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    대황 추출물 또는 이로부터 분리된 활성성분을 포함하는혈압 강하용 조성물
    11.
    发明授权
    대황 추출물 또는 이로부터 분리된 활성성분을 포함하는혈압 강하용 조성물 失效
    대황추출물또는이로부터분리된활성성분을포함하는혈압강강하하용조성물

    公开(公告)号：KR100732888B1

    公开(公告)日：2007-06-27

    申请号：KR1020050126879

    申请日：2005-12-21

    Applicant: 한국화학연구원

    Inventor： 김영섭 ,  유시용 ,  연규환 ,  이병호 ,  오광석 ,  서호원 ,  유미영 ,  이정원 ,  권대영

    IPC: A61K36/708 ,  A61K31/05 ,  A61P9/12

    Abstract: An anti-hypertensive composition comprising the extract of Rhei rhizoma or active compounds isolated therefrom is provided to induce smooth muscle relaxation of the blood vessel, so that the composition is useful for treatment of hypersensitive and hypersensitive complications. The anti-hypertensive composition comprises the extract of Rhei rhizoma or active compounds isolated therefrom including piceatannol represented by the formula(1), epsilon-viniferin represented by the formula(2), physcion represented by the formula(3) or emodin represented by the formula(4) as an effective ingredient. The Rhei rhizoma extract is prepared with an organic solvent of methanol, ethanol, butanol, dichloromethane or ethylacetate; and the active compounds are isolated from the Rhei rhizoma extract by subjecting the Rhei rhizoma extract to reverse phase or silica gel column chromatography.

    Abstract translation: 提供包含大黄提取物或从其中分离的活性化合物的抗高血压组合物，以诱导血管的平滑肌松弛，使得该组合物可用于治疗过敏和过敏性并发症。 该抗高血压组合物含有大黄提取物或由其分离的活性化合物，包括由式（1）表示的白皮素醇，由式（2）表示的ε-v草素，由式（3）表示的化合物或由 公式（4）作为有效成分。 大黄提取物用甲醇，乙醇，丁醇，二氯甲烷或乙酸乙酯等有机溶剂制备; 通过将大黄根茎提取物进行反相或硅胶柱色谱从大黄根提取物中分离活性化合物。

    목단피 추출물 또는 이로부터 분리된 활성성분을 포함하는 혈압강하용 조성물
    14.
    发明公开
    목단피 추출물 또는 이로부터 분리된 활성성분을 포함하는 혈압강하용 조성물 失效
    用于降低血压的组合物包含草药提取物或从其中分离出的活性成分

    公开(公告)号：KR1020070050998A

    公开(公告)日：2007-05-17

    申请号：KR1020050106005

    申请日：2005-11-07

    Applicant: 한국화학연구원

    Inventor： 김영섭 ,  유시용 ,  이병호 ,  오광석 ,  서호원 ,  유미영 ,  서지희 ,  이정원 ,  권대영

    IPC: A61K31/7048 ,  A61K36/65 ,  A61P9/12

    CPC classification number: A61K31/7048 ,  A23L2/52 ,  A23L29/035 ,  A23V2200/326 ,  A23V2200/3262 ,  A61K36/65 ,  A61K2236/55 ,  Y10S514/824 ,  Y10S514/912

    Abstract: 본 발명은 목단피(Moutan Cortex Radicis) 추출물, 옥시패오니플로린(oxypaeoniflorin), 패오니플로린(paeoniflorin), 메틸패오니플로린(methylpaeoniflorin) 또는 패오니다닌(paeonidanin)을 유효성분으로 함유하는 혈압강하용 조성물에 관한 것이다. 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압강하효과를 나타내므로 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계질환의 예방 및 치료를 위한 약학 조성물뿐만 아니라 식품첨가물로도 유용하게 사용될 수 있다.

    Abstract translation: 本发明mokdanpi（牡丹皮皮质Radicis）提取物，氧基大号污泥林（oxypaeoniflorin），L污泥林（芍药苷），甲基1-污泥林（methylpaeoniflorin）或L污泥行进（paeonidanin），用于降低血压，其包含作为活性成分的组合物 Lt。 根据本发明的组合物可以表现出优异的血压通过血管平滑肌松弛作用降低效果使用以及药物组合物，用于预防和治疗由于高血压和高血压并发症各种心血管疾病是作为食品添加剂也是有用的。

    당귀의 주성분인 데쿠르신으로부터 합성된 유도체인 데쿠시놀 벤조에이트를 이용한 비만예방용 또는 비만치료용 조성물
    15.
    发明公开
    당귀의 주성분인 데쿠르신으로부터 합성된 유도체인 데쿠시놀 벤조에이트를 이용한 비만예방용 또는 비만치료용 조성물 有权
    从韩国安哥拉提取的去甲苯酚苯甲酸酯的组合物，用于预防肥胖或治疗肥胖

