤的组合物含有植物提取物作为活性成分。 提取物用水，甲醇，乙醇，丙醇，异丙醇，丁醇，丙酮，乙醚，苯，氯仿，乙酸乙酯，二氯甲烷，正己烷，盐酸，乙酸，甲酸，柠檬酸，乙醚， 或环己烷。 用于预防或治疗肝损伤的功能性食品含有DPHC或含有与活性成分相同的提取物。
-
5.发明公开비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 뇌졸중의 예방 및 치료용 조성물 有权用于预防和治疗含有作为活性成分的林德拉霉素的包含提取物，分离物或化合物的组合物
公开(公告)号：KR1020130142704A
公开(公告)日：2013-12-30
申请号：KR1020120066136
申请日：2012-06-20
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
Abstract: The present invention relates to a composition for prevention and treatment of stroke containing a Lindera erythrocarpa extract, a fraction thereof, or a compound isolated therefrom, as active ingredients. The Lindera erythrocarpa extract, the fraction thereof, or the compound isolated therefrom (methyl lucidone or methyl linderone) has no cytotoxicity to neurons, effectively inhibits neurotoxicity of microglia activated in stroke by effectively suppressing iNOS expression and NO generation in LPS-stimulated microglia; secretion of proinflammatory cytokines; and phosphorylation of ERK, p38, Akt, and the like and NF-κB signaling path, and exhibits neuroprotective effects against neuronal cell death. Therefore, The Lindera erythrocarpa extract, the fraction thereof, or the compound isolated therefrom is useful in prevention, function improvement, treatment, and assistance for treatment of stroke.
Abstract translation: 本发明涉及一种用于预防和治疗含有Lindera erythrocarpa提取物，其一部分或从其分离的化合物作为活性成分的中风的组合物。 Lindera erythrocarpa提取物或其分离的化合物（甲基荧光酮或甲基哌啶酮）对神经元没有细胞毒作用，通过有效抑制LPS刺激的小胶质细胞中的iNOS表达和NO产生，有效抑制卒中活化的小胶质细胞的神经毒性; 促炎细胞因子的分泌; 和ERK，p38，Akt等的磷酸化和NF-κB信号通路，并表现出对神经元细胞死亡的神经保护作用。 因此，Lindera erythrocarpa提取物，其分数或从其分离的化合物可用于预防，功能改善，治疗和帮助治疗中风。
-
Patent Agency Ranking6.发明授权비목나무 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물 有权包含LINDERA ERYTHROCARPA提取物，其分类或其分离的化合物的药物组合物
公开(公告)号：KR101291342B1
公开(公告)日：2013-07-30
申请号：KR1020100110687
申请日：2010-11-08
Applicant: 재단법인 제주테크노파크
Abstract: 본 발명은, 비목나무(Lindera erythrocarpa) 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명의 조성물은 PPAR-γ 길항제로서 암, 동맥경화, 류마티스 관절염, 다발성경화증, 알츠하이머 또는 비만의 예방 또는 치료에 유용하게 사용될 수 있다.
-
公开(公告)号：KR1020110032931A
公开(公告)日：2011-03-30
申请号：KR1020090090696
申请日：2009-09-24
Applicant: 재단법인 제주테크노파크
IPC: C07C43/205 , A61K8/33 , A61K8/97 , A61Q19/02
Abstract: PURPOSE: A Lindera erythrocarpa-derived compound is provided to obtain a composition for skin whitening showing melanin inhibitory activity higher than existing albutin known as a whitening agent. CONSTITUTION: A method for separating a Lindera erythrocarpa-derived compound comprises the steps of: extracting Lindera erythrocarpa in a solvent to obtain Lindera erythrocarpa extracts; partitioning the Lindera erythrocarpa extracts into hexane, methylene chloride, ethyl acetate, and butanol to obtain solvent fractions; partitioning the Lindera erythrocarpa extracts by performing a primary silicagel column chromatography using hexane and ethyl acetate as a solvent; and applying a secondary silica gel column chromatography to the extracts using a mixed solvent of hexane and ethyl acetate.
