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公开(公告)号：KR101347303B1
公开(公告)日：2014-01-06
申请号：KR1020110009687
申请日：2011-01-31
Applicant: 한미사이언스 주식회사 , 한국과학기술연구원 , 가톨릭대학교 산학협력단
Inventor： 손정범 , 정승현 , 최화일 , 정영희 , 최재율 , 송지연 , 이규항 , 이재철 , 김은영 , 안영길 , 김맹섭 , 최환근 , 심태보 , 함영진 , 박동식 , 김환 , 김동욱
IPC: C07D495/04 , A61K31/519 , A61P35/00
CPC classification number: C07D495/04
Abstract: 본 발명에 따르는 신규한 티에노[3,2-d]피리미딘 유도체, 이의 약학적으로 허용가능한 염, 수화물 또는 용매화물은 단백질 키나아제에 대한 저해 활성이 우수하며, 이를 포함하는 약학적 조성물은 비정상 세포 성장 질환의 예방제 또는 치료제로서 효과가 우수하다.
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公开(公告)号：KR101147550B1
公开(公告)日：2012-05-17
申请号：KR1020090100867
申请日：2009-10-22
Applicant: 한국과학기술연구원
IPC: C07D495/04 , C07D495/02 , A61K31/505 , A61P35/00
CPC classification number: C07D495/04 , C07D519/00
Abstract: Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.
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公开(公告)号：KR1020110019584A
公开(公告)日：2011-02-28
申请号：KR1020090077185
申请日：2009-08-20
Applicant: 한국과학기술연구원
IPC: C07D209/04 , C07D403/04 , A61K31/40 , A61P29/00
CPC classification number: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/14
Abstract: PURPOSE: A 1,3,6-substituted indole compound having an activity of suppressing protein kinase is provided to suppress various protein kinases and to prevent and treat abnormal cell growth diseases. CONSTITUTION: A 1,3,6-substituted indole compound is denoted by chemical formula 1. A pharmaceutical composition contains 1,3,6-substituted indole compound of chemical formula 1 as an active ingredient. The pharmaceutical composition prevents and treats abnormal cell growth diseases through protein kinase suppression mechanism selected from Raf, KDR, Fms, Tie2, SAPK2a, Ret, Abl, Abl(T315I), ALK, Aurora A, Bmx, CDK/cyclinE, Kit, Src, EGFR, EphA1, FGFR3, Flt3, Fms, IGF-1R, IKKb, IR, Itk, JAK2, KDR, Met, mTOR, PDGFRa, Plk1, Ret, Syk, Tie2, and TrtB. An agent for preventing and treating tumor contains 1,3,6-substituted indole compound of chemical formula 1.
Abstract translation: 目的：提供具有抑制蛋白激酶活性的1,3,6-取代的吲哚化合物以抑制各种蛋白激酶并预防和治疗异常的细胞生长疾病。 构成：1,3,6-取代的吲哚化合物由化学式1表示。药物组合物含有化学式1的1,3,6-取代的吲哚化合物作为活性成分。 药物组合物通过选自Raf，KDR，Fms，Tie2，SAPK2a，Ret，Abl，Abl（T315I），ALK，Aurora A，Bmx，CDK / cyclinE，Kit，Src的蛋白激酶抑制机制预防和治疗异常细胞生长疾病 ，EGFR，EphA1，FGFR3，Flt3，Fms，IGF-1R，IKKb，IR，Itk，JAK2，KDR，Met，mTOR，PDGFRa，Plk1，Ret，Syk，Tie2和TrtB。 用于预防和治疗肿瘤的药物含有化学式1的1,3,6-取代的吲哚化合物。
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Patent Agency Ranking
公开(公告)号：KR101672975B1
公开(公告)日：2016-11-04
申请号：KR1020140083248
申请日：2014-07-03
Applicant: 한국과학기술연구원
Abstract: 본발명은알로스테릭 PLK1-PBD 저해활성을갖는신규고리형포스포펩티드화합물에관한것으로, 본발명의화합물은 PLK1-PBD 저해활성을가지므로항종양제로유용하다.
Abstract translation: 本发明涉及具有变构PLK1-PBD抑制活性的新型环状磷酸肽化合物。 本发明化合物具有PLK1-PBD抑制活性，可用作抗肿瘤剂。 本发明提供由化学式1表示的环状磷酸酯化合物，其水合物，其溶剂合物，异构体或外消旋体及其药学上可接受的盐。
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公开(公告)号：KR1020160004648A
公开(公告)日：2016-01-13
申请号：KR1020140083248
申请日：2014-07-03
Applicant: 한국과학기술연구원
Abstract: 본발명은알로스테릭 PLK1-PBD 저해활성을갖는신규고리형포스포펩티드화합물에관한것으로, 본발명의화합물은 PLK1-PBD 저해활성을가지므로항종양제로유용하다.
