Abstract:
The invention concerns compounds of formula (1) wherein R stands for methyl or ethyl and stands for prophylene, butylene or pentylene in the case of ring shape formed by bonding two R's; A and A' stand for ammonia, methylamine, isoprophylamine, cycloprophylamine, cyclobutylamine, cyclopentylamine and cyclohexylamine and trans-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-prophanediamine,1,1-cyclobutanediamine, ethylenediamine, 1,1-cyclopentandimethaneamine, 1,1-cyclohexanediamine and stands for terahydro-4H-piran-4,4-dimethaneamine in the case of a chelate form. A platinum chelate compound is produced by reacting a alkali metal and a platinum nitrate derivative or a platinum nitrate derivative of which mole ratio is 1 : 1 by using water as a solvent , followed by condensing and precipitating.
Abstract:
The organo tin malonate derivs. of formula (I) is prepd. by reacting the organo tin halide of formula (II) with the metalic salt of malonate derivs. of formula (III) in the presence of the solvent of halomethane, alcohol or water where pref. the temp. of reaction is -250 - 60 deg.C. Pref. the solvent is dichloro methane, chloro form, ethyl alcohol, methyl alcohol or water, or the mixt. of them. In the formulas, R is phenyl, cyclohexyl, n-butyl, 3-methoxy-3-oxopropyl, methyl, t-butyl, or Cl; x is 2 or 3; R' is thiomethoxy or methyl when non-ring substd. gp. is substd., or ethylene dithio, methylene ditho or acetylene ditho when ring substd. gp. is substd.
Abstract:
흡음구조체및 그제조방법에관한것이다. 본흡음구조체는흡음구조체의두께방향으로길이방향이서로어긋나게배열된제1 소자들을포함하고, 제1 내부채움밀도를가지며, 제1 주파수대역의음파를흡수하는제1 흡음층및 1 흡음층상에배치되고, 제1 내부채움밀도와다른제2 내부채움밀도를가지며, 제1 주파수대역과다른제2 주파수대역의음파를흡수하는제2 흡음층;을포함한다.
Abstract:
PURPOSE: Anticancer (iv) complexes excellent in lipoid solubility when orally administered and absorbable in the stomach and the intestinal and process for preparation thereof by oxidizing diamine platinum complexes with hydrogen oxide and carrying out an electrophilic substitution reaction of four hydroxyl groups of the obtained diaminetetrahydroxyplatinum are provided which exhibit excellent anticancer effect. CONSTITUTION: Platinum complexes for oral administration represented by the structural formula (I) are prepared. In formula A-A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(+/-)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.