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公开(公告)号：KR1020130072983A
公开(公告)日：2013-07-02
申请号：KR1020110140635
申请日：2011-12-22
Applicant: 전북대학교산학협력단
Abstract: PURPOSE: A composition for treating cartilage damage containing 97 %v/v of moisture is provided to absorb shock by injecting into body, and to prevent dissolution by inflammatory reaction or toxic materials without cytotoxicity. CONSTITUTION: A composition for treating cartilage damage contains demineralized bone particle (DBP) gel and a costal chondrocyte composition. The DBP is derived from mammalian bone. The particle size of the DBP is 10-300 micrometer. The weight ratio of the DBP is 5-20 wt%. The composition has pH 6-7.
Abstract translation: 目的：提供一种用于治疗含有97％v / v水分的软骨损伤的组合物，以通过注射到体内吸收冲击，并防止炎症反应或有毒物质溶解而无细胞毒性。 构成：用于治疗软骨损伤的组合物含有脱矿质骨颗粒（DBP）凝胶和软骨软骨细胞组成。 DBP衍生自哺乳动物骨骼。 DBP的粒径为10-300微米。 DBP的重量比为5-20重量％。 组合物的pH为6-7。
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公开(公告)号：KR1020130072982A
公开(公告)日：2013-07-02
申请号：KR1020110140634
申请日：2011-12-22
Applicant: 전북대학교산학협력단
CPC classification number: A61K35/32 , A61K9/06 , A61K38/1841 , A61K38/30 , A61K38/488
Abstract: PURPOSE: A Demineralized bone particle (DBP) gel is provided to simplify preparation, to maintain gel form, and to ensure easy storage and biocompatibility. CONSTITUTION: A gel for chondrogenesis contains demineralized bone particle (DBP), pepsin, and acetic acid. The DBP is mammalian bone. The particle size of the DBP is 10-300 micrometer. The weight ratio of the DBP is 5-20 wt%. A composition for treating cartilage damage has pH 6-7.
Abstract translation: 目的：提供脱矿质骨颗粒（DBP）凝胶，以简化制备，保持凝胶形式，并确保易于储存和生物相容性。 构成：用于软骨形成的凝胶含有脱矿质骨颗粒（DBP），胃蛋白酶和乙酸。 DBP是哺乳动物骨。 DBP的粒径为10-300微米。 DBP的重量比为5-20重量％。 用于治疗软骨损伤的组合物具有pH6-7。
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公开(公告)号：KR1020090075503A
公开(公告)日：2009-07-08
申请号：KR1020080001380
申请日：2008-01-04
Applicant: 전북대학교산학협력단
CPC classification number: A61L27/44 , A61L27/14 , A61L27/20 , A61L27/222 , A61L27/24 , A61L27/26 , A61L27/40 , A61L27/56
Abstract: A method for manufacturing biodegradable porous hybrid carrier and an artificial organ are provided, which obtain the environment that cell can adhere and increase. A method for manufacturing biodegradable porous hybrid carrier comprises a step for injecting the mixture prepared by adding hyaluronic acid solution 10-50 volume% to organic solvent 50-90 volume% containing the biodegradable polymer for providing the bio-compatibility and the vitality in the mold and freeze-drying it. The biodegradable polymer has 0.003-27 weight% concentration. The hyaluronic acid solution has 0.001-3 weight% concentration.
Abstract translation: 提供了一种制造可生物降解的多孔混合载体和人造器官的方法，其获得了细胞粘附和增加的环境。 制造可生物降解的多孔混合载体的方法包括通过将含有10-50体积％的透明质酸溶液加入含有可生物降解聚合物的有机溶剂50-90体积％制备的混合物的方法，以提供生物相容性和模具中的活力 并冷冻干燥。 可生物降解的聚合物浓度为0.003-27％。 透明质酸溶液的浓度为0.001-3重量％。
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公开(公告)号：KR101902194B1
公开(公告)日：2018-09-28
申请号：KR1020160142167
申请日：2016-10-28
Applicant: 전북대학교산학협력단
Abstract: 본발명은커큐민이함유된젤란검하이드로겔조성물과이를이용한연골재생및 골관절염치료용조성물에관한것으로서, 더욱상세하게는연골재생과골관절염치료를위해필러나치료용으로인체의관절부위에직접주입하여사용가능하고조직공학적으로생체적합한커큐민이함유된젤란검하이드로겔조성물의구성에관한것이며, 이러한조성물을이용한연골재생과골관절염치료및 예방용조성물에관한것이다.
