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公开(公告)号：KR100362941B1
公开(公告)日：2002-11-30
申请号：KR1019990017558
申请日：1999-05-17
Applicant: 한국과학기술연구원
IPC: A61K31/335
Abstract: 본발명은유효량의헤마테인을함유하는고지혈증및 동맥경화증예방및 치료용조성물에관한것으로, 본발명의조성물은의약용및 식품용조성물을포함한다. 헤마테인은 LDL-항산화제활성을나타내며, 혈중콜레스테롤을현저하게감소시키고, 간마이크로좀 ACAT 활성을강력하게저해하므로, 헤마테인을함유하는본 발명의조성물은고지혈증및 동맥경화증의치료및 예방을위해유용하게사용될수 있다.
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公开(公告)号：KR100270909B1
公开(公告)日：2000-10-16
申请号：KR1019990024334
申请日：1999-06-25
Applicant: 한국과학기술연구원
IPC: A61K31/09
Abstract: PURPOSE: Pregomisin having antagonistic activity on a platelet activating factor receptor isolated from Schisandrae fructus, a pharmaceutical composition containing the pregomisin, pharmaceutically acceptable carrier and excipient and their use are provided. Therefore, the composition can be used for treatment and prevention of inflammatory disease related to a platelet activating factor receptor. CONSTITUTION: An antagonist on a platelet activating factor receptor contains pregomisin of formula 2 isolated from Schisandrae fructus as an effective component. A pharmaceutical composition for treatment and prevention of inflammatory disease related to a platelet activating factor contains the pregomisin, a pharmaceutically acceptable carrier and excipient.
Abstract translation: 目的：提供了对从五味子分离的血小板活化因子受体具有拮抗活性的前莫西沙星，含有前莫西沙星，药学上可接受的载体和赋形剂的药物组合物及其用途。 因此，该组合物可用于治疗和预防与血小板激活因子受体相关的炎性疾病。 构成：血小板活化因子受体上的拮抗剂含有从五味子中分离出的式2的前列决标作为有效成分。 用于治疗和预防与血小板活化因子相关的炎性疾病的药物组合物含有前莫西星，药学上可接受的载体和赋形剂。
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公开(公告)号：KR1020000001978A
公开(公告)日：2000-01-15
申请号：KR1019980022501
申请日：1998-06-16
Applicant: 한국과학기술연구원
IPC: C07H21/00
Abstract: PURPOSE: A compound, tylinoside, having an anticomplement activity is isolated from Magnolia flos and the structure thereof is examined by spectroscopy. CONSTITUTION: Tylinoside of formula (I) is isolated from Magnolia floes and the pharmaceutical composition, containing the isolated compound of formula (I) as an effective ingredient of complement activity regulating agent, is prepared. Thus, Magnolia flos is crushed and extracted with methanol and the filtrated liquid is vacuum concentrated, suspended in distilled water, and extracted with ethylacetate. The extracts are fractionated with silica gel column chromatography to isolate the tylinoside of formula (I).
Abstract translation: 目的：从玉兰中分离出具有抗补体活性的化合物泰勒糖苷，通过光谱法检测其结构。 构成：制备式（I）的泰洛糖苷从玉兰絮状物中分离出来，制备含有分离的式（I）化合物作为补体活性调节剂的有效成分的药物组合物。 因此，将玉兰粉碎并用甲醇萃取，将滤液真空浓缩，悬浮于蒸馏水中，用乙酸乙酯萃取。 萃取液用硅胶柱色谱分离，分离出式（I）的泰勒糖苷。
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公开(公告)号：KR1019990015091A
公开(公告)日：1999-03-05
申请号：KR1019970036989
申请日：1997-08-01
Applicant: 한국과학기술연구원
IPC: A61K31/575 , A61P37/00
Abstract: 본 발명은 화학식 1, 화학식 2 및 화학식 3으로 표시되고, 항보체활성을 갖는 사포닌 또는 사포게닌 화합물중 최소한 한 개를 함유하는 보체활성 조절제 특히, 보체활성과 관련된 질환 치료제에 관한 것이다.
본 발명의 사포닌 또는 사포게닌 화합물은 진세노사이드 Ra
1 , 진세노사이드 Ra
2 , 진세노사이드 Rb
1 , 진세노사이드 Rb
2 , 진세노사이드 Rc, 진세노사이드 Rd, 진세노사이드 Re, 진세노사이드 Rf, 진세노사이드 Rg
1 , 진세노사이드 Rg
2 , 진세노사이드 Rh
1 , 진세노사이드 Rh
2 , 진세노사이드 Rh
4 , 진세노사이드 Ro, 및 올레아놀 산이다.-
公开(公告)号：KR100370884B1
公开(公告)日：2003-12-01
申请号：KR1019980022501
申请日：1998-06-16
Applicant: 한국과학기술연구원
IPC: C07H21/00
Abstract: PURPOSE: A compound, tylinoside, having an anticomplement activity is isolated from Magnolia flos and the structure thereof is examined by spectroscopy. CONSTITUTION: Tylinoside of formula (I) is isolated from Magnolia floes and the pharmaceutical composition, containing the isolated compound of formula (I) as an effective ingredient of complement activity regulating agent, is prepared. Thus, Magnolia flos is crushed and extracted with methanol and the filtrated liquid is vacuum concentrated, suspended in distilled water, and extracted with ethylacetate. The extracts are fractionated with silica gel column chromatography to isolate the tylinoside of formula (I).
