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公开(公告)号：KR100164460B1
公开(公告)日：1999-03-20
申请号：KR1019950033694
申请日：1995-10-02
IPC: C07F17/02
CPC classification number: C07F15/0093
Abstract: 다음 일반식(I)로 표시되는 신규한 고분자 백금 착화합물 및 그의 제조방법, 그리고 항암제로서의 그의 용도.
식 중 R, A, M, x, m 및 n은 상기 정의한 바와 같다.-
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Patent Agency Ranking
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公开(公告)号：KR1020010045493A
公开(公告)日：2001-06-05
申请号：KR1019990048800
申请日：1999-11-05
Applicant: 한국과학기술연구원
IPC: C07F9/00
CPC classification number: C07F9/65815
Abstract: PURPOSE: A temperature-sensitive cyclic phosphazene trimer and its manufacturing method are provided. CONSTITUTION: The method for manufacturing a temperature-sensitive cyclic phosphazene trimer of the formula (1) comprises the steps of: i) reacting alcohol of the formula (2) with 1.5 equivalent of sodium or hydride sodium in solvent such as THF, benzene, or toluene to obtain a compound of the formula (3); ii) adding 3-4 equivalents of the compound of the formula (3) to solution containing solvent; iii) reacting the mixture in solution having dry-ice and acetone for 2-4 hours and for 10-12 hours at room temperature to obtain an intermediate of the formula (5); iv) reacting the intermediate in solution containing solvent such as triethylamine for 2-4 hours at room temperature and 40-60 deg.C for 1-3 days; and v) centrifuging the solution, eliminating sediments, and purifying the product. In the formula, R is an ethyl or benzyl group. m is an integer of 2, 7, 2, or 16. n is an integer of 0, 1, or 3.
Abstract translation: 目的：提供温度敏感的环磷腈三聚体及其制备方法。 构成：制备式（1）的温度敏感的环磷腈三聚体的方法包括以下步骤：i）使式（2）的醇与1.5当量的钠或氢化钠在溶剂如THF，苯， 或甲苯，得到式（3）的化合物; ii）向含溶剂的溶液中加入3-4当量的式（3）化合物; iii）使混合物在干冰和丙酮溶液中反应2-4小时，并在室温下反应10-12小时，得到式（5）的中间体; iv）使中间体在含溶剂如三乙胺的溶液中在室温和40-60℃下反应1-4天; 和v）离心溶液，消除沉淀物并净化产物。 在该式中，R是乙基或苄基。 m是2，7，2或16的整数.n是0,1或3的整数。
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公开(公告)号：KR1020000061648A
公开(公告)日：2000-10-25
申请号：KR1019990010847
申请日：1999-03-29
Applicant: 한국과학기술연구원
IPC: A61K33/24
Abstract: PURPOSE: A saccharide-platinum(II) complex anti-cancer drug is provided, inwhich platinum(II) complex is bound to a saccharide, so platinum(II) complex can act on cancer cells easily, so shows good anti-cancer effect and good solubility to water. CONSTITUTION: A process for the preparation of β-galactose-platinum(II) complex anti-cancer drug comprises of: dissolving lactonolactone in dimethylsulfoxide, and reacting with 1,4-diaminobutane for 2hrs at 60°C to get N-aminobutyl-O-β-D-galactopyranosyl-(1->4)-D-gluconeamide; dissolving 2-carboxyamidobenzylglutamate in DMF, maintaining the solution at 5°C, and adding isobutylchloroformate(IBCF) and tributylamine; reacting the solution for 15minutes at 5°C, adding the N-aminobutyl-O-β-D-galactopyranosyl-(1->4)-D-gluconeamide and reacting for 45minutes at 5°C, and for 2hrs at room temperature, concentrating under vacuum, and precipitating after pouring diethylether; filtering and drying, eliminating benzyl branch, precipitating in ether, filtering and drying; dissolving in methanol, adding Ba(OH)2 to get precipitates; dissolving in distilled water, adding (DACH)PtSO4, and reacting for 4hrs; filtering the BaSO4 precipitates, freeze-drying the filtered solution to get the objective product.
