公开(公告)号：KR1020020008242A

公开(公告)日：2002-01-30

申请号：KR1020000041639

申请日：2000-07-20

Applicant: 한국화학연구원

Inventor： 박창식 ,  최은복 ,  김은숙 ,  최경자

IPC: C07D403/04

Abstract: PURPOSE: Provided is 3- or 5-amino 4-imidazolyl pyrazole derivatives which has selective bacteriocidal effect on plants. And method of preparing them and an antifungal composition comprising them for agriculture are also provided. CONSTITUTION: 3- or 5-amino 4-imidazolyl pyrazole derivatives are represented by the formula(1), wherein X is hydrogen, chloro group having 1-3 benzene rings, fluoro group having 1-3 benzene rings and C-C3 alkoxy group having 1-3 benzene cycles, nitro group, or phenyl group substituted or unsubstituted trihaloalkyl group; Y is C1-C3 alkyl group; hydrogen; chloro group having 1-3 benzene rings, fluoro group having 1-3 benzene rings, C1-C3 alkoxy group having 1-3 benzene rings, nitro group,or trihaloalkyl group substituted or unsubstituted benzyl group; or chloro group having 1-3 benzene rings, fluoro group having 1-3 benzene rings, C1-C3 alkoxy group having 1-3 benzene rings, nitro group,or trihaloalkyl group substituted or unsubstituted penethyl group; and R is C1-C4 alkyl group; hydrogen; or chloro group having 1-3 benzene rings, fluoro group having 1-3 benzene rings, C1-C3 alkyl group having 1-3 benzene rings, C-C4 alkoxy group having 1-3 benzene rings, nitro group,or trihaloalkyl group substituted or unsubstituted phenyl group.

Abstract translation: 目的：提供对植物具有选择性杀菌作用的3-或5-氨基-4-咪唑基吡唑衍生物。 还提供了制备它们的方法和包含它们用于农业的抗真菌组合物。 构成：3-或5-氨基-4-咪唑基吡唑衍生物由式（1）表示，其中X是氢，具有1-3个苯环的氯基，具有1-3个苯环的氟基和C-C3烷氧基 具有1-3个苯环，硝基或苯基取代或未取代的三卤代烷基; Y为C1-C3烷基; 氢; 具有1-3个苯环的氯基团，具有1-3个苯环的氟基团，具有1-3个苯环的C1-C3烷氧基，硝基或三卤代烷基取代或未取代的苄基; 或具有1-3个苯环的氯基，具有1-3个苯环的氟基，具有1-3个苯环的C1-C3烷氧基，硝基或三卤代烷基取代或未取代的乙基; 并且R是C 1 -C 4烷基; 氢; 或具有1-3个苯环的氯基，具有1-3个苯环的氟基，具有1-3个苯环的C1-C3烷基，具有1-3个苯环的C-C4烷氧基，硝基或三卤代烷基取代的 或未取代的苯基。

公开(公告)号：KR1020010017960A

公开(公告)日：2001-03-05

申请号：KR1019990033722

申请日：1999-08-16

Applicant: 한국화학연구원

Inventor： 김범태 ,  박노균 ,  김진철 ,  박창식

IPC: C07C207/00

Abstract: PURPOSE: Provided is a novel propenoic ester and amide compound being cross-linked by an oxime group and substituted by a fluorinated vinyl group. The novel compound has excellent sterilizability and a broad antibacterial activity. Also, its preparation method and a bactericide composition including these are provided. CONSTITUTION: A novel propenoic ester compound being cross-linked by an oxime group and substituted by a fluorinated vinyl group is represented by the formula (1), wherein X is CH or N ; Y is O or NH ; R1 is hydrogen, C1-4 alkyl or C1-4 alkyl substituted with halogen ; and R2 is phenyl, C1-4 alkyl,, C1-4 alkyl substituted with halogen, C1-4 alkoxy, methylenedioxy, phenyl in which more than one group is substituted with halogen or naphthalene. The novel propenoic ester compound is prepared by reacting a brominated compound of the formula (2) and an oxime compound of the formula (3) in the presence of a base, to obtain compound of the formula (4); debenzylating the resultant compound, to obtain phenolic ester compound of the formula (5); and reacting the resultant compound with a fluorinated vinyl compound of the formula (6) in the presence of a base.