Abstract translation: 本发明涉及具有变构PLK1-PBD抑制活性的新型环状磷酸肽化合物。 本发明化合物具有PLK1-PBD抑制活性，可用作抗肿瘤剂。 本发明提供由化学式1表示的环状磷酸酯化合物，其水合物，其溶剂合物，异构体或外消旋体及其药学上可接受的盐。
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公开(公告)号：KR101088827B1
公开(公告)日：2011-12-06
申请号：KR1020100007674
申请日：2010-01-28
Applicant: 한국과학기술연구원
IPC: C07D207/46 , C07D207/00
Abstract: 본 발명은 광학활성 1,4-디데옥시-1,4-이미노-아라비니톨의 제조방법에 관한 것으로, 더욱 상세하게는 상업적으로 쉽게 구입이 가능한
N- 보호된 아지리딘일메탄올 화합물을 출발물질로 사용하고, 광학활성 락탐 화합물을 반응 중간체로 합성하는 새로운 경로를 통하여 광학활성 1,4-디데옥시-1,4-이미노-아라비니톨을 보다 용이하게 합성하는 신규 제조방법에 관한 것이다.-
公开(公告)号：KR1020110088960A
公开(公告)日：2011-08-04
申请号：KR1020100008720
申请日：2010-01-29
Inventor： 정승현 , 정영희 , 최화일 , 손정범 , 전은주 , 양인호 , 송태헌 , 이미경 , 고명실 , 안영길 , 김맹섭 , 함영진 , 심태보 , 최환근 , 하정미 , 박동식 , 김환
IPC: C07D487/04 , C07D495/04 , A61K31/519 , A61P43/00
CPC classification number: C07D495/04
Abstract: PURPOSE: A bicyclic derivative having an activity of suppressing protein kinase is provided to prevent and treat abnormal cell growth diseases. CONSTITUTION: A bicyclic heteroaryl derivative with an activity of suppressing protein kinase has a structure of chemical formula 1. A pharmaceutical composition for preventing and treating abnormal cell growth disease due to excessive activation of protein kinase contains the compound of chemical formula 1 as an active ingredient.
Abstract translation: 目的：提供具有抑制蛋白激酶活性的双环衍生物，以预防和治疗异常细胞生长疾病。 构成：具有抑制蛋白激酶活性的双环杂芳基衍生物具有化学式1的结构。用于预防和治疗由蛋白激酶过度激活引起的异常细胞生长疾病的药物组合物含有化学式1的化合物作为活性成分 。
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公开(公告)号：KR1020110044053A
公开(公告)日：2011-04-28
申请号：KR1020090100867
申请日：2009-10-22
Applicant: 한국과학기술연구원
IPC: C07D495/04 , C07D495/02 , A61K31/505 , A61P35/00
CPC classification number: C07D495/04 , C07D519/00
Abstract: PURPOSE: A 2,7-substituted thieno[3,2-d]pyrimidine compound is provided to ensure excellent effect of suppressing various protein kinases and to prevent and treat abnormal cell growth diseases. CONSTITUTION: A 2,7-substituted thieno[3,2-d]pyrimidine compound is denoted by chemical formula 1. A pharmaceutical composition contains the compound of chemical formula 1 as an active ingredient. The pharmaceutical composition is used for preventing and treating abnormal cell growth diseases through ALK, Aurora A, EphA1, FAK, Flt3, Fms, Itk, KDR, Kit, Met, Ret, Src, Syk, Tie2, or TrkB protein kinase suppression mechanism. An agent for preventing and treating tumor contains the compound of chemical formula 1 as an active ingredient.
Abstract translation: 目的：提供2,7-取代的噻吩并[3,2-d]嘧啶化合物，以确保抑制各种蛋白激酶和预防和治疗异常细胞生长疾病的优异效果。 构成：2,7-取代的噻吩并[3,2-d]嘧啶化合物由化学式1表示。药物组合物含有化学式1的化合物作为活性成分。 该药物组合物用于通过ALK，Aurora A，EphA1，FAK，Flt3，Fms，Itk，KDR，Kit，Met，Ret，Src，Syk，Tie2或TrkB蛋白激酶抑制机制预防和治疗异常细胞生长疾病。 用于预防和治疗肿瘤的药物含有化学式1的化合物作为活性成分。
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