Abstract translation: 目的：提供一种来源于林德拉克罗car甙的化合物，以获得一种皮肤美白组合物，其显示比已知的作为增白剂的已有的琥珀酸高的黑色素抑制活性。 构成：分离林多鱼赤藓醇衍生化合物的方法，包括以下步骤：在溶剂中提取枸杞子，获得枸杞子赤芍提取物; 将Lindera erythrocarpa提取物分配到己烷，二氯甲烷，乙酸乙酯和丁醇中，得到溶剂级分; 通过使用己烷和乙酸乙酯作为溶剂进行初级硅胶柱色谱法分离林德罗氏赤霉素提取物; 并使用己烷和乙酸乙酯的混合溶剂，在萃取液中进行二次硅胶柱色谱。
-
公开(公告)号：KR1020100005557A
公开(公告)日：2010-01-15
申请号：KR1020080065646
申请日：2008-07-07
Applicant: 재단법인 제주테크노파크
Abstract: PURPOSE: A composition containing Aster subulatus extract for improving skin condition is provided to ensure anti-inflammatory effect through anti-oxidation, meganogenesis suppression, and NO generation suppression. CONSTITUTION: A composition for improving skin condition contains Aster subulatus extract or its solvent fraction as an active ingredient. The Aster subulatu extract is obtained by pulverizing dried Aster subulatu, dipping the pulverized Aster subulatu in 70% ethanol, stirring for 2-3 days, filtering, compress-concentrating, and freeze-drying. The solvent fraction is ethanol extract, hexane fraction, methylenechloride fraction, ethylacetate fraction, butanol fraction, water fraction, or their mixture. The composition for improving skin condition is for skin whitening or anti-inflammation. The composition is formulated in a cosmetic composition or pharmaceutical composition.
Abstract translation: 目的：提供含有改善皮肤状况的Aster subulatus提取物的组合物，以通过抗氧化，组织抑制和NO产生抑制来确保抗炎作用。 构成：用于改善皮肤状况的组合物含有Aster subulatus提取物或其溶剂级分作为活性成分。 通过粉碎干燥的Aster subulatu，将粉碎的Aster subulatu浸入70％乙醇中，搅拌2-3天，过滤，压缩浓缩和冷冻干燥获得Aster subulatu提取物。 溶剂馏分为乙醇提取物，己烷馏分，二氯甲烷馏分，乙酸乙酯馏分，丁醇馏分，水馏分或其混合物。 用于改善皮肤状况的组合物用于皮肤美白或抗炎。 将组合物配制在化妆品组合物或药物组合物中。
-
公开(公告)号：KR1020130107947A
公开(公告)日：2013-10-02
申请号：KR1020120030154
申请日：2012-03-23
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
IPC: A61K31/357 , A61K31/36 , A61K36/03 , A61P25/28
Abstract: PURPOSE: A composition containing diphlorethohydroxycarmalol compounds as active ingredients for protecting nerve cells is provided to prevent or treat brain diseases caused by glutamate neurotoxicity and to be used in functional foods for treating brain diseases. CONSTITUTION: A composition for protecting nerve cells contains diphlorethohydroxycarmalol compounds of chemical formula as active ingredients. The compound is derived from Ishigeaceae plants. The compound suppresses neurotoxicity caused by glutamate and activation of microglial cells. The compound prevents or treats brain diseases caused by glutamate neurotoxicity.
Abstract translation: 目的：提供一种含有双缓冲羟基卡马洛尔化合物作为保护神经细胞的有效成分的组合物，用于预防或治疗由谷氨酸神经毒性引起的脑部疾病，并用于治疗脑部疾病的功能性食品。 构成：用于保护神经细胞的组合物含有化学式的双倍亮氨酸羟基卡马洛尔化合物作为活性成分。 该化合物衍生自石ae科植物。 该化合物抑制谷氨酸引起的神经毒性和小胶质细胞的活化。 该化合物预防或治疗由谷氨酸神经毒性引起的脑部疾病。
-
公开(公告)号：KR101042005B1
公开(公告)日：2011-06-16
申请号：KR1020090090696
申请日：2009-09-24
Applicant: 재단법인 제주테크노파크
IPC: C07C43/205 , A61K8/33 , A61K8/97 , A61Q19/02
Abstract: 본 발명은 비목나무 유래 화합물, 이의 분리 방법 및 이를 함유하는 피부 미백용 조성물에 관한 것으로, 더욱 상세하게는 비목나무(
Lindera erythrocarpa ) 추출물의 용매 분획물로부터 분리한 화합물과 이의 분리 방법 및 상기 화합물을 함유함으로써 멜라닌 생합성을 억제할 수 있는 피부 미백용 조성물에 관한 것이다.
페닐프로판(phenylpropane) 화합물, 비목나무, 추출물, 용매분획, 미백, 멜라닌, 티로시나제
-
-
-
-
-
-
-
-
-
Search Results
16
records
(took 0.025 seconds)