Abstract translation: 目的：提供一种糖 - 铂（II）复合抗癌药物，其中铂（II）配合物与糖结合，因此铂（II）络合物可以容易地作用于癌细胞，因此显示出良好的抗癌作用和 对水的溶解度好。 构成：制备β-半乳糖 - 铂（II）复合抗癌药物的方法包括：将内酯内酯溶解在二甲基亚砜中，并在60℃下与1,4-二氨基丁烷反应2小时，得到N-氨基丁基-O -β-D-吡喃半乳糖（1-> 4）-D-gluconeamide; 将2-羧酰氨基苄基谷氨酸盐溶解在DMF中，保持溶液在5℃，并加入氯甲酸异丁酯（IBCF）和三丁胺; 在5℃下使该溶液反应15分钟，加入N-氨基丁基-O-β-D-吡喃半乳糖基 - （1-> 4）-D-葡糖胺并在5℃下反应45分钟，并在室温下反应2小时， 在真空下浓缩，倒入二乙醚后沉淀; 过滤干燥，消除苄支，在乙醚中沉淀，过滤干燥; 溶于甲醇，加入Ba（OH）2得到沉淀物; 溶于蒸馏水，加入（DACH）PtSO4，反应4小时; 过滤BaSO4沉淀，冷冻干燥过滤溶液得到目标产物。
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公开(公告)号：KR100239682B1
公开(公告)日：2000-01-15
申请号：KR1019970061454
申请日：1997-11-20
Applicant: 한국과학기술연구원
IPC: A23K1/16
Abstract: 본 발명에 따라, 피콜린산크롬(+3)이 균질하게 혼합된 동물사료 첨가용 조성물이 제공된다. 본 발명에 따라 중간희석제로서 미세한 식품규격의 금속 산화물에 피콜린산크롬(+3) 원제분말을 먼저 혼합하여 중간혼합물을 형성한 다음 이를 운반체로서 석회석, 제올라이트, 또는 벤토나이트와 혼합함으로써, 피콜린산이 균일하게 분산된 조성물을 얻을 수 있다.
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公开(公告)号：KR1019970010594B1
公开(公告)日：1997-06-28
申请号：KR1019930021558
申请日：1993-10-16
Applicant: 한국과학기술연구원
IPC: C07F17/02
CPC classification number: C07F15/0093
Abstract: The invention concerns compounds of formula (1) wherein R stands for methyl or ethyl and stands for prophylene, butylene or pentylene in the case of ring shape formed by bonding two R's; A and A' stand for ammonia, methylamine, isoprophylamine, cycloprophylamine, cyclobutylamine, cyclopentylamine and cyclohexylamine and trans-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-prophanediamine,1,1-cyclobutanediamine, ethylenediamine, 1,1-cyclopentandimethaneamine, 1,1-cyclohexanediamine and stands for terahydro-4H-piran-4,4-dimethaneamine in the case of a chelate form. A platinum chelate compound is produced by reacting a alkali metal and a platinum nitrate derivative or a platinum nitrate derivative of which mole ratio is 1 : 1 by using water as a solvent , followed by condensing and precipitating.
Abstract translation: 本发明涉及式（1）的化合物，其中R代表甲基或乙基，代表通过键合两个R而形成环形的情况下的亚芳基或亚丁基; A和A'代表氨，甲胺，异丙胺，环丙胺，环丁胺，环戊胺和环己胺，反式-1,2-二氨基环己烷，2,2-二甲基-1,3-正己二胺，1,1-环丁烷二胺，乙二胺， 在一种螯合形式的情况下，1-环戊烷二甲烷，1,1-环己烷二胺代替三氢-4H-吡喃-4,4-二甲胺。 通过使用水作为溶剂使碱金属和硝酸铂衍生物或摩尔比为1：1的硝酸铂衍生物反应，然后冷凝和沉淀来制备铂螯合化合物。
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