-
公开(公告)号：KR101239837B1
公开(公告)日：2013-03-06
申请号：KR1020120012620
申请日：2012-02-08
Applicant: 부산대학교 산학협력단 , 충남대학교산학협력단
IPC: A61K48/00 , C07C317/32 , C07C317/24 , A61K31/10
CPC classification number: G01N33/5748 , A61K31/10 , A61K31/122 , C07C317/44 , C07C323/52 , C07C2602/10
Abstract: 본 발명은 스네일-p53 간의 결합을 저해하는 화합물 및 이를 유효성분으로 함유하는 암질환 치료제에 관한 것으로, 상기 스네일-p53 간의 결합 저해제는 K-Ras 돌연변이 세포주에서 p53의 발현을 유도함으로써 췌장암, 폐암, 담관암 및 대장암과 같이 진단이나 치료가 용이하지 않은 K-Ras 돌연변이성 암질환을 효과적으로 치료하거나 예방할 수 있다.
Abstract translation: 本发明涉及含有所述化合物和抑制蜗牛-p53之间的结合这种活性成分的癌症治疗剂，抑制剂蜗牛-p53之间的结合是通过诱导K-Ras突变细胞系p53表达胰腺癌， 肺癌可与诊断和治疗得到有效治疗是不容易的K-ras突变癌性疾病如胆管癌和结肠直肠癌或防止。
-
公开(公告)号：KR1020120044948A
公开(公告)日：2012-05-08
申请号：KR1020120012620
申请日：2012-02-08
Applicant: 부산대학교 산학협력단 , 충남대학교산학협력단
IPC: A61K48/00 , C07C317/32 , C07C317/24 , A61K31/10
CPC classification number: G01N33/5748 , A61K31/10 , A61K31/122 , C07C317/44 , C07C323/52 , C07C2602/10
Abstract: PURPOSE: A specific drug transmission method of K-Ras mutant cell is provided to detect cancer caused by K-Ras mutant in initial, to be very useful for the treatment of cancer, thereby extending the survival rate of cancer patients. CONSTITUTION: A specific drug transmission method comprises: a step of treating DNA bonding domain of p53 and drug for transferring to cells, and a step of transferring drug to neighbored K-Ras mutant cell by endocytosis by the DNA bonding domain of p53.
Abstract translation: 目的：提供K-Ras突变体细胞的特异性药物传播方法，用于检测初期由K-Ras突变体引起的癌症，对治疗癌症非常有用，从而延长癌症患者的存活率。 构成：具体的药物传播方法包括：处理p53的DNA结合结构域和转移至细胞的药物的步骤，以及通过p53的DNA结合结构域的胞吞作用将药物转移至邻近的K-Ras突变细胞的步骤。
-
公开(公告)号：KR1020100057502A
公开(公告)日：2010-05-31
申请号：KR1020090111710
申请日：2009-11-18
Applicant: 부산대학교 산학협력단 , 충남대학교산학협력단
IPC: C07C317/32 , C07C317/24 , A61K31/10 , G01N33/574
CPC classification number: G01N33/5748 , A61K31/10 , A61K31/122 , C07C317/44 , C07C323/52 , C07C2602/10
Abstract: PURPOSE: A chemical inhibitor for the bond between snail-p53 is provided to effectively treat K-Ras mutagenic cancer disease by inducing the revelation of the p-53 in K-Ras mutant cell strain. CONSTITUTION: A chemical inhibitor has a structure marked as a chemical formula 1. In the chemical formula 1, m is an integer of 0-10, n and p is 0 or 1. In the chemical formula 1, Z is selected from a group comprising NH(CH2)qCH3, -OH, 4-phenylpiperidine group, isobutylamine, and isobutyloxy group and q is integer of 0-9. A pharmaceutical composition for treating cancer disease contains a compound for inhibiting the bond of snail-p53 as an active ingredient.