    公开(公告)号：KR1020110125940A

    公开(公告)日：2011-11-22

    申请号：KR1020100045593

    申请日：2010-05-14

    Applicant: 한국식품연구원 ,  한국화학연구원

    Inventor： 권대영 ,  황진택 ,  양혜정 ,  김성희 ,  박재호 ,  김영섭 ,  유시용 ,  연규환

    IPC: A61K36/232 ,  A61K31/37 ,  A61P3/04 ,  A61P3/00

    CPC classification number: A61K36/232 ,  A61K31/216 ,  A61K31/235 ,  A61K31/366 ,  Y10S514/909

    Abstract: PURPOSE: A composition containing derivatives synthesized from decursin for preventing or treating obesity is provided to suppress fatty acid synthesis. CONSTITUTION: A composition for preventing or treating obesity contains decursinol benzoate which is synthedized from decursin. The decursinol benzoate suppresses fatty acid synthesis by AMPK(5' adenosine monophosphate-activated protein kinase) activity. A method for synthesizing decursinol benzoate comprises: a step of performing enfleurage of dried Angelicae gigantis Radix in methanol at room temperature for seven days and filtering; a step of suspending the methanol extract in distilled water and isolating dichloromethane; and a step of freeze-drying and performing silicagel column chromatography to prepare six fraction.

    Abstract translation: 目的：提供含有由前代素合成的用于预防或治疗肥胖症的衍生物的组合物以抑制脂肪酸合成。 构成：用于预防或治疗肥胖症的组合物含有由前胡素合成的去甲基苯甲酸酯。 苯酚去甲酚抑制AMPK（5'腺苷单磷酸激活蛋白激酶）活性的脂肪酸合成。 合成前酚醇苯甲酸酯的方法包括：在室温下在甲醇中进行七天的过滤干燥的当归香草， 将甲醇提取物悬浮在蒸馏水中并分离二氯甲烷的步骤; 和冷冻干燥并进行硅胶柱色谱以制备6份。

    삼백초 추출물 또는 이로부터 분리된 활성성분을 포함하는면역억제용 조성물
    18.
    发明公开
    삼백초 추출물 또는 이로부터 분리된 활성성분을 포함하는면역억제용 조성물 失效
    包含SAURURUS CHINENSIS或活性化合物的提取物的免疫组织化学物质分离

    公开(公告)号：KR1020070068689A

    公开(公告)日：2007-07-02

    申请号：KR1020050130601

    申请日：2005-12-27

    Applicant: 한국화학연구원 ,  한국식품연구원

    Inventor： 고우석 ,  이성학 ,  최우혁 ,  김영섭 ,  유시용 ,  연규환 ,  유미영 ,  서지희 ,  권대영

    IPC: A61K31/34 ,  A61K31/36 ,  A61K36/78 ,  A61P37/06

    Abstract: A composition for immunosuppression comprising the extract of Saururus chinensis or active compounds isolated therefrom is provided to inhibit abnormal proliferation of B cell and T cell, so that the composition is useful for prevention and treatment of diseases caused by hypersensitive immune responses. The composition for immunosuppression comprises the extract of Saururus chinensis or an active compound isolated from the Saururus chinensis extract selected from (-)-saucerneol, saucerneol C, manassantin A, manassantin B and a mixture thereof as effective ingredient, wherein the Saururus chinensis extract is prepared by using an organic solvent selected from methanol, methanol solution, ethanol, ethanol solution, butanol, dichloromethane, ethylacetate and a mixture thereof. The composition is a pharmaceutical or health food composition. The pharmaceutical composition prevents or treats diseases caused by hypersensitive immune responses including organ transplant rejection, autoimmune disease including lupous erythematosus and rheumatoid arthritis, and allergy disease including rhinitis, asthma and atopic dermatitis, and the health food composition is formulated as drink.

    Abstract translation: 提供了包含中华黄牛提取物或从其分离的活性化合物的免疫抑制组合物以抑制B细胞和T细胞的异常增殖，使得该组合物可用于预防和治疗由过敏免疫应答引起的疾病。 用于免疫抑制的组合物包含中华黄牛提取物或从中选出的（ - ） - 沙美拉诺，沙门氏菌素C，马那敏蛋白A，他曼那丁B及其混合物中选择的中华黄瓜提取物作为有效成分分离的活性化合物，其中中华黄瓜提取物为 通过使用选自甲醇，甲醇溶液，乙醇，乙醇溶液，丁醇，二氯甲烷，乙酸乙酯及其混合物的有机溶剂制备。 该组合物是药物或保健食品组合物。 药物组合物预防或治疗由过敏免疫应答引起的疾病，包括器官移植排斥反应，自身免疫性疾病，包括红斑狼疮和类风湿性关节炎，以及过敏疾病，包括鼻炎，哮喘和特应性皮炎，健康食品组合物配制成饮料。

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