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Patent Agency Ranking
公开(公告)号：KR20180046685A
公开(公告)日：2018-05-09
申请号：KR20160142167
申请日：2016-10-28
Applicant: 전북대학교산학협력단
CPC classification number: A61L27/52 , A61K9/0019 , A61K9/08 , A61K31/12 , A61L27/20 , A61L27/54 , A61L27/58 , A61L2300/802 , A61L2400/06 , A61L2430/06 , A61L2430/24
Abstract: 본발명은커큐민이함유된젤란검하이드로겔조성물과이를이용한연골재생및 골관절염치료용조성물에관한것으로서, 더욱상세하게는연골재생과골관절염치료를위해필러나치료용으로인체의관절부위에직접주입하여사용가능하고조직공학적으로생체적합한커큐민이함유된젤란검하이드로겔조성물의구성에관한것이며, 이러한조성물을이용한연골재생과골관절염치료및 예방용조성물에관한것이다.
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公开(公告)号：KR1020160112541A
公开(公告)日：2016-09-28
申请号：KR1020150038437
申请日：2015-03-19
Applicant: 전북대학교산학협력단
Abstract: 본발명은조직공학용생분해성고분자지지체와그 제조방법에관한것으로서, 더욱상세하게는난용성플라보노이드를수용성고분자를사용하여용해도를증가시켜생체이용률을높인생분해성플라보노이드고체분산체를제조함으로써, 이러한고체분산체를이용하여고분자지지체를구성하는경우유용성분의용해도증가, 생체이용률증가및 항산화및 항염증효능을가짐으로써생체고분자의염증반응을줄이고생체적합성이우수한조직공학용생분해성고분자지지체에관한것이다.
Abstract translation: 本发明涉及用于组织工程的生物可降解聚合物支架及其制造方法。 更具体地说，可生物降解的类黄酮固体分散体是通过使用水溶性聚合物增加难溶性类黄酮的溶解度而制造的，从而具有增强的生物利用度。 在使用可生物降解的类黄酮固体分散体制造用于组织工程的可生物降解的聚合物支架的情况下，用于组织工程的可生物降解的聚合物支架增加了有效成分的溶解度，生物利用度，并且具有增强的抗氧化和抗炎功效。 因此，用于组织工程的可生物降解的聚合物支架已经降低了生物聚合物的炎症反应，并且具有优异的生物相容性。
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公开(公告)号：KR100814504B1
公开(公告)日：2008-03-18
申请号：KR1020060108483
申请日：2006-11-03
Applicant: 전북대학교산학협력단
IPC: C12N5/0793
CPC classification number: C12N5/0619 , C12N2501/115 , C12N2501/195 , C12N2506/1353
Abstract: A method for differentiating mesenchymal stem cells into neurons is provided to induce the differentiation of the mesenchymal stem cells into the neurons effectively using a poly lactic acid-co-glycolic acid(PLGA) film and show excellent efficiency compared with the differentiation into the neurons using a conventional culture solution. A method for differentiating mesenchymal stem cells into neurons comprises a step of differentiating the mesenchymal stem cells on a poly lactic acid-co-glycolic acid(PLGA) film including neurogenic differentiation inducing materials such as butylated hydroxy anisole(BHA), beta-mercaptoethanol and dimethylsulfoxide(DMSO), wherein the mesenchymal stem cells are pre-treated with a basic-fibroblast growth factor for 12-24 hours.
Abstract translation: 提供了将间充质干细胞分化为神经元的方法，以使用聚乳酸 - 共 - 乙醇酸（PLGA）膜有效地诱导间充质干细胞分化为神经元，与使用 常规培养方案。 用于将间充质干细胞分化为神经元的方法包括将间充质干细胞分离在聚乳酸 - 共 - 乙醇酸（PLGA）膜上的步骤，所述聚乳酸 - 共 - 乙醇酸（PLGA）膜包括神经源性分化诱导材料，例如丁基化羟基苯甲醚（BHA），β-巯基乙醇和 二甲基亚砜（DMSO），其中间充质干细胞用碱性成纤维细胞生长因子预处理12-24小时。
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公开(公告)号：KR102210056B1
公开(公告)日：2021-02-01
申请号：KR1020180123754
申请日：2018-10-17
Applicant: 전북대학교산학협력단
Abstract: 본발명은오골계유래의탈미네랄화된골분(demineralized bone powder; DBP)이첨가된젤란검을지지체로이용하여하이드로겔형태로구성되는조성물과, 이러한조성물을이용한연골또는골연골의재생, 골관절염의치료및 예방을위한조성물에관한것이다.
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公开(公告)号：KR101489916B1
公开(公告)日：2015-02-06
申请号：KR1020130039326
申请日：2013-04-10
Applicant: 전북대학교산학협력단
IPC: A23L29/281 , A23L13/20
Abstract: 본 발명은 축산 부산물로부터 고순도 콜라겐을 추출하는 방법에 관한 것으로서, 더욱 상세하게는 질병 등으로부터 오염되지 않은 축산 부산물로부터 비 콜라겐 물질을 제거하여 고순도의 콜라겐을 추출 정제함으로써 식용, 화장품용 또는 의료용 원료로 사용할 수 있는 고순도의 콜라겐을 추출하는 방법에 관한 것이다.
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