Abstract translation: 目的：提供snail-p53之间的结合的化学抑制剂，通过诱导K-Ras突变细胞株中p-53的启示来有效地治疗K-Ras致突变性癌症。 构成：化学抑制剂具有标记为化学式1的结构。在化学式1中，m是0-10的整数，n和p是0或1.在化学式1中，Z选自 包括NH（CH 2）q CH 3，-OH，4-苯基哌啶基，异丁胺和异丁氧基，q是0-9的整数。 用于治疗癌症疾病的药物组合物含有抑制蜗牛-β53作为活性成分的结合的化合物。
-
14.发明授权
公开(公告)号：KR100543954B1
公开(公告)日：2007-04-12
申请号：KR1020030073575
申请日：2003-10-21
Applicant: 충남대학교산학협력단
Abstract: 본 발명은 하기 화학식 (1)로 표시된 신물질 1
N -벤질-4-메틸벤젠-1,2-디아민과 이의 제법 및 이 물질을 유효성분으로 과색소 침착 피부질환을 예방 및 치료할 수 있는 미백기능 화장품 조성물에 관한 것이다.
1N-벤질-4-메틸벤젠-1,2-디아민, 미백, 화장품, 기능성, 멜라닌, 티로신, 티로시나제-
公开(公告)号：KR101625474B1
公开(公告)日：2016-05-31
申请号：KR1020140173837
申请日：2014-12-05
Applicant: 충남대학교산학협력단
Abstract: 본발명은진세노사이드 Re의대량생산방법에관한것으로서, 자세하게는, 진세노사이드 Re에유기산을혼합하고고온고압처리를하여진세노사이드 Rh4를제조하는방법에관한것이다. 진세노사이드 Rh4는백삼에는존재하지않고홍삼이나흑삼에미량존재하는것으로서, 기존의인삼추출물이나홍삼추출물의가공을통해서는화학구조와분자량이유사한형태의진세노사이드들이다양하게존재하기때문에진세노사이드 Rh4의순수정제가쉽지않을뿐만아니라, 상기추출물내에는진세노사이드 Rh4 미량으로존재하기때문에정제된양이매우적다. 그러나, 본발명을통해서는인삼잎으로부터용이하게분리가능한진세노사이드 Re만을이용하여진세노사이드 Rh4를제조하기때문에, 추출물을이용할때와비교하여상대적으로진세노사이드 Rh4의정제가쉽고, 대량생산이아주용이하다. 또한표준정제된진세노사이드 Rh4의가격또한고가이기에, 본발명의진세노사이드 Re의대량생산방법을통해이와같은진세노사이드 Rh4의대량제조를통해고부가가치의창출이가능하다.
Abstract translation: 本发明涉及一种用于大量生产人参皂甙Re的方法，更具体地说，涉及一种大量生产人参皂甙-R Re的方法，其中有机酸与人参皂甙-Re混合，混合物在高温高压下处理 ，以产生人参皂甙Rh4。 人参皂甙Rh4少量存在，只有红参和黑参，而不是白参，常规手段通过人参提取物和红参提取物提取人参皂甙Rh4，不仅无法在人参皂苷中分离纯化人参皂甙 由于存在具有相似化学结构和分子量的各种其他人参皂甙，而且由于人参皂甙-Ro4在这种提取物中仅存在微量的量，所以分离和纯化的人参皂甙-Ro4的产率非常低。 另一方面，本发明仅通过使用能够容易地从人参叶分离的人参皂甙-R而生产人参皂甙-Ro4。 因此，与使用提取物相比，人参皂甙Rh4的分离纯化更容易，其大量生产容易。 此外，由于通过常规方法分离和纯化的人参皂苷-Rh4是昂贵的，因此本发明的批量生产人参皂甙-Ro4的方法能够廉价地生产人参皂甙-R4，可以产生更高的附加值。
-
Patent Agency Ranking
公开(公告)号：KR1020160044084A
公开(公告)日：2016-04-25
申请号：KR1020140138127
申请日：2014-10-14
Applicant: 충남대학교산학협력단
Abstract: 본발명은막걸리나약주제조후 발생되는막걸리로부터단백질을추출하고천연향균제인고추냉이추출물을첨가하여향균성이있는친환경가식성필름의제조방법에관한것으로서, 본발명의막걸리박단백질필름은저가의막걸리박으로부터단백질을추출하여가격경쟁력이있고, 고추냉이추출물이포함되어항균성이있고, 인장강도와신장률및 항균성이우수하므로식품포장재로유용하게사용될수 있다.