Abstract translation: 目的：提供一种新的丙烯酸酯和酰胺化合物，通过肟基交联并被氟化乙烯基取代。 该新型化合物具有优异的灭菌性和广泛的抗菌活性。 此外，还提供了其制备方法和包括这些的杀菌剂组合物。 构成：通过肟基交联并被氟代乙烯基取代的新型丙烯酸酯化合物由式（1）表示，其中X为CH或N; Y是O或NH; R1是氢，C1-4烷基或被卤素取代的C1-4烷基; 和R 2是苯基，C 1-4烷基，被卤素取代的C 1-4烷基，C 1-4烷氧基，亚甲二氧基，其中多于一个基团被卤素或萘取代的苯基。 通过使式（2）的溴化化合物与式（3）的肟化合物在碱的存在下反应制备新的丙烯酸酯化合物，得到式（4）的化合物; 将所得化合物脱苄化，得到式（5）的酚酯化合物; 并使所得化合物与式（6）的氟化乙烯基化合物在碱的存在下反应。

公开(公告)号：KR100270599B1

公开(公告)日：2000-11-01

申请号：KR1019980041817

申请日：1998-10-07

Applicant: 한국화학연구원

Inventor： 박창식 ,  최은복 ,  김은숙 ,  최경자

IPC: C07C251/48

Abstract: 본 발명은 메톡시아크릴레이트 또는 메톡시이미노 아세테이트 유도체, 그의 제조 방법 및 그를 이용한 살균제 조성물에 관한 것이다. 이 유도체 화합물은 하기 화학식 1을 갖고, 아미노산이 치환된 옥심을 갖는다. 이 화합물을 포함하는 살균제 조성물은 내성균을 비롯한 식물 병원균에 대해 광범위한 살균효과를 가지고, 식물에 침투 효과 뿐만 아니라 질병 예방 및 치료 효과가 뛰어나며, 기타 성분과 함께 광범위한 식물 병원균에 대해 사용될 수 있다.
[화학식 1]

상기 식에서,
R
1 는 수소, C
1 -C
3 알킬기, C
1 -C
3 알킬티오- 또는 알킬설폰-치환된 알킬기, 페닐기, 또는 벤질기이고; R
2 은 C
1 -C
5 알킬기이고; X는 벤질옥시, C
1 -C
3 알콕시, C
1 -C
3 알킬기, 1 내지 3개의 클로로 또는 플루오로, C
1 -C
3 트리할로알킬기, 또는 C
1-3 알킬 또는 알콕시-치환되거나 치환되지 않은 페녹시기이고; Z는 CH 또는 N 이다.

公开(公告)号：KR100124946B1

公开(公告)日：1997-12-08

申请号：KR1019930011382

申请日：1993-06-22

Applicant: 한국화학연구원

Inventor： 박창식 ,  최은복 ,  연규환 ,  양희철 ,  이현규 ,  이계형 ,  이진표 ,  최경자

IPC: C07D215/42 ,  C07D215/20 ,  C07H17/04

CPC classification number: C07D401/12 ,  A01N43/42 ,  A01N43/50 ,  A01N43/90 ,  A01N55/00 ,  C07D215/42 ,  C07D221/10 ,  C07D405/12 ,  C07D409/12 ,  C07D491/04 ,  C07F7/0812

Abstract: 4-Alkylsulfoxy-2-quinolinon(ii) and HNR6R7(iii) were reacted in the presence of inactive solvent such as diethylether, diisopropylether, tetrahydrofurane, benzene, toluene, dichloroethane, chloroform,ethylacetate, ethylpropionate, chlorobenzene at 0-260 deg.C for 0.5-24hr to give(I) which is useful for herbicide and insecticide.In formula R1-4=h, allyl or allyloxy, C1-10 aralkyl or alkyl, R6=H or C1-5 alkyl, alkoxyalkyl, phenylacetyl or (R19)Si, R17-18=H or C1-5 alkyl,or-T-(CH2)-T Y=O,S Z=hetero ring, T=O,S, R20=C1-3 alkyl, m,n,p,q,r=1-4, R21=C1-3 alkyl.