Abstract translation: 目的：从Magnolia flos分离具有抗补体活性的化合物，tylinoside，并通过光谱检查其结构。 构成：从Magnolia絮凝物中分离式（I）的Tylinoside，并制备含有分离的式（I）化合物作为补体活性调节剂的有效成分的药物组合物。 因此，将白玉兰花粉碎并用甲醇萃取，将过滤的液体真空浓缩，悬浮于蒸馏水中，并用乙酸乙酯萃取。 将提取物用硅胶柱色谱分离以分离式（I）的泰瑞诺苷。
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Patent Agency Ranking
公开(公告)号：KR100328478B1
公开(公告)日：2002-09-04
申请号：KR1019980043424
申请日：1998-10-17
Applicant: 한국과학기술연구원
Abstract: 본 발명은 항천식 효능을 가지는 신이 (
Magnoliae flos ) 추출물 및 신이로부터 분리한 리그난 화합물에 관한 것으로, 신이를 유기용매로 추출하여 얻어지는 본 발명의 신이 추출물 및 이로부터 분리되는 하기 화학식 1 내지 화학식 4의 리그난 화합물은 천식의 예방제, 치료제 및 치료보조제를 비롯한 항천식 효능제로 유용하게 사용될 수 있다.
[화학식 1]
[화학식 2]
[화학식 3]-
公开(公告)号：KR100302063B1
公开(公告)日：2001-10-26
申请号：KR1019970036989
申请日：1997-08-01
Applicant: 한국과학기술연구원
IPC: A61K31/575 , A61P37/00
Abstract: PURPOSE: A complement activity controlling agent containing at least one of ginseng saponin or sapogenin compounds capable of being produced by extracting, separating or purifying ginseng or red ginseng and a therapeutic agent associated with complement activity is provided which can be effectively used for treatment of various diseases such as asthma, allergy, atopic dermatitis or the like. CONSTITUTION: The complement activity-controlling agent contains at least one of ginseng saponin or sapogenin compounds represented by the formula 1. The saponin or sapogenin compounds are ginsenoside Ra1, ginsenoside Ra2, ginsenoside Rb1, ginsenoside Rb2, ginsenoside Rc, ginsenoside Rd, ginsenoside Re, ginsenoside Rf, ginsenoside Rg1, ginsenoside Rg2, ginsenoside Rh1, ginsenoside Rh2, ginsenoside Rh4, ginsenoside R0 and olenolic acid.
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18.发明公开
公开(公告)号：KR1020000026053A
公开(公告)日：2000-05-06
申请号：KR1019980043425
申请日：1998-10-17
Applicant: 한국과학기술연구원
CPC classification number: A61K36/57 , A61K31/34 , A61K2236/33 , A61K2236/51
Abstract: PURPOSE: A lignan compound isolated from magnolia floss or extract of magnolia floss having excellent inhibition activity for generation of leukotrienes is provided, which can be used as a medicine for various inflammatory disease like as asthma, whooping cough, arthritis, septic shock, ischemia, allergic rhinitis related with activity of leukotrienes. CONSTITUTION: A lignan compound is gained by the process of: extracting from magnolia floss using primary alcohol like as methanol; concentration; adding distilled water and hexane; isolating hexane layer; concentrating and adding ethylacetate; isolating ethylacetate layer; concentrating and separating by silicagel column chromatography; gaining dimethoxy aschantin of formula 1, aschantin of formula 2, fargesin from 8th part, and gaining pinoresinol dimethyl ether of formula 4, mandolin, liroresinol-B-dimethyl ether and (+)-epimandolin A from 11th part using reverse-phase silicagel column chromatography and high speed liquid column chromatography repeatedly.
Abstract translation: 目的：提供从木兰中分离的木脂素化合物或具有优异的白三烯产生抑制活性的木兰提取物，其可用作各种炎性疾病如哮喘，百日咳，关节炎，败血性休克，缺血， 过敏性鼻炎与白细胞三烯的活性有关。 构成：通过以下方法获得木脂素化合物：使用伯醇如甲醇从木兰提取; 浓度; 加入蒸馏水和己烷; 分离己烷层; 浓缩并加入乙酸乙酯; 分离乙酸乙酯层; 通过硅胶柱色谱法浓缩和分离; 获得式1的二甲氧基香豆素，式2的as子，第8部分的法尔金，第11部分使用反相硅胶柱，得到第4部分的式4的曼诺替林，间苯二酚-b-二甲醚和（+） - 表雌激素A 色谱法和高速液相色谱法反复进行。
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19.发明公开(20S)-진세노사이드Rg3및/또는진세노사이드Rg5을함유하는,혈소판활성화인자수용체결합에대한길항제 失效（20S） - 岩藻酰胺Rg3和/或人参皂苷Rg5，它是血小板活化因子受体结合的拮抗剂
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