Abstract translation: 本发明涉及一种生产抗菌，环保和可食用薄膜的方法，通过在生产makgeolli或饮料后生产的makgeolli中提取蛋白质后，加入辣根提取物作为天然抗菌剂。 本发明的makgeolli残留蛋白质膜是低成本竞争性的，因为蛋白质是从低价的makgeolli提取的，并且由于含有辣根提取物而表现出抗菌性能。 麦芽糖残留蛋白膜也显示出优异的拉伸强度，伸长率和抗菌性能，因此可用作食品包装材料。
-
公开(公告)号：KR101594167B1
公开(公告)日：2016-02-15
申请号：KR1020150019390
申请日：2015-02-09
Applicant: 충남대학교산학협력단
Abstract: 본발명은불가사리로부터추출된단백질에천연항균제인자몽종자추출물을첨가하여항균성을함유하는가식성필름(edible film)을제조하는방법에관한것으로, 본발명의자몽종자추출물을포함한불가사리단백질필름은인장강도, 신장률및 항균성이우수하므로기능성식품포장재로유용하게사용될수 있으며, 해양생태계파괴의주범으로알려진불가사리를이용하여저렴하게단백질을추출하고필름을제조함으로써가격경쟁력이뛰어나다.
Abstract translation: 本发明涉及通过向海星提取的蛋白质中加入作为天然抗菌剂的葡萄柚籽提取物来制造含有抗菌性的可食用膜的方法。 含有根据本发明的葡萄柚种子提取物的海星蛋白质膜具有优异的拉伸强度，拉伸伸长率和抗菌性能，因此可用作功能性食品包装材料; 并以低廉的价格提取蛋白质，并通过使用被称为破坏海洋生态系统的主要原因的海星制造电影，从而具有极好的价格竞争力。
-
18.发明公开프로게린 및 라민 Ａ간의 결합 억제제를 유효성분으로 포함하는 노화 관련 질환 예방 또는 치료용 약학 조성물 및 상기 결합 억제제의 스크리닝 방법 有权用于预防或治疗包含前列腺素和粘蛋白阻断剂的老化相关疾病的药物组合物的结合及其筛选方法
公开(公告)号：KR1020130104991A
公开(公告)日：2013-09-25
申请号：KR1020120027028
申请日：2012-03-16
Applicant: 부산대학교 산학협력단 , 충남대학교산학협력단
IPC: C07D493/04 , C07D311/06 , A61K31/352 , A61P35/00
Abstract: PURPOSE: A pharmaceutical composition for preventing or treating aging-related diseases and a method for screening a binding inhibitor are provided to effectively treat or prevent diseases caused by progerin and to specifically select a drug which suppresses binding between progerin and lamin A. CONSTITUTION: A compound of chemical formula 1 or 2 or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for preventing or treating aging-related diseases contains the compound of chemical formula 1 or 2 or a pharmaceutically acceptable salt thereof as an active ingredient. A method for screening a therapeutic agent for treating aging-related diseases comprises the step of selecting candidate drugs which suppress binding between progerin and lamin A.