Abstract translation: 在惰性溶剂如乙醚，二异丙基醚，四氢呋喃，苯，甲苯，二氯乙烷，氯仿，乙酸乙酯，丙酸乙酯，氯苯在0-260度的存在下，使4-烷基亚磺酰基-2-喹啉酮（ⅱ）和HNR6R7（ⅲ） 在式R1-4 = h中，烯丙基或烯丙氧基，C 1-10芳烷基或烷基，R 6 = H或C 1-5烷基，烷氧基烷基，苯乙酰基或 （R19）Si，R17-18 = H或C1-5烷基或-T-（CH2）-TY = O，SZ =杂环，T = O，S，R20 = C1-3烷基，m， p，q，r = 1-4，R 21 = C 1-3烷基。

公开(公告)号：KR100070672B1

公开(公告)日：1994-02-03

申请号：KR1019910005391

申请日：1991-04-03

Applicant: 한국화학연구원

Inventor： 박창식 ,  최은복 ,  양희철 ,  연규환 ,  이계형 ,  이현규 ,  김성기 ,  이연수 ,  이광우 ,  김흥태

IPC: C07D215/22

公开(公告)号：KR1019920019754A

公开(公告)日：1992-11-19

申请号：KR1019910005391

申请日：1991-04-03

Applicant: 한국화학연구원

Inventor： 박창식 ,  최은복 ,  양희철 ,  연규환 ,  이계형 ,  이현규 ,  김성기 ,  이연수 ,  이광우 ,  김흥태

IPC: C07D215/22

Abstract: 내용 없음

公开(公告)号：KR100054014B1

公开(公告)日：1992-08-22

申请号：KR1019890018670

申请日：1989-12-15

Applicant: 한국화학연구원

Inventor： 박창식 ,  윤인권

IPC: C07C25/08 ,  C07C25/02

公开(公告)号：KR101335458B1

公开(公告)日：2013-12-10

申请号：KR1020110000445

申请日：2011-01-04

Applicant: 국립암센터 ,  한국화학연구원

Inventor： 정경채 ,  김선신 ,  안경옥 ,  최은복 ,  이현규 ,  양희철 ,  박창식

IPC: A61K31/4704 ,  A61K31/47 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K31/47

Abstract: 본 발명은 백혈병 치료용 약학조성물에 관한 것으로, 보다 상세하게는 4- 퀴놀린온 유도체를 포함하는 Myc 단백질 활성 저해제 및 상기 4- 퀴놀린온 유도체를 유효성분으로 하는 암 치료용 약학조성물로, 상기 본 발명에 따른 백혈병 치료용 약학조성물은 Myc/Max/DNA의 콤플렉스(complex) 형성을 억제시켜 세포주기정지(cell cycle arrest)를 유도함으로써 다양한 인체 백혈병 세포주의 증식을 억제할 수 있어, 백혈병을 예방 및 치료하는데 유용하게 사용될 수 있는 장점이 있다.

公开(公告)号：KR1020100123937A

公开(公告)日：2010-11-26

申请号：KR1020090042909

申请日：2009-05-18

Applicant: 원광대학교산학협력단 ,  한국화학연구원

Inventor： 박현 ,  박창식 ,  최은복 ,  이현규 ,  양희철

IPC: A01N43/42 ,  A01P5/00

CPC classification number: A01N43/42 ,  A01N25/06 ,  A01N43/84

Abstract: PURPOSE: An insecticide composition containing 4-quinolinone derivative compound is provided to ensure high insecticidal effect against Bursaphelenchus xylophilus. CONSTITUTION: An insecticide composition for preventing pest contains 4-quinolinone derivative compound of general formula I as an active ingredient. The pest is Bursaphelenchus xylophilus, Bursaphelenchus mucronatus, Bursaphelenchus fraudulentus Ruhm or Bursaphelenchus kolymensis Korenchenko. The insecticide composition is treated to insects or habitat of insects by spraying.

Abstract translation: 目的：提供含有4-喹啉酮衍生物化合物的杀虫剂组合物，以确保木麻黄的杀虫效果。 构成：用于防治害虫的杀虫剂组合物含有作为活性成分的通式I的4-喹啉酮衍生物化合物。 害虫是Bursaphelenchus xylophilus，Bursaphelenchus mucronatus，Bursaphelenchus fraudulentus Ruhm或Bursaphelenchus kolymensis Korenchenko。 杀虫剂组合物通过喷雾处理昆虫或昆虫栖息地。

公开(公告)号：KR1020080077889A

公开(公告)日：2008-08-26

申请号：KR1020070061580

申请日：2007-06-22

Applicant: 주식회사 앤씨비아이티 ,  한국화학연구원

Inventor： 정광회 ,  박창식 ,  홍성유 ,  강수정 ,  손영덕 ,  황재훈 ,  최은복 ,  연규환 ,  이현규 ,  양희철

IPC: A61K31/47 ,  A61P35/00

CPC classification number: A61K31/47

Abstract: A composition comprising a novel compound is provided to exhibit an IC50 value of less than 0.16muM for cancer cells to inhibit proliferation of the cancer cells efficiently, thereby showing therapeutic or prophylactic effect on the cancer. A pharmaceutical composition for preventing or treating cancer comprises a pharmaceutically effective amount of a compound represented by a formula(1) and a pharmaceutically acceptable carrier. In the formula(1), each R1, R2, R3, R4, R5, R6, and R7 is independently H, halo, hydroxy, cyano, amino, nitroso, carboxyl, C1-12 alkyl, C2-6 alkenyl, C3-8 cycloalkyl, C5-7 cycloalkenyl, C1-6 alkylamino, C1-6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl or alkylaryl; each X and Y is independently O or S; Z is H, halo, hydroxy, cyano, amino, nitro, nitroso, carboxyl, C1-12 alkyl, C2-6 alkenyl, C3-8 cycloalkyl, C5-7 cycloalkenyl, C1-6 alkylamino, C1-6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl, alkylaryl or -NH-R8; R8 is H, halo, hydroxy, cyano, amino, nitro, nitroso, carboxyl, C1-12 alkyl, C2-6 alkenyl, C3-8 cycloalkyl, C5-7 cycloalkenyl, C1-6 alkylamino, C1-6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl, or alkylaryl; and n is an integer from 0 to 3.

Abstract translation: 提供包含新化合物的组合物，以显示癌细胞的IC 50值小于0.16muM，以有效抑制癌细胞的增殖，从而显示对癌症的治疗或预防效果。 用于预防或治疗癌症的药物组合物包含药学有效量的由式（1）表示的化合物和药学上可接受的载体。 在式（1）中，每个R 1，R 2，R 3，R 4，R 5，R 6和R 7独立地为H，卤素，羟基，氰基，氨基，亚硝基，羧基，C 1-12烷基，C 2-6烯基， 8环烷基，C 5-7环烯基，C 1-6烷基氨基，C 1-6烷氧基，芳基，杂芳基，芳基烷基，芳基烯基或烷基芳基; 每个X和Y独立地是O或S; Z是H，卤素，羟基，氰基，氨基，硝基，亚硝基，羧基，C 1-12烷基，C 2-6烯基，C 3-8环烷基，C 5-7环烯基，C 1-6烷基氨基，C 1-6烷氧基，芳基， 杂芳基，芳基烷基，芳基烯基，烷基芳基或-NH-R8; R8是H，卤素，羟基，氰基，氨基，硝基，亚硝基，羧基，C1-12烷基，C2-6烯基，C3-8环烷基，C5-7环烯基，C1-6烷基氨基，C1-6烷氧基，芳基， 杂芳基，芳基烷基，芳基烯基或烷基芳基; n为0〜3的整数。