Abstract translation: 目的：提供用于预防或治疗老化相关疾病的药物组合物和筛选结合抑制剂的方法，以有效治疗或预防由progerin引起的疾病，并具体选择抑制progerin和lamin A之间结合的药物。构成：A 提供化学式1或2的化合物或其药学上可接受的盐。 用于预防或治疗老化相关疾病的药物组合物含有化学式1或2的化合物或其药学上可接受的盐作为活性成分。 用于筛选治疗老化相关疾病的治疗剂的方法包括选择抑制脯氨酸和lamin lamin A之间结合的候选药物的步骤。
-
公开(公告)号：KR101304032B1
公开(公告)日：2013-09-04
申请号：KR1020130015691
申请日：2013-02-14
Applicant: 충남대학교산학협력단
Abstract: PURPOSE: A production method of an environment-friendly edible film is provided to mix a specific plasticizer with an excellent physical property and a cross-linking agent with persimmon skin for producing the edible film. CONSTITUTION: Persimmon skin is finely cut, and a persimmon skin solution is produced. A plasticizer and a cross-linking agent are mixed with the persimmon skin solution to obtain a persimmon skin film solution. The persimmon skin solution is coated into a thickness of 0.1 mm, and dried. The cutting step is performed by using an autoclave, a homogenizer, and a high pressure homogenizer. 3-10 wt% of persimmon skin is added for the total amount of edible film. The persimmon skin solution is produced by the following steps: processing the persimmon skin using the autoclave at 100-140°C and in the pressure of 0.05-0.15 MPa for 15 minutes; and homogenizing the processed persimmon skin using the homogenizer for 5-30 minutes, and high pressure homogenizing the persimmon skin under 10,000-15,000 psi for 1-10 times. [Reference numerals] (AA) Collect persimmon skins produced during processing persimmons; (BB) Wash the persimmon skins with water and dry at 50°C for 48 hours; (CC) Pulverize the dried skins and select the powder of persimmon skins under the size of 80 mesh; (DD) Produce 5 weight% of a persimmon skin solution; (EE) Process the solution in a sterilizer at 121°C, 0.1 MPa for 15 minutes; (FF) Homogenize the solution in a homogenizer at 20,000 rpm; (GG) High-pressure Homogenize the solution in a high-pressure homogenizer at 13,000 psi for 20 minutes; (HH) Remove bubbles; (II) Add 1.5 weight% cane sugar; (JJ) Add 0.01 weight% of cinnamon aldehyde; (KK) Stir the solution for 1 hour; (LL) Divide the solution at the thickness of 0.1 mm on a module; (MM) Dry at room temperature; (NN) Edible persimmon skin film
Abstract translation: 目的：提供一种环保食用膜的制造方法，以将具有优异物理性能的特定增塑剂与具有柿子皮的交联剂混合以制造可食用膜。 构成：柿子皮被切割，产生柿子皮肤溶液。 将增塑剂和交联剂与柿子皮肤溶液混合以获得柿子皮肤膜溶液。 将柿子皮肤溶液涂布成0.1mm的厚度，并干燥。 切割步骤通过使用高压釜，均化器和高压均化器进行。 加入3-10重量％的柿子皮可食用膜的总量。 通过以下步骤制备柿子皮肤溶液：使用高压釜在100-140℃和0.05-0.15MPa的压力下加工柿子皮肤15分钟; 并使用均化器将经加工的柿子皮均匀化5-30分钟，并在10,000-15,000psi下将柿子皮高压匀浆1-10次。 （参考编号）（AA）收集在加工柿子期间产生的柿子皮; （BB）用水冲洗柿子皮，50℃干燥48小时; （CC）粉碎干燥的皮肤，选择80目尺寸的柿子粉末; （DD）生产5重量％的柿子皮肤溶液; （EE）将溶液在121℃，0.1MPa下在灭菌器中处理15分钟; （FF）在均质器中以20,000rpm的速度均化溶液; （GG）高压将溶液在高压均化器中以13,000psi均化20分钟; （HH）去除气泡; （II）加入1.5重量％蔗糖; （JJ）加入0.01重量％的肉桂醛; （KK）搅拌溶液1小时; （LL）将模块上的厚度为0.1 mm的溶液分开; （MM）室温干燥; （NN）食用柿子皮膜
-
公开(公告)号：KR101162647B1
公开(公告)日：2012-07-04
申请号：KR1020100025588
申请日：2010-03-23
Applicant: 충남대학교산학협력단
IPC: A61K31/122 , A61P9/00
Abstract: 본 발명은 5,8-디메톡시-1,4-나프토퀴논 (5,8-Dimethxy-1,4-naphthoquinone, DMNQ) 의 유도체인 2-치환-5,8-디메톡시-1,4-나프토퀴논(2-substituted-5,8-dimethoxy-1,4-naphthoquinone) 화합물에 관한 것으로 상기 화합물은 혈소판 유래 성장인자(platelet derived growth factor, PDGF)를 억제함으로써 심혈관 질환의 예방 및 치료용 조성물로 유용하게 이용될 수 있다.
-
-
-
-
-
-
-
-
-
Search Results
45
records
(took 0.027 seconds)
